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Items: 1 to 50 of 265

1.

O-GlcNAc Site Mapping by Using a Combination of Chemoenzymatic Labeling, Copper-Free Click Chemistry, Reductive Cleavage, and Electron-Transfer Dissociation Mass Spectrometry.

Ma J, Wang WH, Li Z, Shabanowitz J, Hunt DF, Hart GW.

Anal Chem. 2019 Feb 19;91(4):2620-2625. doi: 10.1021/acs.analchem.8b05688. Epub 2019 Feb 4.

PMID:
30657688
2.

Nutrient regulation of signaling and transcription.

Hart GW.

J Biol Chem. 2019 Feb 15;294(7):2211-2231. doi: 10.1074/jbc.AW119.003226. Epub 2019 Jan 9. Review.

3.

AANL (Agrocybe aegerita lectin 2) is a new facile tool to probe for O-GlcNAcylation.

Liu W, Han G, Yin Y, Jiang S, Yu G, Yang Q, Yu W, Ye X, Su Y, Yang Y, Hart GW, Sun H.

Glycobiology. 2018 Jun 1;28(6):363-373. doi: 10.1093/glycob/cwy029.

4.

The O-GlcNAc Modification.

Zachara N, Akimoto Y, Hart GW.

In: Varki A, Cummings RD, Esko JD, Stanley P, Hart GW, Aebi M, Darvill AG, Kinoshita T, Packer NH, Prestegard JH, Schnaar RL, Seeberger PH, editors. Essentials of Glycobiology [Internet]. 3rd edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2015-2017. Chapter 19.
2017.

5.

Glycosylation Precursors.

Freeze HH, Hart GW, Schnaar RL.

In: Varki A, Cummings RD, Esko JD, Stanley P, Hart GW, Aebi M, Darvill AG, Kinoshita T, Packer NH, Prestegard JH, Schnaar RL, Seeberger PH, editors. Essentials of Glycobiology [Internet]. 3rd edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2015-2017. Chapter 5.
2017.

6.

Nucleocytoplasmic Glycosylation.

West CM, Hart GW.

In: Varki A, Cummings RD, Esko JD, Stanley P, Hart GW, Aebi M, Darvill AG, Kinoshita T, Packer NH, Prestegard JH, Schnaar RL, Seeberger PH, editors. Essentials of Glycobiology [Internet]. 3rd edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2015-2017. Chapter 18.
2017.

7.

Future Directions in Glycosciences.

Hart GW, Varki A.

In: Varki A, Cummings RD, Esko JD, Stanley P, Hart GW, Aebi M, Darvill AG, Kinoshita T, Packer NH, Prestegard JH, Schnaar RL, Seeberger PH, editors. Essentials of Glycobiology [Internet]. 3rd edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2015-2017. Chapter 60.
2017.

8.

Glycosylphosphatidylinositol Anchors.

Ferguson MAJ, Hart GW, Kinoshita T.

In: Varki A, Cummings RD, Esko JD, Stanley P, Hart GW, Aebi M, Darvill AG, Kinoshita T, Packer NH, Prestegard JH, Schnaar RL, Seeberger PH, editors. Essentials of Glycobiology [Internet]. 3rd edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2015-2017. Chapter 12.
2017.

9.

Analysis of Protein O-GlcNAcylation by Mass Spectrometry.

Ma J, Hart GW.

Curr Protoc Protein Sci. 2017 Feb 2;87:24.10.1-24.10.16. doi: 10.1002/cpps.24.

10.

O-GlcNAc transferase regulates excitatory synapse maturity.

Lagerlöf O, Hart GW, Huganir RL.

Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1684-1689. doi: 10.1073/pnas.1621367114. Epub 2017 Jan 31.

11.

Myriad Roles of Glycans in Biology.

Hart GW.

J Mol Biol. 2016 Aug 14;428(16):3147-3149. doi: 10.1016/j.jmb.2016.06.010. Epub 2016 Jun 22. No abstract available.

PMID:
27342936
12.

Nutrient regulation of gene expression by O-GlcNAcylation of chromatin.

Hardivillé S, Hart GW.

Curr Opin Chem Biol. 2016 Aug;33:88-94. doi: 10.1016/j.cbpa.2016.06.005. Epub 2016 Jun 17. Review.

13.

Roles of O-GlcNAc in chronic diseases of aging.

