Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 38

1.

A standardized approach to the evaluation of antivirals against DNA viruses: Polyomaviruses and lymphotropic herpesviruses.

Keith KA, Hartline CB, Bowlin TL, Prichard MN.

Antiviral Res. 2018 Nov;159:122-129. doi: 10.1016/j.antiviral.2018.09.016. Epub 2018 Oct 1.

PMID:
30287227
2.

A standardized approach to the evaluation of antivirals against DNA viruses: Orthopox-, adeno-, and herpesviruses.

Hartline CB, Keith KA, Eagar J, Harden EA, Bowlin TL, Prichard MN.

Antiviral Res. 2018 Nov;159:104-112. doi: 10.1016/j.antiviral.2018.09.015. Epub 2018 Oct 1.

PMID:
30287226
3.

Xenotransplantation panel for the detection of infectious agents in pigs.

Hartline CB, Conner RL, James SH, Potter J, Gray E, Estrada J, Tector M, Tector AJ, Prichard MN.

Xenotransplantation. 2018 Jul;25(4):e12427. doi: 10.1111/xen.12427.

4.

USC-087 protects Syrian hamsters against lethal challenge with human species C adenoviruses.

Toth K, Spencer JF, Ying B, Tollefson AE, Hartline CB, Richard ET, Fan J, Lyu J, Kashemirov BA, Harteg C, Reyna D, Lipka E, Prichard MN, McKenna CE, Wold WSM.

Antiviral Res. 2018 May;153:1-9. doi: 10.1016/j.antiviral.2018.03.001. Epub 2018 Mar 3.

5.

Dihydropyrimidinones and -thiones with improved activity against human polyomavirus family members.

Manos-Turvey A, Al-Ashtal HA, Needham PG, Hartline CB, Prichard MN, Wipf P, Brodsky JL.

Bioorg Med Chem Lett. 2016 Oct 15;26(20):5087-5091. doi: 10.1016/j.bmcl.2016.08.080. Epub 2016 Aug 25.

6.

Brincidofovir treatment of acyclovir-resistant disseminated varicella zoster virus infection in an immunocompromised host.

Mullane KM, Nuss C, Ridgeway J, Prichard MN, Hartline CB, Theusch J, Mommeja-Marin H, Larson RA.

Transpl Infect Dis. 2016 Oct;18(5):785-790. doi: 10.1111/tid.12583. Epub 2016 Sep 16.

PMID:
27481400
7.

TAOK3 phosphorylates the methylenecyclopropane nucleoside MBX 2168 to its monophosphate.

Komazin-Meredith G, Cardinale SC, Comeau K, Magalhaes KJ, Hartline CB, Williams JD, Opperman TJ, Prichard MN, Bowlin TL.

Antiviral Res. 2015 Jul;119:23-7. doi: 10.1016/j.antiviral.2015.04.001. Epub 2015 Apr 7.

8.

Human cytomegalovirus UL97 kinase is involved in the mechanism of action of methylenecyclopropane analogs with 6-ether and -thioether substitutions.

Komazin-Meredith G, Chou S, Prichard MN, Hartline CB, Cardinale SC, Comeau K, Williams JD, Khan AR, Peet NP, Bowlin TL.

Antimicrob Agents Chemother. 2014;58(1):274-8. doi: 10.1128/AAC.01726-13. Epub 2013 Oct 21.

9.

Synthesis and antiviral activities of methylenecyclopropane analogs with 6-alkoxy and 6-alkylthio substitutions that exhibit broad-spectrum antiviral activity against human herpesviruses.

Prichard MN, Williams JD, Komazin-Meredith G, Khan AR, Price NB, Jefferson GM, Harden EA, Hartline CB, Peet NP, Bowlin TL.

Antimicrob Agents Chemother. 2013 Aug;57(8):3518-27. doi: 10.1128/AAC.00429-13. Epub 2013 May 13.

10.

Selection and recombinant phenotyping of a novel CMX001 and cidofovir resistance mutation in human cytomegalovirus.

James SH, Price NB, Hartline CB, Lanier ER, Prichard MN.

Antimicrob Agents Chemother. 2013 Jul;57(7):3321-5. doi: 10.1128/AAC.00062-13. Epub 2013 May 6.

11.

Synthesis and antiviral activity of certain second generation methylenecyclopropane nucleosides.

Williams JD, Khan AR, Harden EA, Hartline CB, Jefferson GM, Keith KA, Prichard MN, Zemlicka J, Peet NP, Bowlin TL.

Bioorg Med Chem. 2012 Jun 15;20(12):3710-8. doi: 10.1016/j.bmc.2012.04.049. Epub 2012 May 1.

