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Items: 1 to 50 of 1025

1.

Benzophenones as xanthone-open model CYP11B1 inhibitors potentially useful for promoting wound healing.

Gobbi S, Hu Q, Foschi G, Catanzaro E, Belluti F, Rampa A, Fimognari C, Hartmann RW, Bisi A.

Bioorg Chem. 2019 Jan 30;86:401-409. doi: 10.1016/j.bioorg.2019.01.066. [Epub ahead of print]

PMID:
30769265
2.

Heart Rate Variability as Indicator of Clinical State in Depression.

Hartmann R, Schmidt FM, Sander C, Hegerl U.

Front Psychiatry. 2019 Jan 17;9:735. doi: 10.3389/fpsyt.2018.00735. eCollection 2018.

3.

2-Aminothiazole Derivatives as Selective Allosteric Modulators of the Protein Kinase CK2. 1. Identification of an Allosteric Binding Site.

Bestgen B, Krimm I, Kufareva I, Kamal AAM, Seetoh WG, Abell C, Hartmann RW, Abagyan R, Cochet C, Le Borgne M, Engel M, Lomberget T.

J Med Chem. 2019 Feb 18. doi: 10.1021/acs.jmedchem.8b01766. [Epub ahead of print]

PMID:
30689953
4.

2-Aminothiazole Derivatives as Selective Allosteric Modulators of the Protein Kinase CK2. 2. Structure-Based Optimization and Investigation of Effects Specific to the Allosteric Mode of Action.

Bestgen B, Kufareva I, Seetoh W, Abell C, Hartmann RW, Abagyan R, Le Borgne M, Filhol O, Cochet C, Lomberget T, Engel M.

J Med Chem. 2019 Feb 13. doi: 10.1021/acs.jmedchem.8b01765. [Epub ahead of print]

PMID:
30689946
5.

Hit evaluation of an α-helical peptide: Ala-scan, truncation and sidechain-to-sidechain macrocyclization of an RNA polymerase Inhibitor.

Kamal AAM, Habib M, Haupenthal J, Hartmann RW, Empting M.

Biol Chem. 2019 Feb 25;400(3):333-342. doi: 10.1515/hsz-2018-0333.

PMID:
30657738
6.

Targeted Endocrine Therapy: Design, Synthesis, and Proof-of-Principle of 17β-Hydroxysteroid Dehydrogenase Type 2 Inhibitors in Bone Fracture Healing.

Abdelsamie AS, Herath S, Biskupek Y, Börger C, Siebenbürger L, Salah M, Scheuer C, Marchais-Oberwinkler S, Frotscher M, Pohlemann T, Menger MD, Hartmann RW, Laschke MW, van Koppen CJ.

J Med Chem. 2019 Jan 15. doi: 10.1021/acs.jmedchem.8b01493. [Epub ahead of print]

PMID:
30645111
7.

Correction to: Influence of foraminal enlargement on the healing of periapical lesions in rat molars.

Brandão PM, de Figueiredo JAP, Morgental RD, Scarparo RK, Hartmann RC, Waltrick SBG, Souza RA.

Clin Oral Investig. 2019 Jan 11. doi: 10.1007/s00784-018-2780-8. [Epub ahead of print]

PMID:
30635786
8.

Learning the space-time phase diagram of bacterial swarm expansion.

Jeckel H, Jelli E, Hartmann R, Singh PK, Mok R, Totz JF, Vidakovic L, Eckhardt B, Dunkel J, Drescher K.

Proc Natl Acad Sci U S A. 2019 Jan 29;116(5):1489-1494. doi: 10.1073/pnas.1811722116. Epub 2019 Jan 11.

9.

2'-Fluoro-Pyrimidine-Modified RNA Aptamers Specific for Lipopolysaccharide Binding Protein (LBP).

Aldag J, Persson T, Hartmann RK.

Int J Mol Sci. 2018 Dec 5;19(12). pii: E3883. doi: 10.3390/ijms19123883.

10.

Anti-inflammatory and antioxidant effect of melatonin on recovery from muscular trauma induced in rats.

Ostjen CA, Rosa CGS, Hartmann RM, Schemitt EG, Colares JR, Marroni NP.

Exp Mol Pathol. 2019 Feb;106:52-59. doi: 10.1016/j.yexmp.2018.12.001. Epub 2018 Dec 4.

PMID:
30521792
11.

Aspherical and Spherical InvA497-Functionalized Nanocarriers for Intracellular Delivery of Anti-Infective Agents.

