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Items: 1 to 50 of 130

1.

Wasted TMEM16A channels are rescued by phosphatidylinositol 4,5-bisphosphate.

Arreola J, Hartzell HC.

Cell Calcium. 2019 Dec;84:102103. doi: 10.1016/j.ceca.2019.102103. Epub 2019 Oct 18.

PMID:
31683182
2.

A network of phosphatidylinositol 4,5-bisphosphate binding sites regulates gating of the Ca2+-activated Cl- channel ANO1 (TMEM16A).

Yu K, Jiang T, Cui Y, Tajkhorshid E, Hartzell HC.

Proc Natl Acad Sci U S A. 2019 Oct 1;116(40):19952-19962. doi: 10.1073/pnas.1904012116. Epub 2019 Sep 12.

PMID:
31515451
3.

Tropomodulin Isoform-Specific Regulation of Dendrite Development and Synapse Formation.

Omotade OF, Rui Y, Lei W, Yu K, Hartzell HC, Fowler VM, Zheng JQ.

J Neurosci. 2018 Nov 28;38(48):10271-10285. doi: 10.1523/JNEUROSCI.3325-17.2018. Epub 2018 Oct 9.

4.

Anoctamin 5/TMEM16E facilitates muscle precursor cell fusion.

Whitlock JM, Yu K, Cui YY, Hartzell HC.

J Gen Physiol. 2018 Nov 5;150(11):1498-1509. doi: 10.1085/jgp.201812097. Epub 2018 Sep 26.

5.

Phosphatidylinositol 4,5-bisphosphate, cholesterol, and fatty acids modulate the calcium-activated chloride channel TMEM16A (ANO1).

De Jesús-Pérez JJ, Cruz-Rangel S, Espino-Saldaña ÁE, Martínez-Torres A, Qu Z, Hartzell HC, Corral-Fernandez NE, Pérez-Cornejo P, Arreola J.

Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Mar;1863(3):299-312. doi: 10.1016/j.bbalip.2017.12.009. Epub 2017 Dec 22.

6.

Lipids and ions traverse the membrane by the same physical pathway in the nhTMEM16 scramblase.

Jiang T, Yu K, Hartzell HC, Tajkhorshid E.

Elife. 2017 Sep 16;6. pii: e28671. doi: 10.7554/eLife.28671.

7.

Poring over furrows.

Fisher SI, Hartzell HC.

Elife. 2017 May 31;6. pii: e27933. doi: 10.7554/eLife.27933.

8.

Anoctamins/TMEM16 Proteins: Chloride Channels Flirting with Lipids and Extracellular Vesicles.

Whitlock JM, Hartzell HC.

Annu Rev Physiol. 2017 Feb 10;79:119-143. doi: 10.1146/annurev-physiol-022516-034031. Epub 2016 Nov 16. Review.

9.

Extracellular protons enable activation of the calcium-dependent chloride channel TMEM16A.

Cruz-Rangel S, De Jesús-Pérez JJ, Aréchiga-Figueroa IA, Rodríguez-Menchaca AA, Pérez-Cornejo P, Hartzell HC, Arreola J.

J Physiol. 2017 Mar 1;595(5):1515-1531. doi: 10.1113/JP273111. Epub 2017 Jan 3.

10.

TMEM16 chloride channels are two-faced.

Hartzell HC, Whitlock JM.

J Gen Physiol. 2016 Nov;148(5):367-373. No abstract available.

11.

Revealing the activation pathway for TMEM16A chloride channels from macroscopic currents and kinetic models.

Contreras-Vite JA, Cruz-Rangel S, De Jesús-Pérez JJ, Figueroa IAA, Rodríguez-Menchaca AA, Pérez-Cornejo P, Hartzell HC, Arreola J.

Pflugers Arch. 2016 Jul;468(7):1241-1257. doi: 10.1007/s00424-016-1830-9. Epub 2016 May 2.

12.

Defective membrane fusion and repair in Anoctamin5-deficient muscular dystrophy.

Griffin DA, Johnson RW, Whitlock JM, Pozsgai ER, Heller KN, Grose WE, Arnold WD, Sahenk Z, Hartzell HC, Rodino-Klapac LR.

