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Items: 1 to 50 of 230

1.

Correction: Single cell analysis of the developing mouse kidney provides deeper insight into marker gene expression and ligand-receptor crosstalk (doi:10.1242/dev.178673).

Combes AN, Phipson B, Lawlor KT, Dorison A, Patrick R, Zappia L, Harvey RP, Oshlack A, Little MH.

Development. 2019 Jul 11;146(13). pii: dev182162. doi: 10.1242/dev.182162. No abstract available.

PMID:
31296520
2.

Single cell analysis of the developing mouse kidney provides deeper insight into marker gene expression and ligand-receptor crosstalk.

Combes AN, Phipson B, Lawlor KT, Dorison A, Patrick R, Zappia L, Harvey RP, Oshlack A, Little MH.

Development. 2019 Jun 12;146(12). pii: dev178673. doi: 10.1242/dev.178673. Erratum in: Development. 2019 Jul 11;146(13):.

PMID:
31118232
3.

Single-cell expression profiling reveals dynamic flux of cardiac stromal, vascular and immune cells in health and injury.

Farbehi N, Patrick R, Dorison A, Xaymardan M, Janbandhu V, Wystub-Lis K, Ho JW, Nordon RE, Harvey RP.

Elife. 2019 Mar 26;8. pii: e43882. doi: 10.7554/eLife.43882.

4.

Gene-environment interaction impacts on heart development and embryo survival.

Moreau JLM, Kesteven S, Martin EMMA, Lau KS, Yam MX, O'Reilly VC, Del Monte-Nieto G, Baldini A, Feneley MP, Moon AM, Harvey RP, Sparrow DB, Chapman G, Dunwoodie SL.

Development. 2019 Feb 20;146(4). pii: dev172957. doi: 10.1242/dev.172957.

5.

Endothelial to Mesenchymal Transition in Cardiovascular Disease: JACC State-of-the-Art Review.

Kovacic JC, Dimmeler S, Harvey RP, Finkel T, Aikawa E, Krenning G, Baker AH.

J Am Coll Cardiol. 2019 Jan 22;73(2):190-209. doi: 10.1016/j.jacc.2018.09.089. Review.

6.

Identification of clinically actionable variants from genome sequencing of families with congenital heart disease.

Alankarage D, Ip E, Szot JO, Munro J, Blue GM, Harrison K, Cuny H, Enriquez A, Troup M, Humphreys DT, Wilson M, Harvey RP, Sholler GF, Graham RM, Ho JWK, Kirk EP, Pachter N, Chapman G, Winlaw DS, Giannoulatou E, Dunwoodie SL.

Genet Med. 2019 May;21(5):1111-1120. doi: 10.1038/s41436-018-0296-x. Epub 2018 Oct 8.

PMID:
30293987
7.

Correction: Deletion of Nkx2-5 in trabecular myocardium reveals the developmental origins of pathological heterogeneity associated with ventricular non-compaction cardiomyopathy.

Choquet C, Nguyen THM, Sicard P, Buttigieg E, Tran TT, Kober F, Varlet I, Sturny R, Costa MW, Harvey RP, Nguyen C, Rihet P, Richard S, Bernard M, Kelly RG, Lalevée N, Miquerol L.

PLoS Genet. 2018 Aug 15;14(8):e1007610. doi: 10.1371/journal.pgen.1007610. eCollection 2018 Aug.

8.

Deletion of Nkx2-5 in trabecular myocardium reveals the developmental origins of pathological heterogeneity associated with ventricular non-compaction cardiomyopathy.

Choquet C, Nguyen THM, Sicard P, Buttigieg E, Tran TT, Kober F, Varlet I, Sturny R, Costa MW, Harvey RP, Nguyen C, Rihet P, Richard S, Bernard M, Kelly RG, Lalevée N, Miquerol L.

