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Midgut Laterality Is Driven by Hyaluronan on the Right.

Sivakumar A, Mahadevan A, Lauer ME, Narvaez RJ, Ramesh S, Demler CM, Souchet NR, Hascall VC, Midura RJ, Garantziotis S, Frank DB, Kimata K, Kurpios NA.

Dev Cell. 2018 Sep 10;46(5):533-551.e5. doi: 10.1016/j.devcel.2018.08.002. Epub 2018 Aug 30.


Variation in primary and culture-expanded cells derived from connective tissue progenitors in human bone marrow space, bone trabecular surface and adipose tissue.

Qadan MA, Piuzzi NS, Boehm C, Bova W, Moos M Jr, Midura RJ, Hascall VC, Malcuit C, Muschler GF.

Cytotherapy. 2018 Mar;20(3):343-360. doi: 10.1016/j.jcyt.2017.11.013. Epub 2018 Feb 1.


Intra-articular hyaluronan injections for the treatment of osteoarthritis: perspective for the mechanism of action.

Piuzzi NS, Midura RJ, Muschler GF, Hascall VC.

Ther Adv Musculoskelet Dis. 2018 Feb;10(2):55-57. doi: 10.1177/1759720X17752038. Epub 2018 Jan 22. No abstract available.


Quantification of hyaluronan (HA) using a simplified fluorophore-assisted carbohydrate electrophoresis (FACE) procedure.

Midura RJ, Cali V, Lauer ME, Calabro A, Hascall VC.

Methods Cell Biol. 2018;143:297-316. doi: 10.1016/bs.mcb.2017.08.017. Epub 2017 Oct 13.


Nuclear hyaluronidase 2 drives alternative splicing of CD44 pre-mRNA to determine profibrotic or antifibrotic cell phenotype.

Midgley AC, Oltean S, Hascall V, Woods EL, Steadman R, Phillips AO, Meran S.

Sci Signal. 2017 Nov 21;10(506). pii: eaao1822. doi: 10.1126/scisignal.aao1822.


The eukaryotic translation initiation factor eIF4E harnesses hyaluronan production to drive its malignant activity.

Zahreddine HA, Culjkovic-Kraljacic B, Emond A, Pettersson F, Midura R, Lauer M, Del Rincon S, Cali V, Assouline S, Miller WH, Hascall V, Borden KL.

Elife. 2017 Nov 7;6. pii: e29830. doi: 10.7554/eLife.29830.



Hascall V, Esko JD.

In: Varki A, Cummings RD, Esko JD, Stanley P, Hart GW, Aebi M, Darvill AG, Kinoshita T, Packer NH, Prestegard JH, Schnaar RL, Seeberger PH, editors. Essentials of Glycobiology [Internet]. 3rd edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2015-2017. Chapter 16.


Hyaluronan Rich Microenvironment in the Limbal Stem Cell Niche Regulates Limbal Stem Cell Differentiation.

Gesteira TF, Sun M, Coulson-Thomas YM, Yamaguchi Y, Yeh LK, Hascall V, Coulson-Thomas VJ.

Invest Ophthalmol Vis Sci. 2017 Sep 1;58(11):4407-4421. doi: 10.1167/iovs.17-22326.


Transforming growth factor β1 (TGFβ1) regulates CD44V6 expression and activity through extracellular signal-regulated kinase (ERK)-induced EGR1 in pulmonary fibrogenic fibroblasts.

Ghatak S, Markwald RR, Hascall VC, Dowling W, Lottes RG, Baatz JE, Beeson G, Beeson CC, Perrella MA, Thannickal VJ, Misra S.

J Biol Chem. 2017 Jun 23;292(25):10465-10489. doi: 10.1074/jbc.M116.752451. Epub 2017 Apr 7.


Transforming growth factor β1 (TGFβ1)-induced CD44V6-NOX4 signaling in pathogenesis of idiopathic pulmonary fibrosis.

Ghatak S, Hascall VC, Markwald RR, Feghali-Bostwick C, Artlett CM, Gooz M, Bogatkevich GS, Atanelishvili I, Silver RM, Wood J, Thannickal VJ, Misra S.

