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Items: 1 to 50 of 72

1.

Curcumin and derivatives function through protein phosphatase 2A and presenilin orthologues in Dictyostelium discoideum.

Cocorocchio M, Baldwin AJ, Stewart B, Kim L, Harwood AJ, Thompson CRL, Andrews PLR, Williams RSB.

Dis Model Mech. 2018 Jan 29;11(1). pii: dmm032375. doi: 10.1242/dmm.032375.

2.

Regulation of nucleosome positioning by a CHD Type III chromatin remodeler and its relationship to developmental gene expression in Dictyostelium.

Platt JL, Kent NA, Kimmel AR, Harwood AJ.

Genome Res. 2017 Apr;27(4):591-600. doi: 10.1101/gr.216309.116. Epub 2017 Mar 22.

3.

Modeling psychiatric disorders: from genomic findings to cellular phenotypes.

Falk A, Heine VM, Harwood AJ, Sullivan PF, Peitz M, Brüstle O, Shen S, Sun YM, Glover JC, Posthuma D, Djurovic S.

Mol Psychiatry. 2016 Sep;21(9):1321. doi: 10.1038/mp.2016.100. Epub 2016 Jun 21. No abstract available.

PMID:
27324182
4.

Modeling psychiatric disorders: from genomic findings to cellular phenotypes.

Falk A, Heine VM, Harwood AJ, Sullivan PF, Peitz M, Brüstle O, Shen S, Sun YM, Glover JC, Posthuma D, Djurovic S.

Mol Psychiatry. 2016 Sep;21(9):1167-79. doi: 10.1038/mp.2016.89. Epub 2016 May 31. Review. Erratum in: Mol Psychiatry. 2016 Sep;21(9):1321.

5.

Biological interaction of living cells with COSAN-based synthetic vesicles.

Tarrés M, Canetta E, Paul E, Forbes J, Azzouni K, Viñas C, Teixidor F, Harwood AJ.

Sci Rep. 2015 Jan 15;5:7804. doi: 10.1038/srep07804.

6.

Imaging in living cells using νB-H Raman spectroscopy: monitoring COSAN uptake.

Tarrés M, Canetta E, Viñas C, Teixidor F, Harwood AJ.

Chem Commun (Camb). 2014 Mar 28;50(25):3370-2. doi: 10.1039/c3cc49658a. Epub 2014 Feb 18.

PMID:
24549036
7.

Different CHD chromatin remodelers are required for expression of distinct gene sets and specific stages during development of Dictyostelium discoideum.

Platt JL, Rogers BJ, Rogers KC, Harwood AJ, Kimmel AR.

Development. 2013 Dec;140(24):4926-36. doi: 10.1242/dev.099879.

8.

Aberrant spindle dynamics and cytokinesis in Dictyostelium discoideum cells that lack glycogen synthase kinase 3.

Harwood AJ, Forde-Thomas JE, Williams H, Samereier M, Müller-Taubenberger A.

Eur J Cell Biol. 2013 Jun-Jul;92(6-7):222-8. doi: 10.1016/j.ejcb.2013.05.001. Epub 2013 May 16.

9.

Analysis of chromatin organization by deep sequencing technologies.

Platt JL, Kent NA, Harwood AJ, Kimmel AR.

Methods Mol Biol. 2013;983:173-83. doi: 10.1007/978-1-62703-302-2_9.

PMID:
23494307
10.

Prolyl oligopeptidase, inositol phosphate signalling and lithium sensitivity.

Harwood AJ.

CNS Neurol Disord Drug Targets. 2011 May;10(3):333-9. Review.

11.

Genetic control of lithium sensitivity and regulation of inositol biosynthetic genes.

King J, Keim M, Teo R, Weening KE, Kapur M, McQuillan K, Ryves J, Rogers B, Dalton E, Williams RS, Harwood AJ.

PLoS One. 2010 Jun 17;5(6):e11151. doi: 10.1371/journal.pone.0011151.

12.

Glycogen synthase kinase-3 is required for efficient Dictyostelium chemotaxis.

Teo R, Lewis KJ, Forde JE, Ryves WJ, Reddy JV, Rogers BJ, Harwood AJ.

Mol Biol Cell. 2010 Aug 1;21(15):2788-96. doi: 10.1091/mbc.E09-10-0891. Epub 2010 Jun 9.

13.

PtdIns(3,4,5)P(3) and inositol depletion as a cellular target of mood stabilizers.

Teo R, King J, Dalton E, Ryves J, Williams RS, Harwood AJ.

Biochem Soc Trans. 2009 Oct;37(Pt 5):1110-4. doi: 10.1042/BST0371110.

