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Items: 1 to 50 of 129

1.

Plasmacytoid Dendritic Cells Provide Protection Against Bacterial-Induced Colitis.

Rahman T, Brown AS, Hartland EL, van Driel IR, Fung KY.

Front Immunol. 2019 Apr 9;10:608. doi: 10.3389/fimmu.2019.00608. eCollection 2019.

2.

Salmonella Effectors SseK1 and SseK3 Target Death Domain Proteins in the TNF and TRAIL Signaling Pathways.

Newson JPM, Scott NE, Yeuk Wah Chung I, Wong Fok Lung T, Giogha C, Gan J, Wang N, Strugnell RA, Brown NF, Cygler M, Pearson JS, Hartland EL.

Mol Cell Proteomics. 2019 Jun;18(6):1138-1156. doi: 10.1074/mcp.RA118.001093. Epub 2019 Mar 22.

PMID:
30902834
3.

The Mouse as a Model for Pulmonary Legionella Infection.

Ng GZ, Solomatina A, van Driel IR, Hartland EL.

Methods Mol Biol. 2019;1921:399-417. doi: 10.1007/978-1-4939-9048-1_25.

PMID:
30694506
4.

More than 18,000 effectors in the Legionella genus genome provide multiple, independent combinations for replication in human cells.

Gomez-Valero L, Rusniok C, Carson D, Mondino S, Pérez-Cobas AE, Rolando M, Pasricha S, Reuter S, Demirtas J, Crumbach J, Descorps-Declere S, Hartland EL, Jarraud S, Dougan G, Schroeder GN, Frankel G, Buchrieser C.

Proc Natl Acad Sci U S A. 2019 Feb 5;116(6):2265-2273. doi: 10.1073/pnas.1808016116. Epub 2019 Jan 18.

PMID:
30659146
5.

Editorial: Biology and Pathogenesis of Legionella.

Newton HJ, Hartland EL, Machner MP.

Front Cell Infect Microbiol. 2018 Sep 19;8:328. doi: 10.3389/fcimb.2018.00328. eCollection 2018. No abstract available.

6.

Targeting of RNA Polymerase II by a nuclear Legionella pneumophila Dot/Icm effector SnpL.

Schuelein R, Spencer H, Dagley LF, Li PF, Luo L, Stow JL, Abraham G, Naderer T, Gomez-Valero L, Buchrieser C, Sugimoto C, Yamagishi J, Webb AI, Pasricha S, Hartland EL.

Cell Microbiol. 2018 Sep;20(9):e12852. doi: 10.1111/cmi.12852. Epub 2018 May 18.

PMID:
29691989
7.

Citrobacter rodentium Infection Model for the Analysis of Bacterial Pathogenesis and Mucosal Immunology.

Kennedy CL, Hartland EL.

Methods Mol Biol. 2018;1725:77-89. doi: 10.1007/978-1-4939-7568-6_7.

PMID:
29322410
8.

Methylomic and phenotypic analysis of the ModH5 phasevarion of Helicobacter pylori.

Srikhanta YN, Gorrell RJ, Power PM, Tsyganov K, Boitano M, Clark TA, Korlach J, Hartland EL, Jennings MP, Kwok T.

Sci Rep. 2017 Nov 23;7(1):16140. doi: 10.1038/s41598-017-15721-x.

9.

Post-translational Mechanisms of Host Subversion by Bacterial Effectors.

Scott NE, Hartland EL.

Trends Mol Med. 2017 Dec;23(12):1088-1102. doi: 10.1016/j.molmed.2017.10.003. Epub 2017 Nov 14. Review.

PMID:
29150361
10.

Phasevarion-Regulated Virulence in the Emerging Pediatric Pathogen Kingella kingae.

Srikhanta YN, Fung KY, Pollock GL, Bennett-Wood V, Howden BP, Hartland EL.

Infect Immun. 2017 Nov 17;85(12). pii: e00319-17. doi: 10.1128/IAI.00319-17. Print 2017 Dec.

11.

The bacterial arginine glycosyltransferase effector NleB preferentially modifies Fas-associated death domain protein (FADD).

