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CG dinucleotides enhance promoter activity independent of DNA methylation.

Hartl D, Krebs AR, Grand RS, Baubec T, Isbel L, Wirbelauer C, Burger L, Schubeler D.

Genome Res. 2019 Feb 1. pii: gr.241653.118. doi: 10.1101/gr.241653.118. [Epub ahead of print]


Parathyroid gland management using optical technologies during thyroidectomy or parathyroidectomy: A systematic review.

Abbaci M, De Leeuw F, Breuskin I, Casiraghi O, Lakhdar AB, Ghanem W, Laplace-Builhé C, Hartl D.

Oral Oncol. 2018 Dec;87:186-196. doi: 10.1016/j.oraloncology.2018.11.011. Epub 2018 Nov 16. Review.


Occult Contralateral Lateral Lymph Node Metastases in Unilateral N1b Papillary Thyroid Carcinoma.

Bohec H, Breuskin I, Hadoux J, Schlumberger M, Leboulleux S, Hartl DM.

World J Surg. 2019 Mar;43(3):818-823. doi: 10.1007/s00268-018-4862-9.


Mutations in Plasmodium falciparum actin-binding protein coronin confer reduced artemisinin susceptibility.

Demas AR, Sharma AI, Wong W, Early AM, Redmond S, Bopp S, Neafsey DE, Volkman SK, Hartl DL, Wirth DF.

Proc Natl Acad Sci U S A. 2018 Dec 11;115(50):12799-12804. doi: 10.1073/pnas.1812317115. Epub 2018 Nov 12.


Anti-inflammatory role of CD11b+Ly6G+ neutrophilic cells in allergic airway inflammation in mice.

Nowroozilarki N, Öz HH, Schroth C, Hector A, Nürnberg B, Hartl D, Kolahian S.

Immunol Lett. 2018 Dec;204:67-74. doi: 10.1016/j.imlet.2018.10.007. Epub 2018 Oct 28.


The fungal ligand chitin directly binds TLR2 and triggers inflammation dependent on oligomer size.

Fuchs K, Cardona Gloria Y, Wolz OO, Herster F, Sharma L, Dillen CA, Täumer C, Dickhöfer S, Bittner Z, Dang TM, Singh A, Haischer D, Schlöffel MA, Koymans KJ, Sanmuganantham T, Krach M, Roger T, Le Roy D, Schilling NA, Frauhammer F, Miller LS, Nürnberger T, LeibundGut-Landmann S, Gust AA, Macek B, Frank M, Gouttefangeas C, Dela Cruz CS, Hartl D, Weber AN.

EMBO Rep. 2018 Dec;19(12). pii: e46065. doi: 10.15252/embr.201846065. Epub 2018 Oct 18.


Combined antifungal therapy is superior to monotherapy in pulmonary scedosporiosis in cystic fibrosis.

Schwarz C, Brandt C, Melichar V, Runge C, Heuer E, Sahly H, Schebek M, Köster H, Bouchara JP, Biedermann T, Meißner P, Große-Onnebrink J, Skopnik H, Hartl D, Sedlacek L, Tintelnot K.

J Cyst Fibros. 2018 Oct 5. pii: S1569-1993(18)30794-X. doi: 10.1016/j.jcf.2018.08.012. [Epub ahead of print]


International neuromonitoring study group guidelines 2018: Part II: Optimal recurrent laryngeal nerve management for invasive thyroid cancer-incorporation of surgical, laryngeal, and neural electrophysiologic data.

Wu CW, Dionigi G, Barczynski M, Chiang FY, Dralle H, Schneider R, Al-Quaryshi Z, Angelos P, Brauckhoff K, Brooks JA, Cernea CR, Chaplin J, Chen AY, Davies L, Diercks GR, Duh QY, Fundakowski C, Goretzki PE, Hales NW, Hartl D, Kamani D, Kandil E, Kyriazidis N, Liddy W, Miyauchi A, Orloff L, Rastatter JC, Scharpf J, Serpell J, Shin JJ, Sinclair CF, Stack BC Jr, Tolley NS, Slycke SV, Snyder SK, Urken ML, Volpi E, Witterick I, Wong RJ, Woodson G, Zafereo M, Randolph GW.

Laryngoscope. 2018 Oct;128 Suppl 3:S18-S27. doi: 10.1002/lary.27360. Epub 2018 Oct 6. Review.