Banerjee PS, Lagerlöf O, Hart GW.

Mol Aspects Med. 2016 Oct;51:1-15. doi: 10.1016/j.mam.2016.05.005. Epub 2016 May 31. Review.

PMID:
27259471
14.

Comparative Proteomics Reveals Dysregulated Mitochondrial O-GlcNAcylation in Diabetic Hearts.

Ma J, Banerjee P, Whelan SA, Liu T, Wei AC, Ramirez-Correa G, McComb ME, Costello CE, O'Rourke B, Murphy A, Hart GW.

J Proteome Res. 2016 Jul 1;15(7):2254-64. doi: 10.1021/acs.jproteome.6b00250. Epub 2016 Jun 2.

PMID:
27213235
15.

The nutrient sensor OGT in PVN neurons regulates feeding.

Lagerlöf O, Slocomb JE, Hong I, Aponte Y, Blackshaw S, Hart GW, Huganir RL.

Science. 2016 Mar 18;351(6279):1293-6. doi: 10.1126/science.aad5494.

16.

Mass Spectrometry-Based Quantitative O-GlcNAcomic Analysis.

Ma J, Hart GW.

Methods Mol Biol. 2016;1410:91-103. doi: 10.1007/978-1-4939-3524-6_6.

PMID:
26867740
17.

New insights: A role for O-GlcNAcylation in diabetic complications.

Peterson SB, Hart GW.

Crit Rev Biochem Mol Biol. 2016 May-Jun;51(3):150-61. doi: 10.3109/10409238.2015.1135102. Epub 2016 Jan 24. Review.

PMID:
26806492
18.

A Quarter Century of Glycobiology.

Hart GW, Schnaar RL, Haltiwanger RS.

Glycobiology. 2015 Dec;25(12):1321-2. doi: 10.1093/glycob/cwv090. No abstract available.

19.

O-GlcNAcomic Profiling Identifies Widespread O-Linked β-N-Acetylglucosamine Modification (O-GlcNAcylation) in Oxidative Phosphorylation System Regulating Cardiac Mitochondrial Function.

Ma J, Liu T, Wei AC, Banerjee P, O'Rourke B, Hart GW.

J Biol Chem. 2015 Dec 4;290(49):29141-53. doi: 10.1074/jbc.M115.691741. Epub 2015 Oct 7.

20.

Removal of Abnormal Myofilament O-GlcNAcylation Restores Ca2+ Sensitivity in Diabetic Cardiac Muscle.

Ramirez-Correa GA, Ma J, Slawson C, Zeidan Q, Lugo-Fagundo NS, Xu M, Shen X, Gao WD, Caceres V, Chakir K, DeVine L, Cole RN, Marchionni L, Paolocci N, Hart GW, Murphy AM.

Diabetes. 2015 Oct;64(10):3573-87. doi: 10.2337/db14-1107. Epub 2015 Jun 24.

21.

Reconstitution of Formylglycine-generating Enzyme with Copper(II) for Aldehyde Tag Conversion.

Holder PG, Jones LC, Drake PM, Barfield RM, Bañas S, de Hart GW, Baker J, Rabuka D.

J Biol Chem. 2015 Jun 19;290(25):15730-45. doi: 10.1074/jbc.M115.652669. Epub 2015 Apr 30.

22.

Diabetes-associated dysregulation of O-GlcNAcylation in rat cardiac mitochondria.

Banerjee PS, Ma J, Hart GW.

Proc Natl Acad Sci U S A. 2015 May 12;112(19):6050-5. doi: 10.1073/pnas.1424017112. Epub 2015 Apr 27.

23.

Generating site-specifically modified proteins via a versatile and stable nucleophilic carbon ligation.

Kudirka R, Barfield RM, McFarland J, Albers AE, de Hart GW, Drake PM, Holder PG, Banas S, Jones LC, Garofalo AW, Rabuka D.

Chem Biol. 2015 Feb 19;22(2):293-8. doi: 10.1016/j.chembiol.2014.11.019. Epub 2015 Jan 22.

24.

Three Decades of Research on O-GlcNAcylation - A Major Nutrient Sensor That Regulates Signaling, Transcription and Cellular Metabolism.

Hart GW.

Front Endocrinol (Lausanne). 2014 Oct 27;5:183. doi: 10.3389/fendo.2014.00183. eCollection 2014. Review.