Scott NE, Giogha C, Pollock GL, Kennedy CL, Webb AI, Williamson NA, Pearson JS, Hartland EL.

J Biol Chem. 2017 Oct 20;292(42):17337-17350. doi: 10.1074/jbc.M117.805036. Epub 2017 Aug 31.

12.

The role of mass spectrometry analysis in bacterial effector characterization.

Scott NE, Hartland EL.

Biochem J. 2017 Aug 7;474(16):2779-2784. doi: 10.1042/BCJ20160797.

PMID:
28784697
13.

Bacterial pathogenesis: Legionella phosphoinositide tailoring.

Hartland EL.

Nat Microbiol. 2017 Feb 22;2:17013. doi: 10.1038/nmicrobiol.2017.13. No abstract available.

PMID:
28224977
14.

Erratum: EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation.

Pearson JS, Giogha C, Mühlen S, Nachbur U, Pham CL, Zhang Y, Hildebrand JM, Oates CV, Lung TW, Ingle D, Dagley LF, Bankovacki A, Petrie EJ, Schroeder GN, Crepin VF, Frankel G, Masters SL, Vince J, Murphy JM, Sunde M, Webb AI, Silke J, Hartland EL.

Nat Microbiol. 2017 Feb 13;2:17024. doi: 10.1038/nmicrobiol.2017.24. No abstract available.

15.

Distinct Roles of the Antiapoptotic Effectors NleB and NleF from Enteropathogenic Escherichia coli.

Pollock GL, Oates CVL, Giogha C, Wong Fok Lung T, Ong SY, Pearson JS, Hartland EL.

Infect Immun. 2017 Mar 23;85(4). pii: e01071-16. doi: 10.1128/IAI.01071-16. Print 2017 Apr.

16.

EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation.

Pearson JS, Giogha C, Mühlen S, Nachbur U, Pham CL, Zhang Y, Hildebrand JM, Oates CV, Lung TW, Ingle D, Dagley LF, Bankovacki A, Petrie EJ, Schroeder GN, Crepin VF, Frankel G, Masters SL, Vince J, Murphy JM, Sunde M, Webb AI, Silke J, Hartland EL.

Nat Microbiol. 2017 Jan 13;2:16258. doi: 10.1038/nmicrobiol.2016.258. Erratum in: Nat Microbiol. 2017 Feb 13;2:17024.

17.

The regulation of acute immune responses to the bacterial lung pathogen Legionella pneumophila.

Brown AS, Yang C, Hartland EL, van Driel IR.

J Leukoc Biol. 2017 Apr;101(4):875-886. doi: 10.1189/jlb.4MR0816-340R. Epub 2016 Dec 29. Review.

PMID:
28034914
18.

The Genetics of Enteropathogenic Escherichia coli Virulence.

Pearson JS, Giogha C, Wong Fok Lung T, Hartland EL.

Annu Rev Genet. 2016 Nov 23;50:493-513. Review.

PMID:
27893961
19.

The Type III Effector NleD from Enteropathogenic Escherichia coli Differentiates between Host Substrates p38 and JNK.

Creuzburg K, Giogha C, Wong Fok Lung T, Scott NE, Mühlen S, Hartland EL, Pearson JS.

Infect Immun. 2017 Jan 26;85(2). pii: e00620-16. doi: 10.1128/IAI.00620-16. Print 2017 Feb.

20.

Eliminating Legionella by inhibiting BCL-XL to induce macrophage apoptosis.

Speir M, Lawlor KE, Glaser SP, Abraham G, Chow S, Vogrin A, Schulze KE, Schuelein R, O'Reilly LA, Mason K, Hartland EL, Lithgow T, Strasser A, Lessene G, Huang DC, Vince JE, Naderer T.

Nat Microbiol. 2016 Feb 24;1:15034. doi: 10.1038/nmicrobiol.2015.34.

PMID:
27572165
21.

Inhibitors for the bacterial ectonucleotidase Lp1NTPDase from Legionella pneumophila.

Fiene A, Baqi Y, Malik EM, Newton P, Li W, Lee SY, Hartland EL, Müller CE.

