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A Survey of Academic Intensivists' Use of Neuromuscular Blockade in Subjects With ARDS.

Dodia NN, Richert ME, Deitchman AR, Quinn CC, Marciniak ET, Brown CH, Terrin ML, Amariei DE, Shanholtz CB, Hasday JD.

Respir Care. 2019 Sep 10. pii: respcare.07026. doi: 10.4187/respcare.07026. [Epub ahead of print]


A temperature-dependent conformational shift in p38α MAPK substrate-binding region associated with changes in substrate phosphorylation profile.

Deredge D, Wintrode PL, Tulapurkar ME, Nagarsekar A, Zhang Y, Weber DJ, Shapiro P, Hasday JD.

J Biol Chem. 2019 Aug 23;294(34):12624-12637. doi: 10.1074/jbc.RA119.007525. Epub 2019 Jun 18.


An atypical pulmonary fibrosis is associated with co-inheritance of mutations in the calcium binding protein genes S100A3 and S100A13.

Al-Mutairy EA, Imtiaz FA, Khalid M, Al Qattan S, Saleh S, Mahmoud LM, Al-Saif MM, Al-Haj L, Al-Enazi A, AlJebreen AM, Mohammed SF, Mobeireek AF, Alkattan K, Chisti MA, Luzina IG, Al-Owain M, Weheba I, Abdelsayed AM, Ramzan K, Janssen LJ, Conca W, Alaiya A, Collison KS, Meyer BF, Atamas SP, Khabar KS, Hasday JD, Al-Mohanna F.

Eur Respir J. 2019 Jul 18;54(1). pii: 1802041. doi: 10.1183/13993003.02041-2018. Print 2019 Jul.


Effects of binge alcohol consumption on sleep and inflammation in healthy volunteers.

Wilkinson AN, Afshar M, Ali O, Bhatti W, Hasday JD, Netzer G, Verceles AC.

J Int Med Res. 2018 Sep;46(9):3938-3947. doi: 10.1177/0300060518782020. Epub 2018 Jul 6.


Inflammation and asthma control in children with comorbid obstructive sleep apnea.

Rogers VE, Bollinger ME, Tulapurkar ME, Zhu S, Hasday JD, Pereira KD, Scharf SM.

Pediatr Pulmonol. 2018 Sep;53(9):1200-1207. doi: 10.1002/ppul.24074. Epub 2018 Jun 3.


Transcriptomic evidence of immune activation in macroscopically normal-appearing and scarred lung tissues in idiopathic pulmonary fibrosis.

Luzina IG, Salcedo MV, Rojas-Peña ML, Wyman AE, Galvin JR, Sachdeva A, Clerman A, Kim J, Franks TJ, Britt EJ, Hasday JD, Pham SM, Burke AP, Todd NW, Atamas SP.

Cell Immunol. 2018 Mar;325:1-13. doi: 10.1016/j.cellimm.2018.01.002. Epub 2018 Jan 3.


The author replies.

Hasday JD.

Crit Care Med. 2017 Nov;45(11):e1203. doi: 10.1097/CCM.0000000000002656. No abstract available.


Exposure to febrile-range hyperthermia potentiates Wnt signalling and epithelial-mesenchymal transition gene expression in lung epithelium.

Potla R, Tulapurkar ME, Luzina IG, Atamas SP, Singh IS, Hasday JD.

Int J Hyperthermia. 2018 Feb;34(1):1-10. doi: 10.1080/02656736.2017.1316875. Epub 2017 Apr 26.


Pilot Feasibility Study of Therapeutic Hypothermia for Moderate to Severe Acute Respiratory Distress Syndrome.

Slack DF, Corwin DS, Shah NG, Shanholtz CB, Verceles AC, Netzer G, Jones KM, Brown CH, Terrin ML, Hasday JD.

Crit Care Med. 2017 Jul;45(7):1152-1159. doi: 10.1097/CCM.0000000000002338.


Novel Noncatalytic Substrate-Selective p38α-Specific MAPK Inhibitors with Endothelial-Stabilizing and Anti-Inflammatory Activity.

Shah NG, Tulapurkar ME, Ramarathnam A, Brophy A, Martinez R 3rd, Hom K, Hodges T, Samadani R, Singh IS, MacKerell AD Jr, Shapiro P, Hasday JD.

J Immunol. 2017 Apr 15;198(8):3296-3306. doi: 10.4049/jimmunol.1602059. Epub 2017 Mar 15.


Activation of heat shock response augments fibroblast growth factor-1 expression in wounded lung epithelium.

