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Items: 1 to 50 of 1048

1.

Brominated Azaphilones from the Sponge-Associated Fungus Penicillium canescens Strain 4.14.6a.

Frank M, Hartmann R, Plenker M, Mándi A, Kurtán T, Özkaya FC, Müller WEG, Kassack MU, Hamacher A, Lin W, Liu Z, Proksch P.

J Nat Prod. 2019 Jul 30. doi: 10.1021/acs.jnatprod.9b00151. [Epub ahead of print]

PMID:
31359750
2.

Design, Synthesis, and Biological Characterization of Orally Active 17β-Hydroxysteroid Dehydrogenase Type 2 Inhibitors Targeting the Prevention of Osteoporosis.

Abdelsamie AS, Salah M, Siebenbürger L, Merabet A, Scheuer C, Frotscher M, Müller ST, Zierau O, Vollmer G, Menger MD, Laschke MW, van Koppen CJ, Marchais-Oberwinkler S, Hartmann RW.

J Med Chem. 2019 Aug 8;62(15):7289-7301. doi: 10.1021/acs.jmedchem.9b00932. Epub 2019 Jul 25.

PMID:
31343176
3.

Homologs of aquifex aeolicus protein-only RNase P are not the major RNase P activities in the archaea haloferax volcanii and methanosarcina mazei.

Schwarz TS, Wäber NB, Feyh R, Weidenbach K, Schmitz RA, Marchfelder A, Hartmann RK.

IUBMB Life. 2019 Aug;71(8):1109-1116. doi: 10.1002/iub.2122. Epub 2019 Jul 8.

PMID:
31283101
4.

Identification of an IRF3 variant and defective antiviral interferon responses in a patient with severe influenza.

Thomsen MM, Jørgensen SE, Storgaard M, Kristensen LS, Gjedsted J, Christiansen M, Gad HH, Hartmann R, Mogensen TH.

Eur J Immunol. 2019 Jun 28. doi: 10.1002/eji.201848083. [Epub ahead of print] No abstract available.

PMID:
31250433
5.

Exact open quantum system dynamics: Optimal frequency vs time representation of bath correlations.

Hartmann R, Werther M, Grossmann F, Strunz WT.

J Chem Phys. 2019 Jun 21;150(23):234105. doi: 10.1063/1.5097158.

PMID:
31228905
6.

Effects of 17β-HSD2 inhibition in bones on osteoporosis based on an animal rat model.

Müller ST, Pählig S, Merabet A, Abdelsamie AS, van Koppen CJ, Marchais-Oberwinkler S, Hartmann RW, Zierau O, Vollmer G.

J Steroid Biochem Mol Biol. 2019 Jun 8;192:105405. doi: 10.1016/j.jsbmb.2019.105405. [Epub ahead of print]

PMID:
31185280
7.

Development of potential preclinical candidates with promising in vitro ADME profile for the inhibition of type 1 and type 2 17β-Hydroxysteroid dehydrogenases: Design, synthesis, and biological evaluation.

Abdelsamie AS, Salah M, Siebenbürger L, Hamed MM, Börger C, van Koppen CJ, Frotscher M, Hartmann RW.

Eur J Med Chem. 2019 Sep 15;178:93-107. doi: 10.1016/j.ejmech.2019.05.084. Epub 2019 May 31.

PMID:
31176098
8.

Defective interferon priming and impaired antiviral responses in a patient with an IRF7 variant and severe influenza.

Thomsen MM, Jørgensen SE, Gad HH, Storgaard M, Gjedsted J, Christiansen M, Hartmann R, Mogensen TH.

Med Microbiol Immunol. 2019 Jun 6. doi: 10.1007/s00430-019-00623-8. [Epub ahead of print]

PMID:
31172279
9.

Melatonin effects on pulmonary tissue in the experimental model of Hepatopulmonary Syndrome.

Bosco AD, Schedler FB, Colares JR, Schemitt EG, Hartmann RM, Forgiarini Junior LA, Dias AS, Marroni NP.

J Bras Pneumol. 2019 May 30;45(3):e20170164. doi: 10.1590/1806-3713/e20170164. English, Portuguese.

10.

Emergence of three-dimensional order and structure in growing biofilms.

Hartmann R, Singh PK, Pearce P, Mok R, Song B, Díaz-Pascual F, Dunkel J, Drescher K.

Nat Phys. 2019 Apr 26;15(3):251-256. doi: 10.1038/s41567-018-0356-9. Epub 2018 Nov 26.