Bioorg Med Chem. 2016 Sep 15;24(18):4363-4371. doi: 10.1016/j.bmc.2016.07.027. Epub 2016 Jul 17.

PMID:
27522579
22.

Identification of a Distinct Substrate-binding Domain in the Bacterial Cysteine Methyltransferase Effectors NleE and OspZ.

Zhang Y, Mühlen S, Oates CV, Pearson JS, Hartland EL.

J Biol Chem. 2016 Sep 16;291(38):20149-62. doi: 10.1074/jbc.M116.734079. Epub 2016 Jul 21.

23.

Cooperation between Monocyte-Derived Cells and Lymphoid Cells in the Acute Response to a Bacterial Lung Pathogen.

Brown AS, Yang C, Fung KY, Bachem A, Bourges D, Bedoui S, Hartland EL, van Driel IR.

PLoS Pathog. 2016 Jun 14;12(6):e1005691. doi: 10.1371/journal.ppat.1005691. eCollection 2016 Jun.

24.

Mutagenesis and Functional Analysis of the Bacterial Arginine Glycosyltransferase Effector NleB1 from Enteropathogenic Escherichia coli.

Wong Fok Lung T, Giogha C, Creuzburg K, Ong SY, Pollock GL, Zhang Y, Fung KY, Pearson JS, Hartland EL.

Infect Immun. 2016 Apr 22;84(5):1346-1360. doi: 10.1128/IAI.01523-15. Print 2016 May.

25.

Legionella pneumophila S1P-lyase targets host sphingolipid metabolism and restrains autophagy.

Rolando M, Escoll P, Nora T, Botti J, Boitez V, Bedia C, Daniels C, Abraham G, Stogios PJ, Skarina T, Christophe C, Dervins-Ravault D, Cazalet C, Hilbi H, Rupasinghe TW, Tull D, McConville MJ, Ong SY, Hartland EL, Codogno P, Levade T, Naderer T, Savchenko A, Buchrieser C.

Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):1901-6. doi: 10.1073/pnas.1522067113. Epub 2016 Feb 1.

26.

Editorial overview: Host-microbe interactions: bacteria: Secretion systems, effectors, immunity and metabolism.

Hartland EL, Richardson AR.

Curr Opin Microbiol. 2016 Feb;29:v-vii. doi: 10.1016/j.mib.2015.12.003. Epub 2016 Jan 11. No abstract available.

PMID:
26792669
27.

Legionella pneumophila Effector LpdA Is a Palmitoylated Phospholipase D Virulence Factor.

Schroeder GN, Aurass P, Oates CV, Tate EW, Hartland EL, Flieger A, Frankel G.

Infect Immun. 2015 Oct;83(10):3989-4002. doi: 10.1128/IAI.00785-15. Epub 2015 Jul 27.

28.

The Inflammatory Response during Enterohemorrhagic Escherichia coli Infection.

Pearson JS, Hartland EL.

Microbiol Spectr. 2014 Aug;2(4):EHEC-0012-2013. doi: 10.1128/microbiolspec.EHEC-0012-2013. Review.

PMID:
26104206
29.

Substrate recognition by the zinc metalloprotease effector NleC from enteropathogenic Escherichia coli.

Giogha C, Lung TW, Mühlen S, Pearson JS, Hartland EL.

Cell Microbiol. 2015 Dec;17(12):1766-78. doi: 10.1111/cmi.12469. Epub 2015 Jul 15.

PMID:
26096513
30.

A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production.

Nachbur U, Stafford CA, Bankovacki A, Zhan Y, Lindqvist LM, Fiil BK, Khakham Y, Ko HJ, Sandow JJ, Falk H, Holien JK, Chau D, Hildebrand J, Vince JE, Sharp PP, Webb AI, Jackman KA, Mühlen S, Kennedy CL, Lowes KN, Murphy JM, Gyrd-Hansen M, Parker MW, Hartland EL, Lew AM, Huang DC, Lessene G, Silke J.

Nat Commun. 2015 Mar 17;6:6442. doi: 10.1038/ncomms7442.

PMID:
25778803
31.

BTB-ZF transcriptional regulator PLZF modifies chromatin to restrain inflammatory signaling programs.