J Biol Chem. 2017 Jun 23;292(25):10490-10519. doi: 10.1074/jbc.M116.752469. Epub 2017 Apr 7.


Endotoxin free hyaluronan and hyaluronan fragments do not stimulate TNF-α, interleukin-12 or upregulate co-stimulatory molecules in dendritic cells or macrophages.

Dong Y, Arif A, Olsson M, Cali V, Hardman B, Dosanjh M, Lauer M, Midura RJ, Hascall VC, Brown KL, Johnson P.

Sci Rep. 2016 Nov 21;6:36928. doi: 10.1038/srep36928.


Tumor Necrosis Factor-stimulated Gene-6 (TSG-6) Is Constitutively Expressed in Adult Central Nervous System (CNS) and Associated with Astrocyte-mediated Glial Scar Formation following Spinal Cord Injury.

Coulson-Thomas VJ, Lauer ME, Soleman S, Zhao C, Hascall VC, Day AJ, Fawcett JW.

J Biol Chem. 2016 Sep 16;291(38):19939-52. doi: 10.1074/jbc.M115.710673. Epub 2016 Jul 19.


Probing Beneath the Surface: Discovering O-GlcNAc on Intracellular Proteins.

Hascall V, Taylor A.

J Biol Chem. 2016 Mar 18;291(12):6607-8. doi: 10.1074/jbc.O116.000001. No abstract available.


Training the next generation of biomedical investigators in glycosciences.

Agre P, Bertozzi C, Bissell M, Campbell KP, Cummings RD, Desai UR, Estes M, Flotte T, Fogleman G, Gage F, Ginsburg D, Gordon JI, Hart G, Hascall V, Kiessling L, Kornfeld S, Lowe J, Magnani J, Mahal LK, Medzhitov R, Roberts RJ, Sackstein R, Sarkar R, Schnaar R, Schwartz N, Varki A, Walt D, Weissman I.

J Clin Invest. 2016 Feb;126(2):405-8. doi: 10.1172/JCI85905. Epub 2016 Feb 1. Review.


Hyaluronidase and Hyaluronan Oligosaccharides Promote Neurological Recovery after Intraventricular Hemorrhage.

Vinukonda G, Dohare P, Arshad A, Zia MT, Panda S, Korumilli R, Kayton R, Hascall VC, Lauer ME, Ballabh P.

J Neurosci. 2016 Jan 20;36(3):872-89. doi: 10.1523/JNEUROSCI.3297-15.2016.


Hyaluronan Rafts on Airway Epithelial Cells.

Abbadi A, Lauer M, Swaidani S, Wang A, Hascall V.

J Biol Chem. 2016 Jan 15;291(3):1448-55. doi: 10.1074/jbc.M115.704288. Epub 2015 Nov 24.


Roles of Proteoglycans and Glycosaminoglycans in Wound Healing and Fibrosis.

Ghatak S, Maytin EV, Mack JA, Hascall VC, Atanelishvili I, Moreno Rodriguez R, Markwald RR, Misra S.

Int J Cell Biol. 2015;2015:834893. doi: 10.1155/2015/834893. Epub 2015 Sep 10. Review.


Utilization of Glycosaminoglycans/Proteoglycans as Carriers for Targeted Therapy Delivery.

Misra S, Hascall VC, Atanelishvili I, Moreno Rodriguez R, Markwald RR, Ghatak S.

Int J Cell Biol. 2015;2015:537560. doi: 10.1155/2015/537560. Epub 2015 Sep 10. Review.


The Responses of Hyperglycemic Dividing Mesangial Cells to Heparin Are Mediated by the Non-reducing Terminal Trisaccharide.

Wang CP, Hascall VC, Zhang F, Linhardt RJ, Abbadi A, Wang A.

J Biol Chem. 2015 Nov 27;290(48):29045-50. doi: 10.1074/jbc.M115.677401. Epub 2015 Sep 16.