PLoS Genet. 2018 Jul 6;14(7):e1007502. doi: 10.1371/journal.pgen.1007502. eCollection 2018 Jul. Erratum in: PLoS Genet. 2018 Aug 15;14(8):e1007610.

9.

Genetic burden and associations with adverse neurodevelopment in neonates with congenital heart disease.

Blue GM, Ip E, Walker K, Kirk EP, Loughran-Fowlds A, Sholler GF, Dunwoodie SL, Harvey RP, Giannoulatou E, Badawi N, Winlaw DS.

Am Heart J. 2018 Jul;201:33-39. doi: 10.1016/j.ahj.2018.03.021. Epub 2018 Apr 5.

PMID:
29910053
10.

Intravital Imaging to Monitor Therapeutic Response in Moving Hypoxic Regions Resistant to PI3K Pathway Targeting in Pancreatic Cancer.

Conway JRW, Warren SC, Herrmann D, Murphy KJ, Cazet AS, Vennin C, Shearer RF, Killen MJ, Magenau A, Mélénec P, Pinese M, Nobis M, Zaratzian A, Boulghourjian A, Da Silva AM, Del Monte-Nieto G, Adam ASA, Harvey RP, Haigh JJ, Wang Y, Croucher DR, Sansom OJ, Pajic M, Caldon CE, Morton JP, Timpson P.

Cell Rep. 2018 Jun 12;23(11):3312-3326. doi: 10.1016/j.celrep.2018.05.038.

11.

Control of cardiac jelly dynamics by NOTCH1 and NRG1 defines the building plan for trabeculation.

Del Monte-Nieto G, Ramialison M, Adam AAS, Wu B, Aharonov A, D'Uva G, Bourke LM, Pitulescu ME, Chen H, de la Pompa JL, Shou W, Adams RH, Harten SK, Tzahor E, Zhou B, Harvey RP.

Nature. 2018 May;557(7705):439-445. doi: 10.1038/s41586-018-0110-6. Epub 2018 May 9.

PMID:
29743679
12.

NKX2-5 regulates human cardiomyogenesis via a HEY2 dependent transcriptional network.

Anderson DJ, Kaplan DI, Bell KM, Koutsis K, Haynes JM, Mills RJ, Phelan DG, Qian EL, Leitoguinho AR, Arasaratnam D, Labonne T, Ng ES, Davis RP, Casini S, Passier R, Hudson JE, Porrello ER, Costa MW, Rafii A, Curl CL, Delbridge LM, Harvey RP, Oshlack A, Cheung MM, Mummery CL, Petrou S, Elefanty AG, Stanley EG, Elliott DA.

Nat Commun. 2018 Apr 10;9(1):1373. doi: 10.1038/s41467-018-03714-x.

13.

Comparative regenerative mechanisms across different mammalian tissues.

Iismaa SE, Kaidonis X, Nicks AM, Bogush N, Kikuchi K, Naqvi N, Harvey RP, Husain A, Graham RM.

NPJ Regen Med. 2018 Feb 23;3:6. doi: 10.1038/s41536-018-0044-5. eCollection 2018. Review.

14.

Analysis of cardiac stem cell self-renewal dynamics in serum-free medium by single cell lineage tracking.

Cornwell JA, Nordon RE, Harvey RP.

Stem Cell Res. 2018 Apr;28:115-124. doi: 10.1016/j.scr.2018.02.004. Epub 2018 Feb 8.

15.

Wnt inhibition promotes vascular specification of embryonic cardiac progenitors.

Reichman DE, Park L, Man L, Redmond D, Chao K, Harvey RP, Taketo MM, Rosenwaks Z, James D.

Development. 2018 Jan 8;145(1). pii: dev159905. doi: 10.1242/dev.159905.

16.

A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contexts.