Sadler AJ, Rossello FJ, Yu L, Deane JA, Yuan X, Wang D, Irving AT, Kaparakis-Liaskos M, Gantier MP, Ying H, Yim HC, Hartland EL, Notini AJ, de Boer S, White SJ, Mansell A, Liu JP, Watkins DN, Gerondakis S, Williams BR, Xu D.

Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1535-40. doi: 10.1073/pnas.1409728112. Epub 2015 Jan 20.

32.

A surprising sweetener from enteropathogenic Escherichia coli.

Pearson JS, Hartland EL.

Gut Microbes. 2014;5(6):766-9. doi: 10.4161/19490976.2014.983762.

33.

The Escherichia coli effector EspJ blocks Src kinase activity via amidation and ADP ribosylation.

Young JC, Clements A, Lang AE, Garnett JA, Munera D, Arbeloa A, Pearson J, Hartland EL, Matthews SJ, Mousnier A, Barry DJ, Way M, Schlosser A, Aktories K, Frankel G.

Nat Commun. 2014 Dec 19;5:5887. doi: 10.1038/ncomms6887.

34.

Golgi-located NTPDase1 of Leishmania major is required for lipophosphoglycan elongation and normal lesion development whereas secreted NTPDase2 is dispensable for virulence.

Sansom FM, Ralton JE, Sernee MF, Cohen AM, Hooker DJ, Hartland EL, Naderer T, McConville MJ.

PLoS Negl Trop Dis. 2014 Dec 18;8(12):e3402. doi: 10.1371/journal.pntd.0003402. eCollection 2014 Dec.

35.

Soluble NSF attachment protein receptor molecular mimicry by a Legionella pneumophila Dot/Icm effector.

King NP, Newton P, Schuelein R, Brown DL, Petru M, Zarsky V, Dolezal P, Luo L, Bugarcic A, Stanley AC, Murray RZ, Collins BM, Teasdale RD, Hartland EL, Stow JL.

Cell Microbiol. 2015 Jun;17(6):767-84. doi: 10.1111/cmi.12405. Epub 2015 Jan 24.

PMID:
25488819
36.

Fas regulates neutrophil lifespan during viral and bacterial infection.

O'Donnell JA, Kennedy CL, Pellegrini M, Nowell CJ, Zhang JG, O'Reilly LA, Cengia L, Dias S, Masters SL, Hartland EL, Roberts AW, Gerlic M, Croker BA.

J Leukoc Biol. 2015 Feb;97(2):321-6. doi: 10.1189/jlb.3AB1113-594RR. Epub 2014 Dec 3.

PMID:
25473101
37.

Post-modern pathogens: surprising activities of translocated effectors from E. coli and Legionella.

Pearson JS, Zhang Y, Newton HJ, Hartland EL.

Curr Opin Microbiol. 2015 Feb;23:73-9. doi: 10.1016/j.mib.2014.11.005. Epub 2014 Nov 25. Review.

PMID:
25461576
38.

Comparative analyses of Legionella species identifies genetic features of strains causing Legionnaires' disease.

Gomez-Valero L, Rusniok C, Rolando M, Neou M, Dervins-Ravault D, Demirtas J, Rouy Z, Moore RJ, Chen H, Petty NK, Jarraud S, Etienne J, Steinert M, Heuner K, Gribaldo S, Médigue C, Glöckner G, Hartland EL, Buchrieser C.

Genome Biol. 2014;15(11):505.

39.

The cell death response to enteropathogenic Escherichia coli infection.

Wong Fok Lung T, Pearson JS, Schuelein R, Hartland EL.

Cell Microbiol. 2014 Dec;16(12):1736-45. doi: 10.1111/cmi.12371. Epub 2014 Oct 30. Review.

PMID:
25266336
40.

A horizontally acquired transcription factor coordinates Salmonella adaptations to host microenvironments.

Brown NF, Rogers LD, Sanderson KL, Gouw JW, Hartland EL, Foster LJ.

MBio. 2014 Sep 23;5(5):e01727-14. doi: 10.1128/mBio.01727-14.

41.

The type III secretion effector NleF of enteropathogenic Escherichia coli activates NF-κB early during infection.

