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Items: 1 to 50 of 397

1.

The Hsp70 Chaperone System Stabilizes a Thermo-sensitive Subproteome in E. coli.

Zhao L, Vecchi G, Vendruscolo M, Körner R, Hayer-Hartl M, Hartl FU.

Cell Rep. 2019 Jul 30;28(5):1335-1345.e6. doi: 10.1016/j.celrep.2019.06.081.

2.

The nucleolus functions as a phase-separated protein quality control compartment.

Frottin F, Schueder F, Tiwary S, Gupta R, Körner R, Schlichthaerle T, Cox J, Jungmann R, Hartl FU, Hipp MS.

Science. 2019 Jul 26;365(6451):342-347. doi: 10.1126/science.aaw9157. Epub 2019 Jul 11.

PMID:
31296649
3.

Publisher Correction: Structure and function of Vms1 and Arb1 in RQC and mitochondrial proteome homeostasis.

Su T, Izawa T, Thoms M, Yamashita Y, Cheng J, Berninghausen O, Hartl FU, Inada T, Neupert W, Beckmann R.

Nature. 2019 Jul;571(7764):E4. doi: 10.1038/s41586-019-1360-7.

PMID:
31235950
4.

Structure and function of Vms1 and Arb1 in RQC and mitochondrial proteome homeostasis.

Su T, Izawa T, Thoms M, Yamashita Y, Cheng J, Berninghausen O, Hartl FU, Inada T, Neupert W, Beckmann R.

Nature. 2019 Jun;570(7762):538-542. doi: 10.1038/s41586-019-1307-z. Epub 2019 Jun 12. Erratum in: Nature. 2019 Jun 25;:.

PMID:
31189955
5.

A protein quality control pathway regulated by linear ubiquitination.

van Well EM, Bader V, Patra M, Sánchez-Vicente A, Meschede J, Furthmann N, Schnack C, Blusch A, Longworth J, Petrasch-Parwez E, Mori K, Arzberger T, Trümbach D, Angersbach L, Showkat C, Sehr DA, Berlemann LA, Goldmann P, Clement AM, Behl C, Woerner AC, Saft C, Wurst W, Haass C, Ellrichmann G, Gold R, Dittmar G, Hipp MS, Hartl FU, Tatzelt J, Winklhofer KF.

EMBO J. 2019 May 2;38(9). pii: e100730. doi: 10.15252/embj.2018100730. Epub 2019 Mar 18.

PMID:
30886048
6.

Chaperone Function of Hgh1 in the Biogenesis of Eukaryotic Elongation Factor 2.

Mönkemeyer L, Klaips CL, Balchin D, Körner R, Hartl FU, Bracher A.

Mol Cell. 2019 Apr 4;74(1):88-100.e9. doi: 10.1016/j.molcel.2019.01.034. Epub 2019 Mar 12.

PMID:
30876804
7.

Functional Modules of the Proteostasis Network.

Jayaraj GG, Hipp MS, Hartl FU.

Cold Spring Harb Perspect Biol. 2019 Mar 4. pii: a033951. doi: 10.1101/cshperspect.a033951. [Epub ahead of print]

PMID:
30833457
8.

Improved recombinant expression and purification of functional plant Rubisco.

Wilson RH, Thieulin-Pardo G, Hartl FU, Hayer-Hartl M.

FEBS Lett. 2019 Mar;593(6):611-621. doi: 10.1002/1873-3468.13352. Epub 2019 Mar 14.

9.

The proteostasis network and its decline in ageing.

Hipp MS, Kasturi P, Hartl FU.

Nat Rev Mol Cell Biol. 2019 Jul;20(7):421-435. doi: 10.1038/s41580-019-0101-y. Review.

PMID:
30733602
10.

Rubisco condensate formation by CcmM in β-carboxysome biogenesis.

Wang H, Yan X, Aigner H, Bracher A, Nguyen ND, Hee WY, Long BM, Price GD, Hartl FU, Hayer-Hartl M.

Nature. 2019 Feb;566(7742):131-135. doi: 10.1038/s41586-019-0880-5. Epub 2019 Jan 23.

PMID:
30675061
11.