International neural monitoring study group guideline 2018 part I: Staging bilateral thyroid surgery with monitoring loss of signal.

Schneider R, Randolph GW, Dionigi G, Wu CW, Barczynski M, Chiang FY, Al-Quaryshi Z, Angelos P, Brauckhoff K, Cernea CR, Chaplin J, Cheetham J, Davies L, Goretzki PE, Hartl D, Kamani D, Kandil E, Kyriazidis N, Liddy W, Orloff L, Scharpf J, Serpell J, Shin JJ, Sinclair CF, Singer MC, Snyder SK, Tolley NS, Van Slycke S, Volpi E, Witterick I, Wong RJ, Woodson G, Zafereo M, Dralle H.

Laryngoscope. 2018 Oct;128 Suppl 3:S1-S17. doi: 10.1002/lary.27359. Epub 2018 Oct 5. Review.


Staphylococcal Enterotoxins Dose-Dependently Modulate the Generation of Myeloid-Derived Suppressor Cells.

Stoll H, Ost M, Singh A, Mehling R, Neri D, Schäfer I, Velic A, Macek B, Kretschmer D, Weidenmaier C, Hector A, Handgretinger R, Götz F, Peschel A, Hartl D, Rieber N.

Front Cell Infect Microbiol. 2018 Sep 13;8:321. doi: 10.3389/fcimb.2018.00321. eCollection 2018.


Human T cells modulate myeloid-derived suppressor cells through a TNF-α-mediated mechanism.

Bauswein M, Singh A, Ralhan A, Neri D, Fuchs K, Blanz KD, Schäfer I, Hector A, Handgretinger R, Hartl D, Rieber N.

Immunol Lett. 2018 Oct;202:31-37. doi: 10.1016/j.imlet.2018.07.010. Epub 2018 Aug 1.


A rare loss-of-function variant of ADAM17 is associated with late-onset familial Alzheimer disease.

Hartl D, May P, Gu W, Mayhaus M, Pichler S, Spaniol C, Glaab E, Bobbili DR, Antony P, Koegelsberger S, Kurz A, Grimmer T, Morgan K, Vardarajan BN, Reitz C, Hardy J, Bras J, Guerreiro R, Balling R, Schneider JG, Riemenschneider M; AESG.

Mol Psychiatry. 2018 Jul 9. doi: 10.1038/s41380-018-0091-8. [Epub ahead of print]


Myeloid-Derived Suppressor Cells in Infection: A General Overview.

Medina E, Hartl D.

J Innate Immun. 2018;10(5-6):407-413. doi: 10.1159/000489830. Epub 2018 Jun 26. Review.


Smoking impact on HPV driven head and neck cancer's oncological outcomes?

Mirghani H, Leroy C, Chekourry Y, Casiraghi O, Aupérin A, Tao Y, Nguyen F, Caroline E, Breuskin I, Plana AM, Hartl D, Janot F, Temam S, Gorphe P, Blanchard P.

Oral Oncol. 2018 Jul;82:131-137. doi: 10.1016/j.oraloncology.2018.05.007. Epub 2018 May 26.


Pathogenesis, imaging and clinical characteristics of CF and non-CF bronchiectasis.

Schäfer J, Griese M, Chandrasekaran R, Chotirmall SH, Hartl D.

BMC Pulm Med. 2018 May 22;18(1):79. doi: 10.1186/s12890-018-0630-8. Review.


Correction: mRNA-Mediated Gene Supplementation of Toll-Like Receptors as Treatment Strategy for Asthma In Vivo.

Zeyer F, Mothes B, Will C, Carevic M, Rottenberger J, Nürnberg B, Hartl D, Handgretinger R, Beer-Hammer S, Kormann MSD.

PLoS One. 2018 May 15;13(5):e0197705. doi: 10.1371/journal.pone.0197705. eCollection 2018.


De Novo Mutations Resolve Disease Transmission Pathways in Clonal Malaria.

Redmond SN, MacInnis BM, Bopp S, Bei AK, Ndiaye D, Hartl DL, Wirth DF, Volkman SK, Neafsey DE.

Mol Biol Evol. 2018 Jul 1;35(7):1678-1689. doi: 10.1093/molbev/msy059.


