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An aggregation-prone mutant of eIF3a forms reversible assemblies escaping spatial control in exponentially growing yeast cells.

Senohrabkova L, Malcova I, Hasek J.

Curr Genet. 2019 Aug;65(4):919-940. doi: 10.1007/s00294-019-00940-8. Epub 2019 Feb 4.


The defense and signaling role of NADPH oxidases in eukaryotic cells : Review.

Breitenbach M, Rinnerthaler M, Weber M, Breitenbach-Koller H, Karl T, Cullen P, Basu S, Haskova D, Hasek J.

Wien Med Wochenschr. 2018 Sep;168(11-12):286-299. doi: 10.1007/s10354-018-0640-4. Epub 2018 Aug 6. Review.


Yeast phospholipase C is required for stability of casein kinase I Yck2p and expression of hexose transporters.

Zhang T, Galdieri L, Hasek J, Vancura A.

FEMS Microbiol Lett. 2017 Dec 1;364(22). doi: 10.1093/femsle/fnx227.


Clearing the outer mitochondrial membrane from harmful proteins via lipid droplets.

Bischof J, Salzmann M, Streubel MK, Hasek J, Geltinger F, Duschl J, Bresgen N, Briza P, Haskova D, Lejskova R, Sopjani M, Richter K, Rinnerthaler M.

Cell Death Discov. 2017 Mar 20;3:17016. doi: 10.1038/cddiscovery.2017.16. eCollection 2017.


Formaldehyde fixation is detrimental to actin cables in glucose-depleted S. cerevisiae cells.

Vasicova P, Rinnerthaler M, Haskova D, Novakova L, Malcova I, Breitenbach M, Hasek J.

Microb Cell. 2016 Apr 12;3(5):206-214. doi: 10.15698/mic2016.05.499.


Structural and Catalytic Properties of S1 Nuclease from Aspergillus oryzae Responsible for Substrate Recognition, Cleavage, Non-Specificity, and Inhibition.

Kovaľ T, Østergaard LH, Lehmbeck J, Nørgaard A, Lipovová P, Dušková J, Skálová T, Trundová M, Kolenko P, Fejfarová K, Stránský J, Švecová L, Hašek J, Dohnálek J.

PLoS One. 2016 Dec 30;11(12):e0168832. doi: 10.1371/journal.pone.0168832. eCollection 2016.


New integrative modules for multicolor-protein labeling and live-cell imaging in Saccharomyces cerevisiae.

Malcova I, Farkasovsky M, Senohrabkova L, Vasicova P, Hasek J.

FEMS Yeast Res. 2016 May;16(3). pii: fow027. doi: 10.1093/femsyr/fow027. Epub 2016 Mar 17.


Stoichiometry and Change of the mRNA Closed-Loop Factors as Translating Ribosomes Transit from Initiation to Elongation.

Wang X, Xi W, Toomey S, Chiang YC, Hasek J, Laue TM, Denis CL.

PLoS One. 2016 Mar 8;11(3):e0150616. doi: 10.1371/journal.pone.0150616. eCollection 2016.


Crystallization of nepenthesin I using a low-pH crystallization screen.

Fejfarová K, Kádek A, Mrázek H, Hausner J, Tretyachenko V, Koval' T, Man P, Hašek J, Dohnálek J.

Acta Crystallogr F Struct Biol Commun. 2016 Jan;72(Pt 1):24-8. doi: 10.1107/S2053230X15022323. Epub 2016 Jan 1.


Phosphate binding in the active centre of tomato multifunctional nuclease TBN1 and analysis of superhelix formation by the enzyme.

Stránský J, Koval' T, Podzimek T, Týcová A, Lipovová P, Matoušek J, Kolenko P, Fejfarová K, Dušková J, Skálová T, Hašek J, Dohnálek J.

Acta Crystallogr F Struct Biol Commun. 2015 Nov;71(Pt 11):1408-15. doi: 10.1107/S2053230X15018324. Epub 2015 Oct 23.


The Stationary-Phase Cells of Saccharomyces cerevisiae Display Dynamic Actin Filaments Required for Processes Extending Chronological Life Span.

Vasicova P, Lejskova R, Malcova I, Hasek J.

Mol Cell Biol. 2015 Nov;35(22):3892-908. doi: 10.1128/MCB.00811-15. Epub 2015 Sep 8.


Evolutionarily conserved 5'-3' exoribonuclease Xrn1 accumulates at plasma membrane-associated eisosomes in post-diauxic yeast.

Grousl T, Opekarová M, Stradalova V, Hasek J, Malinsky J.

PLoS One. 2015 Mar 26;10(3):e0122770. doi: 10.1371/journal.pone.0122770. eCollection 2015. Erratum in: PLoS One. 2015;10(4):e0126788.