Hum Mol Genet. 2016 May 15;25(10):1900-1911. Epub 2016 Feb 23.

13.

A Pore Idea: the ion conduction pathway of TMEM16/ANO proteins is composed partly of lipid.

Whitlock JM, Hartzell HC.

Pflugers Arch. 2016 Mar;468(3):455-73. doi: 10.1007/s00424-015-1777-2. Epub 2016 Jan 6. Review.

14.

Gating modes of calcium-activated chloride channels TMEM16A and TMEM16B.

Cruz-Rangel S, De Jesús-Pérez JJ, Contreras-Vite JA, Pérez-Cornejo P, Hartzell HC, Arreola J.

J Physiol. 2015 Dec 15;593(24):5283-98. doi: 10.1113/JP271256. Epub 2015 Dec 7.

15.

Identification of a lipid scrambling domain in ANO6/TMEM16F.

Yu K, Whitlock JM, Lee K, Ortlund EA, Cui YY, Hartzell HC.

Elife. 2015 Jun 9;4:e06901. doi: 10.7554/eLife.06901.

16.

Two helices in the third intracellular loop determine anoctamin 1 (TMEM16A) activation by calcium.

Lee J, Jung J, Tak MH, Wee J, Lee B, Jang Y, Chun H, Yang DJ, Yang YD, Park SH, Han BW, Hyun S, Yu J, Cho H, Hartzell HC, Oh U.

Pflugers Arch. 2015 Aug;467(8):1677-87. doi: 10.1007/s00424-014-1603-2. Epub 2014 Sep 19.

17.

Characterization of Cardiac Anoctamin1 Ca²⁺-Activated Chloride Channels and Functional Role in Ischemia-Induced Arrhythmias.

Ye Z, Wu MM, Wang CY, Li YC, Yu CJ, Gong YF, Zhang J, Wang QS, Song BL, Yu K, Hartzell HC, Duan DD, Zhao D, Zhang ZR.

J Cell Physiol. 2015 Feb;230(2):337-46. doi: 10.1002/jcp.24709.

18.

Hypoxia augments the calcium-activated chloride current carried by anoctamin-1 in cardiac vascular endothelial cells of neonatal mice.

Wu MM, Lou J, Song BL, Gong YF, Li YC, Yu CJ, Wang QS, Ma TX, Ma K, Hartzell HC, Duan DD, Zhao D, Zhang ZR.

Br J Pharmacol. 2014 Aug;171(15):3680-92. doi: 10.1111/bph.12730.

19.

The Ca2+-activated Cl- channel ANO1/TMEM16A regulates primary ciliogenesis.

Ruppersburg CC, Hartzell HC.

Mol Biol Cell. 2014 Jun;25(11):1793-807. doi: 10.1091/mbc.E13-10-0599. Epub 2014 Apr 2.

20.

Activation of the Ano1 (TMEM16A) chloride channel by calcium is not mediated by calmodulin.

Yu K, Zhu J, Qu Z, Cui YY, Hartzell HC.

J Gen Physiol. 2014 Feb;143(2):253-67. doi: 10.1085/jgp.201311047. Epub 2014 Jan 13.

21.

Functional reconstitution of a chloride channel bares its soul.

Hartzell HC, Ruppersburg CC.

Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19185-6. doi: 10.1073/pnas.1319415110. Epub 2013 Nov 14. No abstract available.

22.

Activity-dependent regulation of dendritic growth and maintenance by glycogen synthase kinase 3β.

Rui Y, Myers KR, Yu K, Wise A, De Blas AL, Hartzell HC, Zheng JQ.

Nat Commun. 2013;4:2628. doi: 10.1038/ncomms3628.

23.

MONNA, a potent and selective blocker for transmembrane protein with unknown function 16/anoctamin-1.

Oh SJ, Hwang SJ, Jung J, Yu K, Kim J, Choi JY, Hartzell HC, Roh EJ, Lee CJ.

Mol Pharmacol. 2013 Nov;84(5):726-35. doi: 10.1124/mol.113.087502. Epub 2013 Aug 30.

