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Items: 20

1.

The Regional-Specific Relative and Absolute Expression of Gut Transporters in Adult Caucasians: A Meta-Analysis.

Harwood MD, Zhang M, Pathak SM, Neuhoff S.

Drug Metab Dispos. 2019 Aug;47(8):854-864. doi: 10.1124/dmd.119.086959. Epub 2019 May 10.

PMID:
31076413
2.

The Constraints, Construction, and Verification of a Strain-Specific Physiologically Based Pharmacokinetic Rat Model.

Musther H, Harwood MD, Yang J, Turner DB, Rostami-Hodjegan A, Jamei M.

J Pharm Sci. 2017 Sep;106(9):2826-2838. doi: 10.1016/j.xphs.2017.05.003. Epub 2017 May 8.

PMID:
28495566
3.

Abundance of Hepatic Transporters in Caucasians: A Meta-Analysis.

Burt HJ, Riedmaier AE, Harwood MD, Crewe HK, Gill KL, Neuhoff S.

Drug Metab Dispos. 2016 Oct;44(10):1550-61. doi: 10.1124/dmd.116.071183. Epub 2016 Aug 4.

4.

Metformin and cimetidine: Physiologically based pharmacokinetic modelling to investigate transporter mediated drug-drug interactions.

Burt HJ, Neuhoff S, Almond L, Gaohua L, Harwood MD, Jamei M, Rostami-Hodjegan A, Tucker GT, Rowland-Yeo K.

Eur J Pharm Sci. 2016 Jun 10;88:70-82. doi: 10.1016/j.ejps.2016.03.020. Epub 2016 Mar 25.

5.

Breast Cancer Resistance Protein Abundance, but Not mRNA Expression, Correlates With Estrone-3-Sulfate Transport in Caco-2.

Harwood MD, Neuhoff S, Rostami-Hodjegan A, Warhurst G.

J Pharm Sci. 2016 Apr;105(4):1370-5. doi: 10.1016/j.xphs.2016.01.018. Epub 2016 Mar 4.

PMID:
26952881
6.

In Vitro-In Vivo Extrapolation Scaling Factors for Intestinal P-glycoprotein and Breast Cancer Resistance Protein: Part II. The Impact of Cross-Laboratory Variations of Intestinal Transporter Relative Expression Factors on Predicted Drug Disposition.

Harwood MD, Achour B, Neuhoff S, Russell MR, Carlson G, Warhurst G, Rostami-Hodjegan A.

Drug Metab Dispos. 2016 Mar;44(3):476-80. doi: 10.1124/dmd.115.067777. Epub 2016 Feb 3.

PMID:
26842595
7.

In Vitro-In Vivo Extrapolation Scaling Factors for Intestinal P-Glycoprotein and Breast Cancer Resistance Protein: Part I: A Cross-Laboratory Comparison of Transporter-Protein Abundances and Relative Expression Factors in Human Intestine and Caco-2 Cells.

Harwood MD, Achour B, Neuhoff S, Russell MR, Carlson G, Warhurst G; Amin Rostami-Hodjegan.

Drug Metab Dispos. 2016 Mar;44(3):297-307. doi: 10.1124/dmd.115.067371. Epub 2015 Dec 2.

PMID:
26631742
8.

Application of an LC-MS/MS method for the simultaneous quantification of human intestinal transporter proteins absolute abundance using a QconCAT technique.

Harwood MD, Achour B, Russell MR, Carlson GL, Warhurst G, Rostami-Hodjegan A.

J Pharm Biomed Anal. 2015 Jun 10;110:27-33. doi: 10.1016/j.jpba.2015.02.043. Epub 2015 Feb 28.

9.

Lost in centrifugation: accounting for transporter protein losses in quantitative targeted absolute proteomics.

Harwood MD, Russell MR, Neuhoff S, Warhurst G, Rostami-Hodjegan A.

Drug Metab Dispos. 2014 Oct;42(10):1766-72. doi: 10.1124/dmd.114.058446. Epub 2014 Jul 24.

PMID:
25061159
10.

Alternative fusion protein strategies to express recalcitrant QconCAT proteins for quantitative proteomics of human drug metabolizing enzymes and transporters.

Russell MR, Achour B, Mckenzie EA, Lopez R, Harwood MD, Rostami-Hodjegan A, Barber J.

J Proteome Res. 2013 Dec 6;12(12):5934-42. doi: 10.1021/pr400279u. Epub 2013 Oct 31.

PMID:
24124648
11.

Absolute abundance and function of intestinal drug transporters: a prerequisite for fully mechanistic in vitro-in vivo extrapolation of oral drug absorption.

Harwood MD, Neuhoff S, Carlson GL, Warhurst G, Rostami-Hodjegan A.

Biopharm Drug Dispos. 2013 Jan;34(1):2-28. doi: 10.1002/bdd.1810. Epub 2012 Oct 8. Review.

PMID:
22927116
12.

Cyclic rapid fluctuation of hypertension and hypotension in pheochromocytoma.

Ionescu CN, Sakharova OV, Harwood MD, Caracciolo EA, Schoenfeld MH, Donohue TJ.

J Clin Hypertens (Greenwich). 2008 Dec;10(12):936-40. doi: 10.1111/j.1751-7176.2008.00046.x. No abstract available.

13.

Mental health services for preschool children in primary care: a survey of maternal attitudes and beliefs.

Harwood MD, O'Brien KA, Carter CG, Eyberg SM.

J Pediatr Psychol. 2009 Aug;34(7):760-8. doi: 10.1093/jpepsy/jsn128. Epub 2008 Dec 8.

15.

Child-directed interaction: prediction of change in impaired mother-child functioning.

Harwood MD, Eyberg SM.

J Abnorm Child Psychol. 2006 Jun;34(3):335-47. Epub 2006 May 16.

PMID:
16708275
16.

Comparison of P-glycoprotein-mediated drug-digoxin interactions in Caco-2 with human and rodent intestine: relevance to in vivo prediction.

Collett A, Tanianis-Hughes J, Carlson GL, Harwood MD, Warhurst G.

Eur J Pharm Sci. 2005 Dec;26(5):386-93. Epub 2005 Sep 8.

PMID:
16153812
17.

Therapist verbal behavior early in treatment: relation to successful completion of parent-child interaction therapy.

Harwood MD, Eyberg SM.

J Clin Child Adolesc Psychol. 2004 Sep;33(3):601-12.

PMID:
15271617
18.

Absorption of taurocholic acid by the ileum of normal and transgenic DeltaF508 cystic fibrosis mice.

Hardcastle J, Harwood MD, Taylor CJ.

J Pharm Pharmacol. 2004 Apr;56(4):445-52.

PMID:
15099439
19.
20.

Abnormal contraction caused by expression of G(i)-coupled receptor in transgenic model of dilated cardiomyopathy.

Baker AJ, Redfern CH, Harwood MD, Simpson PC, Conklin BR.

Am J Physiol Heart Circ Physiol. 2001 Apr;280(4):H1653-9.

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