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RAIN study: a protocol for a randomised controlled trial evaluating efficacy, safety and cost-effectiveness of intravenous-to-oral antibiotic switch therapy in neonates with a probable bacterial infection.

Keij FM, Kornelisse RF, Hartwig NG, Mauff K, Poley MJ, Allegaert K, Reiss IKM, Tramper-Stranders GA.

BMJ Open. 2019 Jul 9;9(7):e026688. doi: 10.1136/bmjopen-2018-026688.


Oral antibiotics for neonatal infections: a systematic review and meta-analysis.

Keij FM, Kornelisse RF, Hartwig NG, Reiss IKM, Allegaert K, Tramper-Stranders GA.

J Antimicrob Chemother. 2019 Nov 1;74(11):3150-3161. doi: 10.1093/jac/dkz252.


[Periorbital, blue tumour in newborn twins].

Bakker AM, Hartwig NG, Kamerbeek A.

Ned Tijdschr Geneeskd. 2018 Jul 13;162. pii: D2532. Dutch.


[A child with abdominal pain and fever: consider acute lobar nephritis - diagnostic considerations when the appendix is invisible on ultrasound].

Bakker AM, Vijgen GHEJ, Hartwig NG, Tramper-Stranders GA.

Ned Tijdschr Geneeskd. 2018;162:D2392. Dutch.


Normal neonatal hearing screening did not preclude sensorineural hearing loss in two-year-old very preterm infants.

van Noort-van der Spek IL, Goedegebure A, Hartwig NG, Kornelisse RF, Franken MJP, Weisglas-Kuperus N.

Acta Paediatr. 2017 Oct;106(10):1569-1575. doi: 10.1111/apa.13960. Epub 2017 Jul 13.


Sustained Viral Suppression in HIV-infected Children on Once-daily Lopinavir/Ritonavir in Clinical Practice.

Gondrie IPE, Bastiaans DET, Fraaij PLA, Driessen GJA, van der Knaap LC, Visser EG, van Jaarsveld P, de Groot R, Hartwig NG, Burger DM, van Rossum AMC.

Pediatr Infect Dis J. 2017 Oct;36(10):976-980. doi: 10.1097/INF.0000000000001627.


Pitfalls in interpretation of CT-values of RT-PCR in children with acute respiratory tract infections.

Wishaupt JO, Ploeg TV, Smeets LC, Groot R, Versteegh FG, Hartwig NG.

J Clin Virol. 2017 May;90:1-6. doi: 10.1016/j.jcv.2017.02.010. Epub 2017 Feb 24.


Single- and multiple viral respiratory infections in children: disease and management cannot be related to a specific pathogen.

Wishaupt JO, van der Ploeg T, de Groot R, Versteegh FG, Hartwig NG.

BMC Infect Dis. 2017 Jan 11;17(1):62. doi: 10.1186/s12879-016-2118-6.


Paediatric apnoeas are not related to a specific respiratory virus, and parental reports predict hospitalisation.

Wishaupt JO, van den Berg E, van Wijk T, van der Ploeg T, Versteegh FG, Hartwig NG.

Acta Paediatr. 2016 May;105(5):542-8. doi: 10.1111/apa.13375. Epub 2016 Mar 17.


Persistent subclinical immune defects in HIV-1-infected children treated with antiretroviral therapy.

van den Heuvel D, Driessen GJ, Berkowska MA, van der Burg M, Langerak AW, Zhao D, Charif H, Hartwig NG, van Rossum AM, Fraaij PL, van Dongen JJ, van Zelm MC.

AIDS. 2015 Sep 10;29(14):1745-56. doi: 10.1097/QAD.0000000000000765.


Bordetella pertussis: an underreported pathogen in pediatric respiratory infections, a prospective cohort study.

van den Brink G, Wishaupt JO, Douma JC, Hartwig NG, Versteegh FG.

BMC Infect Dis. 2014 Sep 30;14:526. doi: 10.1186/1471-2334-14-526.


PCR testing for paediatric acute respiratory tract infections.

