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Open-Label Randomized Trial of Early Clinical Outcomes of Ceftaroline Fosamil Versus Vancomycin for the Treatment of Acute Bacterial Skin and Skin Structure Infections at Risk of Methicillin-Resistant Staphylococcus aureus.

Claeys KC, Zasowski EJ, Trinh TD, Casapao AM, Pogue JM, Bhatia N, Mynatt RP, Wilson SS, Arthur C, Welch R, Sherwin R, Hafeez W, Levine DP, Kaye KS, Delgado G, Giuliano CA, Takla R, Rieck C, Johnson LB, Murray KP, Gordon J, Reyes K, Hartman P, Davis SL, Rybak MJ.

Infect Dis Ther. 2019 Jun;8(2):199-208. doi: 10.1007/s40121-019-0242-5. Epub 2019 Mar 27.


Next generation sequencing for clinical diagnostics: Five year experience of an academic laboratory.

Hartman P, Beckman K, Silverstein K, Yohe S, Schomaker M, Henzler C, Onsongo G, Lam HC, Munro S, Daniel J, Billstein B, Deshpande A, Hauge A, Mroz P, Lee W, Holle J, Wiens K, Karnuth K, Kemmer T, Leary M, Michel S, Pohlman L, Thayanithy V, Nelson A, Bower M, Thyagarajan B.

Mol Genet Metab Rep. 2019 Mar 1;19:100464. doi: 10.1016/j.ymgmr.2019.100464. eCollection 2019 Jun.


A natural variant and engineered mutation in a GPCR promote DEET resistance in C. elegans.

Dennis EJ, Dobosiewicz M, Jin X, Duvall LB, Hartman PS, Bargmann CI, Vosshall LB.

Nature. 2018 Oct;562(7725):119-123. doi: 10.1038/s41586-018-0546-8. Epub 2018 Sep 26.


Human and animal evidence of potential transgenerational inheritance of health effects: An evidence map and state-of-the-science evaluation.

Walker VR, Boyles AL, Pelch KE, Holmgren SD, Shapiro AJ, Blystone CR, Devito MJ, Newbold RR, Blain R, Hartman P, Thayer KA, Rooney AA.

Environ Int. 2018 Jun;115:48-69. doi: 10.1016/j.envint.2017.12.032. Epub 2018 Mar 14. Review.


Risk Factors for 30-Day Mortality in Patients with Methicillin-Resistant Staphylococcus aureus Bloodstream Infections.

Ayau P, Bardossy AC, Sanchez G, Ortiz R, Moreno D, Hartman P, Rizvi K, Prentiss TC, Perri MB, Mahan M, Huang V, Reyes K, Zervos MJ.

Int J Infect Dis. 2017 Aug;61:3-6. doi: 10.1016/j.ijid.2017.05.010. Epub 2017 May 19.


Ceftaroline fosamil monotherapy for methicillin-resistant Staphylococcus aureus bacteremia: a comparative clinical outcomes study.

Arshad S, Huang V, Hartman P, Perri MB, Moreno D, Zervos MJ.

Int J Infect Dis. 2017 Apr;57:27-31. doi: 10.1016/j.ijid.2017.01.019. Epub 2017 Jan 25.


Visualizing dynamic capabilities as adaptive capacity for municipal water governance.

Widener JM, Gliedt TJ, Hartman P.

Sustain Sci. 2017;12(2):203-219. doi: 10.1007/s11625-016-0408-y. Epub 2016 Nov 4.


Single Plant Derived Nanotechnology for Synergistic Antibacterial Therapies.

Kalluri JR, Gonzalez-Rodriguez R, Hartman PS, Loni A, Canham LT, Coffer JL.

PLoS One. 2016 Sep 29;11(9):e0163270. doi: 10.1371/journal.pone.0163270. eCollection 2016.


Endogenous reactive oxygen species cause astrocyte defects and neuronal dysfunctions in the hippocampus: a new model for aging brain.

