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Items: 1 to 50 of 276

1.

Amplifiers co-translationally enhance CFTR biosynthesis via PCBP1-mediated regulation of CFTR mRNA.

Dukovski D, Villella A, Bastos C, King R, Finley D, Kelly JW, Morimoto RI, Hartl FU, Munoz B, Lee PS, Zecevic M, Miller JP.

J Cyst Fibros. 2020 Feb 14. pii: S1569-1993(20)30052-7. doi: 10.1016/j.jcf.2020.02.006. [Epub ahead of print]

PMID:
32067958
2.

An inventory of interactors of the human HSP60/HSP10 chaperonin in the mitochondrial matrix space.

Bie AS, Cömert C, Körner R, Corydon TJ, Palmfeldt J, Hipp MS, Hartl FU, Bross P.

Cell Stress Chaperones. 2020 Feb 14. doi: 10.1007/s12192-020-01080-6. [Epub ahead of print]

PMID:
32060690
3.

Role for ribosome-associated quality control in sampling proteins for MHC class I-mediated antigen presentation.

Trentini DB, Pecoraro M, Tiwary S, Cox J, Mann M, Hipp MS, Hartl FU.

Proc Natl Acad Sci U S A. 2020 Feb 11. pii: 201914401. doi: 10.1073/pnas.1914401117. [Epub ahead of print]

4.

Bacterial Hsp70 resolves misfolded states and accelerates productive folding of a multi-domain protein.

Imamoglu R, Balchin D, Hayer-Hartl M, Hartl FU.

Nat Commun. 2020 Jan 17;11(1):365. doi: 10.1038/s41467-019-14245-4.

5.

Proteome-wide observation of the phenomenon of life on the edge of solubility.

Vecchi G, Sormanni P, Mannini B, Vandelli A, Tartaglia GG, Dobson CM, Hartl FU, Vendruscolo M.

Proc Natl Acad Sci U S A. 2020 Jan 14;117(2):1015-1020. doi: 10.1073/pnas.1910444117. Epub 2019 Dec 31.

6.

The Hsp70 Chaperone System Stabilizes a Thermo-sensitive Subproteome in E. coli.

Zhao L, Vecchi G, Vendruscolo M, Körner R, Hayer-Hartl M, Hartl FU.

Cell Rep. 2019 Jul 30;28(5):1335-1345.e6. doi: 10.1016/j.celrep.2019.06.081.

7.

The nucleolus functions as a phase-separated protein quality control compartment.

Frottin F, Schueder F, Tiwary S, Gupta R, Körner R, Schlichthaerle T, Cox J, Jungmann R, Hartl FU, Hipp MS.

Science. 2019 Jul 26;365(6451):342-347. doi: 10.1126/science.aaw9157. Epub 2019 Jul 11.

PMID:
31296649
8.

Publisher Correction: Structure and function of Vms1 and Arb1 in RQC and mitochondrial proteome homeostasis.

Su T, Izawa T, Thoms M, Yamashita Y, Cheng J, Berninghausen O, Hartl FU, Inada T, Neupert W, Beckmann R.

Nature. 2019 Jul;571(7764):E4. doi: 10.1038/s41586-019-1360-7.

PMID:
31235950
9.

Structure and function of Vms1 and Arb1 in RQC and mitochondrial proteome homeostasis.

Su T, Izawa T, Thoms M, Yamashita Y, Cheng J, Berninghausen O, Hartl FU, Inada T, Neupert W, Beckmann R.

Nature. 2019 Jun;570(7762):538-542. doi: 10.1038/s41586-019-1307-z. Epub 2019 Jun 12. Erratum in: Nature. 2019 Jun 25;:.

PMID:
31189955
10.

A protein quality control pathway regulated by linear ubiquitination.

van Well EM, Bader V, Patra M, Sánchez-Vicente A, Meschede J, Furthmann N, Schnack C, Blusch A, Longworth J, Petrasch-Parwez E, Mori K, Arzberger T, Trümbach D, Angersbach L, Showkat C, Sehr DA, Berlemann LA, Goldmann P, Clement AM, Behl C, Woerner AC, Saft C, Wurst W, Haass C, Ellrichmann G, Gold R, Dittmar G, Hipp MS, Hartl FU, Tatzelt J, Winklhofer KF.

EMBO J. 2019 May 2;38(9). pii: e100730. doi: 10.15252/embj.2018100730. Epub 2019 Mar 18.

PMID:
30886048
11.

Chaperone Function of Hgh1 in the Biogenesis of Eukaryotic Elongation Factor 2.

Mönkemeyer L, Klaips CL, Balchin D, Körner R, Hartl FU, Bracher A.