Castoldi A, Empting M, De Rossi C, Mayr K, Dersch P, Hartmann R, Müller R, Gordon S, Lehr CM.

Pharm Res. 2018 Dec 5;36(1):22. doi: 10.1007/s11095-018-2521-3.

12.

Highly Potent 17β-HSD2 Inhibitors with a Promising Pharmacokinetic Profile for Targeted Osteoporosis Therapy.

Siebenbuerger L, Hernandez-Olmos V, Abdelsamie AS, Frotscher M, van Koppen CJ, Marchais-Oberwinkler S, Scheuer C, Laschke MW, Menger MD, Boerger C, Hartmann RW.

J Med Chem. 2018 Nov 27. doi: 10.1021/acs.jmedchem.8b01373. [Epub ahead of print]

PMID:
30480443
13.

Influence of foraminal enlargement on the healing of periapical lesions in rat molars.

Brandão PM, de Figueiredo JAP, Morgental RD, Scarparo RK, Hartmann RC, Waltrick SBG, Souza RA.

Clin Oral Investig. 2018 Nov 1. doi: 10.1007/s00784-018-2628-2. [Epub ahead of print] Erratum in: Clin Oral Investig. 2019 Jan 11;:.

PMID:
30386994
14.

Dendritic cells and their relation to apical peridontitis.

Figueiredo JAP, Machado AM, Oliveira VP, Hartmann R, Waltrick SBG, Borba MG, Brew MC, Estrela CRA, Böttcher DE.

Braz Oral Res. 2018 Oct 18;32(suppl 1):e71. doi: 10.1590/1807-3107BOR-2018.vol32.0071. Review.

15.

Chaetolines A and B, Pyrano[3,2- f]isoquinoline Alkaloids from Cultivation of Chaetomium sp. in the Presence of Autoclaved Pseudomonas aeruginosa.

Ancheeva E, Mándi A, Király SB, Kurtán T, Hartmann R, Akone SH, Weber H, Daletos G, Proksch P.

J Nat Prod. 2018 Nov 26;81(11):2392-2398. doi: 10.1021/acs.jnatprod.8b00373. Epub 2018 Oct 21.

PMID:
30343566
16.

Species Specificity of Type III Interferon Activity and Development of a Sensitive Luciferase-Based Bioassay for Quantitation of Mouse Interferon-λ.

Jacobs S, Wavreil F, Schepens B, Gad HH, Hartmann R, Rocha-Pereira J, Neyts J, Saelens X, Michiels T.

J Interferon Cytokine Res. 2018 Nov;38(11):469-479. doi: 10.1089/jir.2018.0066. Epub 2018 Oct 18.

17.

Dentists' knowledge of dental trauma based on the International Association of Dental Traumatology guidelines: A survey in South Brazil.

Hartmann RC, Rossetti BR, Siqueira Pinheiro L, Poli de Figueiredo JA, Rossi-Fedele G, S Gomes M, Gutierrez de Borba M.

Dent Traumatol. 2019 Feb;35(1):27-32. doi: 10.1111/edt.12450. Epub 2018 Nov 20.

PMID:
30318843
18.

Qualitative analysis of antibody-drug conjugates (ADCs): an experimental comparison of analytical techniques of cysteine-linked ADCs.

Källsten M, Hartmann R, Artemenko K, Lind SB, Lehmann F, Bergquist J.

Analyst. 2018 Nov 5;143(22):5487-5496. doi: 10.1039/c8an01178h.

PMID:
30289422
19.

Free-electron laser data for multiple-particle fluctuation scattering analysis.

Pande K, Donatelli JJ, Malmerberg E, Foucar L, Poon BK, Sutter M, Botha S, Basu S, Bruce Doak R, Dörner K, Epp SW, Englert L, Fromme R, Hartmann E, Hartmann R, Hauser G, Hattne J, Hosseinizadeh A, Kassemeyer S, Lomb L, Montero SFC, Menzel A, Rolles D, Rudenko A, Seibert MM, Sierra RG, Schwander P, Ourmazd A, Fromme P, Sauter NK, Bogan M, Bozek J, Bostedt C, Schlichting I, Kerfeld CA, Zwart PH.

Sci Data. 2018 Oct 2;5:180201. doi: 10.1038/sdata.2018.201.

20.

Relationship Between Maximal Dynamic Force in the Deep Back Squat and Sprinting Performance in Consecutive Segments Up to 30 m.

Möck S, Hartmann R, Wirth K, Rosenkranz G, Mickel C.

J Strength Cond Res. 2018 Sep 28. doi: 10.1519/JSC.0000000000002860. [Epub ahead of print]

PMID:
30273292
21.