Spectro-electrochemical Studies on [Ru(TAP)2(dppz)]2+-Insights into the Mechanism of its Photosensitized Oxidation of Oligonucleotides.

Keane PM, Tory J, Towrie M, Sazanovich IV, Cardin CJ, Quinn SJ, Hartl F, Kelly JM, Long C.

Inorg Chem. 2019 Jan 7;58(1):663-671. doi: 10.1021/acs.inorgchem.8b02859. Epub 2018 Dec 12.

PMID:
30540448
12.

Diphenylamine-Substituted Osmanaphthalyne Complexes: Structural, Bonding, and Redox Properties of Unusual Donor-Bridge-Acceptor Systems.

Zhang MX, Zhang J, Jin X, Sun X, Yin J, Hartl F, Liu SH.

Chemistry. 2018 Dec 17;24(71):18998-19009. doi: 10.1002/chem.201804025. Epub 2018 Nov 20.

PMID:
30277605
13.

Accurate Description of Low-Lying Excited States in a Series of Photoreactive Clusters [Os3(CO)10(α-diimine)] by DFT Calculations.

Hartl F, Bakker MJ, Santos VF, Costa PJ, Calhorda MJ.

Inorg Chem. 2018 Sep 17;57(18):11704-11716. doi: 10.1021/acs.inorgchem.8b01847. Epub 2018 Sep 6.

PMID:
30188701
14.

Pathway of Actin Folding Directed by the Eukaryotic Chaperonin TRiC.

Balchin D, Miličić G, Strauss M, Hayer-Hartl M, Hartl FU.

Cell. 2018 Sep 6;174(6):1507-1521.e16. doi: 10.1016/j.cell.2018.07.006. Epub 2018 Aug 9.

15.

Anti-CD3 Fab Fragments Enhance Tumor Killing by Human γδ T Cells Independent of Nck Recruitment to the γδ T Cell Antigen Receptor.

Juraske C, Wipa P, Morath A, Hidalgo JV, Hartl FA, Raute K, Oberg HH, Wesch D, Fisch P, Minguet S, Pongcharoen S, Schamel WW.

Front Immunol. 2018 Jul 9;9:1579. doi: 10.3389/fimmu.2018.01579. eCollection 2018.

16.

Synthesis, electronic structure and redox properties of the diruthenium sandwich complexes [Cp*Ru(μ-C10H8)RuCp*]x (x = 0, 1+; Cp* = C5Me5; C10H8 = naphthalene).

Herrmann D, Rödl C, de Bruin B, Hartl F, Wolf R.

Dalton Trans. 2018 Aug 14;47(32):11058-11069. doi: 10.1039/c8dt02003e.

PMID:
30027943
17.

Excited-State Electronic Asymmetry Prevents Photoswitching in Terthiophene Compounds.

Strudwick BH, Zhang J, Hilbers MF, Buma WJ, Woutersen S, Liu SH, Hartl F.

Inorg Chem. 2018 Aug 6;57(15):9039-9047. doi: 10.1021/acs.inorgchem.8b01005. Epub 2018 Jul 20.

PMID:
30027738
18.

A macrocyclic receptor containing two viologen species connected by conjugated terphenyl groups.

Chen L, Lim KJC, Babra TS, Taylor JO, PiŽl M, Evans R, Chippindale AM, Hartl F, Colquhoun HM, Greenland BW.

Org Biomol Chem. 2018 Jul 11;16(27):5006-5015. doi: 10.1039/c8ob00919h.

PMID:
29946600
19.

Anodic electrochemistry of mono- and dinuclear aminophenylferrocene and diphenylaminoferrocene complexes.

Zhang MX, Zhang J, Yin J, Hartl F, Liu SH.

Dalton Trans. 2018 May 1;47(17):6112-6123. doi: 10.1039/c8dt00584b.

PMID:
29664488
20.

Molecular and structural architecture of polyQ aggregates in yeast.

Gruber A, Hornburg D, Antonin M, Krahmer N, Collado J, Schaffer M, Zubaite G, Lüchtenborg C, Sachsenheimer T, Brügger B, Mann M, Baumeister W, Hartl FU, Hipp MS, Fernández-Busnadiego R.

Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):E3446-E3453. doi: 10.1073/pnas.1717978115. Epub 2018 Mar 26.