Mol Cell. 2019 Apr 4;74(1):88-100.e9. doi: 10.1016/j.molcel.2019.01.034. Epub 2019 Mar 12.

PMID:
30876804
12.

Functional Modules of the Proteostasis Network.

Jayaraj GG, Hipp MS, Hartl FU.

Cold Spring Harb Perspect Biol. 2020 Jan 2;12(1). pii: a033951. doi: 10.1101/cshperspect.a033951.

PMID:
30833457
13.

Improved recombinant expression and purification of functional plant Rubisco.

Wilson RH, Thieulin-Pardo G, Hartl FU, Hayer-Hartl M.

FEBS Lett. 2019 Mar;593(6):611-621. doi: 10.1002/1873-3468.13352. Epub 2019 Mar 14.

14.

The proteostasis network and its decline in ageing.

Hipp MS, Kasturi P, Hartl FU.

Nat Rev Mol Cell Biol. 2019 Jul;20(7):421-435. doi: 10.1038/s41580-019-0101-y. Review.

PMID:
30733602
15.

Rubisco condensate formation by CcmM in β-carboxysome biogenesis.

Wang H, Yan X, Aigner H, Bracher A, Nguyen ND, Hee WY, Long BM, Price GD, Hartl FU, Hayer-Hartl M.

Nature. 2019 Feb;566(7742):131-135. doi: 10.1038/s41586-019-0880-5. Epub 2019 Jan 23.

PMID:
30675061
16.

Pathway of Actin Folding Directed by the Eukaryotic Chaperonin TRiC.

Balchin D, Miličić G, Strauss M, Hayer-Hartl M, Hartl FU.

Cell. 2018 Sep 6;174(6):1507-1521.e16. doi: 10.1016/j.cell.2018.07.006. Epub 2018 Aug 9.

17.

Molecular and structural architecture of polyQ aggregates in yeast.

Gruber A, Hornburg D, Antonin M, Krahmer N, Collado J, Schaffer M, Zubaite G, Lüchtenborg C, Sachsenheimer T, Brügger B, Mann M, Baumeister W, Hartl FU, Hipp MS, Fernández-Busnadiego R.

Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):E3446-E3453. doi: 10.1073/pnas.1717978115. Epub 2018 Mar 26.

18.

In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment.

Guo Q, Lehmer C, Martínez-Sánchez A, Rudack T, Beck F, Hartmann H, Pérez-Berlanga M, Frottin F, Hipp MS, Hartl FU, Edbauer D, Baumeister W, Fernández-Busnadiego R.

Cell. 2018 Feb 8;172(4):696-705.e12. doi: 10.1016/j.cell.2017.12.030. Epub 2018 Feb 1.

19.

GroEL Ring Separation and Exchange in the Chaperonin Reaction.

Yan X, Shi Q, Bracher A, Miličić G, Singh AK, Hartl FU, Hayer-Hartl M.

Cell. 2018 Jan 25;172(3):605-617.e11. doi: 10.1016/j.cell.2017.12.010. Epub 2018 Jan 11.

20.

High capacity of the endoplasmic reticulum to prevent secretion and aggregation of amyloidogenic proteins.

Vincenz-Donnelly L, Holthusen H, Körner R, Hansen EC, Presto J, Johansson J, Sawarkar R, Hartl FU, Hipp MS.

EMBO J. 2018 Feb 1;37(3):337-350. doi: 10.15252/embj.201695841. Epub 2017 Dec 15.

21.

Plant RuBisCo assembly in E. coli with five chloroplast chaperones including BSD2.

Aigner H, Wilson RH, Bracher A, Calisse L, Bhat JY, Hartl FU, Hayer-Hartl M.

Science. 2017 Dec 8;358(6368):1272-1278. doi: 10.1126/science.aap9221.

PMID:
29217567
22.

Spatiotemporal Proteomic Profiling of Huntington's Disease Inclusions Reveals Widespread Loss of Protein Function.

Hosp F, Gutiérrez-Ángel S, Schaefer MH, Cox J, Meissner F, Hipp MS, Hartl FU, Klein R, Dudanova I, Mann M.

Cell Rep. 2017 Nov 21;21(8):2291-2303. doi: 10.1016/j.celrep.2017.10.097.

23.

Pathways of cellular proteostasis in aging and disease.

Klaips CL, Jayaraj GG, Hartl FU.

J Cell Biol. 2018 Jan 2;217(1):51-63. doi: 10.1083/jcb.201709072. Epub 2017 Nov 10. Review.

24.

Cytosolic Protein Vms1 Links Ribosome Quality Control to Mitochondrial and Cellular Homeostasis.

Izawa T, Park SH, Zhao L, Hartl FU, Neupert W.