Four crystal structures of human LLT1, a ligand of human NKR-P1, in varied glycosylation and oligomerization states.

Skálová T, Bláha J, Harlos K, Dušková J, Koval' T, Stránský J, Hašek J, Vaněk O, Dohnálek J.

Acta Crystallogr D Biol Crystallogr. 2015 Mar;71(Pt 3):578-91. doi: 10.1107/S1399004714027928. Epub 2015 Feb 26.


Rheological study of chitosan acetate solutions containing chitin nanofibrils.

Mikešová J, Hašek J, Tishchenko G, Morganti P.

Carbohydr Polym. 2014 Nov 4;112:753-7. doi: 10.1016/j.carbpol.2014.06.043. Epub 2014 Jun 26.


Mmi1, the yeast homologue of mammalian TCTP, associates with stress granules in heat-shocked cells and modulates proteasome activity.

Rinnerthaler M, Lejskova R, Grousl T, Stradalova V, Heeren G, Richter K, Breitenbach-Koller L, Malinsky J, Hasek J, Breitenbach M.

PLoS One. 2013 Oct 28;8(10):e77791. doi: 10.1371/journal.pone.0077791. eCollection 2013.


Organophosphorus acid anhydrolase from Alteromonas macleodii: structural study and functional relationship to prolidases.

Štěpánková A, Dušková J, Skálová T, Hašek J, Koval' T, Østergaard LH, Dohnálek J.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Apr 1;69(Pt 4):346-54. doi: 10.1107/S1744309113002674. Epub 2013 Mar 28.


Heat shock-induced accumulation of translation elongation and termination factors precedes assembly of stress granules in S. cerevisiae.

Grousl T, Ivanov P, Malcova I, Pompach P, Frydlova I, Slaba R, Senohrabkova L, Novakova L, Hasek J.

PLoS One. 2013;8(2):e57083. doi: 10.1371/journal.pone.0057083. Epub 2013 Feb 25.


Plant multifunctional nuclease TBN1 with unexpected phospholipase activity: structural study and reaction-mechanism analysis.

Koval' T, Lipovová P, Podzimek T, Matoušek J, Dušková J, Skálová T, Stěpánková A, Hašek J, Dohnálek J.

Acta Crystallogr D Biol Crystallogr. 2013 Feb;69(Pt 2):213-26. doi: 10.1107/S0907444912043697. Epub 2013 Jan 16. Erratum in: Acta Crystallogr D Biol Crystallogr. 2013 Jun;69(Pt 6):1192.


Vps factors are required for efficient transcription elongation in budding yeast.

Gaur NA, Hasek J, Brickner DG, Qiu H, Zhang F, Wong CM, Malcova I, Vasicova P, Brickner JH, Hinnebusch AG.

Genetics. 2013 Mar;193(3):829-51. doi: 10.1534/genetics.112.146308. Epub 2013 Jan 18.


Nuclear import of chromatin remodeler Isw1 is mediated by atypical bipartite cNLS and classical import pathway.

Vasicova P, Stradalova V, Halada P, Hasek J, Malcova I.

Traffic. 2013 Feb;14(2):176-93. doi: 10.1111/tra.12025. Epub 2012 Nov 26.


Mouse Clr-g, a ligand for NK cell activation receptor NKR-P1F: crystal structure and biophysical properties.

Skálová T, Kotýnková K, Dušková J, Hašek J, Koval T, Kolenko P, Novák P, Man P, Hanč P, Vaněk O, Bezouška K, Dohnálek J.

J Immunol. 2012 Nov 15;189(10):4881-9. doi: 10.4049/jimmunol.1200880. Epub 2012 Oct 15.


Yno1p/Aim14p, a NADPH-oxidase ortholog, controls extramitochondrial reactive oxygen species generation, apoptosis, and actin cable formation in yeast.

Rinnerthaler M, Büttner S, Laun P, Heeren G, Felder TK, Klinger H, Weinberger M, Stolze K, Grousl T, Hasek J, Benada O, Frydlova I, Klocker A, Simon-Nobbe B, Jansko B, Breitenbach-Koller H, Eisenberg T, Gourlay CW, Madeo F, Burhans WC, Breitenbach M.

Proc Natl Acad Sci U S A. 2012 May 29;109(22):8658-63. doi: 10.1073/pnas.1201629109. Epub 2012 May 14.


New active HIV-1 protease inhibitors derived from 3-hexanol: conformation study of the free inhibitors in crystalline state and in complex with the enzyme.

Ziółkowska NE, Bujacz A, Randad RS, Erickson JW, Skálová T, Hašek J, Bujacz G.

