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Addiction associated N40D mu-opioid receptor variant modulates synaptic function in human neurons.

Halikere A, Popova D, Scarnati MS, Hamod A, Swerdel MR, Moore JC, Tischfield JA, Hart RP, Pang ZP.

Mol Psychiatry. 2019 Sep 3. doi: 10.1038/s41380-019-0507-0. [Epub ahead of print]


OLIG2 Drives Abnormal Neurodevelopmental Phenotypes in Human iPSC-Based Organoid and Chimeric Mouse Models of Down Syndrome.

Xu R, Brawner AT, Li S, Liu JJ, Kim H, Xue H, Pang ZP, Kim WY, Hart RP, Liu Y, Jiang P.

Cell Stem Cell. 2019 Jun 6;24(6):908-926.e8. doi: 10.1016/j.stem.2019.04.014. Epub 2019 May 23.


Structural and mechanistic basis of mammalian Nudt12 RNA deNADding.

Grudzien-Nogalska E, Wu Y, Jiao X, Cui H, Mateyak MK, Hart RP, Tong L, Kiledjian M.

Nat Chem Biol. 2019 Jun;15(6):575-582. doi: 10.1038/s41589-019-0293-7. Epub 2019 May 17.


Optogenetic and transcriptomic interrogation of enhanced muscle function in the paralyzed mouse whisker pad.

Vajtay TJ, Bandi A, Upadhyay A, Swerdel MR, Hart RP, Lee CR, Margolis DJ.

J Neurophysiol. 2019 Apr 1;121(4):1491-1500. doi: 10.1152/jn.00837.2018. Epub 2019 Feb 20.


ATM is activated by ATP depletion and modulates mitochondrial function through NRF1.

Chow HM, Cheng A, Song X, Swerdel MR, Hart RP, Herrup K.

J Cell Biol. 2019 Mar 4;218(3):909-928. doi: 10.1083/jcb.201806197. Epub 2019 Jan 14.


Knockdown of Butyrylcholinesterase but Not Inhibition by Chlorpyrifos Alters Early Differentiation Mechanisms in Human Neural Stem Cells.

Tiethof AK, Richardson JR, Hart RP.

Toxics. 2018 Sep 1;6(3). pii: E52. doi: 10.3390/toxics6030052.


Neural progenitors derived from Tuberous Sclerosis Complex patients exhibit attenuated PI3K/AKT signaling and delayed neuronal differentiation.

Zucco AJ, Pozzo VD, Afinogenova A, Hart RP, Devinsky O, D'Arcangelo G.

Mol Cell Neurosci. 2018 Oct;92:149-163. doi: 10.1016/j.mcn.2018.08.004. Epub 2018 Aug 23.


Compartmentalized Devices as Tools for Investigation of Human Brain Network Dynamics.

Fantuzzo JA, Hart RP, Zahn JD, Pang ZP.

Dev Dyn. 2019 Jan;248(1):65-77. doi: 10.1002/dvdy.24665. Epub 2018 Sep 12. Review.


hsa-let-7c miRNA Regulates Synaptic and Neuronal Function in Human Neurons.

McGowan H, Mirabella VR, Hamod A, Karakhanyan A, Mlynaryk N, Moore JC, Tischfield JA, Hart RP, Pang ZP.

Front Synaptic Neurosci. 2018 Jul 17;10:19. doi: 10.3389/fnsyn.2018.00019. eCollection 2018.


Genetics of Alcohol Use Disorder: A Role for Induced Pluripotent Stem Cells?

Prytkova I, Goate A, Hart RP, Slesinger PA.

Alcohol Clin Exp Res. 2018 Sep;42(9):1572-1590. doi: 10.1111/acer.13811. Epub 2018 Jul 5. Review.


Histone acetylation maps in aged mice developmentally exposed to lead: epigenetic drift and Alzheimer-related genes.

Eid A, Bihaqi SW, Hemme C, Gaspar JM, Hart RP, Zawia NH.

Epigenomics. 2018 May;10(5):573-583. doi: 10.2217/epi-2017-0143. Epub 2018 May 3.


DNA methylome and transcriptome alterations and cancer prevention by curcumin in colitis-accelerated colon cancer in mice.

Guo Y, Wu R, Gaspar JM, Sargsyan D, Su ZY, Zhang C, Gao L, Cheng D, Li W, Wang C, Yin R, Fang M, Verzi MP, Hart RP, Kong AN.

Carcinogenesis. 2018 May 3;39(5):669-680. doi: 10.1093/carcin/bgy043.


Epigenetic alterations in TRAMP mice: epigenome DNA methylation profiling using MeDIP-seq.