Nobis M, Herrmann D, Warren SC, Kadir S, Leung W, Killen M, Magenau A, Stevenson D, Lucas MC, Reischmann N, Vennin C, Conway JRW, Boulghourjian A, Zaratzian A, Law AM, Gallego-Ortega D, Ormandy CJ, Walters SN, Grey ST, Bailey J, Chtanova T, Quinn JMW, Baldock PA, Croucher PI, Schwarz JP, Mrowinska A, Zhang L, Herzog H, Masedunskas A, Hardeman EC, Gunning PW, Del Monte-Nieto G, Harvey RP, Samuel MS, Pajic M, McGhee EJ, Johnsson AE, Sansom OJ, Welch HCE, Morton JP, Strathdee D, Anderson KI, Timpson P.

Cell Rep. 2017 Oct 3;21(1):274-288. doi: 10.1016/j.celrep.2017.09.022.

17.

Uncontrolled angiogenic precursor expansion causes coronary artery anomalies in mice lacking Pofut1.

Wang Y, Wu B, Lu P, Zhang D, Wu B, Varshney S, Del Monte-Nieto G, Zhuang Z, Charafeddine R, Kramer AH, Sibinga NE, Frangogiannis NG, Kitsis RN, Adams RH, Alitalo K, Sharp DJ, Harvey RP, Stanley P, Zhou B.

Nat Commun. 2017 Sep 18;8(1):578. doi: 10.1038/s41467-017-00654-w.

18.

Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis.

Vennin C, Chin VT, Warren SC, Lucas MC, Herrmann D, Magenau A, Melenec P, Walters SN, Del Monte-Nieto G, Conway JR, Nobis M, Allam AH, McCloy RA, Currey N, Pinese M, Boulghourjian A, Zaratzian A, Adam AA, Heu C, Nagrial AM, Chou A, Steinmann A, Drury A, Froio D, Giry-Laterriere M, Harris NL, Phan T, Jain R, Weninger W, McGhee EJ, Whan R, Johns AL, Samra JS, Chantrill L, Gill AJ, Kohonen-Corish M, Harvey RP, Biankin AV; Australian Pancreatic Cancer Genome Initiative (APGI), Evans TR, Anderson KI, Grey ST, Ormandy CJ, Gallego-Ortega D, Wang Y, Samuel MS, Sansom OJ, Burgess A, Cox TR, Morton JP, Pajic M, Timpson P.

Sci Transl Med. 2017 Apr 5;9(384). pii: eaai8504. doi: 10.1126/scitranslmed.aai8504.

19.

Point mutations in murine Nkx2-5 phenocopy human congenital heart disease and induce pathogenic Wnt signaling.

Furtado MB, Wilmanns JC, Chandran A, Perera J, Hon O, Biben C, Willow TJ, Nim HT, Kaur G, Simonds S, Wu Q, Willians D, Salimova E, Plachta N, Denegre JM, Murray SA, Fatkin D, Cowley M, Pearson JT, Kaye D, Ramialison M, Harvey RP, Rosenthal NA, Costa MW.

JCI Insight. 2017 Mar 23;2(6):e88271. doi: 10.1172/jci.insight.88271.

20.

Nkx2.5 marks angioblasts that contribute to hemogenic endothelium of the endocardium and dorsal aorta.

Zamir L, Singh R, Nathan E, Patrick R, Yifa O, Yahalom-Ronen Y, Arraf AA, Schultheiss TM, Suo S, Han JJ, Peng G, Jing N, Wang Y, Palpant N, Tam PP, Harvey RP, Tzahor E.

Elife. 2017 Mar 8;6. pii: e20994. doi: 10.7554/eLife.20994.

21.

Advances in the Genetics of Congenital Heart Disease: A Clinician's Guide.

Blue GM, Kirk EP, Giannoulatou E, Sholler GF, Dunwoodie SL, Harvey RP, Winlaw DS.

J Am Coll Cardiol. 2017 Feb 21;69(7):859-870. doi: 10.1016/j.jacc.2016.11.060. Review.

22.

Analysis of steric effects in DamID profiling of transcription factor target genes.

