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Improving Transient Transfection Efficiency in a Differentiated, Polar Epithelial Cell Layer.

Rybakovsky E, Valenzano MC, DiGuilio KM, Buleza NB, Moskalenko DV, Harty RN, Mullin JM.

J Biomol Tech. 2019 Jul;30(2):19-24. doi: 10.7171/jbt.19-3002-001.


Host Protein BAG3 is a Negative Regulator of Lassa VLP Egress.

Han Z, Schwoerer MP, Hicks P, Liang J, Ruthel G, Berry CT, Freedman BD, Sagum CA, Bedford MT, Sidhu SS, Sudol M, Harty RN.

Diseases. 2018 Jul 13;6(3). pii: E64. doi: 10.3390/diseases6030064.


Hemorrhagic Fever Virus Budding Studies.

Harty RN.

Methods Mol Biol. 2018;1604:209-215. doi: 10.1007/978-1-4939-6981-4_15.


Ubiquitin Ligase WWP1 Interacts with Ebola Virus VP40 To Regulate Egress.

Han Z, Sagum CA, Takizawa F, Ruthel G, Berry CT, Kong J, Sunyer JO, Freedman BD, Bedford MT, Sidhu SS, Sudol M, Harty RN.

J Virol. 2017 Sep 27;91(20). pii: e00812-17. doi: 10.1128/JVI.00812-17. Print 2017 Oct 15.


Correction: Chaperone-Mediated Autophagy Protein BAG3 Negatively Regulates Ebola and Marburg VP40-Mediated Egress.

Liang J, Sagum CA, Bedford MT, Sidhu SS, Sudol M, Han Z, Harty RN.

PLoS Pathog. 2017 Jul 19;13(7):e1006519. doi: 10.1371/journal.ppat.1006519. eCollection 2017 Jul.


Chaperone-Mediated Autophagy Protein BAG3 Negatively Regulates Ebola and Marburg VP40-Mediated Egress.

Liang J, Sagum CA, Bedford MT, Sidhu SS, Sudol M, Han Z, Harty RN.

PLoS Pathog. 2017 Jan 11;13(1):e1006132. doi: 10.1371/journal.ppat.1006132. eCollection 2017 Jan. Erratum in: PLoS Pathog. 2017 Jul 19;13(7):e1006519.


ITCH E3 Ubiquitin Ligase Interacts with Ebola Virus VP40 To Regulate Budding.

Han Z, Sagum CA, Bedford MT, Sidhu SS, Sudol M, Harty RN.

J Virol. 2016 Sep 29;90(20):9163-71. doi: 10.1128/JVI.01078-16. Print 2016 Oct 15.


Quinoxaline-based inhibitors of Ebola and Marburg VP40 egress.

Loughran HM, Han Z, Wrobel JE, Decker SE, Ruthel G, Freedman BD, Harty RN, Reitz AB.

Bioorg Med Chem Lett. 2016 Aug 1;26(15):3429-35. doi: 10.1016/j.bmcl.2016.06.053. Epub 2016 Jun 23.


Calcium and filoviruses: a budding relationship.

Freedman BD, Harty RN.

Future Microbiol. 2016 Jun;11:713-5. doi: 10.2217/fmb-2016-0057. Epub 2016 May 18. No abstract available.


Ebola virus mediated infectivity is restricted in canine and feline cells.

Han Z, Bart SM, Ruthel G, Vande Burgt NH, Haines KM, Volk SW, Vite CH, Freedman BD, Bates P, Harty RN.

Vet Microbiol. 2016;182:102-7. doi: 10.1016/j.vetmic.2015.11.011. Epub 2015 Nov 17.


Calcium Regulation of Hemorrhagic Fever Virus Budding: Mechanistic Implications for Host-Oriented Therapeutic Intervention.

Han Z, Madara JJ, Herbert A, Prugar LI, Ruthel G, Lu J, Liu Y, Liu W, Liu X, Wrobel JE, Reitz AB, Dye JM, Harty RN, Freedman BD.

PLoS Pathog. 2015 Oct 29;11(10):e1005220. doi: 10.1371/journal.ppat.1005220. eCollection 2015 Oct.


Suppressor of Cytokine Signaling 3 Is an Inducible Host Factor That Regulates Virus Egress during Ebola Virus Infection.

Okumura A, Rasmussen AL, Halfmann P, Feldmann F, Yoshimura A, Feldmann H, Kawaoka Y, Harty RN, Katze MG.