Wishaupt JO, Versteegh FG, Hartwig NG.

Paediatr Respir Rev. 2015 Jan;16(1):43-8. doi: 10.1016/j.prrv.2014.07.002. Epub 2014 Aug 5. Review.


Fever, diarrhoea and buttock pain in a 15-year-old female traveller (discussion and diagnosis).

Bolt RJ, Øistad LG, Dragoiescu C, Hartwig NG.

Acta Paediatr. 2013 Dec;102(12):1204-5. doi: 10.1111/apa.12390. No abstract available.


Fever, diarrhoea and buttock pain in a 15-year-old female traveller (case presentation).

Bolt RJ, Oistad LG, Dragoiescu C, Hartwig NG.

Acta Paediatr. 2013 Dec;102(12):1125-6. doi: 10.1111/apa.12388. No abstract available.


Similar recombination-activating gene (RAG) mutations result in similar immunobiological effects but in different clinical phenotypes.

IJspeert H, Driessen GJ, Moorhouse MJ, Hartwig NG, Wolska-Kusnierz B, Kalwak K, Pituch-Noworolska A, Kondratenko I, van Montfrans JM, Mejstrikova E, Lankester AC, Langerak AW, van Gent DC, Stubbs AP, van Dongen JJ, van der Burg M.

J Allergy Clin Immunol. 2014 Apr;133(4):1124-33. doi: 10.1016/j.jaci.2013.11.028. Epub 2014 Jan 11.


Functional analysis of the superfamily 1 DNA helicases encoded by Mycoplasma pneumoniae and Mycoplasma genitalium.

Estevão S, van der Heul HU, Sluijter M, Hoogenboezem T, Hartwig NG, van Rossum AM, Vink C.

PLoS One. 2013 Jul 23;8(7):e70870. doi: 10.1371/journal.pone.0070870. Print 2013.


Increased CD4(+) T cell co-inhibitory immune receptor CEACAM1 in neonatal sepsis and soluble-CEACAM1 in meningococcal sepsis: a role in sepsis-associated immune suppression?

van der Flier M, Sharma DB, Estevão S, Emonts M, Rook D, Hazelzet JA, van Goudoever JB, Hartwig NG.

PLoS One. 2013 Jul 22;8(7):e68294. doi: 10.1371/journal.pone.0068294. Print 2013.


Decreased expression of serum and microvascular vascular endothelial growth factor receptor-2 in meningococcal sepsis*.

van der Flier M, Baerveldt EM, Miedema A, Hartwig NG, Hazelzet JA, Emonts M, de Groot R, Prens EP, van Vught AJ, Jansen NJ.

Pediatr Crit Care Med. 2013 Sep;14(7):682-5. doi: 10.1097/PCC.0b013e3182917ccb.


Common variable immunodeficiency and idiopathic primary hypogammaglobulinemia: two different conditions within the same disease spectrum.

Driessen GJ, Dalm VA, van Hagen PM, Grashoff HA, Hartwig NG, van Rossum AM, Warris A, de Vries E, Barendregt BH, Pico I, Posthumus S, van Zelm MC, van Dongen JJ, van der Burg M.

Haematologica. 2013 Oct;98(10):1617-23. doi: 10.3324/haematol.2013.085076. Epub 2013 Jun 10.


Carriage of Mycoplasma pneumoniae in the upper respiratory tract of symptomatic and asymptomatic children: an observational study.

Spuesens EB, Fraaij PL, Visser EG, Hoogenboezem T, Hop WC, van Adrichem LN, Weber F, Moll HA, Broekman B, Berger MY, van Rijsoort-Vos T, van Belkum A, Schutten M, Pas SD, Osterhaus AD, Hartwig NG, Vink C, van Rossum AM.

PLoS Med. 2013;10(5):e1001444. doi: 10.1371/journal.pmed.1001444. Epub 2013 May 14.


Targeted rotavirus vaccination of high-risk infants; a low cost and highly cost-effective alternative to universal vaccination.