PMID:
19754462
14.

Evaluation of the effects of propylisopropylacetic acid (PIA) on neuronal growth cone morphology.

Shimshoni JA, Dalton EC, Watson P, Boris Y, Bialer M, Harwood AJ.

Neuropharmacology. 2009 Mar;56(4):831-7.

15.

A systematic investigation of the protein kinases involved in NMDA receptor-dependent LTD: evidence for a role of GSK-3 but not other serine/threonine kinases.

Peineau S, Nicolas CS, Bortolotto ZA, Bhat RV, Ryves WJ, Harwood AJ, Dournaud P, Fitzjohn SM, Collingridge GL.

Mol Brain. 2009 Jul 7;2:22. doi: 10.1186/1756-6606-2-22.

16.

The mood stabiliser lithium suppresses PIP3 signalling in Dictyostelium and human cells.

King JS, Teo R, Ryves J, Reddy JV, Peters O, Orabi B, Hoeller O, Williams RS, Harwood AJ.

Dis Model Mech. 2009 May-Jun;2(5-6):306-12. doi: 10.1242/dmm.001271. Epub 2009 Apr 21.

17.

Use of the Dictyostelium stalk cell assay to monitor GSK-3 regulation.

Harwood AJ.

Methods Mol Biol. 2008;469:39-43. doi: 10.1007/978-1-60327-469-2_4.

PMID:
19109701
18.

Monitoring patterns of gene expression in Dictyostelium by beta-galacotsidase staining.

Harwood AJ.

Methods Mol Biol. 2008;469:33-7. doi: 10.1007/978-1-60327-469-2_3.

PMID:
19109700
19.

Dictyostelium development: a prototypic Wnt pathway?

Harwood AJ.

Methods Mol Biol. 2008;469:21-32. doi: 10.1007/978-1-60327-469-2_2. Review.

PMID:
19109699
20.

Dephosphorylation of 2,3-bisphosphoglycerate by MIPP expands the regulatory capacity of the Rapoport-Luebering glycolytic shunt.

Cho J, King JS, Qian X, Harwood AJ, Shears SB.

Proc Natl Acad Sci U S A. 2008 Apr 22;105(16):5998-6003. doi: 10.1073/pnas.0710980105. Epub 2008 Apr 14.

21.

Phospholipase C regulation of phosphatidylinositol 3,4,5-trisphosphate-mediated chemotaxis.

Kortholt A, King JS, Keizer-Gunnink I, Harwood AJ, Van Haastert PJ.

Mol Biol Cell. 2007 Dec;18(12):4772-9. Epub 2007 Sep 26. Erratum in: Mol Biol Cell. 2008 Aug;19(8):3613.

22.

Specificity of mood stabilizer action on neuronal growth cones.

Shaltiel G, Dalton EC, Belmaker RH, Harwood AJ, Agam G.

Bipolar Disord. 2007 May;9(3):281-9.

PMID:
17430303
23.

The effects of central nervous system-active valproic acid constitutional isomers, cyclopropyl analogs, and amide derivatives on neuronal growth cone behavior.

Shimshoni JA, Dalton EC, Jenkins A, Eyal S, Ewan K, Williams RS, Pessah N, Yagen B, Harwood AJ, Bialer M.

Mol Pharmacol. 2007 Mar;71(3):884-92. Epub 2006 Dec 13.

24.

Use of a penetratin-linked peptide in Dictyostelium.

Ryves WJ, Harwood AJ.

Mol Biotechnol. 2006 Jun;33(2):123-32.

PMID:
16757799
25.

GSK-3 activity in neocortical cells is inhibited by lithium but not carbamazepine or valproic acid.

Jonathan Ryves W, Dalton EC, Harwood AJ, Williams RS.

Bipolar Disord. 2005 Jun;7(3):260-5.

26.

Dd-Alix, a conserved endosome-associated protein, controls Dictyostelium development.

Mattei S, Ryves WJ, Blot B, Sadoul R, Harwood AJ, Satre M, Klein G, Aubry L.

Dev Biol. 2005 Mar 1;279(1):99-113.

27.
28.

Valproate decreases inositol biosynthesis.

Shaltiel G, Shamir A, Shapiro J, Ding D, Dalton E, Bialer M, Harwood AJ, Belmaker RH, Greenberg ML, Agam G.

Biol Psychiatry. 2004 Dec 1;56(11):868-74.

PMID:
15576064
29.

Lithium and bipolar mood disorder: the inositol-depletion hypothesis revisited.

Harwood AJ.

Mol Psychiatry. 2005 Jan;10(1):117-26. Review.

PMID:
15558078
30.