Pallett MA, Berger CN, Pearson JS, Hartland EL, Frankel G.

Infect Immun. 2014 Nov;82(11):4878-88. doi: 10.1128/IAI.02131-14. Epub 2014 Sep 2.

42.

A new method to determine in vivo interactomes reveals binding of the Legionella pneumophila effector PieE to multiple rab GTPases.

Mousnier A, Schroeder GN, Stoneham CA, So EC, Garnett JA, Yu L, Matthews SJ, Choudhary JS, Hartland EL, Frankel G.

MBio. 2014 Aug 12;5(4). pii: e01148-14. doi: 10.1128/mBio.01148-14.

43.

A screen of Coxiella burnetii mutants reveals important roles for Dot/Icm effectors and host autophagy in vacuole biogenesis.

Newton HJ, Kohler LJ, McDonough JA, Temoche-Diaz M, Crabill E, Hartland EL, Roy CR.

PLoS Pathog. 2014 Jul 31;10(7):e1004286. doi: 10.1371/journal.ppat.1004286. eCollection 2014 Jul.

44.

Rab8a interacts directly with PI3Kγ to modulate TLR4-driven PI3K and mTOR signalling.

Luo L, Wall AA, Yeo JC, Condon ND, Norwood SJ, Schoenwaelder S, Chen KW, Jackson S, Jenkins BJ, Hartland EL, Schroder K, Collins BM, Sweet MJ, Stow JL.

Nat Commun. 2014 Jul 15;5:4407. doi: 10.1038/ncomms5407.

PMID:
25022365
45.

Multiple ecto-nucleoside triphosphate diphosphohydrolases facilitate intracellular replication of Legionella pneumophila.

Riedmaier P, Sansom FM, Sofian T, Beddoe T, Schuelein R, Newton HJ, Hartland EL.

Biochem J. 2014 Sep 1;462(2):279-89. doi: 10.1042/BJ20130923.

PMID:
24957128
46.

Genetic diversity and virulence potential of shiga toxin-producing Escherichia coli O113:H21 strains isolated from clinical, environmental, and food sources.

Feng PC, Delannoy S, Lacher DW, Dos Santos LF, Beutin L, Fach P, Rivas M, Hartland EL, Paton AW, Guth BE.

Appl Environ Microbiol. 2014 Aug;80(15):4757-63. doi: 10.1128/AEM.01182-14. Epub 2014 May 23.

47.

Inhibition of death receptor signaling by bacterial gut pathogens.

Giogha C, Lung TW, Pearson JS, Hartland EL.

Cytokine Growth Factor Rev. 2014 Apr;25(2):235-43. doi: 10.1016/j.cytogfr.2013.12.012. Epub 2013 Dec 25. Review.

PMID:
24440054
48.

CD8 subunit expression by plasmacytoid dendritic cells is variable, and does not define stable subsets.

Brown AS, Bourges D, Ang DK, Hartland EL, van Driel IR.

Mucosal Immunol. 2014 Jan;7(1):200-1. doi: 10.1038/mi.2013.91. Epub 2013 Nov 6. No abstract available.

PMID:
24192911
49.

A type III effector antagonizes death receptor signalling during bacterial gut infection.

Pearson JS, Giogha C, Ong SY, Kennedy CL, Kelly M, Robinson KS, Lung TW, Mansell A, Riedmaier P, Oates CV, Zaid A, Mühlen S, Crepin VF, Marches O, Ang CS, Williamson NA, O'Reilly LA, Bankovacki A, Nachbur U, Infusini G, Webb AI, Silke J, Strasser A, Frankel G, Hartland EL.

Nature. 2013 Sep 12;501(7466):247-51. doi: 10.1038/nature12524.

50.

Disarming bacterial virulence through chemical inhibition of the DNA binding domain of an AraC-like transcriptional activator protein.

Yang J, Hocking DM, Cheng C, Dogovski C, Perugini MA, Holien JK, Parker MW, Hartland EL, Tauschek M, Robins-Browne RM.

J Biol Chem. 2013 Oct 25;288(43):31115-26. doi: 10.1074/jbc.M113.503912. Epub 2013 Sep 9.

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