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Items: 39

1.

Isolation of Cerebral Capillaries from Fresh Human Brain Tissue.

Hartz AMS, Schulz JA, Sokola BS, Edelmann SE, Shen AN, Rempe RG, Zhong Y, Seblani NE, Bauer B.

J Vis Exp. 2018 Sep 12;(139). doi: 10.3791/57346.

PMID:
30272660
2.

Neuroimaging Biomarkers of mTOR Inhibition on Vascular and Metabolic Functions in Aging Brain and Alzheimer's Disease.

Lee J, Yanckello LM, Ma D, Hoffman JD, Parikh I, Thalman S, Bauer B, Hartz AMS, Hyder F, Lin AL.

Front Aging Neurosci. 2018 Jul 26;10:225. doi: 10.3389/fnagi.2018.00225. eCollection 2018. Review.

3.

The concerted amyloid-beta clearance of LRP1 and ABCB1/P-gp across the blood-brain barrier is linked by PICALM.

Storck SE, Hartz AMS, Bernard J, Wolf A, Kachlmeier A, Mahringer A, Weggen S, Pahnke J, Pietrzik CU.

Brain Behav Immun. 2018 Oct;73:21-33. doi: 10.1016/j.bbi.2018.07.017. Epub 2018 Jul 21.

PMID:
30041013
4.

Preventing P-gp Ubiquitination Lowers Aβ Brain Levels in an Alzheimer's Disease Mouse Model.

Hartz AMS, Zhong Y, Shen AN, Abner EL, Bauer B.

Front Aging Neurosci. 2018 Jun 26;10:186. doi: 10.3389/fnagi.2018.00186. eCollection 2018.

5.

Ketogenic diet enhances neurovascular function with altered gut microbiome in young healthy mice.

Ma D, Wang AC, Parikh I, Green SJ, Hoffman JD, Chlipala G, Murphy MP, Sokola BS, Bauer B, Hartz AMS, Lin AL.

Sci Rep. 2018 Apr 27;8(1):6670. doi: 10.1038/s41598-018-25190-5.

6.

Role of l-Type Amino Acid Transporter 1 at the Inner Blood-Retinal Barrier in the Blood-to-Retina Transport of Gabapentin.

Akanuma SI, Yamakoshi A, Sugouchi T, Kubo Y, Hartz AMS, Bauer B, Hosoya KI.

Mol Pharm. 2018 Jun 4;15(6):2327-2337. doi: 10.1021/acs.molpharmaceut.8b00179. Epub 2018 May 2.

PMID:
29688723
7.

Matrix Metalloproteinase-Mediated Blood-Brain Barrier Dysfunction in Epilepsy.

Rempe RG, Hartz AMS, Soldner ELB, Sokola BS, Alluri SR, Abner EL, Kryscio RJ, Pekcec A, Schlichtiger J, Bauer B.

J Neurosci. 2018 May 2;38(18):4301-4315. doi: 10.1523/JNEUROSCI.2751-17.2018. Epub 2018 Apr 9.

8.

Age Drives Distortion of Brain Metabolic, Vascular and Cognitive Functions, and the Gut Microbiome.

Hoffman JD, Parikh I, Green SJ, Chlipala G, Mohney RP, Keaton M, Bauer B, Hartz AMS, Lin AL.

Front Aging Neurosci. 2017 Sep 25;9:298. doi: 10.3389/fnagi.2017.00298. eCollection 2017.

9.

Drug-Resistant Epilepsy: Multiple Hypotheses, Few Answers.

Tang F, Hartz AMS, Bauer B.

Front Neurol. 2017 Jul 6;8:301. doi: 10.3389/fneur.2017.00301. eCollection 2017. Review.

10.

P-gp Protein Expression and Transport Activity in Rodent Seizure Models and Human Epilepsy.

Hartz AM, Pekcec A, Soldner EL, Zhong Y, Schlichtiger J, Bauer B.

Mol Pharm. 2017 Apr 3;14(4):999-1011. doi: 10.1021/acs.molpharmaceut.6b00770. Epub 2017 Mar 2.

11.

Caloric restriction preserves memory and reduces anxiety of aging mice with early enhancement of neurovascular functions.

Parikh I, Guo J, Chuang KH, Zhong Y, Rempe RG, Hoffman JD, Armstrong R, Bauer B, Hartz AM, Lin AL.

Aging (Albany NY). 2016 Nov 8;8(11):2814-2826. doi: 10.18632/aging.101094.

12.

Matrix metalloproteinases in the brain and blood-brain barrier: Versatile breakers and makers.