Challenging pre-surgical localization of hyperfunctioning parathyroid glands in primary hyperparathyroidism: the added value of 18F-Fluorocholine PET/CT.

Grimaldi S, Young J, Kamenicky P, Hartl D, Terroir M, Leboulleux S, Berdelou A, Hadoux J, Hescot S, Remy H, Baudin E, Schlumberger M, Deandreis D.

Eur J Nucl Med Mol Imaging. 2018 Sep;45(10):1772-1780. doi: 10.1007/s00259-018-4018-z. Epub 2018 Apr 22.


Rare ABCA7 variants in 2 German families with Alzheimer disease.

May P, Pichler S, Hartl D, Bobbili DR, Mayhaus M, Spaniol C, Kurz A, Balling R, Schneider JG, Riemenschneider M.

Neurol Genet. 2018 Mar 21;4(2):e224. doi: 10.1212/NXG.0000000000000224. eCollection 2018 Apr.


Mechanisms and disease relevance of neutrophil extracellular trap formation.

Van Avondt K, Hartl D.

Eur J Clin Invest. 2018 Nov;48 Suppl 2:e12919. doi: 10.1111/eci.12919. Epub 2018 Apr 2. Review.


Surgical management of the recurrent laryngeal nerve in thyroidectomy: American Head and Neck Society Consensus Statement.

Fundakowski CE, Hales NW, Agrawal N, Barczyński M, Camacho PM, Hartl DM, Kandil E, Liddy WE, McKenzie TJ, Morris JC, Ridge JA, Schneider R, Serpell J, Sinclair CF, Snyder SK, Terris DJ, Tuttle RM, Wu CW, Wong RJ, Zafereo M, Randolph GW.

Head Neck. 2018 Apr;40(4):663-675. doi: 10.1002/hed.24928. Epub 2018 Feb 20.


Innate Immunity of the Lung: From Basic Mechanisms to Translational Medicine.

Hartl D, Tirouvanziam R, Laval J, Greene CM, Habiel D, Sharma L, Yildirim AÖ, Dela Cruz CS, Hogaboam CM.

J Innate Immun. 2018;10(5-6):487-501. doi: 10.1159/000487057. Epub 2018 Feb 13.


Macrophages and platelets join forces to release kidney-damaging DNA traps.

Hartl D.

Nat Med. 2018 Feb 7;24(2):128-129. doi: 10.1038/nm.4486. No abstract available.


Dramatic Changes in Malaria Population Genetic Complexity in Dielmo and Ndiop, Senegal, Revealed Using Genomic Surveillance.

Bei AK, Niang M, Deme AB, Daniels RF, Sarr FD, Sokhna C, Talla C, Faye J, Diagne N, Doucoure S, Mboup S, Wirth DF, Tall A, Ndiaye D, Hartl DL, Volkman SK, Toure-Balde A.

J Infect Dis. 2018 Jan 30;217(4):622-627. doi: 10.1093/infdis/jix580.


Modeling the genetic relatedness of Plasmodium falciparum parasites following meiotic recombination and cotransmission.

Wong W, Wenger EA, Hartl DL, Wirth DF.

PLoS Comput Biol. 2018 Jan 9;14(1):e1005923. doi: 10.1371/journal.pcbi.1005923. eCollection 2018 Jan.


An informative intragenic microsatellite marker suggests the IL-1 receptor as a genetic modifier in cystic fibrosis.

Stanke F, Hector A, Hedtfeld S, Hartl D, Griese M, Tümmler B, Mall MA.

Eur Respir J. 2017 Dec 28;50(6). pii: 1700426. doi: 10.1183/13993003.00426-2017. Print 2017 Dec. No abstract available.


Rescue transtracheal jet ventilation during difficult intubation in patients with upper airway cancer.

Bouroche G, Motamed C, de Guibert JM, Hartl D, Bourgain JL.

Anaesth Crit Care Pain Med. 2018 Dec;37(6):539-544. doi: 10.1016/j.accpm.2017.10.005. Epub 2017 Nov 10.


Janus-Faced Neutrophil Extracellular Traps in Periodontitis.

Vitkov L, Hartl D, Minnich B, Hannig M.

Front Immunol. 2017 Oct 26;8:1404. doi: 10.3389/fimmu.2017.01404. eCollection 2017. Review.


