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Molecular Response of Rabbit Menisci to Surgically Induced Hemarthrosis and a Single Intra-Articular Dexamethasone Treatment.

Heard BJ, Barton KI, Agbojo OM, Chung M, Sevick JL, Bader TJ, Martin CR, Shrive NG, Hart DA.

J Orthop Res. 2019 Sep;37(9):2043-2052. doi: 10.1002/jor.24346. Epub 2019 Jun 20.


Three-dimensional in vivo kinematics and finite helical axis variables of the ovine stifle joint following partial anterior cruciate ligament transection.

Barton KI, Shekarforoush M, Heard BJ, Sevick JL, Martin CR, Frank CB, Hart DA, Shrive NG.

J Biomech. 2019 May 9;88:78-87. doi: 10.1016/j.jbiomech.2019.03.021. Epub 2019 Mar 22.


The mechanical and biochemical properties of tail tendon in a rat model of obesity: Effect of moderate exercise and prebiotic fibre supplementation.

Rios JL, Ko L, Joumaa V, Liu S, Diefenthaeler F, Sawatsky A, Hart DA, Reimer RA, Herzog W.

J Biomech. 2019 May 9;88:148-154. doi: 10.1016/j.jbiomech.2019.03.031. Epub 2019 Mar 30.


Protective effect of prebiotic and exercise intervention on knee health in a rat model of diet-induced obesity.

Rios JL, Bomhof MR, Reimer RA, Hart DA, Collins KH, Herzog W.

Sci Rep. 2019 Mar 7;9(1):3893. doi: 10.1038/s41598-019-40601-x.


NF-κB-Associated Pain-Related Neuropeptide Expression in Patients with Degenerative Disc Disease.

Ahmed AS, Berg S, Alkass K, Druid H, Hart DA, Svensson CI, Kosek E.

Int J Mol Sci. 2019 Feb 3;20(3). pii: E658. doi: 10.3390/ijms20030658.


Intervertebral disc regeneration with an adipose mesenchymal stem cell-derived tissue-engineered construct in a rat nucleotomy model.

Ishiguro H, Kaito T, Yarimitsu S, Hashimoto K, Okada R, Kushioka J, Chijimatsu R, Takenaka S, Makino T, Sakai Y, Moriguchi Y, Otsuru S, Hart DA, Fujie H, Nakamura N, Yoshikawa H.

Acta Biomater. 2019 Mar 15;87:118-129. doi: 10.1016/j.actbio.2019.01.050. Epub 2019 Jan 25.


Alterations in Joint Angular Velocity Following Traumatic Knee Injury in Ovine Models.

Shekarforoush M, Barton KI, Beveridge JE, Scott M, Martin CR, Muench G, Heard BJ, Sevick JL, Hart DA, Frank CB, Shrive NG.

Ann Biomed Eng. 2019 Mar;47(3):790-801. doi: 10.1007/s10439-019-02203-6. Epub 2019 Jan 17.


Effect of the small compound TD-198946 on glycosaminoglycan synthesis and transforming growth factor β3-associated chondrogenesis of human synovium-derived stem cells in vitro.

Chijimatsu R, Yano F, Saito T, Kobayashi M, Hamamoto S, Kaito T, Kushioka J, Hart DA, Chung UI, Tanaka S, Yoshikawa H, Nakamura N.

J Tissue Eng Regen Med. 2019 Mar;13(3):446-458. doi: 10.1002/term.2795. Epub 2019 Feb 20.


Maternal prebiotic supplementation reduces fatty liver development in offspring through altered microbial and metabolomic profiles in rats.

Paul HA, Collins KH, Nicolucci AC, Urbanski SJ, Hart DA, Vogel HJ, Reimer RA.

FASEB J. 2019 Apr;33(4):5153-5167. doi: 10.1096/fj.201801551R. Epub 2019 Jan 10.


Enhanced repair of meniscal hoop structure injuries using an aligned electrospun nanofibrous scaffold combined with a mesenchymal stem cell-derived tissue engineered construct.

Shimomura K, Rothrauff BB, Hart DA, Hamamoto S, Kobayashi M, Yoshikawa H, Tuan RS, Nakamura N.

Biomaterials. 2019 Feb;192:346-354. doi: 10.1016/j.biomaterials.2018.11.009. Epub 2018 Nov 13.


Meniscal repair and regeneration: Current strategies and future perspectives.

Shimomura K, Hamamoto S, Hart DA, Yoshikawa H, Nakamura N.

J Clin Orthop Trauma. 2018 Jul-Sep;9(3):247-253. doi: 10.1016/j.jcot.2018.07.008. Epub 2018 Jul 17. Review.