Chem Biol Drug Des. 2012 May;79(5):798-809. doi: 10.1111/j.1747-0285.2012.01328.x. Epub 2012 Mar 7.


Structure of the H107R variant of the extracellular domain of mouse NKR-P1A at 2.3 Å resolution.

Kolenko P, Rozbeský D, Vaněk O, Bezouška K, Hašek J, Dohnálek J.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Dec 1;67(Pt 12):1519-23. doi: 10.1107/S1744309111046203. Epub 2011 Nov 30.


Chitinolytic enzymes from bacterium inhabiting human gastrointestinal tract -- critical parameters of protein isolation from anaerobic culture.

Dušková J, Tishchenko G, Ponomareva E, Šimůnek J, Koppová I, Skálová T, Štěpánková A, Hašek J, Dohnálek J.

Acta Biochim Pol. 2011;58(2):261-3. Epub 2011 Jun 13.


Molecular architecture of mouse activating NKR-P1 receptors.

Kolenko P, Rozbeský D, Vaněk O, Kopecký V Jr, Hofbauerová K, Novák P, Pompach P, Hašek J, Skálová T, Bezouška K, Dohnálek J.

J Struct Biol. 2011 Sep;175(3):434-41. doi: 10.1016/j.jsb.2011.05.001. Epub 2011 May 12.


Crystallization of recombinant bifunctional nuclease TBN1 from tomato.

Koval' T, Lipovová P, Podzimek T, Matoušek J, Dušková J, Skálová T, Stěpánková A, Hašek J, Dohnálek J.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Jan 1;67(Pt 1):124-8. doi: 10.1107/S1744309110048177. Epub 2010 Dec 23.


Structure of laccase from Streptomyces coelicolor after soaking with potassium hexacyanoferrate and at an improved resolution of 2.3 Å.

Skálová T, Dušková J, Hašek J, Stěpánková A, Koval T, Østergaard LH, Dohnálek J.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Jan 1;67(Pt 1):27-32. doi: 10.1107/S1744309110046099. Epub 2010 Dec 21.


Protein surface shielding agents in protein crystallization.

Hašek J.

J Synchrotron Radiat. 2011 Jan;18(1):50-2. doi: 10.1107/S0909049510032450. Epub 2010 Nov 5.


The high-resolution structure of the extracellular domain of human CD69 using a novel polymer.

Kolenko P, Skálová T, Vanek O, Stepánková A, Dusková J, Hasek J, Bezouska K, Dohnálek J.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Dec 1;65(Pt 12):1258-60. doi: 10.1107/S1744309109043152. Epub 2009 Nov 27.


Measurement of electrical oscillations and mechanical vibrations of yeast cells membrane around 1 kHz.

Jelínek F, Cifra M, Pokorný J, Vanis J, Simsa J, Hasek J, Frýdlová I.

Electromagn Biol Med. 2009;28(2):223-32.


Crystallization of carbohydrate oxidase from Microdochium nivale.

Dusková J, Dohnálek J, Skálová T, Østergaard LH, Fuglsang CC, Kolenko P, Stepánková A, Hasek J.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Jun 1;65(Pt 6):638-40. doi: 10.1107/S1744309109017643. Epub 2009 May 23.


Robust heat shock induces eIF2alpha-phosphorylation-independent assembly of stress granules containing eIF3 and 40S ribosomal subunits in budding yeast, Saccharomyces cerevisiae.

Grousl T, Ivanov P, Frýdlová I, Vasicová P, Janda F, Vojtová J, Malínská K, Malcová I, Nováková L, Janosková D, Valásek L, Hasek J.

J Cell Sci. 2009 Jun 15;122(Pt 12):2078-88. doi: 10.1242/jcs.045104. Epub 2009 May 26.


Cystathionine gamma-lyase: Clinical, metabolic, genetic, and structural studies.

Kraus JP, Hasek J, Kozich V, Collard R, Venezia S, Janosíková B, Wang J, Stabler SP, Allen RH, Jakobs C, Finn CT, Chien YH, Hwu WL, Hegele RA, Mudd SH.

Mol Genet Metab. 2009 Aug;97(4):250-9. doi: 10.1016/j.ymgme.2009.04.001. Epub 2009 Apr 9.


Deregulation of DSE1 gene expression results in aberrant budding within the birth scar and cell wall integrity pathway activation in Saccharomyces cerevisiae.

Frydlová I, Malcová I, Vasicová P, Hasek J.

Eukaryot Cell. 2009 Apr;8(4):586-94. doi: 10.1128/EC.00376-08. Epub 2009 Feb 27.


The structure of the small laccase from Streptomyces coelicolor reveals a link between laccases and nitrite reductases.

