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Items: 26

1.

A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria.

Phillips MA, Lotharius J, Marsh K, White J, Dayan A, White KL, Njoroge JW, El Mazouni F, Lao Y, Kokkonda S, Tomchick DR, Deng X, Laird T, Bhatia SN, March S, Ng CL, Fidock DA, Wittlin S, Lafuente-Monasterio M, Benito FJ, Alonso LM, Martinez MS, Jimenez-Diaz MB, Bazaga SF, Angulo-Barturen I, Haselden JN, Louttit J, Cui Y, Sridhar A, Zeeman AM, Kocken C, Sauerwein R, Dechering K, Avery VM, Duffy S, Delves M, Sinden R, Ruecker A, Wickham KS, Rochford R, Gahagen J, Iyer L, Riccio E, Mirsalis J, Bathhurst I, Rueckle T, Ding X, Campo B, Leroy D, Rogers MJ, Rathod PK, Burrows JN, Charman SA.

Sci Transl Med. 2015 Jul 15;7(296):296ra111. doi: 10.1126/scitranslmed.aaa6645.

2.

Molecular phenotyping of a UK population: defining the human serum metabolome.

Dunn WB, Lin W, Broadhurst D, Begley P, Brown M, Zelena E, Vaughan AA, Halsall A, Harding N, Knowles JD, Francis-McIntyre S, Tseng A, Ellis DI, O'Hagan S, Aarons G, Benjamin B, Chew-Graham S, Moseley C, Potter P, Winder CL, Potts C, Thornton P, McWhirter C, Zubair M, Pan M, Burns A, Cruickshank JK, Jayson GC, Purandare N, Wu FC, Finn JD, Haselden JN, Nicholls AW, Wilson ID, Goodacre R, Kell DB.

Metabolomics. 2015;11:9-26. Epub 2014 Jul 25.

3.

Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry.

Dunn WB, Broadhurst D, Begley P, Zelena E, Francis-McIntyre S, Anderson N, Brown M, Knowles JD, Halsall A, Haselden JN, Nicholls AW, Wilson ID, Kell DB, Goodacre R; Human Serum Metabolome (HUSERMET) Consortium.

Nat Protoc. 2011 Jun 30;6(7):1060-83. doi: 10.1038/nprot.2011.335.

PMID:
21720319
4.
5.

Metabonomic characterization of the 3-nitropropionic acid rat model of Huntington's disease.

Tsang TM, Haselden JN, Holmes E.

Neurochem Res. 2009 Jul;34(7):1261-71. doi: 10.1007/s11064-008-9904-5. Epub 2009 Jan 16.

PMID:
19148750
6.

Metabolic profiling as a tool for understanding mechanisms of toxicity.

Clarke CJ, Haselden JN.

Toxicol Pathol. 2008 Jan;36(1):140-7. doi: 10.1177/0192623307310947. Review.

PMID:
18337232
7.

A gender-specific discriminator in Sprague-Dawley rat urine: the deployment of a metabolic profiling strategy for biomarker discovery and identification.

Hodson MP, Dear GJ, Roberts AD, Haylock CL, Ball RJ, Plumb RS, Stumpf CL, Griffin JL, Haselden JN.

Anal Biochem. 2007 Mar 15;362(2):182-92. Epub 2006 Dec 28.

PMID:
17266915
8.

A metabolomic comparison of urinary changes in type 2 diabetes in mouse, rat, and human.

Salek RM, Maguire ML, Bentley E, Rubtsov DV, Hough T, Cheeseman M, Nunez D, Sweatman BC, Haselden JN, Cox RD, Connor SC, Griffin JL.

Physiol Genomics. 2007 Apr 24;29(2):99-108. Epub 2006 Dec 26.

PMID:
17190852
9.

Personalized medicine progresses.

Haselden JN, Nicholls AW.

Nat Med. 2006 May;12(5):510-1. No abstract available.

PMID:
16675996
10.

Peak alignment of urine NMR spectra using fuzzy warping.

Wu W, Daszykowski M, Walczak B, Sweatman BC, Connor SC, Haselden JN, Crowther DJ, Gill RW, Lutz MW.

J Chem Inf Model. 2006 Mar-Apr;46(2):863-75.

PMID:
16563018
11.

Summary recommendations for standardization and reporting of metabolic analyses.

Lindon JC, Nicholson JK, Holmes E, Keun HC, Craig A, Pearce JT, Bruce SJ, Hardy N, Sansone SA, Antti H, Jonsson P, Daykin C, Navarange M, Beger RD, Verheij ER, Amberg A, Baunsgaard D, Cantor GH, Lehman-McKeeman L, Earll M, Wold S, Johansson E, Haselden JN, Kramer K, Thomas C, Lindberg J, Schuppe-Koistinen I, Wilson ID, Reily MD, Robertson DG, Senn H, Krotzky A, Kochhar S, Powell J, van der Ouderaa F, Plumb R, Schaefer H, Spraul M; Standard Metabolic Reporting Structures working group.

