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Items: 1 to 50 of 81

1.

Molecular basis for the sensitivity of TRP channels to polyunsaturated fatty acids.

Riehle M, Tsvetkov D, Gohlke BO, Preissner R, Harteneck C, Gollasch M, Nürnberg B.

Naunyn Schmiedebergs Arch Pharmacol. 2018 May 8. doi: 10.1007/s00210-018-1507-3. [Epub ahead of print]

2.

TRPV4 plays a role in breast cancer cell migration via Ca2+-dependent activation of AKT and downregulation of E-cadherin cell cortex protein.

Lee WH, Choong LY, Jin TH, Mon NN, Chong S, Liew CS, Putti T, Lu SY, Harteneck C, Lim YP.

Oncogenesis. 2017 May 22;6(5):e338. doi: 10.1038/oncsis.2017.39.

3.

Nanodiscs for INPHARMA NMR Characterization of GPCRs: Ligand Binding to the Human A2A Adenosine Receptor.

Fredriksson K, Lottmann P, Hinz S, Onila I, Shymanets A, Harteneck C, Müller CE, Griesinger C, Exner TE.

Angew Chem Int Ed Engl. 2017 May 15;56(21):5750-5754. doi: 10.1002/anie.201612547. Epub 2017 Apr 21.

PMID:
28429411
4.

A novel form of capsaicin-modified amygdala LTD mediated by TRPM1.

Gebhardt C, von Bohlen Und Halbach O, Hadler MD, Harteneck C, Albrecht D.

Neurobiol Learn Mem. 2016 Dec;136:1-12. doi: 10.1016/j.nlm.2016.09.005. Epub 2016 Sep 12.

PMID:
27633915
5.

Better Understanding of Phosphoinositide 3-Kinase (PI3K) Pathways in Vasculature: Towards Precision Therapy Targeting Angiogenesis and Tumor Blood Supply.

Tsvetkov D, Shymanets A, Huang Y, Bucher K, Piekorz R, Hirsch E, Beer-Hammer S, Harteneck C, Gollasch M, Nürnberg B.

Biochemistry (Mosc). 2016 Jul;81(7):691-9. doi: 10.1134/S0006297916070051.

6.

TRPV4 Regulates Breast Cancer Cell Extravasation, Stiffness and Actin Cortex.

Lee WH, Choong LY, Mon NN, Lu S, Lin Q, Pang B, Yan B, Krishna VS, Singh H, Tan TZ, Thiery JP, Lim CT, Tan PB, Johansson M, Harteneck C, Lim YP.

Sci Rep. 2016 Jun 13;6:27903. doi: 10.1038/srep27903.

7.

A CD2AP Mutation Associated with Focal Segmental Glomerulosclerosis in Young Adulthood.

Tsvetkov D, Hohmann M, Anistan YM, Mannaa M, Harteneck C, Rudolph B, Gollasch M.

Clin Med Insights Case Rep. 2016 Mar 14;9:15-9. doi: 10.4137/CCRep.S30867. eCollection 2016.

8.

TRPC6 G757D Loss-of-Function Mutation Associates with FSGS.

Riehle M, Büscher AK, Gohlke BO, Kaßmann M, Kolatsi-Joannou M, Bräsen JH, Nagel M, Becker JU, Winyard P, Hoyer PF, Preissner R, Krautwurst D, Gollasch M, Weber S, Harteneck C.

J Am Soc Nephrol. 2016 Sep;27(9):2771-83. doi: 10.1681/ASN.2015030318. Epub 2016 Feb 18.

9.

Hyperforin: To Be or Not to Be an Activator of TRPC(6).

Friedland K, Harteneck C.

Rev Physiol Biochem Pharmacol. 2015;169:1-24. doi: 10.1007/112_2015_25. Review.

PMID:
26384487
10.

Regulation of the perilymphatic-endolymphatic water shunt in the cochlea by membrane translocation of aquaporin-5.

Eckhard A, Dos Santos A, Liu W, Bassiouni M, Arnold H, Gleiser C, Hirt B, Harteneck C, Müller M, Rask-Andersen H, Löwenheim H.

Pflugers Arch. 2015 Dec;467(12):2571-88. doi: 10.1007/s00424-015-1720-6. Epub 2015 Jul 25.

11.

Different inhibition of Gβγ-stimulated class IB phosphoinositide 3-kinase (PI3K) variants by a monoclonal antibody. Specific function of p101 as a Gβγ-dependent regulator of PI3Kγ enzymatic activity.

Shymanets A, Prajwal, Vadas O, Czupalla C, LoPiccolo J, Brenowitz M, Ghigo A, Hirsch E, Krause E, Wetzker R, Williams RL, Harteneck C, Nürnberg B.