Li W, Huang Y, Sargsyan D, Khor TO, Guo Y, Shu L, Yang AY, Zhang C, Paredes-Gonzalez X, Verzi M, Hart RP, Kong AN.

Cell Biosci. 2018 Jan 12;8:3. doi: 10.1186/s13578-018-0201-y. eCollection 2018.


Intellicount: High-Throughput Quantification of Fluorescent Synaptic Protein Puncta by Machine Learning.

Fantuzzo JA, Mirabella VR, Hamod AH, Hart RP, Zahn JD, Pang ZP.

eNeuro. 2017 Dec 6;4(6). pii: ENEURO.0219-17.2017. doi: 10.1523/ENEURO.0219-17.2017. eCollection 2017 Nov-Dec.


DMRfinder: efficiently identifying differentially methylated regions from MethylC-seq data.

Gaspar JM, Hart RP.

BMC Bioinformatics. 2017 Nov 29;18(1):528. doi: 10.1186/s12859-017-1909-0.


╬╝Neurocircuitry: Establishing in vitro models of neurocircuits with human neurons.

Fantuzzo JA, De Filippis L, McGowan H, Yang N, Ng YH, Halikere A, Liu JJ, Hart RP, Wernig M, Zahn JD, Pang ZP.

Technology (Singap World Sci). 2017 Jun;5(2):87-97. doi: 10.1142/S2339547817500054.


Neuropsychological Predictors of Trauma Centrality in OIF/OEF Veterans.

Hart RP, Bagrodia R, Rahman N, Bryant RA, Titcombe-Parekh R, Marmar CR, Brown AD.

Front Psychol. 2017 Jun 30;8:1120. doi: 10.3389/fpsyg.2017.01120. eCollection 2017.


Top2b is involved in the formation of outer segment and synapse during late-stage photoreceptor differentiation by controlling key genes of photoreceptor transcriptional regulatory network.

Li Y, Hao H, Swerdel MR, Cho HY, Lee KB, Hart RP, Lyu YL, Cai L.

J Neurosci Res. 2017 Oct;95(10):1951-1964. doi: 10.1002/jnr.24037. Epub 2017 Mar 30.


5' End Nicotinamide Adenine Dinucleotide Cap in Human Cells Promotes RNA Decay through DXO-Mediated deNADding.

Jiao X, Doamekpor SK, Bird JG, Nickels BE, Tong L, Hart RP, Kiledjian M.

Cell. 2017 Mar 9;168(6):1015-1027.e10. doi: 10.1016/j.cell.2017.02.019.


Mechanisms of colitis-accelerated colon carcinogenesis and its prevention with the combination of aspirin and curcumin: Transcriptomic analysis using RNA-seq.

Guo Y, Su ZY, Zhang C, Gaspar JM, Wang R, Hart RP, Verzi MP, Kong AN.

Biochem Pharmacol. 2017 Jul 1;135:22-34. doi: 10.1016/j.bcp.2017.02.021. Epub 2017 Mar 4.


Erratum to: The impact of glutamine supplementation on the symptoms of ataxia-telangiectasia: a preclinical assessment.

Chen J, Chen Y, Vail G, Chow H, Zhang Y, Louie L, Li J, Hart RP, Plummer MR, Herrup K.

Mol Neurodegener. 2017 Jan 12;12(1):4. doi: 10.1186/s13024-017-0151-6. No abstract available.


Bioinformatic Analysis of DNA Methylation in Neural Progenitor Cell Models of Alcohol Abuse.

Oni EN, Hart RP.

Curr Pharmacol Rep. 2016 Oct;2(5):203-210. Epub 2016 Aug 5.


Increased nicotine response in iPSC-derived human neurons carrying the CHRNA5 N398 allele.

Oni EN, Halikere A, Li G, Toro-Ramos AJ, Swerdel MR, Verpeut JL, Moore JC, Bello NT, Bierut LJ, Goate A, Tischfield JA, Pang ZP, Hart RP.

Sci Rep. 2016 Oct 4;6:34341. doi: 10.1038/srep34341.


The impact of glutamine supplementation on the symptoms of ataxia-telangiectasia: a preclinical assessment.

Chen J, Chen Y, Vail G, Chow H, Zhang Y, Louie L, Li J, Hart RP, Plummer MR, Herrup K.

Mol Neurodegener. 2016 Aug 18;11(1):60. doi: 10.1186/s13024-016-0127-y. Erratum in: Mol Neurodegener. 2017 Jan 12;12 (1):4.


The RNA binding protein HuR determines the differential translation of autism-associated FoxP subfamily members in the developing neocortex.