Nat Biotechnol. 2005 Jul;23(7):833-8. No abstract available.

PMID:
16003371
12.

Sexual dimorphism in urinary metabolite profiles of Han Wistar rats revealed by nuclear-magnetic-resonance-based metabonomics.

Stanley EG, Bailey NJ, Bollard ME, Haselden JN, Waterfield CJ, Holmes E, Nicholson JK.

Anal Biochem. 2005 Aug 15;343(2):195-202. Epub 2005 Feb 7.

PMID:
15993369
13.

Tryptophan-NAD+ pathway metabolites as putative biomarkers and predictors of peroxisome proliferation.

Delaney J, Hodson MP, Thakkar H, Connor SC, Sweatman BC, Kenny SP, McGill PJ, Holder JC, Hutton KA, Haselden JN, Waterfield CJ.

Arch Toxicol. 2005 Apr;79(4):208-23. Epub 2004 Nov 11.

PMID:
15838709
14.

Development of a multivariate statistical model to predict peroxisome proliferation in the rat, based on urinary 1H-NMR spectral patterns.

Connor SC, Hodson MP, Ringeissen S, Sweatman BC, McGill PJ, Waterfield CJ, Haselden JN.

Biomarkers. 2004 Jul-Oct;9(4-5):364-85.

PMID:
15764299
15.

A functional analysis of mouse models of cardiac disease through metabolic profiling.

Jones GL, Sang E, Goddard C, Mortishire-Smith RJ, Sweatman BC, Haselden JN, Davies K, Grace AA, Clarke K, Griffin JL.

J Biol Chem. 2005 Mar 4;280(9):7530-9. Epub 2004 Nov 16.

16.

Effects of feeding and body weight loss on the 1H-NMR-based urine metabolic profiles of male Wistar Han rats: implications for biomarker discovery.

Connor SC, Wu W, Sweatman BC, Manini J, Haselden JN, Crowther DJ, Waterfield CJ.

Biomarkers. 2004 Mar-Apr;9(2):156-79.

PMID:
15370873
17.

Use of liquid chromatography/time-of-flight mass spectrometry and multivariate statistical analysis shows promise for the detection of drug metabolites in biological fluids.

Plumb RS, Stumpf CL, Granger JH, Castro-Perez J, Haselden JN, Dear GJ.

Rapid Commun Mass Spectrom. 2003;17(23):2632-8.

PMID:
14648901
18.

Potential urinary and plasma biomarkers of peroxisome proliferation in the rat: identification of N-methylnicotinamide and N-methyl-4-pyridone-3-carboxamide by 1H nuclear magnetic resonance and high performance liquid chromatography.

Ringeissen S, Connor SC, Brown HR, Sweatman BC, Hodson MP, Kenny SP, Haworth RI, McGill P, Price MA, Aylott MC, Nunez DJ, Haselden JN, Waterfield CJ.

Biomarkers. 2003 May-Aug;8(3-4):240-71.

PMID:
12944176
19.
20.

Metabonomics: the use of electrospray mass spectrometry coupled to reversed-phase liquid chromatography shows potential for the screening of rat urine in drug development.

Plumb RS, Stumpf CL, Gorenstein MV, Castro-Perez JM, Dear GJ, Anthony M, Sweatman BC, Connor SC, Haselden JN.

Rapid Commun Mass Spectrom. 2002;16(20):1991-6.

PMID:
12362392
21.

Metabonomic investigations into hydrazine toxicity in the rat.

Nicholls AW, Holmes E, Lindon JC, Shockcor JP, Farrant RD, Haselden JN, Damment SJ, Waterfield CJ, Nicholson JK.

Chem Res Toxicol. 2001 Aug;14(8):975-87.

PMID:
11511171
22.

High-resolution magic angle spinning (1)H NMR spectroscopy of intact liver and kidney: optimization of sample preparation procedures and biochemical stability of tissue during spectral acquisition.

Waters NJ, Garrod S, Farrant RD, Haselden JN, Connor SC, Connelly J, Lindon JC, Holmes E, Nicholson JK.

Anal Biochem. 2000 Jun 15;282(1):16-23.

PMID:
10860494
23.

Chemometric models for toxicity classification based on NMR spectra of biofluids.

Holmes E, Nicholls AW, Lindon JC, Connor SC, Connelly JC, Haselden JN, Damment SJ, Spraul M, Neidig P, Nicholson JK.

Chem Res Toxicol. 2000 Jun;13(6):471-8.

PMID:
10858320
24.
25.
26.

Comparative teratogenicity of nine retinoids in the rat.

Turton JA, Willars GB, Haselden JN, Ward SJ, Steele CE, Hicks RM.

Int J Exp Pathol. 1992 Oct;73(5):551-63.

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