Ishii T, Takanashi Y, Sugita K, Miyazawa M, Yanagihara R, Yasuda K, Onouchi H, Kawabe N, Nakata M, Yamamoto Y, Hartman PS, Ishii N.

Aging Cell. 2017 Feb;16(1):39-51. doi: 10.1111/acel.12523. Epub 2016 Sep 13.


A cluster of trace-concentration methamphetamine identifications in racehorses associated with a methamphetamine-contaminated horse trailer: A report and analysis.

Brewer K, Shults TF, Machin J, Kudrimoti S, Eisenberg RL, Hartman P, Wang C, Fenger C, Beaumier P, Tobin T.

Can Vet J. 2016 Aug;57(8):860-4.


Infertility and recurrent miscarriage with complex II deficiency-dependent mitochondrial oxidative stress in animal models.

Ishii T, Yasuda K, Miyazawa M, Mitsushita J, Johnson TE, Hartman PS, Ishii N.

Mech Ageing Dev. 2016 Apr;155:22-35. doi: 10.1016/j.mad.2016.02.013. Epub 2016 Mar 2. Review.


Five Simultaneous Primary Tumors in a Single Patient: A Case Report and Review of the Literature.

Williamson CW, Paravati A, Ghassemi M, Lethert K, Hua P, Hartman P, Sanghvi P.

Case Rep Oncol. 2015 Oct 20;8(3):432-8. doi: 10.1159/000440799. eCollection 2015 Sep-Dec.


Influence of Surface Chemistry on the Release of an Antibacterial Drug from Nanostructured Porous Silicon.

Wang M, Hartman PS, Loni A, Canham LT, Bodiford N, Coffer JL.

Langmuir. 2015 Jun 9;31(22):6179-85. doi: 10.1021/acs.langmuir.5b01372. Epub 2015 May 26.


Ethyl methanesulfonate induces mutations in Caenorhabditis elegans embryos at a high frequency.

Hartman PS, Barry J, Finstad W, Khan N, Tanaka M, Yasuda K, Ishii N.

Mutat Res. 2014 Aug-Sep;766-767:44-8. doi: 10.1016/j.mrfmmm.2014.05.011. Epub 2014 Jun 10.


Evaluation of in vitro susceptibility trends to vancomycin and daptomycin by strain type of Staphylococcus aureus causing bloodstream infections.

Shoyinka A, Moreno D, Arshad S, Perri MB, Donabedian SM, Jacobsen G, Hartman P, Ziegler R, Huang V, Zervos MJ.

J Glob Antimicrob Resist. 2014 Dec;2(4):280-285. doi: 10.1016/j.jgar.2014.05.002. Epub 2014 Jun 7.


Efficient marker-free recovery of custom genetic modifications with CRISPR/Cas9 in Caenorhabditis elegans.

Arribere JA, Bell RT, Fu BX, Artiles KL, Hartman PS, Fire AZ.

Genetics. 2014 Nov;198(3):837-46. doi: 10.1534/genetics.114.169730. Epub 2014 Aug 26.


Genetically induced oxidative stress in mice causes thrombocytosis, splenomegaly and placental angiodysplasia that leads to recurrent abortion.

Ishii T, Miyazawa M, Takanashi Y, Tanigawa M, Yasuda K, Onouchi H, Kawabe N, Mitsushita J, Hartman PS, Ishii N.

Redox Biol. 2014 May 14;2:679-85. doi: 10.1016/j.redox.2014.05.001. eCollection 2014.


A novel treatment option for MRSA pneumonia: ceftaroline fosamil-yielding new hope in the fight against a persistent infection.

Arshad S, Hartman P, Zervos MJ.

Expert Rev Anti Infect Ther. 2014 Jul;12(7):727-9. doi: 10.1586/14787210.2014.908118. Epub 2014 Jun 5.


Major variation in MICs of tigecycline in Gram-negative bacilli as a function of testing method.