Scheraga RG, Thompson C, Tulapurkar ME, Nagarsekar AC, Cowan M, Potla R, Sun J, Cai R, Logun C, Shelhamer J, Todd NW, Singh IS, Luzina IG, Atamas SP, Hasday JD.

Am J Physiol Lung Cell Mol Physiol. 2016 Nov 1;311(5):L941-L955. doi: 10.1152/ajplung.00262.2016. Epub 2016 Sep 16.


Shifts in temperature within the physiologic range modify strand-specific expression of select human microRNAs.

Potla R, Singh IS, Atamas SP, Hasday JD.

RNA. 2015 Jul;21(7):1261-73. doi: 10.1261/rna.049122.114. Epub 2015 May 27.


Myofiber damage precedes macrophage infiltration after in vivo injury in dysferlin-deficient A/J mouse skeletal muscle.

Roche JA, Tulapurkar ME, Mueller AL, van Rooijen N, Hasday JD, Lovering RM, Bloch RJ.

Am J Pathol. 2015 Jun;185(6):1686-98. doi: 10.1016/j.ajpath.2015.02.020. Epub 2015 Apr 25.


Bacterial lipopolysaccharide augments febrile-range hyperthermia-induced heat shock protein 70 expression and extracellular release in human THP1 cells.

Tulapurkar ME, Ramarathnam A, Hasday JD, Singh IS.

PLoS One. 2015 Feb 6;10(2):e0118010. doi: 10.1371/journal.pone.0118010. eCollection 2015.


Polymorphisms in human heat shock factor-1 and analysis of potential biological consequences.

Bridges TM, Scheraga RG, Tulapurkar ME, Suffredini D, Liggett SB, Ramarathnam A, Potla R, Singh IS, Hasday JD.

Cell Stress Chaperones. 2015 Jan;20(1):47-59. doi: 10.1007/s12192-014-0524-5. Epub 2014 Jul 16.


Fever, immunity, and molecular adaptations.

Hasday JD, Thompson C, Singh IS.

Compr Physiol. 2014 Jan;4(1):109-48. doi: 10.1002/cphy.c130019. Review.


IFN-γ directly controls IL-33 protein level through a STAT1- and LMP2-dependent mechanism.

Kopach P, Lockatell V, Pickering EM, Haskell RE, Anderson RD, Hasday JD, Todd NW, Luzina IG, Atamas SP.

J Biol Chem. 2014 Apr 25;289(17):11829-43. doi: 10.1074/jbc.M113.534396. Epub 2014 Mar 11.


Fever is associated with delayed ventilator liberation in acute lung injury.

Netzer G, Dowdy DW, Harrington T, Chandolu S, Dinglas VD, Shah NG, Colantuoni E, Mendez-Tellez PA, Shanholtz C, Hasday JD, Needham DM.

Ann Am Thorac Soc. 2013 Dec;10(6):608-15. doi: 10.1513/AnnalsATS.201303-052OC.


Fever, hyperthermia and the heat shock response.

Singh IS, Hasday JD.

Int J Hyperthermia. 2013 Aug;29(5):423-35. doi: 10.3109/02656736.2013.808766. Epub 2013 Jul 17. Review.


Interleukin-33 potentiates bleomycin-induced lung injury.

Luzina IG, Kopach P, Lockatell V, Kang PH, Nagarsekar A, Burke AP, Hasday JD, Todd NW, Atamas SP.

Am J Respir Cell Mol Biol. 2013 Dec;49(6):999-1008. doi: 10.1165/rcmb.2013-0093OC.


Toll-like receptor agonists and febrile range hyperthermia synergize to induce heat shock protein 70 expression and extracellular release.

Gupta A, Cooper ZA, Tulapurkar ME, Potla R, Maity T, Hasday JD, Singh IS.

J Biol Chem. 2013 Jan 25;288(4):2756-66. doi: 10.1074/jbc.M112.427336. Epub 2012 Dec 4.


Tolerance for chronic heat exposure is greater in female than male mice.

Bridges TM, Tulapurkar ME, Shah NG, Singh IS, Hasday JD.

Int J Hyperthermia. 2012;28(8):747-55. doi: 10.3109/02656736.2012.734425.


Hyperthermia promotes and prevents respiratory epithelial apoptosis through distinct mechanisms.

Nagarsekar A, Tulapurkar ME, Singh IS, Atamas SP, Shah NG, Hasday JD.

Am J Respir Cell Mol Biol. 2012 Dec;47(6):824-33. doi: 10.1165/rcmb.2012-0105OC. Epub 2012 Sep 6.


Febrile-range hyperthermia augments reversible TNF-α-induced hyperpermeability in human microvascular lung endothelial cells.

