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Items: 1 to 50 of 191

1.

Profilin 1-mediated cytoskeletal rearrangements regulate integrin function in mouse platelets.

Stritt S, Birkholz I, Beck S, Sorrentino S, Sapra KT, Viaud J, Heck J, Gaits-Iacovoni F, Schulze H, Du X, Hartwig JH, Braun A, Bender M, Medalia O, Nieswandt B.

Blood Adv. 2018 May 8;2(9):1040-1045. doi: 10.1182/bloodadvances.2017014001. No abstract available.

2.

Sarcomeric and nonmuscle α-actinin isoforms exhibit differential dynamics at skeletal muscle Z-lines.

Hsu CP, Moghadaszadeh B, Hartwig JH, Beggs AH.

Cytoskeleton (Hoboken). 2018 May;75(5):213-228. doi: 10.1002/cm.21442. Epub 2018 Apr 1.

3.

Synthesis and dephosphorylation of MARCKS in the late stages of megakaryocyte maturation drive proplatelet formation.

Machlus KR, Wu SK, Stumpo DJ, Soussou TS, Paul DS, Campbell RA, Kalwa H, Michel T, Bergmeier W, Weyrich AS, Blackshear PJ, Hartwig JH, Italiano JE Jr.

Blood. 2016 Mar 17;127(11):1468-80. doi: 10.1182/blood-2015-08-663146. Epub 2016 Jan 7.

4.

An adventitious interaction of filamin A with RhoGDI2(Tyr153Glu).

Song M, He Q, Berk BA, Hartwig JH, Stossel TP, Nakamura F.

Biochem Biophys Res Commun. 2016 Jan 15;469(3):659-64. doi: 10.1016/j.bbrc.2015.12.044. Epub 2015 Dec 17.

5.

Platelet actin nodules are podosome-like structures dependent on Wiskott-Aldrich syndrome protein and ARP2/3 complex.

Poulter NS, Pollitt AY, Davies A, Malinova D, Nash GB, Hannon MJ, Pikramenou Z, Rappoport JZ, Hartwig JH, Owen DM, Thrasher AJ, Watson SP, Thomas SG.

Nat Commun. 2015 Jun 1;6:7254. doi: 10.1038/ncomms8254.

6.

FlnA binding to PACSIN2 F-BAR domain regulates membrane tubulation in megakaryocytes and platelets.

Begonja AJ, Pluthero FG, Suphamungmee W, Giannini S, Christensen H, Leung R, Lo RW, Nakamura F, Lehman W, Plomann M, Hoffmeister KM, Kahr WH, Hartwig JH, Falet H.

Blood. 2015 Jul 2;126(1):80-8. doi: 10.1182/blood-2014-07-587600. Epub 2015 Apr 2.

7.

Corrigendum: Megakaryocyte-specific Profilin1-deficiency alters microtubule stability and causes a Wiskott-Aldrich syndrome-like platelet defect.

Bender M, Stritt S, Nurden P, van Eeuwijk JM, Zieger B, Kentouche K, Schulze H, Morbach H, Stegner D, Heinze KG, Dütting S, Gupta S, Witke W, Falet H, Fischer A, Hartwig JH, Nieswandt B.

Nat Commun. 2015 Mar 6;6:6507. doi: 10.1038/ncomms7507. No abstract available.

8.

The Ashwell-Morell receptor regulates hepatic thrombopoietin production via JAK2-STAT3 signaling.

Grozovsky R, Begonja AJ, Liu K, Visner G, Hartwig JH, Falet H, Hoffmeister KM.

Nat Med. 2015 Jan;21(1):47-54. doi: 10.1038/nm.3770. Epub 2014 Dec 8.

9.

Microtubule sliding drives proplatelet elongation and is dependent on cytoplasmic dynein.

Bender M, Thon JN, Ehrlicher AJ, Wu S, Mazutis L, Deschmann E, Sola-Visner M, Italiano JE, Hartwig JH.

Blood. 2015 Jan 29;125(5):860-8. doi: 10.1182/blood-2014-09-600858. Epub 2014 Nov 19.

