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Items: 1 to 50 of 183

1.

Bystander responses impact accurate detection of murine and human antigen-specific CD8 T cells.

Martin MD, Jensen IJ, Ishizuka AS, Lefebvre M, Shan Q, Xue HH, Harty JT, Seder RA, Badovinac VP.

J Clin Invest. 2019 Jun 20;130:3894-3908. doi: 10.1172/JCI124443.

2.

Sepsis-Induced State of Immunoparalysis Is Defined by Diminished CD8 T Cell-Mediated Antitumor Immunity.

Danahy DB, Kurup SP, Winborn CS, Jensen IJ, Harty JT, Griffith TS, Badovinac VP.

J Immunol. 2019 Aug 1;203(3):725-735. doi: 10.4049/jimmunol.1900435. Epub 2019 Jun 12.

PMID:
31189573
3.

Protective role for the N-terminal domain of α-dystroglycan in Influenza A virus proliferation.

de Greef JC, Slütter B, Anderson ME, Hamlyn R, O'Campo Landa R, McNutt EJ, Hara Y, Pewe LL, Venzke D, Matsumura K, Saito F, Harty JT, Campbell KP.

Proc Natl Acad Sci U S A. 2019 Jun 4;116(23):11396-11401. doi: 10.1073/pnas.1904493116. Epub 2019 May 16.

4.

T cell-mediated immunity to malaria.

Kurup SP, Butler NS, Harty JT.

Nat Rev Immunol. 2019 Jul;19(7):457-471. doi: 10.1038/s41577-019-0158-z. Review.

PMID:
30940932
5.

Monocyte-Derived CD11c+ Cells Acquire Plasmodium from Hepatocytes to Prime CD8 T Cell Immunity to Liver-Stage Malaria.

Kurup SP, Anthony SM, Hancox LS, Vijay R, Pewe LL, Moioffer SJ, Sompallae R, Janse CJ, Khan SM, Harty JT.

Cell Host Microbe. 2019 Apr 10;25(4):565-577.e6. doi: 10.1016/j.chom.2019.02.014. Epub 2019 Mar 21.

PMID:
30905437
6.

Repeated Antigen Exposure Extends the Durability of Influenza-Specific Lung-Resident Memory CD8+ T Cells and Heterosubtypic Immunity.

Van Braeckel-Budimir N, Varga SM, Badovinac VP, Harty JT.

Cell Rep. 2018 Sep 25;24(13):3374-3382.e3. doi: 10.1016/j.celrep.2018.08.073.

7.

Memory CD8 T cells mediate severe immunopathology following respiratory syncytial virus infection.

Schmidt ME, Knudson CJ, Hartwig SM, Pewe LL, Meyerholz DK, Langlois RA, Harty JT, Varga SM.

PLoS Pathog. 2018 Jan 2;14(1):e1006810. doi: 10.1371/journal.ppat.1006810. eCollection 2018 Jan.

8.

Revealing the Complexity in CD8 T Cell Responses to Infection in Inbred C57B/6 versus Outbred Swiss Mice.

Martin MD, Danahy DB, Hartwig SM, Harty JT, Badovinac VP.

Front Immunol. 2017 Nov 22;8:1527. doi: 10.3389/fimmu.2017.01527. eCollection 2017.

9.

A T Cell Receptor Locus Harbors a Malaria-Specific Immune Response Gene.

Van Braeckel-Budimir N, Gras S, Ladell K, Josephs TM, Pewe L, Urban SL, Miners KL, Farenc C, Price DA, Rossjohn J, Harty JT.

Immunity. 2017 Nov 21;47(5):835-847.e4. doi: 10.1016/j.immuni.2017.10.013. Epub 2017 Nov 14.

10.

Enzymatic synthesis of core 2 O-glycans governs the tissue-trafficking potential of memory CD8+ T cells.

Osborn JF, Mooster JL, Hobbs SJ, Munks MW, Barry C, Harty JT, Hill AB, Nolz JC.

Sci Immunol. 2017 Oct 13;2(16). pii: eaan6049. doi: 10.1126/sciimmunol.aan6049.

11.

Characterization of Inner and Outer Membrane Proteins from Francisella tularensis Strains LVS and Schu S4 and Identification of Potential Subunit Vaccine Candidates.

Post DMB, Slütter B, Schilling B, Chande AT, Rasmussen JA, Jones BD, D'Souza AK, Reinders LM, Harty JT, Gibson BW, Apicella MA.

MBio. 2017 Oct 10;8(5). pii: e01592-17. doi: 10.1128/mBio.01592-17.

12.

Polymicrobial sepsis impairs bystander recruitment of effector cells to infected skin despite optimal sensing and alarming function of skin resident memory CD8 T cells.