Bruijning-Verhagen P, Mangen MJ, Felderhof M, Hartwig NG, van Houten M, Winkel L, de Waal WJ, Bonten MJ.

BMC Med. 2013 Apr 26;11:112. doi: 10.1186/1741-7015-11-112.


The RuvA homologues from Mycoplasma genitalium and Mycoplasma pneumoniae exhibit unique functional characteristics.

Sluijter M, Estevão S, Hoogenboezem T, Hartwig NG, van Rossum AM, Vink C.

PLoS One. 2012;7(5):e38301. doi: 10.1371/journal.pone.0038301. Epub 2012 May 30.


Macrolide resistance determination and molecular typing of Mycoplasma pneumoniae in respiratory specimens collected between 1997 and 2008 in The Netherlands.

Spuesens EB, Meijer A, Bierschenk D, Hoogenboezem T, Donker GA, Hartwig NG, Koopmans MP, Vink C, van Rossum AM.

J Clin Microbiol. 2012 Jun;50(6):1999-2004. doi: 10.1128/JCM.00400-12. Epub 2012 Apr 11.


[Summary of the multidisciplinary guideline 'Varicella'].

Rothbarth PH, Hartwig NG, Opstelten W.

Ned Tijdschr Geneeskd. 2011;155(51):A3511. Review. Dutch.


B-cell replication history and somatic hypermutation status identify distinct pathophysiologic backgrounds in common variable immunodeficiency.

Driessen GJ, van Zelm MC, van Hagen PM, Hartwig NG, Trip M, Warris A, de Vries E, Barendregt BH, Pico I, Hop W, van Dongen JJ, van der Burg M.

Blood. 2011 Dec 22;118(26):6814-23. doi: 10.1182/blood-2011-06-361881. Epub 2011 Oct 31.


"Mycobacterium tilburgii" infection in two immunocompromised children: importance of molecular tools in culture-negative mycobacterial disease diagnosis.

Hartwig NG, Warris A, van de Vosse E, van der Zanden AG, Schülin-Casonato T, van Ingen J, van Hest R.

J Clin Microbiol. 2011 Dec;49(12):4409-11. doi: 10.1128/JCM.05460-11. Epub 2011 Oct 19.


Clinical impact of RT-PCR for pediatric acute respiratory infections: a controlled clinical trial.

Wishaupt JO, Russcher A, Smeets LC, Versteegh FG, Hartwig NG.

Pediatrics. 2011 Nov;128(5):e1113-20. doi: 10.1542/peds.2010-2779. Epub 2011 Oct 10.


Sequence variation within the P1 gene of Mycoplasma pneumoniae.

Spuesens EB, Hartwig NG, van Rossum AM, Vink C.

J Clin Microbiol. 2011 Oct;49(10):3723; author reply 3723-4. doi: 10.1128/JCM.01318-11. No abstract available.


Functional characterization of the RuvB homologs from Mycoplasma pneumoniae and Mycoplasma genitalium.

Estevão S, Sluijter M, Hartwig NG, van Rossum AM, Vink C.

J Bacteriol. 2011 Dec;193(23):6425-35. doi: 10.1128/JB.06003-11. Epub 2011 Sep 23.


Identification of amino acid residues critical for catalysis of Holliday junction resolution by Mycoplasma genitalium RecU.

Sluijter M, Aslam M, Hartwig NG, van Rossum AM, Vink C.

J Bacteriol. 2011 Aug;193(15):3941-8. doi: 10.1128/JB.00247-11. Epub 2011 Jun 3.


Variation in a surface-exposed region of the Mycoplasma pneumoniae P40 protein as a consequence of homologous DNA recombination between RepMP5 elements.

Spuesens EB, van de Kreeke N, Estevão S, Hoogenboezem T, Sluijter M, Hartwig NG, van Rossum AM, Vink C.

Microbiology. 2011 Feb;157(Pt 2):473-83. doi: 10.1099/mic.0.045591-0. Epub 2010 Oct 21.