10.

Megakaryocyte-specific Profilin1-deficiency alters microtubule stability and causes a Wiskott-Aldrich syndrome-like platelet defect.

Bender M, Stritt S, Nurden P, van Eeuwijk JM, Zieger B, Kentouche K, Schulze H, Morbach H, Stegner D, Heinze KG, Dütting S, Gupta S, Witke W, Falet H, Fischer A, Hartwig JH, Nieswandt B.

Nat Commun. 2014 Sep 4;5:4746. doi: 10.1038/ncomms5746. Erratum in: Nat Commun. 2015;6:6507. Heinze, Katrin [corrected to Heinze, Katrin G].

PMID:
25187265
11.

Documentation and localization of force-mediated filamin A domain perturbations in moving cells.

Nakamura F, Song M, Hartwig JH, Stossel TP.

Nat Commun. 2014 Aug 14;5:4656. doi: 10.1038/ncomms5656.

12.

Regulation of dynamin oligomerization in cells: the role of dynamin-actin interactions and its GTPase activity.

Gu C, Chang J, Shchedrina VA, Pham VA, Hartwig JH, Suphamungmee W, Lehman W, Hyman BT, Bacskai BJ, Sever S.

Traffic. 2014 Aug;15(8):819-38. doi: 10.1111/tra.12178. Epub 2014 Jun 24.

13.

Wiskott-Aldrich syndrome protein (WASp) controls the delivery of platelet transforming growth factor-β1.

Kim H, Falet H, Hoffmeister KM, Hartwig JH.

J Biol Chem. 2013 Nov 29;288(48):34352-63. doi: 10.1074/jbc.M113.459750. Epub 2013 Oct 16.

14.

Platelets lacking PIP5KIγ have normal integrin activation but impaired cytoskeletal-membrane integrity and adhesion.

Wang Y, Zhao L, Suzuki A, Lian L, Min SH, Wang Z, Litvinov RI, Stalker TJ, Yago T, Klopocki AG, Schmidtke DW, Yin H, Choi JK, McEver RP, Weisel JW, Hartwig JH, Abrams CS.

Blood. 2013 Apr 4;121(14):2743-52. doi: 10.1182/blood-2012-07-445205. Epub 2013 Jan 31.

15.

Differential remodeling of actin cytoskeleton architecture by profilin isoforms leads to distinct effects on cell migration and invasion.

Mouneimne G, Hansen SD, Selfors LM, Petrak L, Hickey MM, Gallegos LL, Simpson KJ, Lim J, Gertler FB, Hartwig JH, Mullins RD, Brugge JS.

Cancer Cell. 2012 Nov 13;22(5):615-30. doi: 10.1016/j.ccr.2012.09.027.

16.

Myosin-X facilitates Shigella-induced membrane protrusions and cell-to-cell spread.

Bishai EA, Sidhu GS, Li W, Dhillon J, Bohil AB, Cheney RE, Hartwig JH, Southwick FS.

Cell Microbiol. 2013 Mar;15(3):353-367. doi: 10.1111/cmi.12051. Epub 2012 Nov 13.

17.

Electron microscopy and 3D reconstruction reveals filamin Ig domain binding to F-actin.

Suphamungmee W, Nakamura F, Hartwig JH, Lehman W.

J Mol Biol. 2012 Dec 14;424(5):248-56. doi: 10.1016/j.jmb.2012.09.025. Epub 2012 Oct 4.

18.

Differential roles of cAMP and cGMP in megakaryocyte maturation and platelet biogenesis.

Begonja AJ, Gambaryan S, Schulze H, Patel-Hett S, Italiano JE Jr, Hartwig JH, Walter U.

Exp Hematol. 2013 Jan;41(1):91-101.e4. doi: 10.1016/j.exphem.2012.09.001. Epub 2012 Sep 11.

19.

Microtubule and cortical forces determine platelet size during vascular platelet production.