J Virol. 2015 Oct;89(20):10399-406. doi: 10.1128/JVI.01736-15. Epub 2015 Aug 5.


The multifunctional Ebola virus VP40 matrix protein is a promising therapeutic target.

Madara JJ, Han Z, Ruthel G, Freedman BD, Harty RN.

Future Virol. 2015 May;10(5):537-546.


ALIX Rescues Budding of a Double PTAP/PPEY L-Domain Deletion Mutant of Ebola VP40: A Role for ALIX in Ebola Virus Egress.

Han Z, Madara JJ, Liu Y, Liu W, Ruthel G, Freedman BD, Harty RN.

J Infect Dis. 2015 Oct 1;212 Suppl 2:S138-45. doi: 10.1093/infdis/jiu838. Epub 2015 Mar 18.


Small-molecule probes targeting the viral PPxY-host Nedd4 interface block egress of a broad range of RNA viruses.

Han Z, Lu J, Liu Y, Davis B, Lee MS, Olson MA, Ruthel G, Freedman BD, Schnell MJ, Wrobel JE, Reitz AB, Harty RN.

J Virol. 2014 Jul;88(13):7294-306. doi: 10.1128/JVI.00591-14. Epub 2014 Apr 16.


A host-oriented inhibitor of Junin Argentine hemorrhagic fever virus egress.

Lu J, Han Z, Liu Y, Liu W, Lee MS, Olson MA, Ruthel G, Freedman BD, Harty RN.

J Virol. 2014 May;88(9):4736-43. doi: 10.1128/JVI.03757-13. Epub 2014 Feb 12.


Host IQGAP1 and Ebola virus VP40 interactions facilitate virus-like particle egress.

Lu J, Qu Y, Liu Y, Jambusaria R, Han Z, Ruthel G, Freedman BD, Harty RN.

J Virol. 2013 Jul;87(13):7777-80. doi: 10.1128/JVI.00470-13. Epub 2013 May 1.


Cytopathogenesis of vesicular stomatitis virus is regulated by the PSAP motif of M protein in a species-dependent manner.

Irie T, Liu Y, Drolet BS, Carnero E, García-Sastre A, Harty RN.

Viruses. 2012 Sep;4(9):1605-18. doi: 10.3390/v4091605. Epub 2012 Sep 19.


Virus budding/host interactions.

Harty RN, Schmitt AP, Bouamr F, Lopez CB, Krummenacher C.

Adv Virol. 2011;2011:963192. doi: 10.1155/2011/963192. Epub 2011 Oct 20. No abstract available.


Characterization of filovirus protein-protein interactions in mammalian cells using bimolecular complementation.

Liu Y, Stone S, Harty RN.

J Infect Dis. 2011 Nov;204 Suppl 3:S817-24. doi: 10.1093/infdis/jir293.


Rabies virus assembly and budding.

Okumura A, Harty RN.

Adv Virus Res. 2011;79:23-32. doi: 10.1016/B978-0-12-387040-7.00002-0. Review.


Viral and host proteins that modulate filovirus budding.

Liu Y, Harty RN.

Future Virol. 2010 Jul 1;5(4):481-491.


Conserved motifs within Ebola and Marburg virus VP40 proteins are important for stability, localization, and subsequent budding of virus-like particles.

Liu Y, Cocka L, Okumura A, Zhang YA, Sunyer JO, Harty RN.

J Virol. 2010 Mar;84(5):2294-303. doi: 10.1128/JVI.02034-09. Epub 2009 Dec 23.


Interaction between Ebola virus glycoprotein and host toll-like receptor 4 leads to induction of proinflammatory cytokines and SOCS1.

Okumura A, Pitha PM, Yoshimura A, Harty RN.

J Virol. 2010 Jan;84(1):27-33. doi: 10.1128/JVI.01462-09.


Evaluation of an attenuated vesicular stomatitis virus vector expressing interferon-beta for use in malignant pleural mesothelioma: heterogeneity in interferon responsiveness defines potential efficacy.

Saloura V, Wang LC, Fridlender ZG, Sun J, Cheng G, Kapoor V, Sterman DH, Harty RN, Okumura A, Barber GN, Vile RG, Federspiel MJ, Russell SJ, Litzky L, Albelda SM.

Hum Gene Ther. 2010 Jan;21(1):51-64. doi: 10.1089/hum.2009.088.


Antiviral activity of innate immune protein ISG15.