X-linked lymphoproliferative disease due to SAP/SH2D1A deficiency: a multicenter study on the manifestations, management and outcome of the disease.

Booth C, Gilmour KC, Veys P, Gennery AR, Slatter MA, Chapel H, Heath PT, Steward CG, Smith O, O'Meara A, Kerrigan H, Mahlaoui N, Cavazzana-Calvo M, Fischer A, Moshous D, Blanche S, Pachlopnik Schmid J, Latour S, de Saint-Basile G, Albert M, Notheis G, Rieber N, Strahm B, Ritterbusch H, Lankester A, Hartwig NG, Meyts I, Plebani A, Soresina A, Finocchi A, Pignata C, Cirillo E, Bonanomi S, Peters C, Kalwak K, Pasic S, Sedlacek P, Jazbec J, Kanegane H, Nichols KE, Hanson IC, Kapoor N, Haddad E, Cowan M, Choo S, Smart J, Arkwright PD, Gaspar HB.

Blood. 2011 Jan 6;117(1):53-62. doi: 10.1182/blood-2010-06-284935. Epub 2010 Oct 6. Erratum in: Blood. 2011 Nov 3;118(18):5060. Pachlopnick-Schmid, Jana [corrected to Pachlopnik Schmid, Jana].


Diagnosis of invasive fungal infections by a real-time panfungal PCR assay in immunocompromised pediatric patients.

Landlinger C, Preuner S, Bašková L, van Grotel M, Hartwig NG, Dworzak M, Mann G, Attarbaschi A, Kager L, Peters C, Matthes-Martin S, Lawitschka A, van den Heuvel-Eibrink MM, Lion T.

Leukemia. 2010 Dec;24(12):2032-8. doi: 10.1038/leu.2010.209. Epub 2010 Sep 30.


The Mycoplasma genitalium MG352-encoded protein is a Holliday junction resolvase that has a non-functional orthologue in Mycoplasma pneumoniae.

Sluijter M, Kaptein E, Spuesens EB, Hoogenboezem T, Hartwig NG, Van Rossum AM, Vink C.

Mol Microbiol. 2010 Sep;77(5):1261-77. doi: 10.1111/j.1365-2958.2010.07288.x.


Ultrafast and high-throughput mass spectrometric assay for therapeutic drug monitoring of antiretroviral drugs in pediatric HIV-1 infection applying dried blood spots.

Meesters RJ, van Kampen JJ, Reedijk ML, Scheuer RD, Dekker LJ, Burger DM, Hartwig NG, Osterhaus AD, Luider TM, Gruters RA.

Anal Bioanal Chem. 2010 Sep;398(1):319-28. doi: 10.1007/s00216-010-3952-9. Epub 2010 Jul 15.


Ultra-fast analysis of plasma and intracellular levels of HIV protease inhibitors in children: a clinical application of MALDI mass spectrometry.

van Kampen JJ, Reedijk ML, Burgers PC, Dekker LJ, Hartwig NG, van der Ende IE, de Groot R, Osterhaus AD, Burger DM, Luider TM, Gruters RA.

PLoS One. 2010 Jul 1;5(7):e11409. doi: 10.1371/journal.pone.0011409. Erratum in: PLoS One. 2010;5(7). doi: 10.1371/annotation/9e6e8b98-cc08-47be-9ab1-3f1928e12fed.


Macrolide resistance determination and molecular typing of Mycoplasma pneumoniae by pyrosequencing.

Spuesens EB, Hoogenboezem T, Sluijter M, Hartwig NG, van Rossum AM, Vink C.

J Microbiol Methods. 2010 Sep;82(3):214-22. doi: 10.1016/j.mimet.2010.06.004. Epub 2010 Jun 11.


Beneficial use of immunoglobulins in the treatment of Sydenham chorea.

van Immerzeel TD, van Gilst RM, Hartwig NG.

Eur J Pediatr. 2010 Sep;169(9):1151-4. doi: 10.1007/s00431-010-1172-0. Epub 2010 Mar 30.