Diagnostic and prognostic value of 18F-FDG PET, CT, and MRI in perineural spread of head and neck malignancies.

Dercle L, Hartl D, Rozenblum-Beddok L, Mokrane FZ, Seban RD, Yeh R, Bidault F, Ammari S.

Eur Radiol. 2018 Apr;28(4):1761-1770. doi: 10.1007/s00330-017-5063-x. Epub 2017 Oct 30.


Cis-regulatory landscapes of four cell types of the retina.

Hartl D, Krebs AR, Jüttner J, Roska B, Schübeler D.

Nucleic Acids Res. 2017 Nov 16;45(20):11607-11621. doi: 10.1093/nar/gkx923.


Cohort Profile: The Madagascar Health and Environmental Research (MAHERY) study in north-eastern Madagascar.

Golden CD, Anjaranirina EJG, Fernald LCH, Hartl DL, Kremen C, Milner DA Jr, Ralalason DH, Ramihantaniarivo H, Randriamady H, Rice BL, Vaitla B, Volkman SK, Vonona MA, Myers SS.

Int J Epidemiol. 2017 Dec 1;46(6):1747-1748d. doi: 10.1093/ije/dyx071. No abstract available.


Expression of checkpoint molecules on myeloid-derived suppressor cells.

Ballbach M, Dannert A, Singh A, Siegmund DM, Handgretinger R, Piali L, Rieber N, Hartl D.

Immunol Lett. 2017 Dec;192:1-6. doi: 10.1016/j.imlet.2017.10.001. Epub 2017 Oct 4.


Autophagy Traps Neutrophils into a Protective Alliance during Sepsis.

Laval J, Singh A, Hartl D.

Am J Respir Crit Care Med. 2017 Sep 1;196(5):537-538. doi: 10.1164/rccm.201701-0149ED. No abstract available.


Transcriptomic profile of cystic fibrosis patients identifies type I interferon response and ribosomal stalk proteins as potential modifiers of disease severity.

Kormann MSD, Dewerth A, Eichner F, Baskaran P, Hector A, Regamey N, Hartl D, Handgretinger R, Antony JS.

PLoS One. 2017 Aug 28;12(8):e0183526. doi: 10.1371/journal.pone.0183526. eCollection 2017.


Response assessment after induction chemotherapy for head and neck squamous cell carcinoma: From physical examination to modern imaging techniques and beyond.

de Bree R, Wolf GT, de Keizer B, Nixon IJ, Hartl DM, Forastiere AA, Haigentz M Jr, Rinaldo A, Rodrigo JP, Saba NF, Suárez C, Vermorken JB, Ferlito A.

Head Neck. 2017 Nov;39(11):2329-2349. doi: 10.1002/hed.24883. Epub 2017 Aug 17. Review.


Fungal Pathogens in CF Airways: Leave or Treat?

Singh A, Ralhan A, Schwarz C, Hartl D, Hector A.

Mycopathologia. 2018 Feb;183(1):119-137. doi: 10.1007/s11046-017-0184-y. Epub 2017 Aug 2. Review.


Progress in Definition, Prevention and Treatment of Fungal Infections in Cystic Fibrosis.

Schwarz C, Hartl D, Eickmeier O, Hector A, Benden C, Durieu I, Sole A, Gartner S, Milla CE, Barry PJ.

Mycopathologia. 2018 Feb;183(1):21-32. doi: 10.1007/s11046-017-0182-0. Epub 2017 Jul 31. Review.


Dimethyl fumarate modulates neutrophil extracellular trap formation in a glutathione- and superoxide-dependent manner.

Hoffmann JHO, Schaekel K, Hartl D, Enk AH, Hadaschik EN.

Br J Dermatol. 2018 Jan;178(1):207-214. doi: 10.1111/bjd.15839. Epub 2017 Dec 14.


Myeloid-derived suppressor cells modulate B-cell responses.

Lelis FJN, Jaufmann J, Singh A, Fromm K, Teschner AC, Pöschel S, Schäfer I, Beer-Hammer S, Rieber N, Hartl D.

Immunol Lett. 2017 Aug;188:108-115. doi: 10.1016/j.imlet.2017.07.003. Epub 2017 Jul 4.


A semiquantitative MRI-Score can predict loss of lung function in patients with cystic fibrosis: Preliminary results.

