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Items: 11

1.

N-terminal modification of VEGF-A C terminus-derived peptides delineates structural features involved in neuropilin-1 binding and functional activity.

Jia H, Aqil R, Cheng L, Chapman C, Shaikh S, Jarvis A, Chan AW, Hartzoulakis B, Evans IM, Frolov A, Martin J, Frankel P, Djordevic S, Zachary IC, Selwood DL.

Chembiochem. 2014 May 26;15(8):1161-70. doi: 10.1002/cbic.201300658. Epub 2014 Apr 25.

PMID:
24771685
2.

Ligand- and structure-based virtual screening for clathrodin-derived human voltage-gated sodium channel modulators.

Tomašić T, Hartzoulakis B, Zidar N, Chan F, Kirby RW, Madge DJ, Peigneur S, Tytgat J, Kikelj D.

J Chem Inf Model. 2013 Dec 23;53(12):3223-32. doi: 10.1021/ci400505e. Epub 2013 Nov 19.

PMID:
24215100
3.

VEGF binding to NRP1 is essential for VEGF stimulation of endothelial cell migration, complex formation between NRP1 and VEGFR2, and signaling via FAK Tyr407 phosphorylation.

Herzog B, Pellet-Many C, Britton G, Hartzoulakis B, Zachary IC.

Mol Biol Cell. 2011 Aug 1;22(15):2766-76. doi: 10.1091/mbc.E09-12-1061. Epub 2011 Jun 8.

4.

Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.

Jarvis A, Allerston CK, Jia H, Herzog B, Garza-Garcia A, Winfield N, Ellard K, Aqil R, Lynch R, Chapman C, Hartzoulakis B, Nally J, Stewart M, Cheng L, Menon M, Tickner M, Djordjevic S, Driscoll PC, Zachary I, Selwood DL.

J Med Chem. 2010 Mar 11;53(5):2215-26. doi: 10.1021/jm901755g.

5.

Prediction of ion channel activity using binary kernel discrimination.

Willett P, Wilton D, Hartzoulakis B, Tang R, Ford J, Madge D.

J Chem Inf Model. 2007 Sep-Oct;47(5):1961-6. Epub 2007 Jul 10.

PMID:
17622131
6.

Discovery of inhibitors of the pentein superfamily protein dimethylarginine dimethylaminohydrolase (DDAH), by virtual screening and hit analysis.

Hartzoulakis B, Rossiter S, Gill H, O'Hara B, Steinke E, Gane PJ, Hurtado-Guerrero R, Leiper JM, Vallance P, Rust JM, Selwood DL.

Bioorg Med Chem Lett. 2007 Jul 15;17(14):3953-6. Epub 2007 May 3.

PMID:
17543521
7.

Characterization of a bicyclic peptide neuropilin-1 (NP-1) antagonist (EG3287) reveals importance of vascular endothelial growth factor exon 8 for NP-1 binding and role of NP-1 in KDR signaling.

Jia H, Bagherzadeh A, Hartzoulakis B, Jarvis A, Löhr M, Shaikh S, Aqil R, Cheng L, Tickner M, Esposito D, Harris R, Driscoll PC, Selwood DL, Zachary IC.

J Biol Chem. 2006 May 12;281(19):13493-502. Epub 2006 Mar 2.

8.

Aurora A and B kinases as targets for cancer: will they be selective for tumors?

Matthews N, Visintin C, Hartzoulakis B, Jarvis A, Selwood DL.

Expert Rev Anticancer Ther. 2006 Jan;6(1):109-20. Review.

PMID:
16375648
9.

Imatinib binding and cKIT inhibition is abrogated by the cKIT kinase domain I missense mutation Val654Ala.

McLean SR, Gana-Weisz M, Hartzoulakis B, Frow R, Whelan J, Selwood D, Boshoff C.

Mol Cancer Ther. 2005 Dec;4(12):2008-15.

10.

Copper (II)-mediated arylation with aryl boronic acids for the N-derivatization of pyrazole libraries.

Rossiter S, Woo CK, Hartzoulakis B, Wishart G, Stanyer L, Labadie JW, Selwood DL.

J Comb Chem. 2004 May-Jun;6(3):385-90.

PMID:
15132598
11.

Synthesis of ketomethylene amino pseudopeptide analogues via reductive amination of glyoxals derived from alpha-amino acids.

Groarke M, Hartzoulakis B, McKervey MA, Walker B, Williams CH.

Bioorg Med Chem Lett. 2000 Jan 17;10(2):153-5.

PMID:
10673100

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