Marchaim D, Pogue JM, Tzuman O, Hayakawa K, Lephart PR, Salimnia H, Painter T, Zervos MJ, Johnson LE, Perri MB, Hartman P, Thyagarajan RV, Major S, Goodell M, Fakih MG, Washer LL, Newton DW, Malani AN, Wholehan JM, Mody L, Kaye KS.

J Clin Microbiol. 2014 May;52(5):1617-21. doi: 10.1128/JCM.00001-14. Epub 2014 Mar 5.


Model animals for the study of oxidative stress from complex II.

Ishii T, Miyazawa M, Onouchi H, Yasuda K, Hartman PS, Ishii N.

Biochim Biophys Acta. 2013 May;1827(5):588-97. doi: 10.1016/j.bbabio.2012.10.016. Epub 2012 Nov 6. Review.


Mitochondrial superoxide anion overproduction in Tet-mev-1 transgenic mice accelerates age-dependent corneal cell dysfunctions.

Onouchi H, Ishii T, Miyazawa M, Uchino Y, Yasuda K, Hartman PS, Kawai K, Tsubota K, Ishii N.

Invest Ophthalmol Vis Sci. 2012 Aug 31;53(9):5780-7. doi: 10.1167/iovs.12-9573.


Comparative molecular profiling of the PPARα/γ activator aleglitazar: PPAR selectivity, activity and interaction with cofactors.

Dietz M, Mohr P, Kuhn B, Maerki HP, Hartman P, Ruf A, Benz J, Grether U, Wright MB.

ChemMedChem. 2012 Jun;7(6):1101-11. doi: 10.1002/cmdc.201100598. Epub 2012 Apr 4.


A mutation in a mitochondrial dehydrogenase/reductase gene causes an increased sensitivity to oxidative stress and mitochondrial defects in the nematode Caenorhabditis elegans.

Fujii M, Yasuda K, Hartman PS, Ayusawa D, Ishii N.

Genes Cells. 2011 Oct;16(10):1022-34. doi: 10.1111/j.1365-2443.2011.01547.x. Epub 2011 Sep 7.


Mitochondrial superoxide anion (O(2)(-)) inducible "mev-1" animal models for aging research.

Ishii T, Miyazawa M, Hartman PS, Ishii N.

BMB Rep. 2011 May;44(5):298-305. doi: 10.5483/BMBRep.2011.44.5.298. Review.


Studies in mice, hamsters, and rats demonstrate that repression of hepatic apoA-I expression by taurocholic acid in mice is not mediated by the farnesoid-X-receptor.

Gardès C, Blum D, Bleicher K, Chaput E, Ebeling M, Hartman P, Handschin C, Richter H, Benson GM.

J Lipid Res. 2011 Jun;52(6):1188-99. doi: 10.1194/jlr.M012542. Epub 2011 Apr 4.


Optimization of a novel class of benzimidazole-based farnesoid X receptor (FXR) agonists to improve physicochemical and ADME properties.

Richter HG, Benson GM, Bleicher KH, Blum D, Chaput E, Clemann N, Feng S, Gardes C, Grether U, Hartman P, Kuhn B, Martin RE, Plancher JM, Rudolph MG, Schuler F, Taylor S.

Bioorg Med Chem Lett. 2011 Feb 15;21(4):1134-40. doi: 10.1016/j.bmcl.2010.12.123. Epub 2010 Dec 31.


Interrelationships between mitochondrial fusion, energy metabolism and oxidative stress during development in Caenorhabditis elegans.

Yasuda K, Hartman PS, Ishii T, Suda H, Akatsuka A, Shoyama T, Miyazawa M, Ishii N.

Biochem Biophys Res Commun. 2011 Jan 21;404(3):751-5. doi: 10.1016/j.bbrc.2010.12.017. Epub 2010 Dec 7.


Discovery of novel and orally active FXR agonists for the potential treatment of dyslipidemia & diabetes.

Richter HG, Benson GM, Blum D, Chaput E, Feng S, Gardes C, Grether U, Hartman P, Kuhn B, Martin RE, Plancher JM, Rudolph MG, Schuler F, Taylor S, Bleicher KH.

