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Items: 20

1.

Phosphorylation of TSC2 by PKC-δ reveals a novel signaling pathway that couples protein synthesis to mTORC1 activity.

Zhan J, Chitta RK, Harwood FC, Grosveld GC.

Mol Cell Biochem. 2019 Jun;456(1-2):123-134. doi: 10.1007/s11010-019-03498-8. Epub 2019 Jan 25.

PMID:
30684133
2.

ETV7 is an essential component of a rapamycin-insensitive mTOR complex in cancer.

Harwood FC, Klein Geltink RI, O'Hara BP, Cardone M, Janke L, Finkelstein D, Entin I, Paul L, Houghton PJ, Grosveld GC.

Sci Adv. 2018 Sep 12;4(9):eaar3938. doi: 10.1126/sciadv.aar3938. eCollection 2018 Sep.

3.
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5.

Gefitinib enhances the antitumor activity and oral bioavailability of irinotecan in mice.

Stewart CF, Leggas M, Schuetz JD, Panetta JC, Cheshire PJ, Peterson J, Daw N, Jenkins JJ 3rd, Gilbertson R, Germain GS, Harwood FC, Houghton PJ.

Cancer Res. 2004 Oct 15;64(20):7491-9.

6.

Inhibition of mammalian target of rapamycin activates apoptosis signal-regulating kinase 1 signaling by suppressing protein phosphatase 5 activity.

Huang S, Shu L, Easton J, Harwood FC, Germain GS, Ichijo H, Houghton PJ.

J Biol Chem. 2004 Aug 27;279(35):36490-6. Epub 2004 Jun 24.

7.

Imatinib mesylate is a potent inhibitor of the ABCG2 (BCRP) transporter and reverses resistance to topotecan and SN-38 in vitro.

Houghton PJ, Germain GS, Harwood FC, Schuetz JD, Stewart CF, Buchdunger E, Traxler P.

Cancer Res. 2004 Apr 1;64(7):2333-7.

8.

Sustained activation of the JNK cascade and rapamycin-induced apoptosis are suppressed by p53/p21(Cip1).

Huang S, Shu L, Dilling MB, Easton J, Harwood FC, Ichijo H, Houghton PJ.

Mol Cell. 2003 Jun;11(6):1491-501.

9.

Insulin-like growth factor I-mediated protection from rapamycin-induced apoptosis is independent of Ras-Erk1-Erk2 and phosphatidylinositol 3'-kinase-Akt signaling pathways.

Thimmaiah KN, Easton J, Huang S, Veverka KA, Germain GS, Harwood FC, Houghton PJ.

Cancer Res. 2003 Jan 15;63(2):364-74.

10.

4E-binding proteins, the suppressors of eukaryotic initiation factor 4E, are down-regulated in cells with acquired or intrinsic resistance to rapamycin.

Dilling MB, Germain GS, Dudkin L, Jayaraman AL, Zhang X, Harwood FC, Houghton PJ.

J Biol Chem. 2002 Apr 19;277(16):13907-17. Epub 2002 Feb 14.

11.

Biochemical correlates of mTOR inhibition by the rapamycin ester CCI-779 and tumor growth inhibition.

Dudkin L, Dilling MB, Cheshire PJ, Harwood FC, Hollingshead M, Arbuck SG, Travis R, Sausville EA, Houghton PJ.

Clin Cancer Res. 2001 Jun;7(6):1758-64.

12.

Saskatchewan and state medicine. 1935.

Harwood FC.

J Can Dent Assoc. 1994 Aug;60(8):662-3. No abstract available.

PMID:
8087672
13.
14.

Pharmacological characterization of N-substituted phenoxazines directed toward reversing Vinca alkaloid resistance in multidrug-resistant cancer cells.

Horton JK, Thimmaiah KN, Harwood FC, Kuttesch JF, Houghton PJ.

Mol Pharmacol. 1993 Sep;44(3):552-9.

PMID:
8103911
15.

Proliferation-dependent and -independent cytotoxicity by antitumor diarylsulfonylureas. Indication of multiple mechanisms of drug action.

Sosinski J, Thakar JH, Germain GS, Harwood FC, Houghton PJ.

Biochem Pharmacol. 1993 May 25;45(10):2135-42.

PMID:
8512595
16.

Synthesis and chemical characterization of N-substituted phenoxazines directed toward reversing vinca alkaloid resistance in multidrug-resistant cancer cells.

Thimmaiah KN, Horton JK, Seshadri R, Israel M, Houghton JA, Harwood FC, Houghton PJ.

J Med Chem. 1992 Sep 4;35(18):3358-64.

PMID:
1527786
17.

A phase I clinical trial of 2-chlorodeoxyadenosine in pediatric patients with acute leukemia.

Santana VM, Mirro J Jr, Harwood FC, Cherrie J, Schell M, Kalwinsky D, Blakley RL.

J Clin Oncol. 1991 Mar;9(3):416-22.

PMID:
1671875
18.

Cytostatic effects of 2',3'-dideoxyribonucleosides on transformed human hemopoietic cell lines.

Blakley RL, Harwood FC, Huff KD.

Mol Pharmacol. 1990 Feb;37(2):328-32.

PMID:
2154678
19.
20.

Application of Dust-laying Oils to Hospital Bed-clothes.

Harwood FC, Powney J, Edwards CW.

Br Med J. 1944 May 6;1(4348):615-6. No abstract available.

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