Ramialison M, Waardenberg AJ, Schonrock N, Doan T, de Jong D, Bouveret R, Harvey RP.

Genomics. 2017 Mar;109(2):75-82. doi: 10.1016/j.ygeno.2017.01.006. Epub 2017 Feb 8.

23.

Platelet-derived growth factor (PDGF) signaling directs cardiomyocyte movement toward the midline during heart tube assembly.

Bloomekatz J, Singh R, Prall OW, Dunn AC, Vaughan M, Loo CS, Harvey RP, Yelon D.

Elife. 2017 Jan 18;6. pii: e21172. doi: 10.7554/eLife.21172.

24.

The promises and challenges of exome sequencing in familial, non-syndromic congenital heart disease.

Blue GM, Humphreys D, Szot J, Major J, Chapman G, Bosman A, Kirk EP, Sholler GF, Harvey RP, Dunwoodie SL, Winlaw DS.

Int J Cardiol. 2017 Mar 1;230:155-163. doi: 10.1016/j.ijcard.2016.12.024. Epub 2016 Dec 13.

PMID:
27989580
25.

Loss of Rearranged L-Myc Fusion (RLF) results in defects in heart development in the mouse.

Bourke LM, Del Monte-Nieto G, Outhwaite JE, Bharti V, Pollock PM, Simmons DG, Adam A, Hur SS, Maghzal GJ, Whitelaw E, Stocker R, Suter CM, Harvey RP, Harten SK.

Differentiation. 2017 Mar - Apr;94:8-20. doi: 10.1016/j.diff.2016.11.004. Epub 2016 Dec 5.

PMID:
27930960
26.

Altered cytokine profile, pain sensitivity, and stress responsivity in mice with co-disruption of the developmental genes Neuregulin-1×DISC1.

Desbonnet L, Cox R, Tighe O, Lai D, Harvey RP, Waddington JL, O'Tuathaigh CM.

Behav Brain Res. 2017 Mar 1;320:113-118. doi: 10.1016/j.bbr.2016.11.049. Epub 2016 Dec 1.

PMID:
27916686
27.

Pathophysiological Trends During Withdrawal of Life Support: Implications for Organ Donation After Circulatory Death.

Iyer A, Chew HC, Gao L, Villanueva J, Hicks M, Doyle A, Kumarasinghe G, Jabbour A, Jansz PC, Feneley MP, Harvey RP, Graham RM, Dhital KK, Macdonald PS.

Transplantation. 2016 Dec;100(12):2621-2629.

PMID:
27861290
28.

A rapid co-culture stamping device for studying intercellular communication.

Hassanzadeh-Barforoushi A, Shemesh J, Farbehi N, Asadnia M, Yeoh GH, Harvey RP, Nordon RE, Warkiani ME.

Sci Rep. 2016 Oct 18;6:35618. doi: 10.1038/srep35618.

29.
30.
31.

Epistatic and Independent Effects on Schizophrenia-Related Phenotypes Following Co-disruption of the Risk Factors Neuregulin-1 × DISC1.

O'Tuathaigh CM, Fumagalli F, Desbonnet L, Perez-Branguli F, Moloney G, Loftus S, O'Leary C, Petit E, Cox R, Tighe O, Clarke G, Lai D, Harvey RP, Cryan JF, Mitchell KJ, Dinan TG, Riva MA, Waddington JL.

Schizophr Bull. 2017 Jan;43(1):214-225. doi: 10.1093/schbul/sbw120. Epub 2016 Sep 9.

32.

Large-Scale Production of Cardiomyocytes from Human Pluripotent Stem Cells Using a Highly Reproducible Small Molecule-Based Differentiation Protocol.

Fonoudi H, Ansari H, Abbasalizadeh S, Blue GM, Aghdami N, Winlaw DS, Harvey RP, Bosman A, Baharvand H.

J Vis Exp. 2016 Jul 25;(113). doi: 10.3791/54276.