12.

CMX001 potentiates the efficacy of acyclovir in herpes simplex virus infections.

Prichard MN, Kern ER, Hartline CB, Lanier ER, Quenelle DC.

Antimicrob Agents Chemother. 2011 Oct;55(10):4728-34. doi: 10.1128/AAC.00545-11. Epub 2011 Jul 25.

13.

Cyclopropavir inhibits the normal function of the human cytomegalovirus UL97 kinase.

James SH, Hartline CB, Harden EA, Driebe EM, Schupp JM, Engelthaler DM, Keim PS, Bowlin TL, Kern ER, Prichard MN.

Antimicrob Agents Chemother. 2011 Oct;55(10):4682-91. doi: 10.1128/AAC.00571-11. Epub 2011 Jul 25.

14.

Antiviral evaluation of octadecyloxyethyl esters of (S)-3-hydroxy-2-(phosphonomethoxy)propyl nucleosides against herpesviruses and orthopoxviruses.

Valiaeva N, Prichard MN, Buller RM, Beadle JR, Hartline CB, Keith KA, Schriewer J, Trahan J, Hostetler KY.

Antiviral Res. 2009 Dec;84(3):254-9. doi: 10.1016/j.antiviral.2009.09.012. Epub 2009 Oct 1.

15.

Inhibition of herpesvirus replication by 5-substituted 4'-thiopyrimidine nucleosides.

Prichard MN, Quenelle DC, Hartline CB, Harden EA, Jefferson G, Frederick SL, Daily SL, Whitley RJ, Tiwari KN, Maddry JA, Secrist JA 3rd, Kern ER.

Antimicrob Agents Chemother. 2009 Dec;53(12):5251-8. doi: 10.1128/AAC.00417-09. Epub 2009 Sep 21.

16.
17.

Inhibition of herpesvirus replication by hexadecyloxypropyl esters of purine- and pyrimidine-based phosphonomethoxyethyl nucleoside phosphonates.

Prichard MN, Hartline CB, Harden EA, Daily SL, Beadle JR, Valiaeva N, Kern ER, Hostetler KY.

Antimicrob Agents Chemother. 2008 Dec;52(12):4326-30. doi: 10.1128/AAC.00918-08. Epub 2008 Oct 13.

18.

Effect of oral treatment with (S)-HPMPA, HDP-(S)-HPMPA or ODE-(S)-HPMPA on replication of murine cytomegalovirus (MCMV) or human cytomegalovirus (HCMV) in animal models.

Quenelle DC, Collins DJ, Pettway LR, Hartline CB, Beadle JR, Wan WB, Hostetler KY, Kern ER.

Antiviral Res. 2008 Aug;79(2):133-5. doi: 10.1016/j.antiviral.2008.01.155. Epub 2008 Feb 22.

19.

Human cytomegalovirus UL97 kinase activity is required for the hyperphosphorylation of retinoblastoma protein and inhibits the formation of nuclear aggresomes.

Prichard MN, Sztul E, Daily SL, Perry AL, Frederick SL, Gill RB, Hartline CB, Streblow DN, Varnum SM, Smith RD, Kern ER.

J Virol. 2008 May;82(10):5054-67. doi: 10.1128/JVI.02174-07. Epub 2008 Mar 5.

20.

Synthesis and antiviral evaluation of alkoxyalkyl-phosphate conjugates of cidofovir and adefovir.

Ruiz JC, Beadle JR, Aldern KA, Keith KA, Hartline CB, Kern ER, Hostetler KY.

Antiviral Res. 2007 Jul;75(1):87-90. Epub 2006 Oct 10.

21.

Antiviral activities of novel 5-phosphono-pent-2-en-1-yl nucleosides and their alkoxyalkyl phosphonoesters.

Choo H, Beadle JR, Kern ER, Prichard MN, Keith KA, Hartline CB, Trahan J, Aldern KA, Korba BE, Hostetler KY.

Antimicrob Agents Chemother. 2007 Feb;51(2):611-5. Epub 2006 Nov 27.

22.

Synthesis and antiviral evaluation of alkoxyalkyl esters of phosphonopropoxymethyl-guanine and phosphonopropoxymethyl-diaminopurine.

Ruiz JC, Aldern KA, Beadle JR, Hartline CB, Kern ER, Hostetler KY.

Antivir Chem Chemother. 2006;17(2):89-95.

PMID:
17042330
23.

Human cytomegalovirus UL97 Kinase is required for the normal intranuclear distribution of pp65 and virion morphogenesis.

Prichard MN, Britt WJ, Daily SL, Hartline CB, Kern ER.