Cell. 2017 Nov 2;171(4):890-903.e18. doi: 10.1016/j.cell.2017.10.002. Epub 2017 Oct 26.

25.

Unfolding the chaperone story.

Hartl FU.

Mol Biol Cell. 2017 Nov 1;28(22):2919-2923. doi: 10.1091/mbc.E17-07-0480.

26.

In Situ Architecture and Cellular Interactions of PolyQ Inclusions.

Bäuerlein FJB, Saha I, Mishra A, Kalemanov M, Martínez-Sánchez A, Klein R, Dudanova I, Hipp MS, Hartl FU, Baumeister W, Fernández-Busnadiego R.

Cell. 2017 Sep 21;171(1):179-187.e10. doi: 10.1016/j.cell.2017.08.009. Epub 2017 Sep 7.

27.

Role of the ribosomal quality control machinery in nucleocytoplasmic translocation of polyQ-expanded huntingtin exon-1.

Zheng J, Yang J, Choe YJ, Hao X, Cao X, Zhao Q, Zhang Y, Franssens V, Hartl FU, Nyström T, Winderickx J, Liu B.

Biochem Biophys Res Commun. 2017 Nov 4;493(1):708-717. doi: 10.1016/j.bbrc.2017.08.126. Epub 2017 Aug 30.

28.

Mechanism of Enzyme Repair by the AAA+ Chaperone Rubisco Activase.

Bhat JY, Miličić G, Thieulin-Pardo G, Bracher A, Maxwell A, Ciniawsky S, Mueller-Cajar O, Engen JR, Hartl FU, Wendler P, Hayer-Hartl M.

Mol Cell. 2017 Sep 7;67(5):744-756.e6. doi: 10.1016/j.molcel.2017.07.004. Epub 2017 Aug 10.

29.

Rubisco Activases: AAA+ Chaperones Adapted to Enzyme Repair.

Bhat JY, Thieulin-Pardo G, Hartl FU, Hayer-Hartl M.

Front Mol Biosci. 2017 Apr 10;4:20. doi: 10.3389/fmolb.2017.00020. eCollection 2017. Review.

30.

Protein Misfolding Diseases.

Hartl FU.

Annu Rev Biochem. 2017 Jun 20;86:21-26. doi: 10.1146/annurev-biochem-061516-044518. Epub 2017 Apr 24.

PMID:
28441058
31.

Widespread Proteome Remodeling and Aggregation in Aging C. elegans.

Walther DM, Kasturi P, Zheng M, Pinkert S, Vecchi G, Ciryam P, Morimoto RI, Dobson CM, Vendruscolo M, Mann M, Hartl FU.

Cell. 2017 Feb 23;168(5):944. doi: 10.1016/j.cell.2016.12.041. No abstract available.

32.

Biogenesis and Metabolic Maintenance of Rubisco.

Bracher A, Whitney SM, Hartl FU, Hayer-Hartl M.

Annu Rev Plant Biol. 2017 Apr 28;68:29-60. doi: 10.1146/annurev-arplant-043015-111633. Epub 2017 Jan 11. Review.

PMID:
28125284
33.

Susan Lee Lindquist (1949-2016)-pioneer in the study of cellular protein folding and disease.

Hartl FU.

EMBO J. 2016 Dec 15;35(24):2626-2627. Epub 2016 Dec 5. No abstract available.

34.

Soluble Oligomers of PolyQ-Expanded Huntingtin Target a Multiplicity of Key Cellular Factors.

Kim YE, Hosp F, Frottin F, Ge H, Mann M, Hayer-Hartl M, Hartl FU.

Mol Cell. 2016 Sep 15;63(6):951-64. doi: 10.1016/j.molcel.2016.07.022. Epub 2016 Aug 25.

35.

In vivo aspects of protein folding and quality control.

Balchin D, Hayer-Hartl M, Hartl FU.

Science. 2016 Jul 1;353(6294):aac4354. doi: 10.1126/science.aac4354. Review.

PMID:
27365453
36.

The formation, function and regulation of amyloids: insights from structural biology.

Landreh M, Sawaya MR, Hipp MS, Eisenberg DS, Wüthrich K, Hartl FU.

J Intern Med. 2016 Aug;280(2):164-76. doi: 10.1111/joim.12500. Epub 2016 May 30. Review.

37.

Cellular Homeostasis and Aging.

Hartl FU.

Annu Rev Biochem. 2016 Jun 2;85:1-4. doi: 10.1146/annurev-biochem-011116-110806. Epub 2016 Apr 6. Review.

PMID:
27050288
38.

Failure of RQC machinery causes protein aggregation and proteotoxic stress.