Popovitchenko T, Thompson K, Viljetic B, Jiao X, Kontonyiannis DL, Kiledjian M, Hart RP, Rasin MR.

Sci Rep. 2016 Jul 7;6:28998. doi: 10.1038/srep28998.


Long noncoding RNAs: Central to nervous system development.

Hart RP, Goff LA.

Int J Dev Neurosci. 2016 Dec;55:109-116. doi: 10.1016/j.ijdevneu.2016.06.001. Epub 2016 Jun 11. Review.


Ethanol-mediated activation of the NLRP3 inflammasome in iPS cells and iPS cells-derived neural progenitor cells.

De Filippis L, Halikere A, McGowan H, Moore JC, Tischfield JA, Hart RP, Pang ZP.

Mol Brain. 2016 May 10;9(1):51. doi: 10.1186/s13041-016-0221-7.


Generation and transplantation of reprogrammed human neurons in the brain using 3D microtopographic scaffolds.

Carlson AL, Bennett NK, Francis NL, Halikere A, Clarke S, Moore JC, Hart RP, Paradiso K, Wernig M, Kohn J, Pang ZP, Moghe PV.

Nat Commun. 2016 Mar 17;7:10862. doi: 10.1038/ncomms10862.


Nudt3 is an mRNA decapping enzyme that modulates cell migration.

Grudzien-Nogalska E, Jiao X, Song MG, Hart RP, Kiledjian M.

RNA. 2016 May;22(5):773-81. doi: 10.1261/rna.055699.115. Epub 2016 Mar 1.


Spontaneous ATM Gene Reversion in A-T iPSC to Produce an Isogenic Cell Line.

Lin L, Swerdel MR, Lazaropoulos MP, Hoffman GS, Toro-Ramos AJ, Wright J, Lederman H, Chen J, Moore JC, Hart RP.

Stem Cell Reports. 2015 Dec 8;5(6):1097-1108. doi: 10.1016/j.stemcr.2015.10.010. Epub 2015 Nov 19.


Alteration in 5-hydroxymethylcytosine-mediated epigenetic regulation leads to Purkinje cell vulnerability in ATM deficiency.

Jiang D, Zhang Y, Hart RP, Chen J, Herrup K, Li J.

Brain. 2015 Dec;138(Pt 12):3520-36. doi: 10.1093/brain/awv284. Epub 2015 Oct 27.


Thalamic WNT3 Secretion Spatiotemporally Regulates the Neocortical Ribosome Signature and mRNA Translation to Specify Neocortical Cell Subtypes.

Kraushar ML, Viljetic B, Wijeratne HR, Thompson K, Jiao X, Pike JW, Medvedeva V, Groszer M, Kiledjian M, Hart RP, Rasin MR.

J Neurosci. 2015 Aug 5;35(31):10911-26. doi: 10.1523/JNEUROSCI.0601-15.2015.


Flipping the transcriptional switch from myelin inhibition to axon growth in the CNS.

Carmel JB, Young W, Hart RP.

Front Mol Neurosci. 2015 Jul 17;8:34. doi: 10.3389/fnmol.2015.00034. eCollection 2015.


Association of aberrant DNA methylation in Apc(min/+) mice with the epithelial-mesenchymal transition and Wnt/╬▓-catenin pathways: genome-wide analysis using MeDIP-seq.

Guo Y, Lee JH, Shu L, Huang Y, Li W, Zhang C, Yang AY, Boyanapalli SS, Perekatt A, Hart RP, Verzi M, Kong AN.

Cell Biosci. 2015 May 27;5:24. doi: 10.1186/s13578-015-0013-2. eCollection 2015.


Metallothionein-I/II Promotes Axonal Regeneration in the Central Nervous System.

Siddiq MM, Hannila SS, Carmel JB, Bryson JB, Hou J, Nikulina E, Willis MR, Mellado W, Richman EL, Hilaire M, Hart RP, Filbin MT.

J Biol Chem. 2015 Jun 26;290(26):16343-56. doi: 10.1074/jbc.M114.630574. Epub 2015 May 6.


Mutated in colorectal cancer (MCC) is a novel oncogene in B lymphocytes.

Edwards SK, Baron J, Moore CR, Liu Y, Perlman DH, Hart RP, Xie P.

J Hematol Oncol. 2014 Sep 9;7:56. doi: 10.1186/s13045-014-0056-6.


Temporally defined neocortical translation and polysome assembly are determined by the RNA-binding protein Hu antigen R.

Kraushar ML, Thompson K, Wijeratne HR, Viljetic B, Sakers K, Marson JW, Kontoyiannis DL, Buyske S, Hart RP, Rasin MR.

Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):E3815-24. doi: 10.1073/pnas.1408305111. Epub 2014 Aug 25.


Genome-wide analysis of DNA methylation in UVB- and DMBA/TPA-induced mouse skin cancer models.

Yang AY, Lee JH, Shu L, Zhang C, Su ZY, Lu Y, Huang MT, Ramirez C, Pung D, Huang Y, Verzi M, Hart RP, Kong AN.

Life Sci. 2014 Sep 15;113(1-2):45-54. doi: 10.1016/j.lfs.2014.07.031. Epub 2014 Aug 2.


A positive feedback mechanism that regulates expression of miR-9 during neurogenesis.

Davila JL, Goff LA, Ricupero CL, Camarillo C, Oni EN, Swerdel MR, Toro-Ramos AJ, Li J, Hart RP.

PLoS One. 2014 Apr 8;9(4):e94348. doi: 10.1371/journal.pone.0094348. eCollection 2014. Erratum in: PLoS One. 2014;9(6):e101029.


Multiple knockout mouse models reveal lincRNAs are required for life and brain development.

Sauvageau M, Goff LA, Lodato S, Bonev B, Groff AF, Gerhardinger C, Sanchez-Gomez DB, Hacisuleyman E, Li E, Spence M, Liapis SC, Mallard W, Morse M, Swerdel MR, D'Ecclessis MF, Moore JC, Lai V, Gong G, Yancopoulos GD, Frendewey D, Kellis M, Hart RP, Valenzuela DM, Arlotta P, Rinn JL.

Elife. 2013 Dec 31;2:e01749. doi: 10.7554/eLife.01749.


Illness apprehension, depression, anxiety, and quality of life in liver transplant candidates: implications for psychosocial interventions.

Stewart KE, Hart RP, Gibson DP, Fisher RA.

Psychosomatics. 2014 Nov-Dec;55(6):650-8. doi: 10.1016/j.psym.2013.10.002. Epub 2013 Oct 10.


The Relationship between Marital Status and Psychological Resilience in Chronic Pain.

Wade JB, Hart RP, Wade JH, Bajaj JS, Price DD.

Pain Res Treat. 2013;2013:928473. doi: 10.1155/2013/928473. Epub 2013 Sep 15.


EZH2-mediated H3K27 trimethylation mediates neurodegeneration in ataxia-telangiectasia.

Li J, Hart RP, Mallimo EM, Swerdel MR, Kusnecov AW, Herrup K.

Nat Neurosci. 2013 Dec;16(12):1745-53. doi: 10.1038/nn.3564. Epub 2013 Oct 27. Erratum in: Nat Neurosci. 2014 Sep;17(9):1286.


Post-transcriptional regulatory elements and spatiotemporal specification of neocortical stem cells and projection neurons.

DeBoer EM, Kraushar ML, Hart RP, Rasin MR.

Neuroscience. 2013 Sep 17;248:499-528. doi: 10.1016/j.neuroscience.2013.05.042. Epub 2013 May 30. Review.


Epigenome analysis of pluripotent stem cells.

Ricupero CL, Swerdel MR, Hart RP.

Methods Mol Biol. 2013;997:203-16. doi: 10.1007/978-1-62703-348-0_16.


Secretory leukocyte protease inhibitor reverses inhibition by CNS myelin, promotes regeneration in the optic nerve, and suppresses expression of the transforming growth factor-╬▓ signaling protein Smad2.

Hannila SS, Siddiq MM, Carmel JB, Hou J, Chaudhry N, Bradley PM, Hilaire M, Richman EL, Hart RP, Filbin MT.

J Neurosci. 2013 Mar 20;33(12):5138-51. doi: 10.1523/JNEUROSCI.5321-12.2013.


Glutamate dehydrogenase 1 and SIRT4 regulate glial development.

Komlos D, Mann KD, Zhuo Y, Ricupero CL, Hart RP, Liu AY, Firestein BL.

Glia. 2013 Mar;61(3):394-408. doi: 10.1002/glia.22442. Epub 2012 Dec 22.


miR-886-3p levels are elevated in Friedreich ataxia.

Mahishi LH, Hart RP, Lynch DR, Ratan RR.

J Neurosci. 2012 Jul 4;32(27):9369-73. doi: 10.1523/JNEUROSCI.0059-12.2012.


Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia telangiectasia.

Li J, Chen J, Ricupero CL, Hart RP, Schwartz MS, Kusnecov A, Herrup K.

Nat Med. 2012 May;18(5):783-90. doi: 10.1038/nm.2709.

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