J Virol. 2005 Dec;79(24):15494-502.

24.

Comparative activities of lipid esters of cidofovir and cyclic cidofovir against replication of herpesviruses in vitro.

Williams-Aziz SL, Hartline CB, Harden EA, Daily SL, Prichard MN, Kushner NL, Beadle JR, Wan WB, Hostetler KY, Kern ER.

Antimicrob Agents Chemother. 2005 Sep;49(9):3724-33.

25.
26.

In vitro activity and mechanism of action of methylenecyclopropane analogs of nucleosides against herpesvirus replication.

Kern ER, Kushner NL, Hartline CB, Williams-Aziz SL, Harden EA, Zhou S, Zemlicka J, Prichard MN.

Antimicrob Agents Chemother. 2005 Mar;49(3):1039-45.

27.

Inhibition of herpesvirus replication by a series of 4-oxo-dihydroquinolines with viral polymerase activity.

Hartline CB, Harden EA, Williams-Aziz SL, Kushner NL, Brideau RJ, Kern ER.

Antiviral Res. 2005 Feb;65(2):97-105.

PMID:
15708636
28.

Ether lipid-ester prodrugs of acyclic nucleoside phosphonates: activity against adenovirus replication in vitro.

Hartline CB, Gustin KM, Wan WB, Ciesla SL, Beadle JR, Hostetler KY, Kern ER.

J Infect Dis. 2005 Feb 1;191(3):396-9. Epub 2004 Dec 29.

PMID:
15633099
29.

Oral activity of a methylenecyclopropane analog, cyclopropavir, in animal models for cytomegalovirus infections.

Kern ER, Bidanset DJ, Hartline CB, Yan Z, Zemlicka J, Quenelle DC.

Antimicrob Agents Chemother. 2004 Dec;48(12):4745-53.

30.
31.

Activities of benzimidazole D- and L-ribonucleosides in animal models of cytomegalovirus infections.

Kern ER, Hartline CB, Rybak RJ, Drach JC, Townsend LB, Biron KK, Bidanset DJ.

Antimicrob Agents Chemother. 2004 May;48(5):1749-55.

32.

Efficacy of methylenecyclopropane analogs of nucleosides against herpesvirus replication in vitro.

Kushner NL, Williams SL, Hartline CB, Harden EA, Bidanset DJ, Chen X, Zemlicka J, Kern ER.

Nucleosides Nucleotides Nucleic Acids. 2003 Dec;22(12):2105-19.

PMID:
14714760
33.

In vitro activities of benzimidazole D- and L-ribonucleosides against herpesviruses.

Williams SL, Hartline CB, Kushner NL, Harden EA, Bidanset DJ, Drach JC, Townsend LB, Underwood MR, Biron KK, Kern ER.

Antimicrob Agents Chemother. 2003 Jul;47(7):2186-92.

34.

Predictive efficacy of SCID-hu mouse models for treatment of human cytomegalovirus infections.

Kern ER, Rybak RJ, Hartline CB, Bidanset DJ.

Antivir Chem Chemother. 2001;12 Suppl 1:149-56.

PMID:
11594682
35.

Replication of human cytomegalovirus in severe combined immunodeficient mice implanted with human retinal tissue.

Bidanset DJ, Rybak RJ, Hartline CB, Kern ER.

J Infect Dis. 2001 Jul 15;184(2):192-5. Epub 2001 Jun 8.

PMID:
11424017
36.

Synthesis and enantioselectivity of the antiviral effects of (R,Z)-,(S,Z)-methylenecyclopropane analogues of purine nucleosides and phosphoralaninate prodrugs: influence of heterocyclic base, type of virus and host cells.

Qiu YL, Geiser F, Kira T, Gullen E, Cheng YC, Ptak RG, Breitenbach JM, Drach JC, Hartline CB, Kern ER, Zemlicka J.

Antivir Chem Chemother. 2000 May;11(3):191-202.

PMID:
10901290
37.

In vitro activities of methylenecyclopropane analogues of nucleosides and their phosphoralaninate prodrugs against cytomegalovirus and other herpesvirus infections.

Rybak RJ, Hartline CB, Qiu YL, Zemlicka J, Harden E, Marshall G, Sommadossi JP, Kern ER.

Antimicrob Agents Chemother. 2000 Jun;44(6):1506-11.

38.

Effective treatment of murine cytomegalovirus infections with methylenecyclopropane analogues of nucleosides.

Rybak RJ, Zemlicka J, Qiu YL, Hartline CB, Kern ER.

Antiviral Res. 1999 Oct;43(3):175-88.

PMID:
10551375

Supplemental Content

Loading ...
Support Center