Thon JN, Macleod H, Begonja AJ, Zhu J, Lee KC, Mogilner A, Hartwig JH, Italiano JE Jr.

Nat Commun. 2012 May 22;3:852. doi: 10.1038/ncomms1838.

PMID:
22617292
20.

The origin and function of platelet glycosyltransferases.

Wandall HH, Rumjantseva V, Sørensen AL, Patel-Hett S, Josefsson EC, Bennett EP, Italiano JE Jr, Clausen H, Hartwig JH, Hoffmeister KM.

Blood. 2012 Jul 19;120(3):626-35. doi: 10.1182/blood-2012-02-409235. Epub 2012 May 21.

21.

Extracellular DNA traps are associated with the pathogenesis of TRALI in humans and mice.

Thomas GM, Carbo C, Curtis BR, Martinod K, Mazo IB, Schatzberg D, Cifuni SM, Fuchs TA, von Andrian UH, Hartwig JH, Aster RH, Wagner DD.

Blood. 2012 Jun 28;119(26):6335-43. doi: 10.1182/blood-2012-01-405183. Epub 2012 May 17.

22.

Polymorphism in the protease-activated receptor-4 gene region associates with platelet activation and perioperative myocardial injury.

Muehlschlegel JD, Perry TE, Liu KY, Fox AA, Smith SA, Lichtner P, Collard CD, Shernan SK, Hartwig JH, Body SC, Hoffmeister KM.

Am J Hematol. 2012 Feb;87(2):161-6. doi: 10.1002/ajh.22244. Epub 2012 Jan 7.

23.

Desialylation accelerates platelet clearance after refrigeration and initiates GPIbα metalloproteinase-mediated cleavage in mice.

Jansen AJ, Josefsson EC, Rumjantseva V, Liu QP, Falet H, Bergmeier W, Cifuni SM, Sackstein R, von Andrian UH, Wagner DD, Hartwig JH, Hoffmeister KM.

Blood. 2012 Feb 2;119(5):1263-73. doi: 10.1182/blood-2011-05-355628. Epub 2011 Nov 18.

24.

Mechanical strain in actin networks regulates FilGAP and integrin binding to filamin A.

Ehrlicher AJ, Nakamura F, Hartwig JH, Weitz DA, Stossel TP.

Nature. 2011 Sep 18;478(7368):260-3. doi: 10.1038/nature10430.

25.

Gelsolin-independent podosome formation in dendritic cells.

Hammarfjord O, Falet H, Gurniak C, Hartwig JH, Wallin RP.

PLoS One. 2011;6(7):e21615. doi: 10.1371/journal.pone.0021615. Epub 2011 Jul 11.

26.

RefilinB (FAM101B) targets filamin A to organize perinuclear actin networks and regulates nuclear shape.

Gay O, Gilquin B, Nakamura F, Jenkins ZA, McCartney R, Krakow D, Deshiere A, Assard N, Hartwig JH, Robertson SP, Baudier J.

Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11464-9. doi: 10.1073/pnas.1104211108. Epub 2011 Jun 27.

27.

FlnA-null megakaryocytes prematurely release large and fragile platelets that circulate poorly.

Jurak Begonja A, Hoffmeister KM, Hartwig JH, Falet H.

Blood. 2011 Aug 25;118(8):2285-95. doi: 10.1182/blood-2011-04-348482. Epub 2011 Jun 7.

28.

The spectrin-based membrane skeleton stabilizes mouse megakaryocyte membrane systems and is essential for proplatelet and platelet formation.

Patel-Hett S, Wang H, Begonja AJ, Thon JN, Alden EC, Wandersee NJ, An X, Mohandas N, Hartwig JH, Italiano JE Jr.

Blood. 2011 Aug 11;118(6):1641-52. doi: 10.1182/blood-2011-01-330688. Epub 2011 May 12.

29.

The filamins: organizers of cell structure and function.

Nakamura F, Stossel TP, Hartwig JH.

Cell Adh Migr. 2011 Mar-Apr;5(2):160-9. Epub 2011 Mar 1. Review.

30.