Harty RN, Pitha PM, Okumura A.

J Innate Immun. 2009;1(5):397-404. doi: 10.1159/000226245. Review.


No exit: targeting the budding process to inhibit filovirus replication.

Harty RN.

Antiviral Res. 2009 Mar;81(3):189-97. doi: 10.1016/j.antiviral.2008.12.003. Epub 2008 Dec 27. Review.


The YPLGVG sequence of the Nipah virus matrix protein is required for budding.

Patch JR, Han Z, McCarthy SE, Yan L, Wang LF, Harty RN, Broder CC.

Virol J. 2008 Nov 10;5:137. doi: 10.1186/1743-422X-5-137.


Cigarette smoking products suppress anti-viral effects of Type I interferon via phosphorylation-dependent downregulation of its receptor.

HuangFu WC, Liu J, Harty RN, Fuchs SY.

FEBS Lett. 2008 Sep 22;582(21-22):3206-10. doi: 10.1016/j.febslet.2008.08.013. Epub 2008 Aug 21.


PPEY motif within the rabies virus (RV) matrix protein is essential for efficient virion release and RV pathogenicity.

Wirblich C, Tan GS, Papaneri A, Godlewski PJ, Orenstein JM, Harty RN, Schnell MJ.

J Virol. 2008 Oct;82(19):9730-8. doi: 10.1128/JVI.00889-08. Epub 2008 Jul 30.


ISG15 inhibits Ebola VP40 VLP budding in an L-domain-dependent manner by blocking Nedd4 ligase activity.

Okumura A, Pitha PM, Harty RN.

Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3974-9. doi: 10.1073/pnas.0710629105. Epub 2008 Feb 27.


Role for amino acids 212KLR214 of Ebola virus VP40 in assembly and budding.

McCarthy SE, Johnson RF, Zhang YA, Sunyer JO, Harty RN.

J Virol. 2007 Oct;81(20):11452-60. Epub 2007 Aug 15.


Modifications of the PSAP region of the matrix protein lead to attenuation of vesicular stomatitis virus in vitro and in vivo.

Irie T, Carnero E, Okumura A, García-Sastre A, Harty RN.

J Gen Virol. 2007 Sep;88(Pt 9):2559-67.


Permeabilization of the plasma membrane by Ebola virus GP2.

Han Z, Licata JM, Paragas J, Harty RN.

Virus Genes. 2007 Jun;34(3):273-81. Epub 2006 Aug 22.


A luciferase-based budding assay for Ebola virus.

McCarthy SE, Licata JM, Harty RN.

J Virol Methods. 2006 Oct;137(1):115-9. Epub 2006 Jul 11.


Effect of Ebola virus proteins GP, NP and VP35 on VP40 VLP morphology.

Johnson RF, Bell P, Harty RN.

Virol J. 2006 May 23;3:31.


Ebola virus VP35-VP40 interaction is sufficient for packaging 3E-5E minigenome RNA into virus-like particles.

Johnson RF, McCarthy SE, Godlewski PJ, Harty RN.

J Virol. 2006 Jun;80(11):5135-44.


Packaging of actin into Ebola virus VLPs.

Han Z, Harty RN.

Virol J. 2005 Dec 20;2:92.


Functional characterization of Ebola virus L-domains using VSV recombinants.

Irie T, Licata JM, Harty RN.

Virology. 2005 Jun 5;336(2):291-8.


Phospholipid scramblase 1 potentiates the antiviral activity of interferon.

Dong B, Zhou Q, Zhao J, Zhou A, Harty RN, Bose S, Banerjee A, Slee R, Guenther J, Williams BR, Wiedmer T, Sims PJ, Silverman RH.

J Virol. 2004 Sep;78(17):8983-93.


The NS3 protein of bluetongue virus exhibits viroporin-like properties.

Han Z, Harty RN.

J Biol Chem. 2004 Oct 8;279(41):43092-7. Epub 2004 Aug 3.


Budding of PPxY-containing rhabdoviruses is not dependent on host proteins TGS101 and VPS4A.

Irie T, Licata JM, McGettigan JP, Schnell MJ, Harty RN.

J Virol. 2004 Mar;78(6):2657-65. Erratum in: J Virol. 2004 May;78(10):5532.


Rhabdoviruses and apoptosis.

Licata JM, Harty RN.

Int Rev Immunol. 2003 Sep-Dec;22(5-6):451-76. Review.


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