24.

A comprehensive strategy to identify stoichiometric membrane protein interactomes.

Gokhale A, Perez-Cornejo P, Duran C, Hartzell HC, Faundez V.

Cell Logist. 2012 Oct 1;2(4):189-196.

25.

Drosophila bestrophin-1 currents are regulated by phosphorylation via a CaMKII dependent mechanism.

Duran C, Chien LT, Hartzell HC.

PLoS One. 2013;8(3):e58875. doi: 10.1371/journal.pone.0058875. Epub 2013 Mar 12.

26.

Anoctamin 1 (Tmem16A) Ca2+-activated chloride channel stoichiometrically interacts with an ezrin-radixin-moesin network.

Perez-Cornejo P, Gokhale A, Duran C, Cui Y, Xiao Q, Hartzell HC, Faundez V.

Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10376-81. doi: 10.1073/pnas.1200174109. Epub 2012 Jun 8.

27.

Explaining calcium-dependent gating of anoctamin-1 chloride channels requires a revised topology.

Yu K, Duran C, Qu Z, Cui YY, Hartzell HC.

Circ Res. 2012 Mar 30;110(7):990-9. doi: 10.1161/CIRCRESAHA.112.264440. Epub 2012 Mar 6.

28.

ANOs 3-7 in the anoctamin/Tmem16 Cl- channel family are intracellular proteins.

Duran C, Qu Z, Osunkoya AO, Cui Y, Hartzell HC.

Am J Physiol Cell Physiol. 2012 Feb 1;302(3):C482-93. doi: 10.1152/ajpcell.00140.2011. Epub 2011 Nov 9.

29.

Physiological roles and diseases of Tmem16/Anoctamin proteins: are they all chloride channels?

Duran C, Hartzell HC.

Acta Pharmacol Sin. 2011 Jun;32(6):685-92. doi: 10.1038/aps.2011.48. Review.

30.

Voltage- and calcium-dependent gating of TMEM16A/Ano1 chloride channels are physically coupled by the first intracellular loop.

Xiao Q, Yu K, Perez-Cornejo P, Cui Y, Arreola J, Hartzell HC.

Proc Natl Acad Sci U S A. 2011 May 24;108(21):8891-6. doi: 10.1073/pnas.1102147108. Epub 2011 May 9.

31.

Characterization of the oligomeric structure of the Ca(2+)-activated Cl- channel Ano1/TMEM16A.

Sheridan JT, Worthington EN, Yu K, Gabriel SE, Hartzell HC, Tarran R.

J Biol Chem. 2011 Jan 14;286(2):1381-8. doi: 10.1074/jbc.M110.174847. Epub 2010 Nov 5.

32.

ADF/cofilin-mediated actin dynamics regulate AMPA receptor trafficking during synaptic plasticity.

Gu J, Lee CW, Fan Y, Komlos D, Tang X, Sun C, Yu K, Hartzell HC, Chen G, Bamburg JR, Zheng JQ.

Nat Neurosci. 2010 Oct;13(10):1208-15. doi: 10.1038/nn.2634. Epub 2010 Sep 12.

33.

Bestrophin-2 mediates bicarbonate transport by goblet cells in mouse colon.

Yu K, Lujan R, Marmorstein A, Gabriel S, Hartzell HC.

J Clin Invest. 2010 May;120(5):1722-35. doi: 10.1172/JCI41129. Epub 2010 Apr 19.

34.

Bestrophins and retinopathies.

Xiao Q, Hartzell HC, Yu K.

Pflugers Arch. 2010 Jul;460(2):559-69. doi: 10.1007/s00424-010-0821-5. Epub 2010 Mar 28. Review.

35.

Inhibition of AMPA receptor trafficking at hippocampal synapses by beta-amyloid oligomers: the mitochondrial contribution.

Rui Y, Gu J, Yu K, Hartzell HC, Zheng JQ.

Mol Brain. 2010 Mar 26;3:10. doi: 10.1186/1756-6606-3-10.

36.

Tmem16A encodes the Ca2+-activated Cl- channel in mouse submandibular salivary gland acinar cells.