Cell mechanics: Contracting to stiffness.

Ehrlicher A, Hartwig JH.

Nat Mater. 2011 Jan;10(1):12-3. doi: 10.1038/nmat2928. No abstract available.

PMID:
21157494
31.

Cytoskeletal mechanics of proplatelet maturation and platelet release.

Thon JN, Montalvo A, Patel-Hett S, Devine MT, Richardson JL, Ehrlicher A, Larson MK, Hoffmeister K, Hartwig JH, Italiano JE Jr.

J Cell Biol. 2010 Nov 15;191(4):861-74. doi: 10.1083/jcb.201006102.

32.

Extracellular DNA traps promote thrombosis.

Fuchs TA, Brill A, Duerschmied D, Schatzberg D, Monestier M, Myers DD Jr, Wrobleski SK, Wakefield TW, Hartwig JH, Wagner DD.

Proc Natl Acad Sci U S A. 2010 Sep 7;107(36):15880-5. doi: 10.1073/pnas.1005743107. Epub 2010 Aug 23.

33.

A novel interaction between FlnA and Syk regulates platelet ITAM-mediated receptor signaling and function.

Falet H, Pollitt AY, Begonja AJ, Weber SE, Duerschmied D, Wagner DD, Watson SP, Hartwig JH.

J Exp Med. 2010 Aug 30;207(9):1967-79. doi: 10.1084/jem.20100222. Epub 2010 Aug 16.

34.

ADF/n-cofilin-dependent actin turnover determines platelet formation and sizing.

Bender M, Eckly A, Hartwig JH, Elvers M, Pleines I, Gupta S, Krohne G, Jeanclos E, Gohla A, Gurniak C, Gachet C, Witke W, Nieswandt B.

Blood. 2010 Sep 9;116(10):1767-75. doi: 10.1182/blood-2010-03-274340. Epub 2010 Jun 7.

PMID:
20530287
35.

Cystic fibrosis transmembrane conductance regulator interacts with multiple immunoglobulin domains of filamin A.

Playford MP, Nurminen E, Pentikäinen OT, Milgram SL, Hartwig JH, Stossel TP, Nakamura F.

J Biol Chem. 2010 May 28;285(22):17156-65. doi: 10.1074/jbc.M109.080523. Epub 2010 Mar 29.

36.

CLEC-2 activates Syk through dimerization.

Hughes CE, Pollitt AY, Mori J, Eble JA, Tomlinson MG, Hartwig JH, O'Callaghan CA, Fütterer K, Watson SP.

Blood. 2010 Apr 8;115(14):2947-55. doi: 10.1182/blood-2009-08-237834. Epub 2010 Feb 12.

37.

Filamins in cell signaling, transcription and organ development.

Zhou AX, Hartwig JH, Akyürek LM.

Trends Cell Biol. 2010 Feb;20(2):113-23. doi: 10.1016/j.tcb.2009.12.001. Epub 2010 Jan 12. Review.

PMID:
20061151
38.

Dual roles for hepatic lectin receptors in the clearance of chilled platelets.

Rumjantseva V, Grewal PK, Wandall HH, Josefsson EC, Sørensen AL, Larson G, Marth JD, Hartwig JH, Hoffmeister KM.

Nat Med. 2009 Nov;15(11):1273-80. doi: 10.1038/nm.2030. Epub 2009 Sep 27.

39.

Platelet-associated IgAs and impaired GPVI responses in platelets lacking WIP.

Falet H, Marchetti MP, Hoffmeister KM, Massaad MJ, Geha RS, Hartwig JH.

Blood. 2009 Nov 19;114(21):4729-37. doi: 10.1182/blood-2009-02-202721. Epub 2009 Aug 19.

40.

An active biopolymer network controlled by molecular motors.

Koenderink GH, Dogic Z, Nakamura F, Bendix PM, MacKintosh FC, Hartwig JH, Stossel TP, Weitz DA.

Proc Natl Acad Sci U S A. 2009 Sep 8;106(36):15192-7. doi: 10.1073/pnas.0903974106. Epub 2009 Aug 10.