21.

Oncogenic JAK2V617F causes PD-L1 expression, mediating immune escape in myeloproliferative neoplasms.

Prestipino A, Emhardt AJ, Aumann K, O'Sullivan D, Gorantla SP, Duquesne S, Melchinger W, Braun L, Vuckovic S, Boerries M, Busch H, Halbach S, Pennisi S, Poggio T, Apostolova P, Veratti P, Hettich M, Niedermann G, Bartholomä M, Shoumariyeh K, Jutzi JS, Wehrle J, Dierks C, Becker H, Schmitt-Graeff A, Follo M, Pfeifer D, Rohr J, Fuchs S, Ehl S, Hartl FA, Minguet S, Miething C, Heidel FH, Kröger N, Triviai I, Brummer T, Finke J, Illert AL, Ruggiero E, Bonini C, Duyster J, Pahl HL, Lane SW, Hill GR, Blazar BR, von Bubnoff N, Pearce EL, Zeiser R.

Sci Transl Med. 2018 Feb 21;10(429). pii: eaam7729. doi: 10.1126/scitranslmed.aam7729.

22.

In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment.

Guo Q, Lehmer C, Martínez-Sánchez A, Rudack T, Beck F, Hartmann H, Pérez-Berlanga M, Frottin F, Hipp MS, Hartl FU, Edbauer D, Baumeister W, Fernández-Busnadiego R.

Cell. 2018 Feb 8;172(4):696-705.e12. doi: 10.1016/j.cell.2017.12.030. Epub 2018 Feb 1.

23.

GroEL Ring Separation and Exchange in the Chaperonin Reaction.

Yan X, Shi Q, Bracher A, Miličić G, Singh AK, Hartl FU, Hayer-Hartl M.

Cell. 2018 Jan 25;172(3):605-617.e11. doi: 10.1016/j.cell.2017.12.010. Epub 2018 Jan 11.

24.

High capacity of the endoplasmic reticulum to prevent secretion and aggregation of amyloidogenic proteins.

Vincenz-Donnelly L, Holthusen H, Körner R, Hansen EC, Presto J, Johansson J, Sawarkar R, Hartl FU, Hipp MS.

EMBO J. 2018 Feb 1;37(3):337-350. doi: 10.15252/embj.201695841. Epub 2017 Dec 15.

25.

Plant RuBisCo assembly in E. coli with five chloroplast chaperones including BSD2.

Aigner H, Wilson RH, Bracher A, Calisse L, Bhat JY, Hartl FU, Hayer-Hartl M.

Science. 2017 Dec 8;358(6368):1272-1278. doi: 10.1126/science.aap9221.

PMID:
29217567
26.

Spatiotemporal Proteomic Profiling of Huntington's Disease Inclusions Reveals Widespread Loss of Protein Function.

Hosp F, Gutiérrez-Ángel S, Schaefer MH, Cox J, Meissner F, Hipp MS, Hartl FU, Klein R, Dudanova I, Mann M.

Cell Rep. 2017 Nov 21;21(8):2291-2303. doi: 10.1016/j.celrep.2017.10.097.

27.

Structural Variability of 4f and 5f Thiocyanate Complexes and Dissociation of Uranium(III)-Thiocyanate Bonds with Increased Ionicity.

Biswas S, Ma S, Nuzzo S, Twamley B, Russell AT, Platts JA, Hartl F, Baker RJ.

Inorg Chem. 2017 Dec 4;56(23):14426-14437. doi: 10.1021/acs.inorgchem.7b01560. Epub 2017 Nov 16.

PMID:
29144747
28.

Pathways of cellular proteostasis in aging and disease.

Klaips CL, Jayaraj GG, Hartl FU.

J Cell Biol. 2018 Jan 2;217(1):51-63. doi: 10.1083/jcb.201709072. Epub 2017 Nov 10. Review.

29.

Cytosolic Protein Vms1 Links Ribosome Quality Control to Mitochondrial and Cellular Homeostasis.

Izawa T, Park SH, Zhao L, Hartl FU, Neupert W.

Cell. 2017 Nov 2;171(4):890-903.e18. doi: 10.1016/j.cell.2017.10.002. Epub 2017 Oct 26.

