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The dPix-Git complex is essential to coordinate epithelial morphogenesis and regulate myosin during Drosophila egg chamber development.

Dent LG, Manning SA, Kroeger B, Williams AM, Saiful Hilmi AJ, Crea L, Kondo S, Horne-Badovinac S, Harvey KF.

PLoS Genet. 2019 May 22;15(5):e1008083. doi: 10.1371/journal.pgen.1008083. eCollection 2019 May.


Somatic Hypermutation of the YAP Oncogene in a Human Cutaneous Melanoma.

Zhang X, Tang JZ, Vergara IA, Zhang Y, Szeto P, Yang L, Mintoff C, Colebatch A, McIntosh L, Mitchell KA, Shaw E, Rizos H, Long GV, Hayward N, McArthur GA, Papenfuss AT, Harvey KF, Shackleton M.

Mol Cancer Res. 2019 Jul;17(7):1435-1449. doi: 10.1158/1541-7786.MCR-18-0407. Epub 2019 Mar 4.


A Hippo-like Signaling Pathway Controls Tracheal Morphogenesis in Drosophila melanogaster.

Poon CLC, Liu W, Song Y, Gomez M, Kulaberoglu Y, Zhang X, Xu W, Veraksa A, Hergovich A, Ghabrial A, Harvey KF.

Dev Cell. 2018 Dec 3;47(5):564-575.e5. doi: 10.1016/j.devcel.2018.09.024. Epub 2018 Oct 25.


The Scalloped and Nerfin-1 Transcription Factors Cooperate to Maintain Neuronal Cell Fate.

Vissers JHA, Froldi F, Schröder J, Papenfuss AT, Cheng LY, Harvey KF.

Cell Rep. 2018 Nov 6;25(6):1561-1576.e7. doi: 10.1016/j.celrep.2018.10.038.


Dynamic Fluctuations in Subcellular Localization of the Hippo Pathway Effector Yorkie In Vivo.

Manning SA, Dent LG, Kondo S, Zhao ZW, Plachta N, Harvey KF.

Curr Biol. 2018 May 21;28(10):1651-1660.e4. doi: 10.1016/j.cub.2018.04.018. Epub 2018 May 10.


Regulation of Tissue Growth by the Mammalian Hippo Signaling Pathway.

Watt KI, Harvey KF, Gregorevic P.

Front Physiol. 2017 Nov 24;8:942. doi: 10.3389/fphys.2017.00942. eCollection 2017. Review.


Hippo Wades into Cancer Immunology.

Gebhardt T, Harvey KF.

Dev Cell. 2016 Dec 19;39(6):635-637. doi: 10.1016/j.devcel.2016.12.010.


The Hippo Pathway Regulates Neuroblasts and Brain Size in Drosophila melanogaster.

Poon CL, Mitchell KA, Kondo S, Cheng LY, Harvey KF.

Curr Biol. 2016 Apr 25;26(8):1034-42. doi: 10.1016/j.cub.2016.02.009. Epub 2016 Mar 17.


A Drosophila RNAi library modulates Hippo pathway-dependent tissue growth.

Vissers JH, Manning SA, Kulkarni A, Harvey KF.

Nat Commun. 2016 Jan 13;7:10368. doi: 10.1038/ncomms10368.


Warts Opens Up for Activation.

Manning SA, Harvey KF.

Dev Cell. 2015 Dec 21;35(6):666-8. doi: 10.1016/j.devcel.2015.12.004.


Control of organ growth by patterning and hippo signaling in Drosophila.

Irvine KD, Harvey KF.

Cold Spring Harb Perspect Biol. 2015 Jun 1;7(6). pii: a019224. doi: 10.1101/cshperspect.a019224. Review.


Growth control: re-examining Zyxin's role in the hippo pathway.

Harvey KF.

Curr Biol. 2015 Mar 16;25(6):R230-R231. doi: 10.1016/j.cub.2015.01.019.


The Hippo pathway effector YAP is a critical regulator of skeletal muscle fibre size.

Watt KI, Turner BJ, Hagg A, Zhang X, Davey JR, Qian H, Beyer C, Winbanks CE, Harvey KF, Gregorevic P.

Nat Commun. 2015 Jan 12;6:6048. doi: 10.1038/ncomms7048.


The GTPase regulatory proteins Pix and Git control tissue growth via the Hippo pathway.

Dent LG, Poon CL, Zhang X, Degoutin JL, Tipping M, Veraksa A, Harvey KF.

Curr Biol. 2015 Jan 5;25(1):124-30. doi: 10.1016/j.cub.2014.11.041. Epub 2014 Dec 4.


The Hippo pathway regulates hematopoiesis in Drosophila melanogaster.

Milton CC, Grusche FA, Degoutin JL, Yu E, Dai Q, Lai EC, Harvey KF.