41.

Differential stimulation of monocytic cells results in distinct populations of microparticles.

Bernimoulin M, Waters EK, Foy M, Steele BM, Sullivan M, Falet H, Walsh MT, Barteneva N, Geng JG, Hartwig JH, Maguire PB, Wagner DD.

J Thromb Haemost. 2009 Jun;7(6):1019-28. doi: 10.1111/j.1538-7836.2009.03434.x.

42.

Role of sialic acid for platelet life span: exposure of beta-galactose results in the rapid clearance of platelets from the circulation by asialoglycoprotein receptor-expressing liver macrophages and hepatocytes.

Sørensen AL, Rumjantseva V, Nayeb-Hashemi S, Clausen H, Hartwig JH, Wandall HH, Hoffmeister KM.

Blood. 2009 Aug 20;114(8):1645-54. doi: 10.1182/blood-2009-01-199414. Epub 2009 Jun 11.

43.

Activating mutations of N-WASP alter Shigella pathogenesis.

Adamovich DA, Nakamura F, Worth A, Burns S, Thrasher AJ, Hartwig JH, Snapper SB.

Biochem Biophys Res Commun. 2009 Jul 3;384(3):284-9. doi: 10.1016/j.bbrc.2009.04.050. Epub 2009 Apr 18.

44.

Molecular basis of filamin A-FilGAP interaction and its impairment in congenital disorders associated with filamin A mutations.

Nakamura F, Heikkinen O, Pentikäinen OT, Osborn TM, Kasza KE, Weitz DA, Kupiainen O, Permi P, Kilpeläinen I, Ylänne J, Hartwig JH, Stossel TP.

PLoS One. 2009;4(3):e4928. doi: 10.1371/journal.pone.0004928. Epub 2009 Mar 18.

45.

Loss of PIP5KIbeta demonstrates that PIP5KI isoform-specific PIP2 synthesis is required for IP3 formation.

Wang Y, Chen X, Lian L, Tang T, Stalker TJ, Sasaki T, Kanaho Y, Brass LF, Choi JK, Hartwig JH, Abrams CS.

Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):14064-9. doi: 10.1073/pnas.0804139105. Epub 2008 Sep 4. Erratum in: Proc Natl Acad Sci U S A. 2009 Jan 27;106(4):1291. Kanaho, Yasunori [added].

46.

GLUT4 vesicle recruitment and fusion are differentially regulated by Rac, AS160, and Rab8A in muscle cells.

Randhawa VK, Ishikura S, Talior-Volodarsky I, Cheng AW, Patel N, Hartwig JH, Klip A.

J Biol Chem. 2008 Oct 3;283(40):27208-19. doi: 10.1074/jbc.M804282200. Epub 2008 Jul 23.

47.

Protein 4.1R-dependent multiprotein complex: new insights into the structural organization of the red blood cell membrane.

Salomao M, Zhang X, Yang Y, Lee S, Hartwig JH, Chasis JA, Mohandas N, An X.

Proc Natl Acad Sci U S A. 2008 Jun 10;105(23):8026-31. doi: 10.1073/pnas.0803225105. Epub 2008 Jun 4.

48.

Visualization of microtubule growth in living platelets reveals a dynamic marginal band with multiple microtubules.

Patel-Hett S, Richardson JL, Schulze H, Drabek K, Isaac NA, Hoffmeister K, Shivdasani RA, Bulinski JC, Galjart N, Hartwig JH, Italiano JE Jr.

Blood. 2008 May 1;111(9):4605-16. doi: 10.1182/blood-2007-10-118844. Epub 2008 Jan 29.

49.

Galactosylation does not prevent the rapid clearance of long-term, 4 degrees C-stored platelets.

Wandall HH, Hoffmeister KM, Sørensen AL, Rumjantseva V, Clausen H, Hartwig JH, Slichter SJ.

Blood. 2008 Mar 15;111(6):3249-56. Epub 2007 Dec 20.

PMID:
18096766

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