Danahy DB, Anthony SM, Jensen IJ, Hartwig SM, Shan Q, Xue HH, Harty JT, Griffith TS, Badovinac VP.

PLoS Pathog. 2017 Sep 14;13(9):e1006569. doi: 10.1371/journal.ppat.1006569. eCollection 2017 Sep.

13.

Regulatory T cells impede acute and long-term immunity to blood-stage malaria through CTLA-4.

Kurup SP, Obeng-Adjei N, Anthony SM, Traore B, Doumbo OK, Butler NS, Crompton PD, Harty JT.

Nat Med. 2017 Oct;23(10):1220-1225. doi: 10.1038/nm.4395. Epub 2017 Sep 11.

14.

Dynamics of influenza-induced lung-resident memory T cells underlie waning heterosubtypic immunity.

Slütter B, Van Braeckel-Budimir N, Abboud G, Varga SM, Salek-Ardakani S, Harty JT.

Sci Immunol. 2017 Jan 6;2(7). pii: eaag2031. doi: 10.1126/sciimmunol.aag2031. Epub 2017 Jan 6.

15.

Differential Requirements for Tcf1 Long Isoforms in CD8+ and CD4+ T Cell Responses to Acute Viral Infection.

Gullicksrud JA, Li F, Xing S, Zeng Z, Peng W, Badovinac VP, Harty JT, Xue HH.

J Immunol. 2017 Aug 1;199(3):911-919. doi: 10.4049/jimmunol.1700595. Epub 2017 Jun 26.

16.

The transcription factor Runx3 guards cytotoxic CD8+ effector T cells against deviation towards follicular helper T cell lineage.

Shan Q, Zeng Z, Xing S, Li F, Hartwig SM, Gullicksrud JA, Kurup SP, Van Braeckel-Budimir N, Su Y, Martin MD, Varga SM, Taniuchi I, Harty JT, Peng W, Badovinac VP, Xue HH.

Nat Immunol. 2017 Aug;18(8):931-939. doi: 10.1038/ni.3773. Epub 2017 Jun 12.

17.

Differential requirements for myeloid leukemia IFN-γ conditioning determine graft-versus-leukemia resistance and sensitivity.

Matte-Martone C, Liu J, Zhou M, Chikina M, Green DR, Harty JT, Shlomchik WD.

J Clin Invest. 2017 Jun 30;127(7):2765-2776. doi: 10.1172/JCI85736. Epub 2017 Jun 12.

18.

Suppression of autoimmune demyelinating disease by preferential stimulation of CNS-specific CD8 T cells using Listeria-encoded neuroantigen.

Itani FR, Sinha S, Brate AA, Pewe LL, Gibson-Corley KN, Harty JT, Karandikar NJ.

Sci Rep. 2017 May 8;7(1):1519. doi: 10.1038/s41598-017-01771-8.

19.

Influenza-induced lung Trm: not all memories last forever.

Van Braeckel-Budimir N, Harty JT.

Immunol Cell Biol. 2017 Sep;95(8):651-655. doi: 10.1038/icb.2017.32. Epub 2017 Apr 13. Review.

PMID:
28405016
20.

Perforin Expression by CD8 T Cells Is Sufficient To Cause Fatal Brain Edema during Experimental Cerebral Malaria.

Huggins MA, Johnson HL, Jin F, N Songo A, Hanson LM, LaFrance SJ, Butler NS, Harty JT, Johnson AJ.

Infect Immun. 2017 Apr 21;85(5). pii: e00985-16. doi: 10.1128/IAI.00985-16. Print 2017 May.

21.

Antigen Exposure History Defines CD8 T Cell Dynamics and Protection during Localized Pulmonary Infections.

Van Braeckel-Budimir N, Martin MD, Hartwig SM, Legge KL, Badovinac VP, Harty JT.

Front Immunol. 2017 Jan 27;8:40. doi: 10.3389/fimmu.2017.00040. eCollection 2017.

22.

CD8+ T Cells Utilize Highly Dynamic Enhancer Repertoires and Regulatory Circuitry in Response to Infections.

He B, Xing S, Chen C, Gao P, Teng L, Shan Q, Gullicksrud JA, Martin MD, Yu S, Harty JT, Badovinac VP, Tan K, Xue HH.

Immunity. 2016 Dec 20;45(6):1341-1354. doi: 10.1016/j.immuni.2016.11.009. Epub 2016 Dec 13.

23.

Regulatory issues in immunity to liver and blood-stage malaria.

Van Braeckel-Budimir N, Kurup SP, Harty JT.