CAMP@FLASH: an end-station for imaging, electron- and ion-spectroscopy, and pump-probe experiments at the FLASH free-electron laser.

Erk B, Müller JP, Bomme C, Boll R, Brenner G, Chapman HN, Correa J, Düsterer S, Dziarzhytski S, Eisebitt S, Graafsma H, Grunewald S, Gumprecht L, Hartmann R, Hauser G, Keitel B, von Korff Schmising C, Kuhlmann M, Manschwetus B, Mercadier L, Müller E, Passow C, Plönjes E, Ramm D, Rompotis D, Rudenko A, Rupp D, Sauppe M, Siewert F, Schlosser D, Strüder L, Swiderski A, Techert S, Tiedtke K, Tilp T, Treusch R, Schlichting I, Ullrich J, Moshammer R, Möller T, Rolles D.

J Synchrotron Radiat. 2018 Sep 1;25(Pt 5):1529-1540. doi: 10.1107/S1600577518008585. Epub 2018 Aug 2.

22.

The role of IFN in the development of NAFLD and NASH.

Møhlenberg M, Terczynska-Dyla E, Thomsen KL, George J, Eslam M, Grønbæk H, Hartmann R.

Cytokine. 2018 Aug 21. pii: S1043-4666(18)30347-8. doi: 10.1016/j.cyto.2018.08.013. [Epub ahead of print]

PMID:
30139548
23.

The Kinase IKKβ Regulates a STING- and NF-κB-Dependent Antiviral Response Pathway in Drosophila.

Goto A, Okado K, Martins N, Cai H, Barbier V, Lamiable O, Troxler L, Santiago E, Kuhn L, Paik D, Silverman N, Holleufer A, Hartmann R, Liu J, Peng T, Hoffmann JA, Meignin C, Daeffler L, Imler JL.

Immunity. 2018 Aug 21;49(2):225-234.e4. doi: 10.1016/j.immuni.2018.07.013. Epub 2018 Aug 14.

PMID:
30119996
24.

Antimicrobial efficacy of 0.5% peracetic acid and EDTA with passive ultrasonic or manual agitation in an Enterococcus faecalis biofilm model.

Hartmann RC, Neuvald L, Barth V Jr, de Figueiredo JAP, de Oliveira SD, Scarparo RK, Waltrick SB, Rossi-Fedele G.

Aust Endod J. 2018 Aug 13. doi: 10.1111/aej.12279. [Epub ahead of print]

PMID:
30105835
25.

Conformational Sampling of the Intrinsically Disordered C-Terminal Tail of DERA Is Important for Enzyme Catalysis.

Schulte M, Petrović D, Neudecker P, Hartmann R, Pietruszka J, Willbold S, Willbold D, Panwalkar V.

ACS Catal. 2018 May 4;8(5):3971-3984. doi: 10.1021/acscatal.7b04408. Epub 2018 Mar 27.

26.

Methods for measurement of root canal curvature: a systematic and critical review.

Hartmann RC, Fensterseifer M, Peters OA, de Figueiredo JAP, Gomes MS, Rossi-Fedele G.

Int Endod J. 2019 Feb;52(2):169-180. doi: 10.1111/iej.12996. Epub 2018 Sep 10. Review.

PMID:
30099748
27.

Tackling Pseudomonas aeruginosa Virulence by a Hydroxamic Acid-Based LasB Inhibitor.

Kany AM, Sikandar A, Yahiaoui S, Haupenthal J, Walter I, Empting M, Köhnke J, Hartmann RW.

ACS Chem Biol. 2018 Sep 21;13(9):2449-2455. doi: 10.1021/acschembio.8b00257. Epub 2018 Aug 24.

PMID:
30088919
28.

Correlation of dynamic strength in the standing calf raise with sprinting performance in consecutive sections up to 30 meters.

Möck S, Hartmann R, Wirth K, Rosenkranz G, Mickel C.

Res Sports Med. 2018 Oct-Dec;26(4):474-481. doi: 10.1080/15438627.2018.1492397. Epub 2018 Jul 2.

PMID:
29963928
29.

In vitro studies show synergistic effects of a procoagulant bispecific antibody and bypassing agents.

Hartmann R, Feenstra T, Valentino L, Dockal M, Scheiflinger F.

J Thromb Haemost. 2018 Jun 11. doi: 10.1111/jth.14203. [Epub ahead of print]

PMID:
29888855
30.

Division of Labor during Biofilm Matrix Production.