A molecular cell biology of lithium.

Williams R, Ryves WJ, Dalton EC, Eickholt B, Shaltiel G, Agam G, Harwood AJ.

Biochem Soc Trans. 2004 Nov;32(Pt 5):799-802. Review.

PMID:
15494019
31.

cAMP-induced degradation of cyclin D3 through association with GSK-3beta.

Naderi S, Gutzkow KB, Låhne HU, Lefdal S, Ryves WJ, Harwood AJ, Blomhoff HK.

J Cell Sci. 2004 Aug 1;117(Pt 17):3769-83. Epub 2004 Jul 13.

32.

Two peptidase activities decrease in treated bipolar disorder not schizophrenic patients.

Breen G, Harwood AJ, Gregory K, Sinclair M, Collier D, St Clair D, Williams RS.

Bipolar Disord. 2004 Apr;6(2):156-61.

PMID:
15005755
33.

An inverse PCR technique to rapidly isolate the flanking DNA of dictyostelium insertion mutants.

Keim M, Williams RS, Harwood AJ.

Mol Biotechnol. 2004 Mar;26(3):221-4.

PMID:
15004291
34.

Cell polarity and Dictyostelium development.

Williams HP, Harwood AJ.

Curr Opin Microbiol. 2003 Dec;6(6):621-7. Review.

PMID:
14662359
35.

The interaction of glycogen synthase kinase-3 (GSK-3) with the cell cycle.

Ryves WJ, Harwood AJ.

Prog Cell Cycle Res. 2003;5:489-95. Review.

PMID:
14593744
36.

Neurodevelopment and mood stabilizers.

Harwood AJ.

Curr Mol Med. 2003 Aug;3(5):472-82. Review.

PMID:
12943000
37.

Search for a common mechanism of mood stabilizers.

Harwood AJ, Agam G.

Biochem Pharmacol. 2003 Jul 15;66(2):179-89. Review.

PMID:
12826261
38.

Loss of the beta-catenin homologue aardvark causes ectopic stalk formation in Dictyostelium.

Coates JC, Grimson MJ, Williams RS, Bergman W, Blanton RL, Harwood AJ.

Mech Dev. 2002 Aug;116(1-2):117-27.

39.

A common mechanism of action for three mood-stabilizing drugs.

Williams RS, Cheng L, Mudge AW, Harwood AJ.

Nature. 2002 May 16;417(6886):292-5.

PMID:
12015604
40.

End-labeling of DNA probes.

Harwood AJ.

Methods Mol Biol. 2002;187:17-22. No abstract available.

PMID:
12013744
41.

Signal transduction in development: holding the key.

Harwood AJ.

Dev Cell. 2002 Apr;2(4):384-5. Review.

42.

Glycogen synthase kinase-3 inhibition by lithium and beryllium suggests the presence of two magnesium binding sites.

Ryves WJ, Dajani R, Pearl L, Harwood AJ.

Biochem Biophys Res Commun. 2002 Jan 25;290(3):967-72.

PMID:
11798168
43.

Cell-cell adhesion and signal transduction during Dictyostelium development.

Coates JC, Harwood AJ.

J Cell Sci. 2001 Dec;114(Pt 24):4349-58. Review.

44.

Regulation of GSK-3: a cellular multiprocessor.

Harwood AJ.

Cell. 2001 Jun 29;105(7):821-4. Review. No abstract available.

45.

'Super glue'.

Braga V, Harwood AJ.

Nat Cell Biol. 2001 Jul;3(7):E168-70.

PMID:
11433315
46.

Signal transduction and Dictyostelium development.

Harwood AJ.

Protist. 2001 May;152(1):17-29. No abstract available.

PMID:
11401032
47.

Lithium inhibits glycogen synthase kinase-3 by competition for magnesium.

Ryves WJ, Harwood AJ.

Biochem Biophys Res Commun. 2001 Jan 26;280(3):720-5.

PMID:
11162580
48.

Adherens junctions and beta-catenin-mediated cell signalling in a non-metazoan organism.

Grimson MJ, Coates JC, Reynolds JP, Shipman M, Blanton RL, Harwood AJ.

Nature. 2000 Dec 7;408(6813):727-31.

PMID:
11130075
49.

Glycogen synthase kinase-3 enhances nuclear export of a Dictyostelium STAT protein.

Ginger RS, Dalton EC, Ryves WJ, Fukuzawa M, Williams JG, Harwood AJ.

EMBO J. 2000 Oct 16;19(20):5483-91.

50.

Signal transduction: Life, the universe and ... development.

Harwood AJ.

Curr Biol. 2000 Feb 10;10(3):R116-9.

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