Romanenko VG, Catalán MA, Brown DA, Putzier I, Hartzell HC, Marmorstein AD, Gonzalez-Begne M, Rock JR, Harfe BD, Melvin JE.

J Biol Chem. 2010 Apr 23;285(17):12990-3001. doi: 10.1074/jbc.M109.068544. Epub 2010 Feb 22.

37.

Suppression of Ca2+ signaling in a mouse model of Best disease.

Zhang Y, Stanton JB, Wu J, Yu K, Hartzell HC, Peachey NS, Marmorstein LY, Marmorstein AD.

Hum Mol Genet. 2010 Mar 15;19(6):1108-18. doi: 10.1093/hmg/ddp583. Epub 2010 Jan 6.

38.

Chloride channels: often enigmatic, rarely predictable.

Duran C, Thompson CH, Xiao Q, Hartzell HC.

Annu Rev Physiol. 2010;72:95-121. doi: 10.1146/annurev-physiol-021909-135811. Review.

39.

Dysregulation of human bestrophin-1 by ceramide-induced dephosphorylation.

Xiao Q, Yu K, Cui YY, Hartzell HC.

J Physiol. 2009 Sep 15;587(Pt 18):4379-91. doi: 10.1113/jphysiol.2009.176800. Epub 2009 Jul 27.

40.

Regulation of bestrophin Cl channels by calcium: role of the C terminus.

Xiao Q, Prussia A, Yu K, Cui YY, Hartzell HC.

J Gen Physiol. 2008 Dec;132(6):681-92. doi: 10.1085/jgp.200810056.

41.

Anoctamin/TMEM16 family members are Ca2+-activated Cl- channels.

Hartzell HC, Yu K, Xiao Q, Chien LT, Qu Z.

J Physiol. 2009 May 15;587(Pt 10):2127-39. doi: 10.1113/jphysiol.2008.163709. Epub 2008 Nov 17. Review.

42.

Rescue of volume-regulated anion current by bestrophin mutants with altered charge selectivity.

Chien LT, Hartzell HC.

J Gen Physiol. 2008 Nov;132(5):537-46. doi: 10.1085/jgp.200810065.

43.

Physiology. CaCl-ing channels get the last laugh.

Hartzell HC.

Science. 2008 Oct 24;322(5901):534-5. doi: 10.1126/science.1165668. No abstract available.

PMID:
18948525
44.

The best disease-linked Cl- channel hBest1 regulates Ca V 1 (L-type) Ca2+ channels via src-homology-binding domains.

Yu K, Xiao Q, Cui G, Lee A, Hartzell HC.

J Neurosci. 2008 May 28;28(22):5660-70. doi: 10.1523/JNEUROSCI.0065-08.2008.

45.

Bestrophin Cl- channels are highly permeable to HCO3-.

Qu Z, Hartzell HC.

Am J Physiol Cell Physiol. 2008 Jun;294(6):C1371-7. doi: 10.1152/ajpcell.00398.2007. Epub 2008 Apr 9.

46.

Molecular physiology of bestrophins: multifunctional membrane proteins linked to best disease and other retinopathies.

Hartzell HC, Qu Z, Yu K, Xiao Q, Chien LT.

Physiol Rev. 2008 Apr;88(2):639-72. doi: 10.1152/physrev.00022.2007. Review.

47.

Bestrophin-2 is involved in the generation of intraocular pressure.

Bakall B, McLaughlin P, Stanton JB, Zhang Y, Hartzell HC, Marmorstein LY, Marmorstein AD.

Invest Ophthalmol Vis Sci. 2008 Apr;49(4):1563-70. doi: 10.1167/iovs.07-1338.

48.
49.

Chloride channel activity of bestrophin mutants associated with mild or late-onset macular degeneration.

Yu K, Qu Z, Cui Y, Hartzell HC.

Invest Ophthalmol Vis Sci. 2007 Oct;48(10):4694-705.

PMID:
17898294
50.

Cell biology. The stress of relaxation.

Hartzell HC.

Science. 2007 Sep 7;317(5843):1331-2. No abstract available.

PMID:
17823336

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