33.

Quantifying intrinsic and extrinsic control of single-cell fates in cancer and stem/progenitor cell pedigrees with competing risks analysis.

Cornwell JA, Hallett RM, der Mauer SA, Motazedian A, Schroeder T, Draper JS, Harvey RP, Nordon RE.

Sci Rep. 2016 Jun 1;6:27100. doi: 10.1038/srep27100.

34.

Erratum to: 'CompGO: an R package for comparing and visualizing Gene Ontology enrichment differences between DNA binding experiments'.

Waardenberg AJ, Bassett SD, Bouveret R, Harvey RP.

BMC Bioinformatics. 2016 Apr 25;17(1):179. No abstract available.

35.

Developmental origin and lineage plasticity of endogenous cardiac stem cells.

Santini MP, Forte E, Harvey RP, Kovacic JC.

Development. 2016 Apr 15;143(8):1242-58. doi: 10.1242/dev.111591. Review.

36.

A novel conditional mouse model for Nkx2-5 reveals transcriptional regulation of cardiac ion channels.

Furtado MB, Wilmanns JC, Chandran A, Tonta M, Biben C, Eichenlaub M, Coleman HA, Berger S, Bouveret R, Singh R, Harvey RP, Ramialison M, Pearson JT, Parkington HC, Rosenthal NA, Costa MW.

Differentiation. 2016 Jan-Mar;91(1-3):29-41. doi: 10.1016/j.diff.2015.12.003. Epub 2016 Feb 17.

PMID:
26897459
37.

Bioengineered FSTL1 Patches Restore Cardiac Function Following Myocardial Infarction.

Alteköester AK, Harvey RP.

Trends Mol Med. 2015 Dec;21(12):731-733. doi: 10.1016/j.molmed.2015.10.006. Epub 2015 Nov 17.

PMID:
26596868
38.

Cardiomyocytes Replicate and their Numbers Increase in Young Hearts.

Naqvi N, Singh R, Iismaa SE, Li M, Calvert JW, Martin DI, Harvey RP, Graham RM, Husain A.

Cell. 2015 Nov 5;163(4):783-4. doi: 10.1016/j.cell.2015.10.038. No abstract available.

39.

A Universal and Robust Integrated Platform for the Scalable Production of Human Cardiomyocytes From Pluripotent Stem Cells.

Fonoudi H, Ansari H, Abbasalizadeh S, Larijani MR, Kiani S, Hashemizadeh S, Zarchi AS, Bosman A, Blue GM, Pahlavan S, Perry M, Orr Y, Mayorchak Y, Vandenberg J, Talkhabi M, Winlaw DS, Harvey RP, Aghdami N, Baharvand H.

Stem Cells Transl Med. 2015 Dec;4(12):1482-94. doi: 10.5966/sctm.2014-0275. Epub 2015 Oct 28.

40.

Pressure Overload by Transverse Aortic Constriction Induces Maladaptive Hypertrophy in a Titin-Truncated Mouse Model.

Zhou Q, Kesteven S, Wu J, Aidery P, Gawaz M, Gramlich M, Feneley MP, Harvey RP.

Biomed Res Int. 2015;2015:163564. doi: 10.1155/2015/163564. Epub 2015 Oct 4.

41.

Cardiac Regeneration Therapies - Targeting Neuregulin 1 Signalling.

Harvey RP, Wystub-Lis K, del Monte-Nieto G, Graham RM, Tzahor E.

Heart Lung Circ. 2016 Jan;25(1):4-7. doi: 10.1016/j.hlc.2015.08.014. Epub 2015 Sep 25. No abstract available.

PMID:
26476583
42.

CompGO: an R package for comparing and visualizing Gene Ontology enrichment differences between DNA binding experiments.

Waardenberg AJ, Basset SD, Bouveret R, Harvey RP.