26.

Exploring the effects of linker composition on site-specifically modified antibody-drug conjugates.

Albers AE, Garofalo AW, Drake PM, Kudirka R, de Hart GW, Barfield RM, Baker J, Banas S, Rabuka D.

Eur J Med Chem. 2014 Dec 17;88:3-9. doi: 10.1016/j.ejmech.2014.08.062. Epub 2014 Aug 23.

PMID:
25176286
27.

O-GlcNAcylation of Neuronal Proteins: Roles in Neuronal Functions and in Neurodegeneration.

Lagerlöf O, Hart GW.

Adv Neurobiol. 2014;9:343-66. doi: 10.1007/978-1-4939-1154-7_16.

PMID:
25151387
28.

Nutrient regulation of signaling, transcription, and cell physiology by O-GlcNAcylation.

Hardivillé S, Hart GW.

Cell Metab. 2014 Aug 5;20(2):208-13. doi: 10.1016/j.cmet.2014.07.014. Review.

29.

Aldehyde tag coupled with HIPS chemistry enables the production of ADCs conjugated site-specifically to different antibody regions with distinct in vivo efficacy and PK outcomes.

Drake PM, Albers AE, Baker J, Banas S, Barfield RM, Bhat AS, de Hart GW, Garofalo AW, Holder P, Jones LC, Kudirka R, McFarland J, Zmolek W, Rabuka D.

Bioconjug Chem. 2014 Jul 16;25(7):1331-41. doi: 10.1021/bc500189z. Epub 2014 Jun 23.

30.

O-GlcNAc profiling: from proteins to proteomes.

Ma J, Hart GW.

Clin Proteomics. 2014 Mar 5;11(1):8. doi: 10.1186/1559-0275-11-8.

31.

Cross-talk between two essential nutrient-sensitive enzymes: O-GlcNAc transferase (OGT) and AMP-activated protein kinase (AMPK).

Bullen JW, Balsbaugh JL, Chanda D, Shabanowitz J, Hunt DF, Neumann D, Hart GW.

J Biol Chem. 2014 Apr 11;289(15):10592-606. doi: 10.1074/jbc.M113.523068. Epub 2014 Feb 21.

32.

The role of O-GlcNAc signaling in the pathogenesis of diabetic retinopathy.

Semba RD, Huang H, Lutty GA, Van Eyk JE, Hart GW.

Proteomics Clin Appl. 2014 Apr;8(3-4):218-31. doi: 10.1002/prca.201300076. Epub 2014 Feb 19. Review.

33.

The dynamic metabolism of hyaluronan regulates the cytosolic concentration of UDP-GlcNAc.

Hascall VC, Wang A, Tammi M, Oikari S, Tammi R, Passi A, Vigetti D, Hanson RW, Hart GW.

Matrix Biol. 2014 Apr;35:14-7. doi: 10.1016/j.matbio.2014.01.014. Epub 2014 Jan 30. Review.

34.

Post-translational modifications: a major focus for the future of proteomics.

Hart GW, Ball LE.

Mol Cell Proteomics. 2013 Dec;12(12):3443. doi: 10.1074/mcp.E113.036491. Epub 2013 Nov 25. No abstract available.

35.

Diabetic hyperglycaemia activates CaMKII and arrhythmias by O-linked glycosylation.

Erickson JR, Pereira L, Wang L, Han G, Ferguson A, Dao K, Copeland RJ, Despa F, Hart GW, Ripplinger CM, Bers DM.

Nature. 2013 Oct 17;502(7471):372-6. doi: 10.1038/nature12537. Epub 2013 Sep 29.

36.

Protein O-GlcNAcylation in diabetes and diabetic complications.

Ma J, Hart GW.

Expert Rev Proteomics. 2013 Aug;10(4):365-80. doi: 10.1586/14789450.2013.820536. Review.

37.

Nutrient regulation of immunity: O-GlcNAcylation regulates stimulus-specific NF-κB-dependent transcription.

Hart GW.

Sci Signal. 2013 Aug 27;6(290):pe26. doi: 10.1126/scisignal.2004596.

PMID:
23982203
38.

Hydrazino-Pictet-Spengler ligation as a biocompatible method for the generation of stable protein conjugates.

Agarwal P, Kudirka R, Albers AE, Barfield RM, de Hart GW, Drake PM, Jones LC, Rabuka D.