Schaefer JF, Hector A, Schmidt K, Teufel M, Fleischer S, Graepler-Mainka U, Riethmueller J, Gatidis S, Schaefer S, Nikolaou K, Hartl D, Tsiflikas I.

Eur Radiol. 2018 Jan;28(1):74-84. doi: 10.1007/s00330-017-4870-4. Epub 2017 Jun 29.


Toxicities of systemic agents in squamous cell carcinoma of the head and neck (SCCHN); A new perspective in the era of immunotherapy.

Saba NF, Mody MD, Tan ES, Gill HS, Rinaldo A, Takes RP, Strojan P, Hartl DM, Vermorken JB, Haigentz M Jr, Ferlito A.

Crit Rev Oncol Hematol. 2017 Jul;115:50-58. doi: 10.1016/j.critrevonc.2017.04.011. Epub 2017 Apr 27. Review.


Treatment of differentiated thyroid cancers

Leboulleux S, Berdelou A, Hartl D.

Rev Prat. 2017 Jun;67(6):680-684. French.


Design and simulation of origami structures with smooth folds.

Peraza Hernandez EA, Hartl DJ, Lagoudas DC.

Proc Math Phys Eng Sci. 2017 Apr;473(2200):20160716. doi: 10.1098/rspa.2016.0716. Epub 2017 Apr 26.


Surgery for Neck Recurrence of Differentiated Thyroid Cancer: Outcomes and Risk Factors.

Lamartina L, Borget I, Mirghani H, Al Ghuzlan A, Berdelou A, Bidault F, Deandreis D, Baudin E, Travagli JP, Schlumberger M, Hartl DM, Leboulleux S.

J Clin Endocrinol Metab. 2017 Mar 1;102(3):1020-1031. doi: 10.1210/jc.2016-3284.


Ethical issues in non-intervention trials for thyroid cancer.

Angelos P, Hartl DM, Shah JP, Nixon IJ, Owen RP, Rinaldo A, Rodrigo JP, Shaha AR, Silver CE, Suárez C, Ferlito A.

Eur J Surg Oncol. 2018 Mar;44(3):316-320. doi: 10.1016/j.ejso.2017.03.002. Epub 2017 Mar 16.


Pulmonary manifestations of rheumatologic diseases.

Cidon M, Bansal M, Hartl D.

Curr Opin Pediatr. 2017 Jun;29(3):311-319. doi: 10.1097/MOP.0000000000000496. Review.


Otorhinolaryngological Toxicities of New Drugs in Oncology.

Hartl DM, Morel D, Saavedra E, Massard C, Rinaldo A, Saba NF, Ferlito A, Soria JC.

Adv Ther. 2017 Apr;34(4):866-894. doi: 10.1007/s12325-017-0512-0. Epub 2017 Mar 17. Review.


Lost in neutrophil heterogeneity? CD10!

Brandau S, Hartl D.

Blood. 2017 Mar 9;129(10):1240-1241. doi: 10.1182/blood-2017-01-761585. No abstract available.


Suspicion of respiratory tract infection with multidrug-resistant Enterobacteriaceae: epidemiology and risk factors from a Paediatric Intensive Care Unit.

Renk H, Stoll L, Neunhoeffer F, Hölzl F, Kumpf M, Hofbeck M, Hartl D.

BMC Infect Dis. 2017 Feb 21;17(1):163. doi: 10.1186/s12879-017-2251-x.


Human NACHT, LRR, and PYD domain-containing protein 3 (NLRP3) inflammasome activity is regulated by and potentially targetable through Bruton tyrosine kinase.

Liu X, Pichulik T, Wolz OO, Dang TM, Stutz A, Dillen C, Delmiro Garcia M, Kraus H, Dickhöfer S, Daiber E, Münzenmayer L, Wahl S, Rieber N, Kümmerle-Deschner J, Yazdi A, Franz-Wachtel M, Macek B, Radsak M, Vogel S, Schulte B, Walz JS, Hartl D, Latz E, Stilgenbauer S, Grimbacher B, Miller L, Brunner C, Wolz C, Weber ANR.

J Allergy Clin Immunol. 2017 Oct;140(4):1054-1067.e10. doi: 10.1016/j.jaci.2017.01.017. Epub 2017 Feb 16.


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