Identification and classification of P1 variants of Mycoplasma pneumoniae.

Spuesens EB, Hartwig NG, van Rossum AM, Vink C.

J Clin Microbiol. 2010 Feb;48(2):680; author reply 680. doi: 10.1128/JCM.02078-09. No abstract available.


[Vaccination against chickenpox, shingles and rotavirus-infection].

Hartwig NG, Rümke HC, Visser HK.

Ned Tijdschr Geneeskd. 2009;153:A913. Review. Dutch.


The Mycoplasma pneumoniae MPN490 and Mycoplasma genitalium MG339 genes encode reca homologs that promote homologous DNA strand exchange.

Sluijter M, Spuesens EB, Hartwig NG, van Rossum AM, Vink C.

Infect Immun. 2009 Nov;77(11):4905-11. doi: 10.1128/IAI.00747-09. Epub 2009 Sep 8.


Opa+ and Opa- isolates of Neisseria meningitidis and Neisseria gonorrhoeae induce sustained proliferative responses in human CD4+ T cells.

Youssef AR, van der Flier M, Estevão S, Hartwig NG, van der Ley P, Virji M.

Infect Immun. 2009 Nov;77(11):5170-80. doi: 10.1128/IAI.00355-09. Epub 2009 Aug 31.


Mycobacterium mantenii sp. nov., a pathogenic, slowly growing, scotochromogenic species.

van Ingen J, Lindeboom JA, Hartwig NG, de Zwaan R, Tortoli E, Dekhuijzen PN, Boeree MJ, van Soolingen D.

Int J Syst Evol Microbiol. 2009 Nov;59(Pt 11):2782-7. doi: 10.1099/ijs.0.010405-0. Epub 2009 Jul 22.


Sequence variations in RepMP2/3 and RepMP4 elements reveal intragenomic homologous DNA recombination events in Mycoplasma pneumoniae.

Spuesens EB, Oduber M, Hoogenboezem T, Sluijter M, Hartwig NG, van Rossum AM, Vink C.

Microbiology. 2009 Jul;155(Pt 7):2182-96. doi: 10.1099/mic.0.028506-0. Epub 2009 Apr 23.


Raman spectroscopic typing reveals the presence of carotenoids in Mycoplasma pneumoniae.

Maquelin K, Hoogenboezem T, Jachtenberg JW, Dumke R, Jacobs E, Puppels GJ, Hartwig NG, Vink C.

Microbiology. 2009 Jun;155(Pt 6):2068-77. doi: 10.1099/mic.0.026724-0. Epub 2009 Apr 21.


Pharmacokinetics of lopinavir in HIV type-1-infected children taking the new tablet formulation once daily.

van der Flier M, Verweel G, van der Knaap LC, van Jaarsveld P, Driessen GJ, van der Lee M, Hartwig NG, Burger DM.

Antivir Ther. 2008;13(8):1087-90.


Norovirus in a Dutch tertiary care hospital (2002-2007): frequent nosocomial transmission and dominance of GIIb strains in young children.

Beersma MF, Schutten M, Vennema H, Hartwig NG, Mes TH, Osterhaus AD, van Doornum GJ, Koopmans M.

J Hosp Infect. 2009 Mar;71(3):199-205. doi: 10.1016/j.jhin.2008.11.018. Epub 2009 Jan 14.


Low level IGF-1 and common variable immune deficiency: an unusual combination.

van Bilsen K, Driessen GJ, de Paus RA, van de Vosse E, van Lom K, van Zelm MC, Lam KH, Hartwig NG, Baarsma GS, van de Burg M, van Hagen PM.

Neth J Med. 2008 Oct;66(9):368-72.


Cost-effectiveness estimates for antenatal HIV testing in the Netherlands.

Rozenbaum MH, Verweel G, Folkerts DK, Dronkers F, van den Hoek JA, Hartwig NG, de Groot R, Postma MJ.

Int J STD AIDS. 2008 Oct;19(10):668-75. doi: 10.1258/ijsa.2008.008077.


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