Hyaluronan and Its Heavy Chain Modification in Asthma Severity and Experimental Asthma Exacerbation.

Lauer ME, Majors AK, Comhair S, Ruple LM, Matuska B, Subramanian A, Farver C, Dworski R, Grandon D, Laskowski D, Dweik RA, Erzurum SC, Hascall VC, Aronica MA.

J Biol Chem. 2015 Sep 18;290(38):23124-34. doi: 10.1074/jbc.M115.663823. Epub 2015 Jul 24.


Interactions between Hyaluronan and Its Receptors (CD44, RHAMM) Regulate the Activities of Inflammation and Cancer.

Misra S, Hascall VC, Markwald RR, Ghatak S.

Front Immunol. 2015 May 6;6:201. doi: 10.3389/fimmu.2015.00201. eCollection 2015. Review.


Heparin interaction with a receptor on hyperglycemic dividing cells prevents intracellular hyaluronan synthesis and autophagy responses in models of type 1 diabetes.

Wang A, Sankaranarayanan NV, Yanagishita M, Templeton DM, Desai UR, Sugahara K, Wang CP, Hascall VC.

Matrix Biol. 2015 Oct;48:36-41. doi: 10.1016/j.matbio.2015.04.003. Epub 2015 Apr 16. Review.


Hyaluronan regulates bone morphogenetic protein-7-dependent prevention and reversal of myofibroblast phenotype.

Midgley AC, Duggal L, Jenkins R, Hascall V, Steadman R, Phillips AO, Meran S.

J Biol Chem. 2015 May 1;290(18):11218-34. doi: 10.1074/jbc.M114.625939. Epub 2015 Feb 25.


Hyperglycemia diverts dividing stem cells to pathological adipogenesis.

Hascall V, Wang A.

Stem Cell Res Ther. 2014 Nov 17;5(6):128. doi: 10.1186/scrt518.


Heavy chain transfer by tumor necrosis factor-stimulated gene 6 to the bikunin proteoglycan.

Lamkin E, Cheng G, Calabro A, Hascall VC, Joo EJ, Li L, Linhardt RJ, Lauer ME.

J Biol Chem. 2015 Feb 20;290(8):5156-66. doi: 10.1074/jbc.M114.636258. Epub 2015 Jan 5.


Analysis of the heavy-chain modification and TSG-6 activity in pathological hyaluronan matrices.

Lauer ME, Loftis J, de la Motte C, Hascall VC.

Methods Mol Biol. 2015;1229:543-8. doi: 10.1007/978-1-4939-1714-3_42.


Natural antisense transcript for hyaluronan synthase 2 (HAS2-AS1) induces transcription of HAS2 via protein O-GlcNAcylation.

Vigetti D, Deleonibus S, Moretto P, Bowen T, Fischer JW, Grandoch M, Oberhuber A, Love DC, Hanover JA, Cinquetti R, Karousou E, Viola M, D'Angelo ML, Hascall VC, De Luca G, Passi A.

J Biol Chem. 2014 Oct 17;289(42):28816-26. doi: 10.1074/jbc.M114.597401. Epub 2014 Sep 2.


A tribute to Dick Heinegård.

Hascall VC.

Matrix Biol. 2014 Oct;39:2-4. doi: 10.1016/j.matbio.2014.08.005. Epub 2014 Aug 27.


Irreversible heavy chain transfer to chondroitin.

Lauer ME, Hascall VC, Green DE, DeAngelis PL, Calabro A.

J Biol Chem. 2014 Oct 17;289(42):29171-9. doi: 10.1074/jbc.M114.600809. Epub 2014 Aug 18.


Isothiocyanate analogs targeting CD44 receptor as an effective strategy against colon cancer.

Misra S, Ghatak S, Vyas A, O'Brien P, Markwald RR, Khetmalas M, Hascall VC, McCarthy JB, Karamanos NK, Tammi MI, Tammi RH, Prestwitch GD, Padhye S.

Med Chem Res. 2014 Aug 1;23(8):3836-3851.


Umbilical cord mesenchymal stem cells suppress host rejection: the role of the glycocalyx.