30.

Unfolding the chaperone story.

Hartl FU.

Mol Biol Cell. 2017 Nov 1;28(22):2919-2923. doi: 10.1091/mbc.E17-07-0480.

31.

In Situ Architecture and Cellular Interactions of PolyQ Inclusions.

Bäuerlein FJB, Saha I, Mishra A, Kalemanov M, Martínez-Sánchez A, Klein R, Dudanova I, Hipp MS, Hartl FU, Baumeister W, Fernández-Busnadiego R.

Cell. 2017 Sep 21;171(1):179-187.e10. doi: 10.1016/j.cell.2017.08.009. Epub 2017 Sep 7.

32.

Role of the ribosomal quality control machinery in nucleocytoplasmic translocation of polyQ-expanded huntingtin exon-1.

Zheng J, Yang J, Choe YJ, Hao X, Cao X, Zhao Q, Zhang Y, Franssens V, Hartl FU, Nyström T, Winderickx J, Liu B.

Biochem Biophys Res Commun. 2017 Nov 4;493(1):708-717. doi: 10.1016/j.bbrc.2017.08.126. Epub 2017 Aug 30.

33.

Bonding and Electronic Properties of Linear Diethynyl Oligothienoacene-Bridged Diruthenium Complexes and Their Oxidized Forms.

Ou YP, Zhang J, Zhang MX, Zhang F, Kuang D, Hartl F, Liu SH.

Inorg Chem. 2017 Sep 18;56(18):11074-11086. doi: 10.1021/acs.inorgchem.7b01433. Epub 2017 Aug 29.

PMID:
28849928
34.

Caveolin-1-dependent nanoscale organization of the BCR regulates B cell tolerance.

Minguet S, Kläsener K, Schaffer AM, Fiala GJ, Osteso-Ibánez T, Raute K, Navarro-Lérida I, Hartl FA, Seidl M, Reth M, Del Pozo MA.

Nat Immunol. 2017 Oct;18(10):1150-1159. doi: 10.1038/ni.3813. Epub 2017 Aug 14.

35.

Mechanism of Enzyme Repair by the AAA+ Chaperone Rubisco Activase.

Bhat JY, Miličić G, Thieulin-Pardo G, Bracher A, Maxwell A, Ciniawsky S, Mueller-Cajar O, Engen JR, Hartl FU, Wendler P, Hayer-Hartl M.

Mol Cell. 2017 Sep 7;67(5):744-756.e6. doi: 10.1016/j.molcel.2017.07.004. Epub 2017 Aug 10.

36.

New Multiresponsive Chromic Soft Materials: Dynamic Interconversion of Short 2,7-Dicyanomethylenecarbazole-Based Biradicaloid and the Corresponding Cyclophane Tetramer.

Wang D, Capel Ferrón C, Li J, Gámez-Valenzuela S, Ponce Ortiz R, López Navarrete JT, Hernández Jolín V, Yang X, Peña Álvarez M, García Baonza V, Hartl F, Ruiz Delgado MC, Li H.

Chemistry. 2017 Oct 4;23(55):13776-13783. doi: 10.1002/chem.201702659. Epub 2017 Sep 5.

PMID:
28749543
37.

Rubisco Activases: AAA+ Chaperones Adapted to Enzyme Repair.

Bhat JY, Thieulin-Pardo G, Hartl FU, Hayer-Hartl M.

Front Mol Biosci. 2017 Apr 10;4:20. doi: 10.3389/fmolb.2017.00020. eCollection 2017. Review.

38.

Protein Misfolding Diseases.

Hartl FU.

Annu Rev Biochem. 2017 Jun 20;86:21-26. doi: 10.1146/annurev-biochem-061516-044518. Epub 2017 Apr 24.

PMID:
28441058
39.

Widespread Proteome Remodeling and Aggregation in Aging C. elegans.

Walther DM, Kasturi P, Zheng M, Pinkert S, Vecchi G, Ciryam P, Morimoto RI, Dobson CM, Vendruscolo M, Mann M, Hartl FU.

Cell. 2017 Feb 23;168(5):944. doi: 10.1016/j.cell.2016.12.041. No abstract available.

40.