Choe YJ, Park SH, Hassemer T, Körner R, Vincenz-Donnelly L, Hayer-Hartl M, Hartl FU.

Nature. 2016 Mar 10;531(7593):191-5. doi: 10.1038/nature16973. Epub 2016 Feb 29.

PMID:
26934223
39.

Structure of human heat-shock transcription factor 1 in complex with DNA.

Neudegger T, Verghese J, Hayer-Hartl M, Hartl FU, Bracher A.

Nat Struct Mol Biol. 2016 Feb;23(2):140-6. doi: 10.1038/nsmb.3149. Epub 2016 Jan 4.

PMID:
26727489
40.

Cytoplasmic protein aggregates interfere with nucleocytoplasmic transport of protein and RNA.

Woerner AC, Frottin F, Hornburg D, Feng LR, Meissner F, Patra M, Tatzelt J, Mann M, Winklhofer KF, Hartl FU, Hipp MS.

Science. 2016 Jan 8;351(6269):173-6. doi: 10.1126/science.aad2033. Epub 2015 Dec 3.

41.

The GroEL-GroES Chaperonin Machine: A Nano-Cage for Protein Folding.

Hayer-Hartl M, Bracher A, Hartl FU.

Trends Biochem Sci. 2016 Jan;41(1):62-76. doi: 10.1016/j.tibs.2015.07.009. Epub 2015 Sep 25. Review.

PMID:
26422689
42.

Structural Analysis of the Rubisco-Assembly Chaperone RbcX-II from Chlamydomonas reinhardtii.

Bracher A, Hauser T, Liu C, Hartl FU, Hayer-Hartl M.

PLoS One. 2015 Aug 25;10(8):e0135448. doi: 10.1371/journal.pone.0135448. eCollection 2015.

43.

Structure and mechanism of the Rubisco-assembly chaperone Raf1.

Hauser T, Bhat JY, Miličić G, Wendler P, Hartl FU, Bracher A, Hayer-Hartl M.

Nat Struct Mol Biol. 2015 Sep;22(9):720-8. doi: 10.1038/nsmb.3062. Epub 2015 Aug 3.

PMID:
26237510
44.

Proteotoxic stress and ageing triggers the loss of redox homeostasis across cellular compartments.

Kirstein J, Morito D, Kakihana T, Sugihara M, Minnen A, Hipp MS, Nussbaum-Krammer C, Kasturi P, Hartl FU, Nagata K, Morimoto RI.

EMBO J. 2015 Sep 14;34(18):2334-49. doi: 10.15252/embj.201591711. Epub 2015 Jul 29.

45.

Widespread Proteome Remodeling and Aggregation in Aging C. elegans.

Walther DM, Kasturi P, Zheng M, Pinkert S, Vecchi G, Ciryam P, Morimoto RI, Dobson CM, Vendruscolo M, Mann M, Hartl FU.

Cell. 2015 May 7;161(4):919-32. doi: 10.1016/j.cell.2015.03.032. Erratum in: Cell. 2017 Feb 23;168(5):944.

46.

Chaperonin-Assisted Protein Folding: Relative Population of Asymmetric and Symmetric GroEL:GroES Complexes.

Haldar S, Gupta AJ, Yan X, Miličić G, Hartl FU, Hayer-Hartl M.

J Mol Biol. 2015 Jun 19;427(12):2244-55. doi: 10.1016/j.jmb.2015.04.009. Epub 2015 Apr 23.

PMID:
25912285
47.

Action of the Hsp70 chaperone system observed with single proteins.

Nunes JM, Mayer-Hartl M, Hartl FU, Müller DJ.

Nat Commun. 2015 Feb 17;6:6307. doi: 10.1038/ncomms7307.

PMID:
25686738
48.

Opposing effects of folding and assembly chaperones on evolvability of Rubisco.

Durão P, Aigner H, Nagy P, Mueller-Cajar O, Hartl FU, Hayer-Hartl M.

Nat Chem Biol. 2015 Feb;11(2):148-55. doi: 10.1038/nchembio.1715. Epub 2015 Jan 5.

PMID:
25558973
49.

Role of auxiliary proteins in Rubisco biogenesis and function.

Hauser T, Popilka L, Hartl FU, Hayer-Hartl M.

Nat Plants. 2015 Jun 2;1:15065. doi: 10.1038/nplants.2015.65. Review.

PMID:
27250005
50.

Degradation of potent Rubisco inhibitor by selective sugar phosphatase.

Bracher A, Sharma A, Starling-Windhof A, Hartl FU, Hayer-Hartl M.

Nat Plants. 2015 Jan 8;1:14002. doi: 10.1038/nplants.2014.2.

PMID:
27246049

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