Rempe RG, Hartz AMS, Bauer B.

J Cereb Blood Flow Metab. 2016 Sep;36(9):1481-507. doi: 10.1177/0271678X16655551. Epub 2016 Jun 20. Review.

13.

Aβ40 Reduces P-Glycoprotein at the Blood-Brain Barrier through the Ubiquitin-Proteasome Pathway.

Hartz AM, Zhong Y, Wolf A, LeVine H 3rd, Miller DS, Bauer B.

J Neurosci. 2016 Feb 10;36(6):1930-41. doi: 10.1523/JNEUROSCI.0350-15.2016.

14.

A Comprehensive Behavioral Test Battery to Assess Learning and Memory in 129S6/Tg2576 Mice.

Wolf A, Bauer B, Abner EL, Ashkenazy-Frolinger T, Hartz AM.

PLoS One. 2016 Jan 25;11(1):e0147733. doi: 10.1371/journal.pone.0147733. eCollection 2016.

15.

The multidrug resistance pump ABCB1 is a substrate for the ubiquitin ligase NEDD4-1.

Akkaya BG, Zolnerciks JK, Ritchie TK, Bauer B, Hartz AM, Sullivan JA, Linton KJ.

Mol Membr Biol. 2015;32(2):39-45. doi: 10.3109/09687688.2015.1023378. Epub 2015 May 26.

16.

ABC Transporters and the Alzheimer's Disease Enigma.

Wolf A, Bauer B, Hartz AM.

Front Psychiatry. 2012 Jun 4;3:54. doi: 10.3389/fpsyt.2012.00054. eCollection 2012.

17.

Amyloid-β contributes to blood-brain barrier leakage in transgenic human amyloid precursor protein mice and in humans with cerebral amyloid angiopathy.

Hartz AM, Bauer B, Soldner EL, Wolf A, Boy S, Backhaus R, Mihaljevic I, Bogdahn U, Klünemann HH, Schuierer G, Schlachetzki F.

Stroke. 2012 Feb;43(2):514-23. doi: 10.1161/STROKEAHA.111.627562. Epub 2011 Nov 23.

18.

Aryl hydrocarbon receptor-dependent upregulation of Cyp1b1 by TCDD and diesel exhaust particles in rat brain microvessels.

Jacob A, Hartz AM, Potin S, Coumoul X, Yousif S, Scherrmann JM, Bauer B, Declèves X.

Fluids Barriers CNS. 2011 Aug 25;8:23. doi: 10.1186/2045-8118-8-23.

19.

Breast cancer resistance protein and P-glycoprotein in brain cancer: two gatekeepers team up.

Agarwal S, Hartz AM, Elmquist WF, Bauer B.

Curr Pharm Des. 2011;17(26):2793-802. Review.

20.

Synthesis and characterization of a BODIPY conjugate of the BCR-ABL kinase inhibitor Tasigna (nilotinib): evidence for transport of Tasigna and its fluorescent derivative by ABC drug transporters.

Shukla S, Skoumbourdis AP, Walsh MJ, Hartz AM, Fung KL, Wu CP, Gottesman MM, Bauer B, Thomas CJ, Ambudkar SV.

Mol Pharm. 2011 Aug 1;8(4):1292-302. doi: 10.1021/mp2001022. Epub 2011 Jun 16.

21.

ABC transporters in the CNS - an inventory.

Hartz AM, Bauer B.

Curr Pharm Biotechnol. 2011 Apr;12(4):656-73. Review.

PMID:
21118088
22.

Regulation of ABC transporters at the blood-brain barrier: new targets for CNS therapy.

Hartz AM, Bauer B.

Mol Interv. 2010 Oct;10(5):293-304. doi: 10.1124/mi.10.5.6. Review.

PMID:
21045243
23.
24.

17-β-Estradiol: a powerful modulator of blood-brain barrier BCRP activity.

Hartz AM, Mahringer A, Miller DS, Bauer B.

J Cereb Blood Flow Metab. 2010 Oct;30(10):1742-55. doi: 10.1038/jcbfm.2010.36. Epub 2010 Mar 10.

25.

Restoring blood-brain barrier P-glycoprotein reduces brain amyloid-beta in a mouse model of Alzheimer's disease.

Hartz AM, Miller DS, Bauer B.

Mol Pharmacol. 2010 May;77(5):715-23. doi: 10.1124/mol.109.061754. Epub 2010 Jan 25.

26.

Novel and emerging strategies in drug delivery for overcoming the blood-brain barrier.

Stenehjem DD, Hartz AM, Bauer B, Anderson GW.