11.

The Influence of the rs30461 Single Nucleotide Polymorphism on IFN-λ1 Activity and Secretion.

Møhlenberg M, Gad HH, Hartmann R.

J Interferon Cytokine Res. 2019 May 22. doi: 10.1089/jir.2019.0051. [Epub ahead of print]

PMID:
31120365
12.

Autologous Matrix-Induced Chondrogenesis for Osteochondral Lesions of the Talus: A Clinical and Radiological 2- to 8-Year Follow-up Study.

Weigelt L, Hartmann R, Pfirrmann C, Espinosa N, Wirth SH.

Am J Sports Med. 2019 Jun;47(7):1679-1686. doi: 10.1177/0363546519841574. Epub 2019 May 14.

PMID:
31084491
13.

Enantioselective total synthesis of altersolanol A and N.

Mechsner B, Böse D, Hogenkamp F, Ledermann N, Hartmann R, Bochinsky K, Frey W, Pietruszka J.

Bioorg Med Chem. 2019 Jul 1;27(13):2991-2997. doi: 10.1016/j.bmc.2019.04.033. Epub 2019 Apr 27.

PMID:
31072649
14.

Plant species affects establishment of Escherichia coli O157:H7 gfp+ on leafy vegetables.

Darlison J, Mieli M, Bengtsson T, Hartmann R, Mogren L, Vågsholm I, Karlsson M, Alsanius BW.

J Appl Microbiol. 2019 Jul;127(1):292-305. doi: 10.1111/jam.14299. Epub 2019 Jun 3.

PMID:
31054164
15.

Protective action of glutamine in rats with severe acute liver failure.

Schemitt EG, Hartmann RM, Colares JR, Licks F, Salvi JO, Marroni CA, Marroni NP.

World J Hepatol. 2019 Mar 27;11(3):273-286. doi: 10.4254/wjh.v11.i3.273.

16.

Identification of the fungicide epoxiconazole by virtual screening and biological assessment as inhibitor of human 11β-hydroxylase and aldosterone synthase.

Akram M, Patt M, Kaserer T, Temml V, Waratchareeyakul W, Kratschmar DV, Haupenthal J, Hartmann RW, Odermatt A, Schuster D.

J Steroid Biochem Mol Biol. 2019 Apr 6;192:105358. doi: 10.1016/j.jsbmb.2019.04.007. [Epub ahead of print]

PMID:
30965118
17.

Metabolic resistance of the D-peptide RD2 developed for direct elimination of amyloid-β oligomers.

Elfgen A, Hupert M, Bochinsky K, Tusche M, González de San Román Martin E, Gering I, Sacchi S, Pollegioni L, Huesgen PF, Hartmann R, Santiago-Schübel B, Kutzsche J, Willbold D.

Sci Rep. 2019 Apr 5;9(1):5715. doi: 10.1038/s41598-019-41993-6.

18.
19.

Interferon-λ enhances adaptive mucosal immunity by boosting release of thymic stromal lymphopoietin.

Ye L, Schnepf D, Becker J, Ebert K, Tanriver Y, Bernasconi V, Gad HH, Hartmann R, Lycke N, Staeheli P.

Nat Immunol. 2019 May;20(5):593-601. doi: 10.1038/s41590-019-0345-x. Epub 2019 Mar 18.

PMID:
30886417
20.

Insects in anthelminthics research: Lady beetle-derived harmonine affects survival, reproduction and stem cell proliferation of Schistosoma mansoni.

Kellershohn J, Thomas L, Hahnel SR, Grünweller A, Hartmann RK, Hardt M, Vilcinskas A, Grevelding CG, Haeberlein S.

PLoS Negl Trop Dis. 2019 Mar 14;13(3):e0007240. doi: 10.1371/journal.pntd.0007240. eCollection 2019 Mar.

21.

Application of triple quadrupole mass spectrometry for the characterization of antibody-drug conjugates.

Källsten M, Pijnappel M, Hartmann R, Lehmann F, Kovac L, Lind SB, Bergquist J.

Anal Bioanal Chem. 2019 May;411(12):2569-2576. doi: 10.1007/s00216-019-01699-0. Epub 2019 Mar 8.

22.

Insights into the complex role of GRAS transcription factors in the arbuscular mycorrhiza symbiosis.

Hartmann RM, Schaepe S, Nübel D, Petersen AC, Bertolini M, Vasilev J, Küster H, Hohnjec N.