Skálová T, Dohnálek J, Østergaard LH, Østergaard PR, Kolenko P, Dusková J, Stepánková A, Hasek J.

J Mol Biol. 2009 Jan 30;385(4):1165-78. doi: 10.1016/j.jmb.2008.11.024. Epub 2008 Nov 25.


Disrupting vesicular trafficking at the endosome attenuates transcriptional activation by Gcn4.

Zhang F, Gaur NA, Hasek J, Kim SJ, Qiu H, Swanson MJ, Hinnebusch AG.

Mol Cell Biol. 2008 Nov;28(22):6796-818. doi: 10.1128/MCB.00800-08. Epub 2008 Sep 15.


New insights into intra- and intermolecular interactions of immunoglobulins: crystal structure of mouse IgG2b-Fc at 2.1-A resolution.

Kolenko P, Dohnálek J, Dusková J, Skálová T, Collard R, Hasek J.

Immunology. 2009 Mar;126(3):378-85. doi: 10.1111/j.1365-2567.2008.02904.x. Epub 2008 Sep 6.


Biophysical aspects of cancer--electromagnetic mechanism.

Pokorný J, Hasek J, Vanis J, Jelínek F.

Indian J Exp Biol. 2008 May;46(5):310-21. Review.


Auxin transport inhibitors impair vesicle motility and actin cytoskeleton dynamics in diverse eukaryotes.

Dhonukshe P, Grigoriev I, Fischer R, Tominaga M, Robinson DG, Hasek J, Paciorek T, Petrásek J, Seifertová D, Tejos R, Meisel LA, Zazímalová E, Gadella TW Jr, Stierhof YD, Ueda T, Oiwa K, Akhmanova A, Brock R, Spang A, Friml J.

Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4489-94. doi: 10.1073/pnas.0711414105. Epub 2008 Mar 12.


Crystallization and preliminary X-ray diffraction analysis of the small laccase from Streptomyces coelicolor.

Skálová T, Dohnálek J, Ostergaard LH, Ostergaard PR, Kolenko P, Dusková J, Hasek J.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Dec 1;63(Pt 12):1077-9. Epub 2007 Nov 30.


Special type of pheromone-induced invasive growth in Saccharomyces cerevisiae.

Frýdlová I, Basler M, Vasicová P, Malcová I, Hasek J.

Curr Genet. 2007 Aug;52(2):87-95. Epub 2007 Jul 17.


The fission yeast ortholog of eIF3a subunit is not functional in Saccharomyces cerevisiae.

Malcová-Janatová I, Koubek Z, Malínská K, Raková R, Hasek J.

Folia Microbiol (Praha). 2006;51(6):555-64.


Cold-active enzymes studied by comparative molecular dynamics simulation.

Spiwok V, Lipovová P, Skálová T, Dusková J, Dohnálek J, Hasek J, Russell NJ, Králová B.

J Mol Model. 2007 Apr;13(4):485-97. Epub 2007 Jan 18.


HIV-1 protease mutations and inhibitor modifications monitored on a series of complexes. Structural basis for the effect of the A71V mutation on the active site.

Skalova T, Dohnalek J, Duskova J, Petrokova H, Hradílek M, Soucek M, Konvalinka J, Hasek J.

J Med Chem. 2006 Sep 21;49(19):5777-84.


4-acetamido-3,3,5,5-[2H4]-2,2,6,6-tetra([2H3]methyl)piperidin-1-yloxyl 0.33-hydrate.

Duskova J, Labsky J, Cisarova I, Skalova T, Dohnalek J, Hasek J.

Acta Crystallogr C. 2006 Sep;62(Pt 9):o563-6. Epub 2006 Aug 11.


On the role of the R configuration of the reaction-intermediate isostere in HIV-1 protease-inhibitor binding: X-ray structure at 2.0 A resolution.

Dusková J, Dohnálek J, Skálová T, Petroková H, Vondrácková E, Hradílek M, Konvalinka J, Soucek M, Brynda J, Fábry M, Sedlácek J, Hasek J.

Acta Crystallogr D Biol Crystallogr. 2006 May;62(Pt 5):489-97. Epub 2006 Apr 19.


Modelling of carbohydrate-aromatic interactions: ab initio energetics and force field performance.

Spiwok V, Lipovová P, Skálová T, Vondrácková E, Dohnálek J, Hasek J, Králová B.

J Comput Aided Mol Des. 2005 Dec;19(12):887-901. Epub 2006 Apr 11.


Electromagnetic field of microtubules: effects on transfer of mass particles and electrons.

Pokorný J, Hašek J, Jelínek F.

J Biol Phys. 2005 Dec;31(3-4):501-14. doi: 10.1007/s10867-005-1286-1.

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