Bioorg Med Chem Lett. 2011 Jan 1;21(1):191-4. doi: 10.1016/j.bmcl.2010.11.039. Epub 2010 Nov 12.


Sustained antibacterial activity from triclosan-loaded nanostructured mesoporous silicon.

Wang M, Coffer JL, Dorraj K, Hartman PS, Loni A, Canham LT.

Mol Pharm. 2010 Dec 6;7(6):2232-9. doi: 10.1021/mp100227m. Epub 2010 Nov 16.


Mitochondrial reactive oxygen species generation by the SDHC V69E mutation causes low birth weight and neonatal growth retardation.

Ishii T, Miyazawa M, Onodera A, Yasuda K, Kawabe N, Kirinashizawa M, Yoshimura S, Maruyama N, Hartman PS, Ishii N.

Mitochondrion. 2011 Jan;11(1):155-65. doi: 10.1016/j.mito.2010.09.006. Epub 2010 Oct 18.


Mast cell chymase inhibition reduces atherosclerotic plaque progression and improves plaque stability in ApoE-/- mice.

Bot I, Bot M, van Heiningen SH, van Santbrink PJ, Lankhuizen IM, Hartman P, Gruener S, Hilpert H, van Berkel TJ, Fingerle J, Biessen EA.

Cardiovasc Res. 2011 Jan 1;89(1):244-52. doi: 10.1093/cvr/cvq260. Epub 2010 Aug 6.


Post-dauer life span of Caenorhabditis elegans dauer larvae can be modified by X-irradiation.

Onodera A, Yanase S, Ishii T, Yasuda K, Miyazawa M, Hartman PS, Ishii N.

J Radiat Res. 2010;51(1):67-71. Epub 2009 Oct 23.


A community perspective on quantifying the economic impact of teleradiology and telepsychiatry.

Whitacre BE, Hartman PS, Boggs SA, Schott V.

J Rural Health. 2009 Spring;25(2):194-7. doi: 10.1111/j.1748-0361.2009.00217.x. No abstract available.


A vasculature-targeting regimen of preoperative docetaxel with or without bevacizumab for locally advanced breast cancer: impact on angiogenic biomarkers.

Baar J, Silverman P, Lyons J, Fu P, Abdul-Karim F, Ziats N, Wasman J, Hartman P, Jesberger J, Dumadag L, Hohler E, Leeming R, Shenk R, Chen H, McCrae K, Dowlati A, Remick SC, Overmoyer B.

Clin Cancer Res. 2009 May 15;15(10):3583-90. doi: 10.1158/1078-0432.CCR-08-2917. Epub 2009 May 5.


A phase II trial of fosbretabulin in advanced anaplastic thyroid carcinoma and correlation of baseline serum-soluble intracellular adhesion molecule-1 with outcome.

Mooney CJ, Nagaiah G, Fu P, Wasman JK, Cooney MM, Savvides PS, Bokar JA, Dowlati A, Wang D, Agarwala SS, Flick SM, Hartman PH, Ortiz JD, Lavertu PN, Remick SC.

Thyroid. 2009 Mar;19(3):233-40. doi: 10.1089/thy.2008.0321.


Job adjustments, job satisfaction and health experience in upper and lower limb amputees.

van der Sluis CK, Hartman PP, Schoppen T, Dijkstra PU.

Prosthet Orthot Int. 2009 Mar;33(1):41-51. doi: 10.1080/03093640802555917.


Discovery of tetrahydro-cyclopenta[b]indole as selective LXRs modulator.

Ratni H, Blum-Kaelin D, Dehmlow H, Hartman P, Jablonski P, Masciadri R, Maugeais C, Patiny-Adam A, Panday N, Wright M.

Bioorg Med Chem Lett. 2009 Mar 15;19(6):1654-7. doi: 10.1016/j.bmcl.2009.01.109. Epub 2009 Feb 6.


The role of mitochondrial superoxide anion (O2(-)) on physiological aging in C57BL/6J mice.