Sci Rep. 2019 Mar 4;9(1):3360. doi: 10.1038/s41598-019-40214-4.

23.

Site-Specific Cleavage of RNAs Derived from the PIM1 3'-UTR by a Metal-Free Artificial Ribonuclease.

Zellmann F, Thomas L, Scheffer U, Hartmann RK, Göbel MW.

Molecules. 2019 Feb 23;24(4). pii: E807. doi: 10.3390/molecules24040807.

24.

Benzophenones as xanthone-open model CYP11B1 inhibitors potentially useful for promoting wound healing.

Gobbi S, Hu Q, Foschi G, Catanzaro E, Belluti F, Rampa A, Fimognari C, Hartmann RW, Bisi A.

Bioorg Chem. 2019 May;86:401-409. doi: 10.1016/j.bioorg.2019.01.066. Epub 2019 Jan 30.

PMID:
30769265
25.

Heart Rate Variability as Indicator of Clinical State in Depression.

Hartmann R, Schmidt FM, Sander C, Hegerl U.

Front Psychiatry. 2019 Jan 17;9:735. doi: 10.3389/fpsyt.2018.00735. eCollection 2018.

26.

2-Aminothiazole Derivatives as Selective Allosteric Modulators of the Protein Kinase CK2. 1. Identification of an Allosteric Binding Site.

Bestgen B, Krimm I, Kufareva I, Kamal AAM, Seetoh WG, Abell C, Hartmann RW, Abagyan R, Cochet C, Le Borgne M, Engel M, Lomberget T.

J Med Chem. 2019 Feb 28;62(4):1803-1816. doi: 10.1021/acs.jmedchem.8b01766. Epub 2019 Feb 18.

PMID:
30689953
27.

2-Aminothiazole Derivatives as Selective Allosteric Modulators of the Protein Kinase CK2. 2. Structure-Based Optimization and Investigation of Effects Specific to the Allosteric Mode of Action.

Bestgen B, Kufareva I, Seetoh W, Abell C, Hartmann RW, Abagyan R, Le Borgne M, Filhol O, Cochet C, Lomberget T, Engel M.

J Med Chem. 2019 Feb 28;62(4):1817-1836. doi: 10.1021/acs.jmedchem.8b01765. Epub 2019 Feb 13.

PMID:
30689946
28.

Hit evaluation of an α-helical peptide: Ala-scan, truncation and sidechain-to-sidechain macrocyclization of an RNA polymerase Inhibitor.

Kamal AAM, Habib M, Haupenthal J, Hartmann RW, Empting M.

Biol Chem. 2019 Feb 25;400(3):333-342. doi: 10.1515/hsz-2018-0333.

PMID:
30657738
29.

Targeted Endocrine Therapy: Design, Synthesis, and Proof-of-Principle of 17β-Hydroxysteroid Dehydrogenase Type 2 Inhibitors in Bone Fracture Healing.

Abdelsamie AS, Herath S, Biskupek Y, Börger C, Siebenbürger L, Salah M, Scheuer C, Marchais-Oberwinkler S, Frotscher M, Pohlemann T, Menger MD, Hartmann RW, Laschke MW, van Koppen CJ.

J Med Chem. 2019 Feb 14;62(3):1362-1372. doi: 10.1021/acs.jmedchem.8b01493. Epub 2019 Jan 15.

PMID:
30645111
30.

Correction to: Influence of foraminal enlargement on the healing of periapical lesions in rat molars.

Brandão PM, de Figueiredo JAP, Morgental RD, Scarparo RK, Hartmann RC, Waltrick SBG, Souza RA.

Clin Oral Investig. 2019 Apr;23(4):2001-2003. doi: 10.1007/s00784-018-2780-8.

PMID:
30635786
31.

Learning the space-time phase diagram of bacterial swarm expansion.

Jeckel H, Jelli E, Hartmann R, Singh PK, Mok R, Totz JF, Vidakovic L, Eckhardt B, Dunkel J, Drescher K.

Proc Natl Acad Sci U S A. 2019 Jan 29;116(5):1489-1494. doi: 10.1073/pnas.1811722116. Epub 2019 Jan 11.

32.

2'-Fluoro-Pyrimidine-Modified RNA Aptamers Specific for Lipopolysaccharide Binding Protein (LBP).

Aldag J, Persson T, Hartmann RK.

Int J Mol Sci. 2018 Dec 5;19(12). pii: E3883. doi: 10.3390/ijms19123883.

33.