Biochem J. 2015 Jul 1;469(1):59-69. doi: 10.1042/BJ20150099.

12.

TRPM3 and miR-204 establish a regulatory circuit that controls oncogenic autophagy in clear cell renal cell carcinoma.

Hall DP, Cost NG, Hegde S, Kellner E, Mikhaylova O, Stratton Y, Ehmer B, Abplanalp WA, Pandey R, Biesiada J, Harteneck C, Plas DR, Meller J, Czyzyk-Krzeska MF.

Cancer Cell. 2014 Nov 10;26(5):738-53. doi: 10.1016/j.ccell.2014.09.015. Epub 2014 Nov 10.

13.

Calcium--a central regulator of keratinocyte differentiation in health and disease.

Elsholz F, Harteneck C, Muller W, Friedland K.

Eur J Dermatol. 2014 Nov-Dec;24(6):650-61. doi: 10.1684/ejd.2014.2452. Review.

PMID:
25514792
14.

Insulin secretion stimulated by L-arginine and its metabolite L-ornithine depends on Gα(i2).

Leiss V, Flockerzie K, Novakovic A, Rath M, Schönsiegel A, Birnbaumer L, Schürmann A, Harteneck C, Nürnberg B.

Am J Physiol Endocrinol Metab. 2014 Nov 1;307(9):E800-12. doi: 10.1152/ajpendo.00337.2014. Epub 2014 Sep 9.

15.

Functional transient receptor potential vanilloid 1 and transient receptor potential vanilloid 4 channels along different segments of the renal vasculature.

Chen L, Kaßmann M, Sendeski M, Tsvetkov D, Marko L, Michalick L, Riehle M, Liedtke WB, Kuebler WM, Harteneck C, Tepel M, Patzak A, Gollasch M.

Acta Physiol (Oxf). 2015 Feb;213(2):481-91. doi: 10.1111/apha.12355. Epub 2014 Aug 21.

PMID:
25069877
16.

Development of first lead structures for phosphoinositide 3-kinase-C2γ inhibitors.

Freitag A, Prajwal P, Shymanets A, Harteneck C, Nürnberg B, Schächtele C, Kubbutat M, Totzke F, Laufer SA.

J Med Chem. 2015 Jan 8;58(1):212-21. doi: 10.1021/jm5006034. Epub 2014 Jul 14.

PMID:
24983663
17.

No activation of human pregnane X receptor by hyperforin-related phloroglucinols.

Kandel BA, Ekins S, Leuner K, Thasler WE, Harteneck C, Zanger UM.

J Pharmacol Exp Ther. 2014 Mar;348(3):393-400. doi: 10.1124/jpet.113.209916. Epub 2013 Nov 20.

PMID:
24259679
18.

Molecular determinants of PI3Kγ-mediated activation downstream of G-protein-coupled receptors (GPCRs).

Vadas O, Dbouk HA, Shymanets A, Perisic O, Burke JE, Abi Saab WF, Khalil BD, Harteneck C, Bresnick AR, Nürnberg B, Backer JM, Williams RL.

Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):18862-7. doi: 10.1073/pnas.1304801110. Epub 2013 Nov 4.

19.

Pregnenolone sulfate: from steroid metabolite to TRP channel ligand.

Harteneck C.

Molecules. 2013 Sep 27;18(10):12012-28. doi: 10.3390/molecules181012012. Review.

20.

p87 and p101 subunits are distinct regulators determining class IB phosphoinositide 3-kinase (PI3K) specificity.

Shymanets A, Prajwal, Bucher K, Beer-Hammer S, Harteneck C, Nürnberg B.

J Biol Chem. 2013 Oct 25;288(43):31059-68. doi: 10.1074/jbc.M113.508234. Epub 2013 Sep 6.

21.

Transient receptor potential vanilloid 1 (TRPV1), TRPV4, and the kidney.

Kassmann M, Harteneck C, Zhu Z, Nürnberg B, Tepel M, Gollasch M.

Acta Physiol (Oxf). 2013 Mar;207(3):546-64. doi: 10.1111/apha.12051. Epub 2013 Jan 18. Review.

PMID:
23253200
22.

G protein-coupled receptor-mediated activation of p110β by Gβγ is required for cellular transformation and invasiveness.

Dbouk HA, Vadas O, Shymanets A, Burke JE, Salamon RS, Khalil BD, Barrett MO, Waldo GL, Surve C, Hsueh C, Perisic O, Harteneck C, Shepherd PR, Harden TK, Smrcka AV, Taussig R, Bresnick AR, Nürnberg B, Williams RL, Backer JM.

Sci Signal. 2012 Dec 4;5(253):ra89. doi: 10.1126/scisignal.2003264.

23.