Bioconjug Chem. 2013 Jun 19;24(6):846-51. doi: 10.1021/bc400042a. Epub 2013 Jun 3.

PMID:
23731037
39.

O-GlcNAcomics--Revealing roles of O-GlcNAcylation in disease mechanisms and development of potential diagnostics.

Copeland RJ, Han G, Hart GW.

Proteomics Clin Appl. 2013 Oct;7(9-10):597-606. doi: 10.1002/prca.201300001. Epub 2013 Aug 6. Review.

40.

How sugar tunes your clock.

Hart GW.

Cell Metab. 2013 Feb 5;17(2):155-6. doi: 10.1016/j.cmet.2013.01.008.

41.

Glycomics: building upon proteomics to advance glycosciences.

Wells L, Hart GW; Athens Guidelines for the Publication of Glycomics Data.

Mol Cell Proteomics. 2013 Apr;12(4):833-5. doi: 10.1074/mcp.E113.027904. Epub 2013 Feb 1. No abstract available.

42.

Thematic minireview series on glycobiology and extracellular matrices: glycan functions pervade biology at all levels.

Hart GW.

J Biol Chem. 2013 Mar 8;288(10):6903. doi: 10.1074/jbc.R113.453977. Epub 2013 Jan 17. No abstract available.

43.

Chemical approaches to study O-GlcNAcylation.

Banerjee PS, Hart GW, Cho JW.

Chem Soc Rev. 2013 May 21;42(10):4345-57. doi: 10.1039/c2cs35412h. Epub 2012 Dec 18. Review.

44.

Modification of RelA by O-linked N-acetylglucosamine links glucose metabolism to NF-κB acetylation and transcription.

Allison DF, Wamsley JJ, Kumar M, Li D, Gray LG, Hart GW, Jones DR, Mayo MW.

Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):16888-93. doi: 10.1073/pnas.1208468109. Epub 2012 Oct 1.

45.

Evidence of the involvement of O-GlcNAc-modified human RNA polymerase II CTD in transcription in vitro and in vivo.

Ranuncolo SM, Ghosh S, Hanover JA, Hart GW, Lewis BA.

J Biol Chem. 2012 Jul 6;287(28):23549-61. doi: 10.1074/jbc.M111.330910. Epub 2012 May 17.

46.

O-GlcNAcylation of kinases.

Dias WB, Cheung WD, Hart GW.

Biochem Biophys Res Commun. 2012 Jun 1;422(2):224-8. doi: 10.1016/j.bbrc.2012.04.124. Epub 2012 Apr 30.

47.

Tandem mass spectrometry identifies many mouse brain O-GlcNAcylated proteins including EGF domain-specific O-GlcNAc transferase targets.

Alfaro JF, Gong CX, Monroe ME, Aldrich JT, Clauss TR, Purvine SO, Wang Z, Camp DG 2nd, Shabanowitz J, Stanley P, Hart GW, Hunt DF, Yang F, Smith RD.

Proc Natl Acad Sci U S A. 2012 May 8;109(19):7280-5. doi: 10.1073/pnas.1200425109. Epub 2012 Apr 19.

48.

Synthesis of heterobifunctional protein fusions using copper-free click chemistry and the aldehyde tag.

Hudak JE, Barfield RM, de Hart GW, Grob P, Nogales E, Bertozzi CR, Rabuka D.

Angew Chem Int Ed Engl. 2012 Apr 23;51(17):4161-5. doi: 10.1002/anie.201108130. Epub 2012 Mar 12. No abstract available.

49.

Regulation of CK2 by phosphorylation and O-GlcNAcylation revealed by semisynthesis.

Tarrant MK, Rho HS, Xie Z, Jiang YL, Gross C, Culhane JC, Yan G, Qian J, Ichikawa Y, Matsuoka T, Zachara N, Etzkorn FA, Hart GW, Jeong JS, Blackshaw S, Zhu H, Cole PA.

Nat Chem Biol. 2012 Jan 22;8(3):262-9. doi: 10.1038/nchembio.771.

50.

Detection and analysis of proteins modified by O-linked N-acetylglucosamine.

Zachara NE, Vosseller K, Hart GW.

Curr Protoc Protein Sci. 2011 Nov;Chapter 12:Unit12.8. doi: 10.1002/0471140864.ps1208s66.

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