Curr Biol. 2014 Nov 17;24(22):2673-80. doi: 10.1016/j.cub.2014.10.031. Epub 2014 Oct 30.


Riquiqui and minibrain are regulators of the hippo pathway downstream of Dachsous.

Degoutin JL, Milton CC, Yu E, Tipping M, Bosveld F, Yang L, Bellaiche Y, Veraksa A, Harvey KF.

Nat Cell Biol. 2013 Oct;15(10):1176-85. doi: 10.1038/ncb2829. Epub 2013 Aug 18.


The Hippo pathway and human cancer.

Harvey KF, Zhang X, Thomas DM.

Nat Rev Cancer. 2013 Apr;13(4):246-57. doi: 10.1038/nrc3458. Epub 2013 Mar 7. Review.


The Hippo size control pathway--ever expanding.

Lin JI, Poon CL, Harvey KF.

Sci Signal. 2013 Jan 22;6(259):pe4. doi: 10.1126/scisignal.2003813. Review.


Yap controls stem/progenitor cell proliferation in the mouse postnatal epidermis.

Beverdam A, Claxton C, Zhang X, James G, Harvey KF, Key B.

J Invest Dermatol. 2013 Jun;133(6):1497-505. doi: 10.1038/jid.2012.430. Epub 2012 Nov 29.


The Hippo pathway--from top to bottom and everything in between.

Tapon N, Harvey KF.

Semin Cell Dev Biol. 2012 Sep;23(7):768-9. doi: 10.1016/j.semcdb.2012.08.007. Epub 2012 Aug 23. No abstract available.


Homeodomain-interacting protein kinase regulates Hippo pathway-dependent tissue growth.

Poon CL, Zhang X, Lin JI, Manning SA, Harvey KF.

Curr Biol. 2012 Sep 11;22(17):1587-94. doi: 10.1016/j.cub.2012.06.075. Epub 2012 Jul 26.


The hippo pathway.

Harvey KF, Hariharan IK.

Cold Spring Harb Perspect Biol. 2012 Aug 1;4(8):a011288. doi: 10.1101/cshperspect.a011288. Review. No abstract available.


Control of tissue growth and cell transformation by the Salvador/Warts/Hippo pathway.

Zhang X, Grusche FA, Harvey KF.

PLoS One. 2012;7(2):e31994. doi: 10.1371/journal.pone.0031994. Epub 2012 Feb 16.


The sterile 20-like kinase Tao-1 controls tissue growth by regulating the Salvador-Warts-Hippo pathway.

Poon CL, Lin JI, Zhang X, Harvey KF.

Dev Cell. 2011 Nov 15;21(5):896-906. doi: 10.1016/j.devcel.2011.09.012.


Willin/FRMD6 expression activates the Hippo signaling pathway kinases in mammals and antagonizes oncogenic YAP.

Angus L, Moleirinho S, Herron L, Sinha A, Zhang X, Niestrata M, Dholakia K, Prystowsky MB, Harvey KF, Reynolds PA, Gunn-Moore FJ.

Oncogene. 2012 Jan 12;31(2):238-50. doi: 10.1038/onc.2011.224. Epub 2011 Jun 13.


The Hippo pathway transcriptional co-activator, YAP, is an ovarian cancer oncogene.

Zhang X, George J, Deb S, Degoutin JL, Takano EA, Fox SB; AOCS Study group, Bowtell DD, Harvey KF.

Oncogene. 2011 Jun 23;30(25):2810-22. doi: 10.1038/onc.2011.8. Epub 2011 Feb 14.


Wbp2 cooperates with Yorkie to drive tissue growth downstream of the Salvador-Warts-Hippo pathway.

Zhang X, Milton CC, Poon CL, Hong W, Harvey KF.

Cell Death Differ. 2011 Aug;18(8):1346-55. doi: 10.1038/cdd.2011.6. Epub 2011 Feb 11.


The Salvador/Warts/Hippo pathway controls regenerative tissue growth in Drosophila melanogaster.

Grusche FA, Degoutin JL, Richardson HE, Harvey KF.

Dev Biol. 2011 Feb 15;350(2):255-66. doi: 10.1016/j.ydbio.2010.11.020. Epub 2010 Nov 25.


WW domain-mediated interaction with Wbp2 is important for the oncogenic property of TAZ.

Chan SW, Lim CJ, Huang C, Chong YF, Gunaratne HJ, Hogue KA, Blackstock WP, Harvey KF, Hong W.

Oncogene. 2011 Feb 3;30(5):600-10. doi: 10.1038/onc.2010.438. Epub 2010 Oct 25.


Upstream regulation of the hippo size control pathway.

Grusche FA, Richardson HE, Harvey KF.