Shah NG, Tulapurkar ME, Damarla M, Singh IS, Goldblum SE, Shapiro P, Hasday JD.

Int J Hyperthermia. 2012;28(7):627-35. doi: 10.3109/02656736.2012.690547. Epub 2012 Jul 26.


Nonpharmacologic approach to minimizing shivering during surface cooling: a proof of principle study.

Shah NG, Cowan MJ, Pickering E, Sareh H, Afshar M, Fox D, Marron J, Davis J, Herold K, Shanholtz CB, Hasday JD.

J Crit Care. 2012 Dec;27(6):746.e1-8. doi: 10.1016/j.jcrc.2012.04.016. Epub 2012 Jul 2.


Febrile-range hyperthermia modifies endothelial and neutrophilic functions to promote extravasation.

Tulapurkar ME, Almutairy EA, Shah NG, He JR, Puche AC, Shapiro P, Singh IS, Hasday JD.

Am J Respir Cell Mol Biol. 2012 Jun;46(6):807-14. doi: 10.1165/rcmb.2011-0378OC. Epub 2012 Jan 26.


Does temperature make a difference? It depends on how hot (or cold), for how long, and in what clinical context.

Shah NG, Hasday JD.

Crit Care Med. 2012 Jan;40(1):326-7. doi: 10.1097/CCM.0b013e3182372bbb. No abstract available.


Prolonged exposure to hyperthermic stress augments neutrophil recruitment to lung during the post-exposure recovery period.

Tulapurkar ME, Hasday JD, Singh IS.

Int J Hyperthermia. 2011;27(7):717-25. doi: 10.3109/02656736.2011.601528.


Alternatively spliced variants of interleukin-4 promote inflammation differentially.

Luzina IG, Lockatell V, Todd NW, Highsmith K, Keegan AD, Hasday JD, Atamas SP.

J Leukoc Biol. 2011 May;89(5):763-70. doi: 10.1189/jlb.0510271. Epub 2011 Feb 1.


Distinct, gene-specific effect of heat shock on heat shock factor-1 recruitment and gene expression of CXC chemokine genes.

Maity TK, Henry MM, Tulapurkar ME, Shah NG, Hasday JD, Singh IS.

Cytokine. 2011 Apr;54(1):61-7. doi: 10.1016/j.cyto.2010.12.017. Epub 2011 Jan 26.


Splice isoforms of human interleukin-4 are functionally active in mice in vivo.

Luzina IG, Lockatell V, Todd NW, Keegan AD, Hasday JD, Atamas SP.

Immunology. 2011 Mar;132(3):385-93. doi: 10.1111/j.1365-2567.2010.03393.x. Epub 2011 Jan 10.


Response of mice to continuous 5-day passive hyperthermia resembles human heat acclimation.

Sareh H, Tulapurkar ME, Shah NG, Singh IS, Hasday JD.

Cell Stress Chaperones. 2011 May;16(3):297-307. doi: 10.1007/s12192-010-0240-8. Epub 2010 Nov 16.


Prostaglandin E2 potentiates heat shock-induced heat shock protein 72 expression in A549 cells.

Shah NG, Tulapurkar ME, Singh IS, Shelhamer JH, Cowan MJ, Hasday JD.

Prostaglandins Other Lipid Mediat. 2010 Sep;93(1-2):1-7. doi: 10.1016/j.prostaglandins.2010.03.006. Epub 2010 Apr 9.


Febrile range temperature represses TNF-alpha gene expression in LPS-stimulated macrophages by selectively blocking recruitment of Sp1 to the TNF-alpha promoter.

Cooper ZA, Singh IS, Hasday JD.

Cell Stress Chaperones. 2010 Sep;15(5):665-73. doi: 10.1007/s12192-010-0179-9. Epub 2010 Mar 10.


Variable prevalence of pulmonary hypertension in patients with advanced interstitial pneumonia.

Todd NW, Lavania S, Park MH, Iacono AT, Franks TJ, Galvin JR, Jeudy J, Britt EJ, Luzina IG, Hasday JD, Atamas SP.

J Heart Lung Transplant. 2010 Feb;29(2):188-94. doi: 10.1016/j.healun.2009.07.025.


Fever, hyperthermia, and the lung: it's all about context and timing.

Hasday JD, Shah N, Mackowiak PA, Tulapurkar M, Nagarsekar A, Singh I.

Trans Am Clin Climatol Assoc. 2011;122:34-47. Review.


Febrile-range temperature modifies cytokine gene expression in LPS-stimulated macrophages by differentially modifying NF-{kappa}B recruitment to cytokine gene promoters.