Coulson-Thomas VJ, Gesteira TF, Hascall V, Kao W.

J Biol Chem. 2014 Aug 22;289(34):23465-81. doi: 10.1074/jbc.M114.557447. Epub 2014 Jul 1.


Hyperglycemia diverts dividing osteoblastic precursor cells to an adipogenic pathway and induces synthesis of a hyaluronan matrix that is adhesive for monocytes.

Wang A, Midura RJ, Vasanji A, Wang AJ, Hascall VC.

J Biol Chem. 2014 Apr 18;289(16):11410-20. doi: 10.1074/jbc.M113.541458. Epub 2014 Feb 25.


The dynamic metabolism of hyaluronan regulates the cytosolic concentration of UDP-GlcNAc.

Hascall VC, Wang A, Tammi M, Oikari S, Tammi R, Passi A, Vigetti D, Hanson RW, Hart GW.

Matrix Biol. 2014 Apr;35:14-7. doi: 10.1016/j.matbio.2014.01.014. Epub 2014 Jan 30. Review.


Periostin induces intracellular cross-talk between kinases and hyaluronan in atrioventricular valvulogenesis.

Ghatak S, Misra S, Norris RA, Moreno-Rodriguez RA, Hoffman S, Levine RA, Hascall VC, Markwald RR.

J Biol Chem. 2014 Mar 21;289(12):8545-61. doi: 10.1074/jbc.M113.539882. Epub 2014 Jan 27.


Modification of hyaluronan by heavy chains of inter-α-inhibitor in idiopathic pulmonary arterial hypertension.

Lauer ME, Aytekin M, Comhair SA, Loftis J, Tian L, Farver CF, Hascall VC, Dweik RA.

J Biol Chem. 2014 Mar 7;289(10):6791-8. doi: 10.1074/jbc.M113.512491. Epub 2014 Jan 8.


Overexpression of c-Met and CD44v6 receptors contributes to autocrine TGF-β1 signaling in interstitial lung disease.

Ghatak S, Bogatkevich GS, Atnelishvili I, Akter T, Feghali-Bostwick C, Hoffman S, Fresco VM, Fuchs JC, Visconti RP, Markwald RR, Padhye SB, Silver RM, Hascall VC, Misra S.

J Biol Chem. 2014 Mar 14;289(11):7856-72. doi: 10.1074/jbc.M113.505065. Epub 2013 Dec 9.


Oxidized low density lipoprotein (LDL) affects hyaluronan synthesis in human aortic smooth muscle cells.

Viola M, Bartolini B, Vigetti D, Karousou E, Moretto P, Deleonibus S, Sawamura T, Wight TN, Hascall VC, De Luca G, Passi A.

J Biol Chem. 2013 Oct 11;288(41):29595-603. doi: 10.1074/jbc.M113.508341. Epub 2013 Aug 26.


Irreversible heavy chain transfer to hyaluronan oligosaccharides by tumor necrosis factor-stimulated gene-6.

Lauer ME, Glant TT, Mikecz K, DeAngelis PL, Haller FM, Husni ME, Hascall VC, Calabro A.

J Biol Chem. 2013 Jan 4;288(1):205-14. doi: 10.1074/jbc.M112.403998. Epub 2012 Nov 19.


Tumor necrosis factor-stimulated gene-6 (TSG-6) amplifies hyaluronan synthesis by airway smooth muscle cells.

Lauer ME, Cheng G, Swaidani S, Aronica MA, Weigel PH, Hascall VC.

J Biol Chem. 2013 Jan 4;288(1):423-31. doi: 10.1074/jbc.M112.389882. Epub 2012 Nov 5.


TSG-6 protein is crucial for the development of pulmonary hyaluronan deposition, eosinophilia, and airway hyperresponsiveness in a murine model of asthma.

Swaidani S, Cheng G, Lauer ME, Sharma M, Mikecz K, Hascall VC, Aronica MA.

J Biol Chem. 2013 Jan 4;288(1):412-22. doi: 10.1074/jbc.M112.389874. Epub 2012 Nov 1.