Anti-inflammatory and antioxidant effect of melatonin on recovery from muscular trauma induced in rats.

Ostjen CA, Rosa CGS, Hartmann RM, Schemitt EG, Colares JR, Marroni NP.

Exp Mol Pathol. 2019 Feb;106:52-59. doi: 10.1016/j.yexmp.2018.12.001. Epub 2018 Dec 4.

PMID:
30521792
34.

Aspherical and Spherical InvA497-Functionalized Nanocarriers for Intracellular Delivery of Anti-Infective Agents.

Castoldi A, Empting M, De Rossi C, Mayr K, Dersch P, Hartmann R, Müller R, Gordon S, Lehr CM.

Pharm Res. 2018 Dec 5;36(1):22. doi: 10.1007/s11095-018-2521-3.

35.

Highly Potent 17β-HSD2 Inhibitors with a Promising Pharmacokinetic Profile for Targeted Osteoporosis Therapy.

Siebenbuerger L, Hernandez-Olmos V, Abdelsamie AS, Frotscher M, van Koppen CJ, Marchais-Oberwinkler S, Scheuer C, Laschke MW, Menger MD, Boerger C, Hartmann RW.

J Med Chem. 2018 Dec 13;61(23):10724-10738. doi: 10.1021/acs.jmedchem.8b01373. Epub 2018 Nov 27.

PMID:
30480443
36.

Influence of foraminal enlargement on the healing of periapical lesions in rat molars.

Brandão PM, de Figueiredo JAP, Morgental RD, Scarparo RK, Hartmann RC, Waltrick SBG, Souza RA.

Clin Oral Investig. 2019 Apr;23(4):1985-1991. doi: 10.1007/s00784-018-2628-2. Epub 2018 Nov 1. Erratum in: Clin Oral Investig. 2019 Jan 11;:.

PMID:
30386994
37.

Dendritic cells and their relation to apical peridontitis.

Figueiredo JAP, Machado AM, Oliveira VP, Hartmann R, Waltrick SBG, Borba MG, Brew MC, Estrela CRA, Böttcher DE.

Braz Oral Res. 2018 Oct 18;32(suppl 1):e71. doi: 10.1590/1807-3107BOR-2018.vol32.0071. Review.

38.

Chaetolines A and B, Pyrano[3,2- f]isoquinoline Alkaloids from Cultivation of Chaetomium sp. in the Presence of Autoclaved Pseudomonas aeruginosa.

Ancheeva E, Mándi A, Király SB, Kurtán T, Hartmann R, Akone SH, Weber H, Daletos G, Proksch P.

J Nat Prod. 2018 Nov 26;81(11):2392-2398. doi: 10.1021/acs.jnatprod.8b00373. Epub 2018 Oct 21.

PMID:
30343566
39.

Species Specificity of Type III Interferon Activity and Development of a Sensitive Luciferase-Based Bioassay for Quantitation of Mouse Interferon-λ.

Jacobs S, Wavreil F, Schepens B, Gad HH, Hartmann R, Rocha-Pereira J, Neyts J, Saelens X, Michiels T.

J Interferon Cytokine Res. 2018 Nov;38(11):469-479. doi: 10.1089/jir.2018.0066. Epub 2018 Oct 18.

40.

Dentists' knowledge of dental trauma based on the International Association of Dental Traumatology guidelines: A survey in South Brazil.

Hartmann RC, Rossetti BR, Siqueira Pinheiro L, Poli de Figueiredo JA, Rossi-Fedele G, S Gomes M, Gutierrez de Borba M.

Dent Traumatol. 2019 Feb;35(1):27-32. doi: 10.1111/edt.12450. Epub 2018 Nov 20.

PMID:
30318843
41.

Qualitative analysis of antibody-drug conjugates (ADCs): an experimental comparison of analytical techniques of cysteine-linked ADCs.

Källsten M, Hartmann R, Artemenko K, Lind SB, Lehmann F, Bergquist J.

Analyst. 2018 Nov 5;143(22):5487-5496. doi: 10.1039/c8an01178h.

PMID:
30289422
42.

Free-electron laser data for multiple-particle fluctuation scattering analysis.

Pande K, Donatelli JJ, Malmerberg E, Foucar L, Poon BK, Sutter M, Botha S, Basu S, Bruce Doak R, Dörner K, Epp SW, Englert L, Fromme R, Hartmann E, Hartmann R, Hauser G, Hattne J, Hosseinizadeh A, Kassemeyer S, Lomb L, Montero SFC, Menzel A, Rolles D, Rudenko A, Seibert MM, Sierra RG, Schwander P, Ourmazd A, Fromme P, Sauter NK, Bogan M, Bozek J, Bostedt C, Schlichting I, Kerfeld CA, Zwart PH.