Curr Biol. 2010 Jul 13;20(13):R574-82. doi: 10.1016/j.cub.2010.05.023. Review.


Modularity in the Hippo signaling pathway.

Sudol M, Harvey KF.

Trends Biochem Sci. 2010 Nov;35(11):627-33. doi: 10.1016/j.tibs.2010.05.010. Epub 2010 Jul 2. Review.


Lgl, aPKC, and Crumbs regulate the Salvador/Warts/Hippo pathway through two distinct mechanisms.

Grzeschik NA, Parsons LM, Allott ML, Harvey KF, Richardson HE.

Curr Biol. 2010 Apr 13;20(7):573-81. doi: 10.1016/j.cub.2010.01.055. Epub 2010 Apr 1.


Bunched and Madm: a novel growth-regulatory complex?

Harvey KF.

J Biol. 2010;9(1):8. doi: 10.1186/jbiol219. Epub 2010 Feb 11.


Differential requirement of Salvador-Warts-Hippo pathway members for organ size control in Drosophila melanogaster.

Milton CC, Zhang X, Albanese NO, Harvey KF.

Development. 2010 Mar;137(5):735-43. doi: 10.1242/dev.042309. Epub 2010 Jan 28.


A tumor suppressor activity of Drosophila Polycomb genes mediated by JAK-STAT signaling.

Classen AK, Bunker BD, Harvey KF, Vaccari T, Bilder D.

Nat Genet. 2009 Oct;41(10):1150-5. doi: 10.1038/ng.445. Epub 2009 Sep 13.


Transcriptional output of the Salvador/warts/hippo pathway is controlled in distinct fashions in Drosophila melanogaster and mammalian cell lines.

Zhang X, Milton CC, Humbert PO, Harvey KF.

Cancer Res. 2009 Aug 1;69(15):6033-41. doi: 10.1158/0008-5472.CAN-08-4592. Epub 2009 Jul 7.


Making brundlefly, one gene at a time.

Zhang X, Richardson HE, Harvey KF.

Cell Res. 2009 Jan;19(1):5-7. doi: 10.1038/cr.2009.2. No abstract available.


Mutation of the gene encoding the ubiquitin activating enzyme ubal causes tissue overgrowth in Drosophila.

Pfleger CM, Harvey KF, Yan H, Hariharan IK.

Fly (Austin). 2007 Mar-Apr;1(2):95-105.


FOXO-regulated transcription restricts overgrowth of Tsc mutant organs.

Harvey KF, Mattila J, Sofer A, Bennett FC, Ramsey MR, Ellisen LW, Puig O, Hariharan IK.

J Cell Biol. 2008 Feb 25;180(4):691-6. doi: 10.1083/jcb.200710100.


Fat cadherin modulates organ size in Drosophila via the Salvador/Warts/Hippo signaling pathway.

Bennett FC, Harvey KF.

Curr Biol. 2006 Nov 7;16(21):2101-10. Epub 2006 Oct 12.


The Drosophila melanogaster Apaf-1 homologue ARK is required for most, but not all, programmed cell death.

Mills K, Daish T, Harvey KF, Pfleger CM, Hariharan IK, Kumar S.

J Cell Biol. 2006 Mar 13;172(6):809-15.


salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines.

Tapon N, Harvey KF, Bell DW, Wahrer DC, Schiripo TA, Haber D, Hariharan IK.

Cell. 2002 Aug 23;110(4):467-78.


N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein.

Harvey KF, Shearwin-Whyatt LM, Fotia A, Parton RG, Kumar S.

J Biol Chem. 2002 Mar 15;277(11):9307-17. Epub 2001 Dec 17.


Roles of the C termini of alpha -, beta -, and gamma -subunits of epithelial Na+ channels (ENaC) in regulating ENaC and mediating its inhibition by cytosolic Na+.

Dinudom A, Harvey KF, Komwatana P, Jolliffe CN, Young JA, Kumar S, Cook DI.

J Biol Chem. 2001 Apr 27;276(17):13744-9. Epub 2001 Feb 1.


The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel.

Harvey KF, Dinudom A, Cook DI, Kumar S.

J Biol Chem. 2001 Mar 16;276(11):8597-601. Epub 2001 Jan 17.


Na(+)-H(+) exchange in salivary secretory cells is controlled by an intracellular Na(+) receptor.

Ishibashi H, Dinudom A, Harvey KF, Kumar S, Young JA, Cook DI.

Proc Natl Acad Sci U S A. 1999 Aug 17;96(17):9949-53.


All three WW domains of murine Nedd4 are involved in the regulation of epithelial sodium channels by intracellular Na+.

Harvey KF, Dinudom A, Komwatana P, Jolliffe CN, Day ML, Parasivam G, Cook DI, Kumar S.

J Biol Chem. 1999 Apr 30;274(18):12525-30.

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