Curr Opin Immunol. 2016 Oct;42:91-97. doi: 10.1016/j.coi.2016.06.008. Epub 2016 Jun 25. Review.

PMID:
27351448
24.

Manipulating Memory CD8 T Cell Numbers by Timed Enhancement of IL-2 Signals.

Kim MT, Kurup SP, Starbeck-Miller GR, Harty JT.

J Immunol. 2016 Sep 1;197(5):1754-61. doi: 10.4049/jimmunol.1600641. Epub 2016 Jul 20.

25.

Correction: Discriminating Protective from Nonprotective Plasmodium-Specific CD8+ T Cell Responses.

Doll KL, Pewe LL, Kurup SP, Harty JT.

J Immunol. 2016 Aug 1;197(3):1003. doi: 10.4049/jimmunol.1600905. No abstract available.

26.

Exposure of Human CD4 T Cells to IL-12 Results in Enhanced TCR-Induced Cytokine Production, Altered TCR Signaling, and Increased Oxidative Metabolism.

Vacaflores A, Chapman NM, Harty JT, Richer MJ, Houtman JC.

PLoS One. 2016 Jun 9;11(6):e0157175. doi: 10.1371/journal.pone.0157175. eCollection 2016.

27.

Discriminating Protective from Nonprotective Plasmodium-Specific CD8+ T Cell Responses.

Doll KL, Pewe LL, Kurup SP, Harty JT.

J Immunol. 2016 May 15;196(10):4253-62. doi: 10.4049/jimmunol.1600155. Epub 2016 Apr 15. Erratum in: J Immunol. 2016 Aug 1;197(3):1003.

28.

Regulatory IgDhi B Cells Suppress T Cell Function via IL-10 and PD-L1 during Progressive Visceral Leishmaniasis.

Schaut RG, Lamb IM, Toepp AJ, Scott B, Mendes-Aguiar CO, Coutinho JF, Jeronimo SM, Wilson ME, Harty JT, Waldschmidt TJ, Petersen CA.

J Immunol. 2016 May 15;196(10):4100-9. doi: 10.4049/jimmunol.1502678. Epub 2016 Apr 13.

29.

Phenotypic and Functional Alterations in Circulating Memory CD8 T Cells with Time after Primary Infection.

Martin MD, Kim MT, Shan Q, Sompallae R, Xue HH, Harty JT, Badovinac VP.

PLoS Pathog. 2015 Oct 20;11(10):e1005219. doi: 10.1371/journal.ppat.1005219. eCollection 2015 Oct.

30.

The Timing of Stimulation and IL-2 Signaling Regulate Secondary CD8 T Cell Responses.

Khan SH, Martin MD, Starbeck-Miller GR, Xue HH, Harty JT, Badovinac VP.

PLoS Pathog. 2015 Oct 2;11(10):e1005199. doi: 10.1371/journal.ppat.1005199. eCollection 2015 Oct.

31.

Enhancing Dendritic Cell-based Immunotherapy with IL-2/Monoclonal Antibody Complexes for Control of Established Tumors.

Kim MT, Richer MJ, Gross BP, Norian LA, Badovinac VP, Harty JT.

J Immunol. 2015 Nov 1;195(9):4537-44. doi: 10.4049/jimmunol.1501071. Epub 2015 Sep 25.

32.

The Role of Il-12 and Type I Interferon in Governing the Magnitude of CD8 T Cell Responses.

Starbeck-Miller GR, Harty JT.

Adv Exp Med Biol. 2015;850:31-41. doi: 10.1007/978-3-319-15774-0_3. Review.

PMID:
26324344
33.

Inflammatory IL-15 is required for optimal memory T cell responses.

Richer MJ, Pewe LL, Hancox LS, Hartwig SM, Varga SM, Harty JT.

J Clin Invest. 2015 Sep;125(9):3477-90. doi: 10.1172/JCI81261. Epub 2015 Aug 4.

34.

Paradoxical Increase in Mortality and Rupture of Intracranial Aneurysms in Microsomal Prostaglandin E2 Synthase Type 1-Deficient Mice: Attenuation by Aspirin.

Peña Silva RA, Mitchell IJ, Kung DK, Pewe LL, Granja MF, Harty JT, Faraci FM, Heistad DD, Hasan DM.

Neurosurgery. 2015 Oct;77(4):613-20. doi: 10.1227/NEU.0000000000000883.

35.

γδ T cells and immunity to human malaria in endemic regions.

Kurup SP, Harty JT.

Ann Transl Med. 2015 May;3(Suppl 1):S22. doi: 10.3978/j.issn.2305-5839.2015.02.22. No abstract available.

36.

Impact of acute malaria on pre-existing antibodies to viral and vaccine antigens in mice and humans.