Cooper ZA, Ghosh A, Gupta A, Maity T, Benjamin IJ, Vogel SN, Hasday JD, Singh IS.

Am J Physiol Cell Physiol. 2010 Jan;298(1):C171-81. doi: 10.1152/ajpcell.00346.2009. Epub 2009 Oct 21.


Acetaminophen has limited antipyretic activity in critically ill patients.

Greenberg RS, Chen H, Hasday JD.

J Crit Care. 2010 Jun;25(2):363.e1-7. doi: 10.1016/j.jcrc.2009.07.005. Epub 2009 Sep 24.


Core temperature correlates with expression of selected stress and immunomodulatory genes in febrile patients with sepsis and noninfectious SIRS.

Sonna LA, Hawkins L, Lissauer ME, Maldeis P, Towns M, Johnson SB, Moore R, Singh IS, Cowan MJ, Hasday JD.

Cell Stress Chaperones. 2010 Jan;15(1):55-66. doi: 10.1007/s12192-009-0121-1. Epub 2009 Jun 4.


Surfactant protein-A limits Ureaplasma-mediated lung inflammation in a murine pneumonia model.

Famuyide ME, Hasday JD, Carter HC, Chesko KL, He JR, Viscardi RM.

Pediatr Res. 2009 Aug;66(2):162-7. doi: 10.1203/PDR.0b013e3181aabd66.


Hyperthermia in the febrile range induces HSP72 expression proportional to exposure temperature but not to HSF-1 DNA-binding activity in human lung epithelial A549 cells.

Tulapurkar ME, Asiegbu BE, Singh IS, Hasday JD.

Cell Stress Chaperones. 2009 Sep;14(5):499-508. doi: 10.1007/s12192-009-0103-3. Epub 2009 Feb 17.


Role of Ureaplasma species in neonatal chronic lung disease: epidemiologic and experimental evidence.

Viscardi RM, Hasday JD.

Pediatr Res. 2009 May;65(5 Pt 2):84R-90R. doi: 10.1203/PDR.0b013e31819dc2f9. Review.


An essential role for the antiviral endoribonuclease, RNase-L, in antibacterial immunity.

Li XL, Ezelle HJ, Kang TJ, Zhang L, Shirey KA, Harro J, Hasday JD, Mohapatra SK, Crasta OR, Vogel SN, Cross AS, Hassel BA.

Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20816-21. doi: 10.1073/pnas.0807265105. Epub 2008 Dec 15.


Prepartum Depressive Symptoms Correlate Positively with C-Reactive Protein Levels and Negatively with Tryptophan Levels: A Preliminary Report.

Scrandis DA, Langenberg P, Tonelli LH, Sheikh TM, Manogura AC, Alberico LA, Hermanstyne T, Fuchs D, Mighty H, Hasday JD, Boteva K, Postolache TT.

Int J Child Health Hum Dev. 2008 Aug;1(2):167-174.


Febrile-range hyperthermia accelerates caspase-dependent apoptosis in human neutrophils.

Nagarsekar A, Greenberg RS, Shah NG, Singh IS, Hasday JD.

J Immunol. 2008 Aug 15;181(4):2636-43.


Differential expression of toll-like receptor genes: sepsis compared with sterile inflammation 1 day before sepsis diagnosis.

Lissauer ME, Johnson SB, Bochicchio GV, Feild CJ, Cross AS, Hasday JD, Whiteford CC, Nussbaumer WA, Towns M, Scalea TM.

Shock. 2009 Mar;31(3):238-44. doi: 10.1097/SHK.0b013e3181834991.


Heat shock co-activates interleukin-8 transcription.

Singh IS, Gupta A, Nagarsekar A, Cooper Z, Manka C, Hester L, Benjamin IJ, He JR, Hasday JD.

Am J Respir Cell Mol Biol. 2008 Aug;39(2):235-42. doi: 10.1165/rcmb.2007-0294OC. Epub 2008 Mar 26.


Left ventricular dysfunction and associated cellular injury in rats exposed to chronic intermittent hypoxia.

Chen L, Zhang J, Gan TX, Chen-Izu Y, Hasday JD, Karmazyn M, Balke CW, Scharf SM.

J Appl Physiol (1985). 2008 Jan;104(1):218-23. Epub 2007 Nov 15.


Exercise-heat acclimation in humans alters baseline levels and ex vivo heat inducibility of HSP72 and HSP90 in peripheral blood mononuclear cells.

McClung JP, Hasday JD, He JR, Montain SJ, Cheuvront SN, Sawka MN, Singh IS.

Am J Physiol Regul Integr Comp Physiol. 2008 Jan;294(1):R185-91. Epub 2007 Oct 31.

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