In vivo transplantation of autogenous marrow-derived cells following rapid intraoperative magnetic separation based on hyaluronan to augment bone regeneration.

Caralla T, Joshi P, Fleury S, Luangphakdy V, Shinohara K, Pan H, Boehm C, Vasanji A, Hefferan TE, Walker E, Yaszemski M, Hascall V, Zborowski M, Muschler GF.

Tissue Eng Part A. 2013 Jan;19(1-2):125-34. doi: 10.1089/ten.tea.2011.0622. Epub 2012 Oct 19.


Correlation of hyaluronan deposition with infiltration of eosinophils and lymphocytes in a cockroach-induced murine model of asthma.

Cheng G, Swaidani S, Sharma M, Lauer ME, Hascall VC, Aronica MA.

Glycobiology. 2013 Jan;23(1):43-58. doi: 10.1093/glycob/cws122. Epub 2012 Aug 23.


Role of UDP-N-acetylglucosamine (GlcNAc) and O-GlcNAcylation of hyaluronan synthase 2 in the control of chondroitin sulfate and hyaluronan synthesis.

Vigetti D, Deleonibus S, Moretto P, Karousou E, Viola M, Bartolini B, Hascall VC, Tammi M, De Luca G, Passi A.

J Biol Chem. 2012 Oct 12;287(42):35544-55. doi: 10.1074/jbc.M112.402347. Epub 2012 Aug 10.


Hyaluronan as a novel marker for rapid selection of connective tissue progenitors.

Caralla T, Boehm C, Hascall V, Muschler G.

Ann Biomed Eng. 2012 Dec;40(12):2559-67. doi: 10.1007/s10439-012-0608-2. Epub 2012 Jun 15.


Role of receptor for hyaluronic acid-mediated motility (RHAMM) in low molecular weight hyaluronan (LMWHA)-mediated fibrosarcoma cell adhesion.

Kouvidi K, Berdiaki A, Nikitovic D, Katonis P, Afratis N, Hascall VC, Karamanos NK, Tzanakakis GN.

J Biol Chem. 2011 Nov 4;286(44):38509-20. doi: 10.1074/jbc.M111.275875. Epub 2011 Sep 13.


Enhanced inflammation and accelerated wound closure following tetraphorbol ester application or full-thickness wounding in mice lacking hyaluronan synthases Has1 and Has3.

Mack JA, Feldman RJ, Itano N, Kimata K, Lauer M, Hascall VC, Maytin EV.

J Invest Dermatol. 2012 Jan;132(1):198-207. doi: 10.1038/jid.2011.248. Epub 2011 Aug 18.


The inducible kinase IKKi is required for IL-17-dependent signaling associated with neutrophilia and pulmonary inflammation.

Bulek K, Liu C, Swaidani S, Wang L, Page RC, Gulen MF, Herjan T, Abbadi A, Qian W, Sun D, Lauer M, Hascall V, Misra S, Chance MR, Aronica M, Hamilton T, Li X.

Nat Immunol. 2011 Aug 7;12(9):844-52. doi: 10.1038/ni.2080.


Glycosaminoglycans and glucose prevent apoptosis in 4-methylumbelliferone-treated human aortic smooth muscle cells.

Vigetti D, Rizzi M, Moretto P, Deleonibus S, Dreyfuss JM, Karousou E, Viola M, Clerici M, Hascall VC, Ramoni MF, De Luca G, Passi A.

J Biol Chem. 2011 Oct 7;286(40):34497-503. doi: 10.1074/jbc.M111.266312. Epub 2011 Jul 18.


TSG-6 protein, a negative regulator of inflammatory arthritis, forms a ternary complex with murine mast cell tryptases and heparin.

Nagyeri G, Radacs M, Ghassemi-Nejad S, Tryniszewska B, Olasz K, Hutas G, Gyorfy Z, Hascall VC, Glant TT, Mikecz K.

J Biol Chem. 2011 Jul 1;286(26):23559-69. doi: 10.1074/jbc.M111.222026. Epub 2011 May 12.

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