Banga S, Coursen JD, Portugal S, Tran TM, Hancox L, Ongoiba A, Traore B, Doumbo OK, Huang CY, Harty JT, Crompton PD.

PLoS One. 2015 Apr 28;10(4):e0125090. doi: 10.1371/journal.pone.0125090. eCollection 2015.

37.

Splenectomy Alters Distribution and Turnover but not Numbers or Protective Capacity of de novo Generated Memory CD8 T-Cells.

Kim MT, Harty JT.

Front Immunol. 2014 Nov 6;5:568. doi: 10.3389/fimmu.2014.00568. eCollection 2014.

38.

Instructing the instructor: tissue-resident T cells activate innate immunity.

Slütter B, Harty JT.

Cell Host Microbe. 2014 Oct 8;16(4):421-3. doi: 10.1016/j.chom.2014.09.011.

39.

Impact of Inflammatory Cytokines on Effector and Memory CD8+ T Cells.

Kim MT, Harty JT.

Front Immunol. 2014 Jun 19;5:295. doi: 10.3389/fimmu.2014.00295. eCollection 2014. Review.

40.

CD8 T-cell-mediated protection against liver-stage malaria: lessons from a mouse model.

Van Braeckel-Budimir N, Harty JT.

Front Microbiol. 2014 Jun 6;5:272. doi: 10.3389/fmicb.2014.00272. eCollection 2014. Review.

41.

Correlates of protective immunity following whole sporozoite vaccination against malaria.

Doll KL, Harty JT.

Immunol Res. 2014 Aug;59(1-3):166-76. doi: 10.1007/s12026-014-8525-0. Review.

42.

Tim-3 directly enhances CD8 T cell responses to acute Listeria monocytogenes infection.

Gorman JV, Starbeck-Miller G, Pham NL, Traver GL, Rothman PB, Harty JT, Colgan JD.

J Immunol. 2014 Apr 1;192(7):3133-42. doi: 10.4049/jimmunol.1302290. Epub 2014 Feb 24.

43.

IL-15 regulates memory CD8+ T cell O-glycan synthesis and affects trafficking.

Nolz JC, Harty JT.

J Clin Invest. 2014 Mar;124(3):1013-26. doi: 10.1172/JCI72039. Epub 2014 Feb 10.

44.

IL-12 and type I interferon prolong the division of activated CD8 T cells by maintaining high-affinity IL-2 signaling in vivo.

Starbeck-Miller GR, Xue HH, Harty JT.

J Exp Med. 2014 Jan 13;211(1):105-20. doi: 10.1084/jem.20130901. Epub 2013 Dec 23.

45.

Microsphere priming facilitates induction of potent therapeutic T-cell immune responses against autochthonous liver cancers.

Brinkhoff B, Ostroumov D, Heemcke J, Woller N, Gürlevik E, Manns MP, Longerich T, Zender L, Harty JT, Kubicka S, Kühnel F, Wirth TC.

Eur J Immunol. 2014 Apr;44(4):1213-24. doi: 10.1002/eji.201343794. Epub 2014 Jan 16.

46.

CD8 T cell independent immunity after single dose infection-treatment-vaccination (ITV) against Plasmodium yoelii.

Doll KL, Butler NS, Harty JT.

Vaccine. 2014 Jan 16;32(4):483-91. doi: 10.1016/j.vaccine.2013.11.058. Epub 2013 Dec 7.

47.

Cutting edge: Expression of FcγRIIB tempers memory CD8 T cell function in vivo.

Starbeck-Miller GR, Badovinac VP, Barber DL, Harty JT.

J Immunol. 2014 Jan 1;192(1):35-9. doi: 10.4049/jimmunol.1302232. Epub 2013 Nov 27.

48.

Lung airway-surveilling CXCR3(hi) memory CD8(+) T cells are critical for protection against influenza A virus.

Slütter B, Pewe LL, Kaech SM, Harty JT.

Immunity. 2013 Nov 14;39(5):939-48. doi: 10.1016/j.immuni.2013.09.013.

49.

Aged mice exhibit a severely diminished CD8 T cell response following respiratory syncytial virus infection.

Fulton RB, Weiss KA, Pewe LL, Harty JT, Varga SM.

J Virol. 2013 Dec;87(23):12694-700. doi: 10.1128/JVI.02282-12. Epub 2013 Sep 18.

50.

In vivo CD8+ T cell dynamics in the liver of Plasmodium yoelii immunized and infected mice.

Cabrera M, Pewe LL, Harty JT, Frevert U.

PLoS One. 2013 Aug 14;8(8):e70842. doi: 10.1371/journal.pone.0070842. eCollection 2013.

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