Future Med Chem. 2009 Dec;1(9):1623-41. doi: 10.4155/fmc.09.137. Review.

PMID:
21425983
27.

Signaling to P-glycoprotein-A new therapeutic target to treat drug-resistant epilepsy?

Hartz AM, Notenboom S, Bauer B.

Drug News Perspect. 2009 Sep;22(7):393-7. doi: 10.1358/dnp.2009.22.7.1401354. Review.

PMID:
19890496
28.

Targeting prostaglandin E2 EP1 receptors prevents seizure-associated P-glycoprotein up-regulation.

Pekcec A, Unkrüer B, Schlichtiger J, Soerensen J, Hartz AM, Bauer B, van Vliet EA, Gorter JA, Potschka H.

J Pharmacol Exp Ther. 2009 Sep;330(3):939-47. doi: 10.1124/jpet.109.152520. Epub 2009 Jun 3.

PMID:
19494186
29.

Prevention of seizure-induced up-regulation of endothelial P-glycoprotein by COX-2 inhibition.

Zibell G, Unkrüer B, Pekcec A, Hartz AM, Bauer B, Miller DS, Potschka H.

Neuropharmacology. 2009 Apr;56(5):849-55. doi: 10.1016/j.neuropharm.2009.01.009. Epub 2009 Jan 21.

PMID:
19371577
30.

Modulation of P-glycoprotein at the blood-brain barrier: opportunities to improve central nervous system pharmacotherapy.

Miller DS, Bauer B, Hartz AM.

Pharmacol Rev. 2008 Jun;60(2):196-209. doi: 10.1124/pr.107.07109. Epub 2008 Jun 17. Review.

31.

Diesel exhaust particles induce oxidative stress, proinflammatory signaling, and P-glycoprotein up-regulation at the blood-brain barrier.

Hartz AM, Bauer B, Block ML, Hong JS, Miller DS.

FASEB J. 2008 Aug;22(8):2723-33. doi: 10.1096/fj.08-106997. Epub 2008 May 12.

32.

Coordinated nuclear receptor regulation of the efflux transporter, Mrp2, and the phase-II metabolizing enzyme, GSTpi, at the blood-brain barrier.

Bauer B, Hartz AM, Lucking JR, Yang X, Pollack GM, Miller DS.

J Cereb Blood Flow Metab. 2008 Jun;28(6):1222-34. doi: 10.1038/jcbfm.2008.16. Epub 2008 Mar 19.

PMID:
18349876
33.

Seizure-induced up-regulation of P-glycoprotein at the blood-brain barrier through glutamate and cyclooxygenase-2 signaling.

Bauer B, Hartz AM, Pekcec A, Toellner K, Miller DS, Potschka H.

Mol Pharmacol. 2008 May;73(5):1444-53. Epub 2007 Dec 19.

PMID:
18094072
34.

Tumor necrosis factor alpha and endothelin-1 increase P-glycoprotein expression and transport activity at the blood-brain barrier.

Bauer B, Hartz AM, Miller DS.

Mol Pharmacol. 2007 Mar;71(3):667-75. Epub 2006 Nov 28.

PMID:
17132686
35.

In vivo activation of human pregnane X receptor tightens the blood-brain barrier to methadone through P-glycoprotein up-regulation.

Bauer B, Yang X, Hartz AM, Olson ER, Zhao R, Kalvass JC, Pollack GM, Miller DS.

Mol Pharmacol. 2006 Oct;70(4):1212-9. Epub 2006 Jul 12.

PMID:
16837625
36.

Rapid modulation of P-glycoprotein-mediated transport at the blood-brain barrier by tumor necrosis factor-alpha and lipopolysaccharide.

Hartz AM, Bauer B, Fricker G, Miller DS.

Mol Pharmacol. 2006 Feb;69(2):462-70. Epub 2005 Nov 8.

PMID:
16278373
37.

Modulation of p-glycoprotein transport function at the blood-brain barrier.

Bauer B, Hartz AM, Fricker G, Miller DS.

Exp Biol Med (Maywood). 2005 Feb;230(2):118-27. Review.

PMID:
15673560
38.

Pregnane X receptor up-regulation of P-glycoprotein expression and transport function at the blood-brain barrier.

Bauer B, Hartz AM, Fricker G, Miller DS.

Mol Pharmacol. 2004 Sep;66(3):413-9.

PMID:
15322232
39.

Rapid regulation of P-glycoprotein at the blood-brain barrier by endothelin-1.

Hartz AM, Bauer B, Fricker G, Miller DS.

Mol Pharmacol. 2004 Sep;66(3):387-94.

PMID:
15322229

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