Dragoš A, Kiesewalter H, Martin M, Hsu CY, Hartmann R, Wechsler T, Eriksen C, Brix S, Drescher K, Stanley-Wall N, Kümmerli R, Kovács ÁT.

Curr Biol. 2018 Jun 18;28(12):1903-1913.e5. doi: 10.1016/j.cub.2018.04.046. Epub 2018 Jun 7.

31.

Detailed investigation on how the protein corona modulates the physicochemical properties and gene delivery of polyethylenimine (PEI) polyplexes.

Zhu D, Yan H, Zhou Z, Tang J, Liu X, Hartmann R, Parak WJ, Feliu N, Shen Y.

Biomater Sci. 2018 Jun 25;6(7):1800-1817. doi: 10.1039/c8bm00128f.

PMID:
29780981
32.

In Vitro Model of the Gram-Negative Bacterial Cell Envelope for Investigation of Anti-Infective Permeation Kinetics.

Graef F, Richter R, Fetz V, Murgia X, De Rossi C, Schneider-Daum N, Allegretta G, Elgaher W, Haupenthal J, Empting M, Beckmann F, Brönstrup M, Hartmann R, Gordon S, Lehr CM.

ACS Infect Dis. 2018 Aug 10;4(8):1188-1196. doi: 10.1021/acsinfecdis.7b00165. Epub 2018 May 24.

PMID:
29750862
33.

Influence of apical enlargement on the repair of apical periodontitis in rats.

Jara CM, Hartmann RC, Böttcher DE, Souza TS, Gomes MS, Figueiredo JAP.

Int Endod J. 2018 Nov;51(11):1261-1270. doi: 10.1111/iej.12949. Epub 2018 Jun 11.

PMID:
29737545
34.

Root canal preparation in 3-rooted maxillary premolars through hand, rotary, and reciprocating techniques: a microcomputed tomography evaluation.

Giannastasio DFG, Scarparo RK, Iglesias JE, Hartmann RC, Fontanella V, Morgental RD, Vier-Pelisser FV.

Gen Dent. 2018 May-Jun;66(3):26-31.

PMID:
29714696
35.

Association of manual or engine-driven glide path preparation with canal centring and apical transportation: a systematic review.

Hartmann RC, Peters OA, de Figueiredo JAP, Rossi-Fedele G.

Int Endod J. 2018 Nov;51(11):1239-1252. doi: 10.1111/iej.12943. Epub 2018 Jun 5. Review.

PMID:
29704465
36.

Towards ultrafast dynamics with split-pulse X-ray photon correlation spectroscopy at free electron laser sources.

Roseker W, Hruszkewycz SO, Lehmkühler F, Walther M, Schulte-Schrepping H, Lee S, Osaka T, Strüder L, Hartmann R, Sikorski M, Song S, Robert A, Fuoss PH, Sutton M, Stephenson GB, Grübel G.

Nat Commun. 2018 Apr 27;9(1):1704. doi: 10.1038/s41467-018-04178-9.

37.

Cell adhesion and fluid flow jointly initiate genotype spatial distribution in biofilms.

Martínez-García R, Nadell CD, Hartmann R, Drescher K, Bonachela JA.

PLoS Comput Biol. 2018 Apr 16;14(4):e1006094. doi: 10.1371/journal.pcbi.1006094. eCollection 2018 Apr.

38.

Design and synthesis of novel annulated thienopyrimidines as phosphodiesterase 5 (PDE5) inhibitors.

El-Sharkawy LY, El-Sakhawy RA, Abdel-Halim M, Lee K, Piazza GA, Ducho C, Hartmann RW, Abadi AH.

Arch Pharm (Weinheim). 2018 May;351(5):e1800018. doi: 10.1002/ardp.201800018. Epub 2018 Apr 14.

PMID:
29656464
39.

IFN-λ prevents influenza virus spread from the upper airways to the lungs and limits virus transmission.

Klinkhammer J, Schnepf D, Ye L, Schwaderlapp M, Gad HH, Hartmann R, Garcin D, Mahlakõiv T, Staeheli P.

Elife. 2018 Apr 13;7. pii: e33354. doi: 10.7554/eLife.33354.

40.

Spatial Distortion of Vibration Modes via Magnetic Correlation of Impurities.

Krasniqi FS, Zhong Y, Epp SW, Foucar L, Trigo M, Chen J, Reis DA, Wang HL, Zhao JH, Lemke HT, Zhu D, Chollet M, Fritz DM, Hartmann R, Englert L, Strüder L, Schlichting I, Ullrich J.