Biogenesis and Metabolic Maintenance of Rubisco.

Bracher A, Whitney SM, Hartl FU, Hayer-Hartl M.

Annu Rev Plant Biol. 2017 Apr 28;68:29-60. doi: 10.1146/annurev-arplant-043015-111633. Epub 2017 Jan 11. Review.

PMID:
28125284
41.

Sandwich and half-sandwich metal complexes derived from cross-conjugated 3-methylene-penta-1,4-diynes.

Vincent KB, Gluyas JBG, Zeng Q, Yufit DS, Howard JAK, Hartl F, Low PJ.

Dalton Trans. 2017 May 2;46(17):5522-5531. doi: 10.1039/c6dt04470k.

42.

Multistep Oxidation of Diethynyl Oligophenylamine-Bridged Diruthenium and Diiron Complexes.

Zhang J, Guo SZ, Dong YB, Rao L, Yin J, Yu GA, Hartl F, Liu SH.

Inorg Chem. 2017 Jan 17;56(2):1001-1015. doi: 10.1021/acs.inorgchem.6b02809. Epub 2017 Jan 3.

PMID:
28045545
43.

Diacenaphthylene-fused benzo[1,2-b:4,5-b']dithiophenes: polycyclic heteroacenes containing full-carbon five-membered aromatic rings.

Wu H, Fang R, Tao J, Wang D, Qiao X, Yang X, Hartl F, Li H.

Chem Commun (Camb). 2017 Jan 5;53(4):751-754. doi: 10.1039/c6cc09184a.

PMID:
27995232
44.

Manganese Tricarbonyl Complexes with Asymmetric 2-Iminopyridine Ligands: Toward Decoupling Steric and Electronic Factors in Electrocatalytic CO2 Reduction.

Spall SJ, Keane T, Tory J, Cocker DC, Adams H, Fowler H, Meijer AJ, Hartl F, Weinstein JA.

Inorg Chem. 2016 Dec 19;55(24):12568-12582. Epub 2016 Nov 23.

45.

Susan Lee Lindquist (1949-2016)-pioneer in the study of cellular protein folding and disease.

Hartl FU.

EMBO J. 2016 Dec 15;35(24):2626-2627. Epub 2016 Dec 5. No abstract available.

46.

Soluble Oligomers of PolyQ-Expanded Huntingtin Target a Multiplicity of Key Cellular Factors.

Kim YE, Hosp F, Frottin F, Ge H, Mann M, Hayer-Hartl M, Hartl FU.

Mol Cell. 2016 Sep 15;63(6):951-64. doi: 10.1016/j.molcel.2016.07.022. Epub 2016 Aug 25.

47.

Localized Mixed-Valence and Redox Activity within a Triazole-Bridged Dinucleating Ligand upon Coordination to Palladium.

Broere DL, Plessius R, Tory J, Demeshko S, de Bruin B, Siegler MA, Hartl F, van der Vlugt JI.

Chemistry. 2016 Sep 19;22(39):13965-13975. doi: 10.1002/chem.201601900. Epub 2016 Aug 17.

PMID:
27531163
48.

In vivo aspects of protein folding and quality control.

Balchin D, Hayer-Hartl M, Hartl FU.

Science. 2016 Jul 1;353(6294):aac4354. doi: 10.1126/science.aac4354. Review.

PMID:
27365453
49.

Compositional diversity of rehabilitated tropical lands supports multiple ecosystem services and buffers uncertainties.

Knoke T, Paul C, Hildebrandt P, Calvas B, Castro LM, Härtl F, Döllerer M, Hamer U, Windhorst D, Wiersma YF, Curatola Fernández GF, Obermeier WA, Adams J, Breuer L, Mosandl R, Beck E, Weber M, Stimm B, Haber W, Fürst C, Bendix J.

Nat Commun. 2016 Jun 13;7:11877. doi: 10.1038/ncomms11877.

50.

The formation, function and regulation of amyloids: insights from structural biology.

Landreh M, Sawaya MR, Hipp MS, Eisenberg DS, Wüthrich K, Hartl FU.

J Intern Med. 2016 Aug;280(2):164-76. doi: 10.1111/joim.12500. Epub 2016 May 30. Review.

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