BMC Bioinformatics. 2015 Sep 2;16:275. doi: 10.1186/s12859-015-0701-2. Erratum in: BMC Bioinformatics. 2016;17(1):179.

43.

Bioengineering and Stem Cell Technology in the Treatment of Congenital Heart Disease.

Bosman A, Edel MJ, Blue G, Dilley RJ, Harvey RP, Winlaw DS.

J Clin Med. 2015 Apr 22;4(4):768-81. doi: 10.3390/jcm4040768. Review.

44.

NKX2-5 mutations causative for congenital heart disease retain functionality and are directed to hundreds of targets.

Bouveret R, Waardenberg AJ, Schonrock N, Ramialison M, Doan T, de Jong D, Bondue A, Kaur G, Mohamed S, Fonoudi H, Chen CM, Wouters MA, Bhattacharya S, Plachta N, Dunwoodie SL, Chapman G, Blanpain C, Harvey RP.

Elife. 2015 Jul 6;4. doi: 10.7554/eLife.06942.

45.

A common Shox2-Nkx2-5 antagonistic mechanism primes the pacemaker cell fate in the pulmonary vein myocardium and sinoatrial node.

Ye W, Wang J, Song Y, Yu D, Sun C, Liu C, Chen F, Zhang Y, Wang F, Harvey RP, Schrader L, Martin JF, Chen Y.

Development. 2015 Jul 15;142(14):2521-32. doi: 10.1242/dev.120220. Epub 2015 Jul 2.

46.

Lost cold Antarctic deserts inferred from unusual sulfate formation and isotope signatures.

Sun T, Socki RA, Bish DL, Harvey RP, Bao H, Niles PB, Cavicchioli R, Tonui E.

Nat Commun. 2015 Jun 29;6:7579. doi: 10.1038/ncomms8579.

PMID:
26119082
47.

ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation.

D'Uva G, Aharonov A, Lauriola M, Kain D, Yahalom-Ronen Y, Carvalho S, Weisinger K, Bassat E, Rajchman D, Yifa O, Lysenko M, Konfino T, Hegesh J, Brenner O, Neeman M, Yarden Y, Leor J, Sarig R, Harvey RP, Tzahor E.

Nat Cell Biol. 2015 May;17(5):627-38. doi: 10.1038/ncb3149. Epub 2015 Apr 6.

PMID:
25848746
48.

Antisense-mediated exon skipping: a therapeutic strategy for titin-based dilated cardiomyopathy.

Gramlich M, Pane LS, Zhou Q, Chen Z, Murgia M, Schötterl S, Goedel A, Metzger K, Brade T, Parrotta E, Schaller M, Gerull B, Thierfelder L, Aartsma-Rus A, Labeit S, Atherton JJ, McGaughran J, Harvey RP, Sinnecker D, Mann M, Laugwitz KL, Gawaz MP, Moretti A.

EMBO Mol Med. 2015 May;7(5):562-76. doi: 10.15252/emmm.201505047.

49.

Irreversible triggers for hypertrophic cardiomyopathy are established in the early postnatal period.

Cannon L, Yu ZY, Marciniec T, Waardenberg AJ, Iismaa SE, Nikolova-Krstevski V, Neist E, Ohanian M, Qiu MR, Rainer S, Harvey RP, Feneley MP, Graham RM, Fatkin D.

J Am Coll Cardiol. 2015 Feb 17;65(6):560-9. doi: 10.1016/j.jacc.2014.10.069.

50.

Normothermic ex vivo perfusion provides superior organ preservation and enables viability assessment of hearts from DCD donors.

Iyer A, Gao L, Doyle A, Rao P, Cropper JR, Soto C, Dinale A, Kumarasinghe G, Jabbour A, Hicks M, Jansz PC, Feneley MP, Harvey RP, Graham RM, Dhital KK, MacDonald PS.

Am J Transplant. 2015 Feb;15(2):371-80. doi: 10.1111/ajt.12994.

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