Sci Data. 2018 Oct 2;5:180201. doi: 10.1038/sdata.2018.201.

43.

Relationship Between Maximal Dynamic Force in the Deep Back Squat and Sprinting Performance in Consecutive Segments Up to 30 m.

Möck S, Hartmann R, Wirth K, Rosenkranz G, Mickel C.

J Strength Cond Res. 2018 Sep 28. doi: 10.1519/JSC.0000000000002860. [Epub ahead of print]

PMID:
30273292
44.

CAMP@FLASH: an end-station for imaging, electron- and ion-spectroscopy, and pump-probe experiments at the FLASH free-electron laser.

Erk B, Müller JP, Bomme C, Boll R, Brenner G, Chapman HN, Correa J, Düsterer S, Dziarzhytski S, Eisebitt S, Graafsma H, Grunewald S, Gumprecht L, Hartmann R, Hauser G, Keitel B, von Korff Schmising C, Kuhlmann M, Manschwetus B, Mercadier L, Müller E, Passow C, Plönjes E, Ramm D, Rompotis D, Rudenko A, Rupp D, Sauppe M, Siewert F, Schlosser D, Strüder L, Swiderski A, Techert S, Tiedtke K, Tilp T, Treusch R, Schlichting I, Ullrich J, Moshammer R, Möller T, Rolles D.

J Synchrotron Radiat. 2018 Sep 1;25(Pt 5):1529-1540. doi: 10.1107/S1600577518008585. Epub 2018 Aug 2.

45.

The role of IFN in the development of NAFLD and NASH.

Møhlenberg M, Terczynska-Dyla E, Thomsen KL, George J, Eslam M, Grønbæk H, Hartmann R.

Cytokine. 2018 Aug 21. pii: S1043-4666(18)30347-8. doi: 10.1016/j.cyto.2018.08.013. [Epub ahead of print]

PMID:
30139548
46.

The Kinase IKKβ Regulates a STING- and NF-κB-Dependent Antiviral Response Pathway in Drosophila.

Goto A, Okado K, Martins N, Cai H, Barbier V, Lamiable O, Troxler L, Santiago E, Kuhn L, Paik D, Silverman N, Holleufer A, Hartmann R, Liu J, Peng T, Hoffmann JA, Meignin C, Daeffler L, Imler JL.

Immunity. 2018 Aug 21;49(2):225-234.e4. doi: 10.1016/j.immuni.2018.07.013. Epub 2018 Aug 14.

PMID:
30119996
47.

Antimicrobial efficacy of 0.5% peracetic acid and EDTA with passive ultrasonic or manual agitation in an Enterococcus faecalis biofilm model.

Hartmann RC, Neuvald L, Barth V Jr, de Figueiredo JAP, de Oliveira SD, Scarparo RK, Waltrick SB, Rossi-Fedele G.

Aust Endod J. 2019 Apr;45(1):57-63. doi: 10.1111/aej.12279. Epub 2018 Aug 13.

PMID:
30105835
48.

Conformational Sampling of the Intrinsically Disordered C-Terminal Tail of DERA Is Important for Enzyme Catalysis.

Schulte M, Petrović D, Neudecker P, Hartmann R, Pietruszka J, Willbold S, Willbold D, Panwalkar V.

ACS Catal. 2018 May 4;8(5):3971-3984. doi: 10.1021/acscatal.7b04408. Epub 2018 Mar 27.

49.

Methods for measurement of root canal curvature: a systematic and critical review.

Hartmann RC, Fensterseifer M, Peters OA, de Figueiredo JAP, Gomes MS, Rossi-Fedele G.

Int Endod J. 2019 Feb;52(2):169-180. doi: 10.1111/iej.12996. Epub 2018 Sep 10.

PMID:
30099748
50.

Tackling Pseudomonas aeruginosa Virulence by a Hydroxamic Acid-Based LasB Inhibitor.

Kany AM, Sikandar A, Yahiaoui S, Haupenthal J, Walter I, Empting M, Köhnke J, Hartmann RW.

ACS Chem Biol. 2018 Sep 21;13(9):2449-2455. doi: 10.1021/acschembio.8b00257. Epub 2018 Aug 24.

PMID:
30088919

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