Miyazawa M, Ishii T, Yasuda K, Noda S, Onouchi H, Hartman PS, Ishii N.

J Radiat Res. 2009 Jan;50(1):73-83.


Repeated temperature fluctuation extends the life span of Caenorhabditis elegans in a daf-16-dependent fashion.

Galbadage T, Hartman PS.

Mech Ageing Dev. 2008 Sep;129(9):507-14. doi: 10.1016/j.mad.2008.04.012. Epub 2008 May 2.


Cell growth of the mouse SDHC mutant cells was suppressed by apoptosis throughout mitochondrial pathway.

Miyazawa M, Ishii T, Kirinashizawa M, Yasuda K, Hino O, Hartman PS, Ishii N.

Biosci Trends. 2008 Feb;2(1):22-30.


Antiangiogenic activity of thalidomide in combination with fludarabine, carboplatin, and topotecan for high-risk acute myelogenous leukemia.

Barr P, Fu P, Lazarus H, Kane D, Meyerson H, Hartman P, Reyes R, Creger R, Stear K, Laughlin M, Tse W, Cooper B.

Leuk Lymphoma. 2007 Oct;48(10):1940-9.


Inflammatory breast cancer as a model disease to study tumor angiogenesis: results of a phase IB trial of combination SU5416 and doxorubicin.

Overmoyer B, Fu P, Hoppel C, Radivoyevitch T, Shenk R, Persons M, Silverman P, Robertson K, Ziats NP, Wasman JK, Abdul-Karim FW, Jesberger JA, Duerk J, Hartman P, Hanks S, Lewin J, Dowlati A, McCrae K, Ivy P, Remick SC.

Clin Cancer Res. 2007 Oct 1;13(19):5862-8.


[Screening domestic violence. A German-language screening instrument for domestic violence against women].

Nyberg E, Hartman P, Stieglitz R, Riecher-Rössler A.

Fortschr Neurol Psychiatr. 2008 Jan;76(1):28-36. Epub 2007 Jul 24. German.


Chromosome dosage as a life span determinant in Caenorhabiditis elegans.

Hartman PS, Ishii N.

Mech Ageing Dev. 2007 Jul-Aug;128(7-8):437-43. Epub 2007 Jun 19.


The role of the electron transport SDHC gene on lifespan and cancer.

Ishii N, Ishii T, Hartman PS.

Mitochondrion. 2007 Feb-Apr;7(1-2):24-8. Epub 2006 Dec 3. Review.


The role of the electron transport gene SDHC on lifespan and cancer.

Ishii N, Ishii T, Hartman PS.

Exp Gerontol. 2006 Oct;41(10):952-6. Epub 2006 Sep 7. Review.


Age-related changes of mitochondrial structure and function in Caenorhabditis elegans.

Yasuda K, Ishii T, Suda H, Akatsuka A, Hartman PS, Goto S, Miyazawa M, Ishii N.

Mech Ageing Dev. 2006 Oct;127(10):763-70. Epub 2006 Aug 7.


Synthesis and evaluation of anilinohexafluoroisopropanols as activators/modulators of LXRalpha and beta.

Panday N, Benz J, Blum-Kaelin D, Bourgeaux V, Dehmlow H, Hartman P, Kuhn B, Ratni H, Warot X, Wright MB.

Bioorg Med Chem Lett. 2006 Oct 1;16(19):5231-7. Epub 2006 Jul 31.


Novel Phase I dose de-escalation design trial to determine the biological modulatory dose of the antiangiogenic agent SU5416.

Dowlati A, Robertson K, Radivoyevitch T, Waas J, Ziats NP, Hartman P, Abdul-Karim FW, Wasman JK, Jesberger J, Lewin J, McCrae K, Ivy P, Remick SC.

Clin Cancer Res. 2005 Nov 1;11(21):7938-44.


Complex II inactivation is lethal in the nematode Caenorhabditis elegans.

Ichimiya H, Huet RG, Hartman P, Amino H, Kita K, Ishii N.

Mitochondrion. 2002 Dec;2(3):191-8.


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