Phys Rev Lett. 2018 Mar 9;120(10):105501. doi: 10.1103/PhysRevLett.120.105501.

PMID:
29570335
41.

The interferon-stimulated gene product oligoadenylate synthetase-like protein enhances replication of Kaposi's sarcoma-associated herpesvirus (KSHV) and interacts with the KSHV ORF20 protein.

Bussey KA, Lau U, Schumann S, Gallo A, Osbelt L, Stempel M, Arnold C, Wissing J, Gad HH, Hartmann R, Brune W, Jänsch L, Whitehouse A, Brinkmann MM.

PLoS Pathog. 2018 Mar 2;14(3):e1006937. doi: 10.1371/journal.ppat.1006937. eCollection 2018 Mar.

42.

Binding Mode Characterization and Early in Vivo Evaluation of Fragment-Like Thiols as Inhibitors of the Virulence Factor LasB from Pseudomonas aeruginosa.

Kany AM, Sikandar A, Haupenthal J, Yahiaoui S, Maurer CK, Proschak E, Köhnke J, Hartmann RW.

ACS Infect Dis. 2018 Jun 8;4(6):988-997. doi: 10.1021/acsinfecdis.8b00010. Epub 2018 Mar 6.

PMID:
29485268
43.

Defective RNA sensing by RIG-I in severe influenza virus infection.

Jørgensen SE, Christiansen M, Ryø LB, Gad HH, Gjedsted J, Staeheli P, Mikkelsen JG, Storgaard M, Hartmann R, Mogensen TH.

Clin Exp Immunol. 2018 Jun;192(3):366-376. doi: 10.1111/cei.13120. Epub 2018 Mar 24.

PMID:
29453856
44.

Computational prediction of new CYP17 inhibitors based on pharmacophore modeling, virtual screening and docking approach.

Haidar S, Hartmann RW.

Pharmazie. 2017 Sep 1;72(9):529-536. doi: 10.1691/ph.2017.7516.

PMID:
29441980
45.

The mycorrhiza-dependent defensin MtDefMd1 of Medicago truncatula acts during the late restructuring stages of arbuscule-containing cells.

Uhe M, Hogekamp C, Hartmann RM, Hohnjec N, Küster H.

PLoS One. 2018 Jan 25;13(1):e0191841. doi: 10.1371/journal.pone.0191841. eCollection 2018.

46.

Pharmacophore Modeling and in Silico/in Vitro Screening for Human Cytochrome P450 11B1 and Cytochrome P450 11B2 Inhibitors.

Akram M, Waratchareeyakul W, Haupenthal J, Hartmann RW, Schuster D.

Front Chem. 2017 Dec 19;5:104. doi: 10.3389/fchem.2017.00104. eCollection 2017.

47.

Glycomimetic, Orally Bioavailable LecB Inhibitors Block Biofilm Formation of Pseudomonas aeruginosa.

Sommer R, Wagner S, Rox K, Varrot A, Hauck D, Wamhoff EC, Schreiber J, Ryckmans T, Brunner T, Rademacher C, Hartmann RW, Brönstrup M, Imberty A, Titz A.

J Am Chem Soc. 2018 Feb 21;140(7):2537-2545. doi: 10.1021/jacs.7b11133. Epub 2018 Jan 22.

PMID:
29272578
48.

Broad-spectrum antiviral activity of the eIF4A inhibitor silvestrol against corona- and picornaviruses.

Müller C, Schulte FW, Lange-Grünweller K, Obermann W, Madhugiri R, Pleschka S, Ziebuhr J, Hartmann RK, Grünweller A.

Antiviral Res. 2018 Feb;150:123-129. doi: 10.1016/j.antiviral.2017.12.010. Epub 2017 Dec 16.

PMID:
29258862
49.

Crocadepsins-Depsipeptides from the Myxobacterium Chondromyces crocatus Found by a Genome Mining Approach.

Surup F, Viehrig K, Rachid S, Plaza A, Maurer CK, Hartmann RW, Müller R.

ACS Chem Biol. 2018 Jan 19;13(1):267-272. doi: 10.1021/acschembio.7b00900. Epub 2017 Dec 28.

PMID:
29220569
50.

Frequently used bioinformatics tools overestimate the damaging effect of allelic variants.

Andersen LL, Terczyńska-Dyla E, Mørk N, Scavenius C, Enghild JJ, Höning K, Hornung V, Christiansen M, Mogensen TH, Hartmann R.

Genes Immun. 2019 Jan;20(1):10-22. doi: 10.1038/s41435-017-0002-z. Epub 2017 Dec 4.

PMID:
29217828

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