Hyperforin modulates dendritic spine morphology in hippocampal pyramidal neurons by activating Ca(2+) -permeable TRPC6 channels.

Leuner K, Li W, Amaral MD, Rudolph S, Calfa G, Schuwald AM, Harteneck C, Inoue T, Pozzo-Miller L.

Hippocampus. 2013 Jan;23(1):40-52. doi: 10.1002/hipo.22052. Epub 2012 Jul 20.

24.

The p101 subunit of PI3Kγ restores activation by Gβ mutants deficient in stimulating p110γ.

Shymanets A, Ahmadian MR, Kössmeier KT, Wetzker R, Harteneck C, Nürnberg B.

Biochem J. 2012 Feb 1;441(3):851-8. doi: 10.1042/BJ20111664.

PMID:
22054284
25.

Activation of steroid-sensitive TRPM3 channels potentiates glutamatergic transmission at cerebellar Purkinje neurons from developing rats.

Zamudio-Bulcock PA, Everett J, Harteneck C, Valenzuela CF.

J Neurochem. 2011 Nov;119(3):474-85. doi: 10.1111/j.1471-4159.2011.07441.x. Epub 2011 Sep 28.

26.

Reduced TRPC channel expression in psoriatic keratinocytes is associated with impaired differentiation and enhanced proliferation.

Leuner K, Kraus M, Woelfle U, Beschmann H, Harteneck C, Boehncke WH, Schempp CM, Müller WE.

PLoS One. 2011 Feb 22;6(2):e14716. doi: 10.1371/journal.pone.0014716.

27.

Synthetic modulators of TRP channel activity.

Harteneck C, Klose C, Krautwurst D.

Adv Exp Med Biol. 2011;704:87-106. doi: 10.1007/978-94-007-0265-3_4. Review.

PMID:
21290290
28.

TRPV4 and TRPM3 as Volume-Regulated Cation Channels.

Harteneck C, Schultz G.

In: Liedtke WB, Heller S, editors. TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades. Boca Raton (FL): CRC Press/Taylor & Francis; 2007. Chapter 10.

29.

Fenamates as TRP channel blockers: mefenamic acid selectively blocks TRPM3.

Klose C, Straub I, Riehle M, Ranta F, Krautwurst D, Ullrich S, Meyerhof W, Harteneck C.

Br J Pharmacol. 2011 Apr;162(8):1757-69. doi: 10.1111/j.1476-5381.2010.01186.x.

30.

Pharmacological modulation of diacylglycerol-sensitive TRPC3/6/7 channels.

Harteneck C, Gollasch M.

Curr Pharm Biotechnol. 2011 Jan 1;12(1):35-41. Review.

31.

Pregnenolone sulphate- and cholesterol-regulated TRPM3 channels coupled to vascular smooth muscle secretion and contraction.

Naylor J, Li J, Milligan CJ, Zeng F, Sukumar P, Hou B, Sedo A, Yuldasheva N, Majeed Y, Beri D, Jiang S, Seymour VA, McKeown L, Kumar B, Harteneck C, O'Regan D, Wheatcroft SB, Kearney MT, Jones C, Porter KE, Beech DJ.

Circ Res. 2010 May 14;106(9):1507-15. doi: 10.1161/CIRCRESAHA.110.219329. Epub 2010 Apr 1.

32.

TRPM3 is expressed in sphingosine-responsive myelinating oligodendrocytes.

Hoffmann A, Grimm C, Kraft R, Goldbaum O, Wrede A, Nolte C, Hanisch UK, Richter-Landsberg C, Brück W, Kettenmann H, Harteneck C.

J Neurochem. 2010 Aug;114(3):654-65. doi: 10.1111/j.1471-4159.2010.06644.x. Epub 2010 Feb 15.

33.

Transient receptor potential melastatin 2 is required for lipopolysaccharide-induced cytokine production in human monocytes.

Wehrhahn J, Kraft R, Harteneck C, Hauschildt S.

J Immunol. 2010 Mar 1;184(5):2386-93. doi: 10.4049/jimmunol.0902474. Epub 2010 Jan 27.

34.

Simple 2,4-diacylphloroglucinols as classic transient receptor potential-6 activators--identification of a novel pharmacophore.

Leuner K, Heiser JH, Derksen S, Mladenov MI, Fehske CJ, Schubert R, Gollasch M, Schneider G, Harteneck C, Chatterjee SS, Müller WE.

Mol Pharmacol. 2010 Mar;77(3):368-77. doi: 10.1124/mol.109.057513. Epub 2009 Dec 14.

PMID:
20008516
35.

Ras is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110gamma.

Kurig B, Shymanets A, Bohnacker T, Prajwal, Brock C, Ahmadian MR, Schaefer M, Gohla A, Harteneck C, Wymann MP, Jeanclos E, Nürnberg B.

Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20312-7. doi: 10.1073/pnas.0905506106. Epub 2009 Nov 11.

36.

Specific TRPC6 channel activation, a novel approach to stimulate keratinocyte differentiation.

Müller M, Essin K, Hill K, Beschmann H, Rubant S, Schempp CM, Gollasch M, Boehncke WH, Harteneck C, Müller WE, Leuner K.

J Biol Chem. 2008 Dec 5;283(49):33942-54. doi: 10.1074/jbc.M801844200. Epub 2008 Sep 25.

37.

Arterial response to shear stress critically depends on endothelial TRPV4 expression.

Hartmannsgruber V, Heyken WT, Kacik M, Kaistha A, Grgic I, Harteneck C, Liedtke W, Hoyer J, Köhler R.

PLoS One. 2007 Sep 5;2(9):e827.

38.

Hyperforin--a key constituent of St. John's wort specifically activates TRPC6 channels.

Leuner K, Kazanski V, Müller M, Essin K, Henke B, Gollasch M, Harteneck C, Müller WE.

FASEB J. 2007 Dec;21(14):4101-11. Epub 2007 Jul 31.

PMID:
17666455
39.

N-(p-amylcinnamoyl)anthranilic acid (ACA): a phospholipase A(2) inhibitor and TRP channel blocker.

Harteneck C, Frenzel H, Kraft R.

Cardiovasc Drug Rev. 2007 Spring;25(1):61-75. Review.

PMID:
17445088
40.

Increased store-operated and 1-oleoyl-2-acetyl-sn-glycerol-induced calcium influx in monocytes is mediated by transient receptor potential canonical channels in human essential hypertension.

Liu DY, Thilo F, Scholze A, Wittstock A, Zhao ZG, Harteneck C, Zidek W, Zhu ZM, Tepel M.

J Hypertens. 2007 Apr;25(4):799-808.

PMID:
17351372
41.

TRP channels activated by extracellular hypo-osmoticity in epithelia.

Harteneck C, Reiter B.

Biochem Soc Trans. 2007 Feb;35(Pt 1):91-5. Review.

PMID:
17233610
42.

Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels.

Huber TB, Schermer B, Müller RU, Höhne M, Bartram M, Calixto A, Hagmann H, Reinhardt C, Koos F, Kunzelmann K, Shirokova E, Krautwurst D, Harteneck C, Simons M, Pavenstädt H, Kerjaschki D, Thiele C, Walz G, Chalfie M, Benzing T.

Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17079-86. Epub 2006 Nov 1.

43.

TRPV4-mediated regulation of epithelial permeability.

Reiter B, Kraft R, Günzel D, Zeissig S, Schulzke JD, Fromm M, Harteneck C.

FASEB J. 2006 Sep;20(11):1802-12.

PMID:
16940152
44.

Receptor-induced activation of Drosophila TRP gamma by polyunsaturated fatty acids.

Jörs S, Kazanski V, Foik A, Krautwurst D, Harteneck C.

J Biol Chem. 2006 Oct 6;281(40):29693-702. Epub 2006 Aug 10.

45.

Transient receptor potential channels in essential hypertension.

Liu D, Scholze A, Zhu Z, Krueger K, Thilo F, Burkert A, Streffer K, Holz S, Harteneck C, Zidek W, Tepel M.

J Hypertens. 2006 Jun;24(6):1105-14.

PMID:
16685211
46.

Inhibition of TRPM2 cation channels by N-(p-amylcinnamoyl)anthranilic acid.

Kraft R, Grimm C, Frenzel H, Harteneck C.

Br J Pharmacol. 2006 Jun;148(3):264-73.

47.

The mammalian melastatin-related transient receptor potential cation channels: an overview.

Kraft R, Harteneck C.

Pflugers Arch. 2005 Oct;451(1):204-11. Epub 2005 May 14. Review.

PMID:
15895246
48.

Function and pharmacology of TRPM cation channels.

Harteneck C.

Naunyn Schmiedebergs Arch Pharmacol. 2005 Apr;371(4):307-14. Review.

PMID:
15843919
49.

Block of TRPC5 channels by 2-aminoethoxydiphenyl borate: a differential, extracellular and voltage-dependent effect.

Xu SZ, Zeng F, Boulay G, Grimm C, Harteneck C, Beech DJ.

Br J Pharmacol. 2005 Jun;145(4):405-14.

50.

Homo- and heteromeric assembly of TRPV channel subunits.

Hellwig N, Albrecht N, Harteneck C, Schultz G, Schaefer M.

J Cell Sci. 2005 Mar 1;118(Pt 5):917-28. Epub 2005 Feb 15.

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