Activation of NF-κB in Synovium versus Cartilage from Patients with Advanced Knee Osteoarthritis: A Potential Contributor to Inflammatory Aspects of Disease Progression.

Ahmed AS, Gedin P, Hugo A, Bakalkin G, Kanar A, Hart DA, Druid H, Svensson C, Kosek E.

J Immunol. 2018 Oct 1;201(7):1918-1927. doi: 10.4049/jimmunol.1800486. Epub 2018 Aug 22.


First-in-Human Pilot Study of Implantation of a Scaffold-Free Tissue-Engineered Construct Generated From Autologous Synovial Mesenchymal Stem Cells for Repair of Knee Chondral Lesions.

Shimomura K, Yasui Y, Koizumi K, Chijimatsu R, Hart DA, Yonetani Y, Ando W, Nishii T, Kanamoto T, Horibe S, Yoshikawa H, Nakamura N, Sakaue M, Sugita N, Moriguchi Y.

Am J Sports Med. 2018 Aug;46(10):2384-2393. doi: 10.1177/0363546518781825. Epub 2018 Jul 3.


Achilles tendon structure is negatively correlated with body mass index, but not influenced by statin use: A cross-sectional study using ultrasound tissue characterization.

de Sá A, Hart DA, Khan K, Scott A.

PLoS One. 2018 Jun 21;13(6):e0199645. doi: 10.1371/journal.pone.0199645. eCollection 2018.


High-fat/high-sucrose diet-induced obesity results in joint-specific development of osteoarthritis-like degeneration in a rat model.

Collins KH, Hart DA, Seerattan RA, Reimer RA, Herzog W.

Bone Joint Res. 2018 May 5;7(4):274-281. doi: 10.1302/2046-3758.74.BJR-2017-0201.R2. eCollection 2018 Apr.


Correlation between translational and rotational kinematic abnormalities and osteoarthritis-like damage in two in vivo sheep injury models.

Shekarforoush M, Beveridge JE, Hart DA, Frank CB, Shrive NG.

J Biomech. 2018 Jun 25;75:67-76. doi: 10.1016/j.jbiomech.2018.04.046. Epub 2018 May 16.


Production of Adult Human Synovial Fluid-Derived Mesenchymal Stem Cells in Stirred-Suspension Culture.

Jorgenson KD, Hart DA, Krawetz R, Sen A.

Stem Cells Int. 2018 Mar 27;2018:8431053. doi: 10.1155/2018/8431053. eCollection 2018.


Posttraumatic Osteoarthritis Development and Progression in an Ovine Model of Partial Anterior Cruciate Ligament Transection and Effect of Repeated Intra-articular Methylprednisolone Acetate Injections on Early Disease.

Barton KI, Heard BJ, Sevick JL, Martin CR, Shekarforoush SMM, Chung M, Achari Y, Frank CB, Shrive NG, Hart DA.

Am J Sports Med. 2018 Jun;46(7):1596-1605. doi: 10.1177/0363546518765098. Epub 2018 Apr 18.


Fibril deformation under load of the rabbit Achilles tendon and medial collateral ligament femoral entheses.

Sevick JL, Abusara Z, Andrews SH, Xu M, Khurshid S, Chatha J, Hart DA, Shrive NG.

J Orthop Res. 2018 Sep;36(9):2506-2515. doi: 10.1002/jor.23912. Epub 2018 Apr 25.


Quantifying the Effects of Different Treadmill Training Speeds and Durations on the Health of Rat Knee Joints.

Rios JL, Boldt KR, Mather JW, Seerattan RA, Hart DA, Herzog W.

Sports Med Open. 2018 Apr 2;4(1):15. doi: 10.1186/s40798-018-0127-2.


Connexin 43 regulates the expression of wound healing-related genes in human gingival and skin fibroblasts.

Tarzemany R, Jiang G, Jiang JX, Gallant-Behm C, Wiebe C, Hart DA, Larjava H, Häkkinen L.

Exp Cell Res. 2018 Jun 15;367(2):150-161. doi: 10.1016/j.yexcr.2018.03.031. Epub 2018 Mar 27.


Gene-expression changes in knee-joint tissues with aging and menopause: implications for the joint as an organ.

Rollick NC, Lemmex DB, Ono Y, Reno CR, Hart DA, Lo IK, Thornton GM.

Clin Interv Aging. 2018 Mar 1;13:365-375. doi: 10.2147/CIA.S151453. eCollection 2018.


Obesity, Metabolic Syndrome, and Musculoskeletal Disease: Common Inflammatory Pathways Suggest a Central Role for Loss of Muscle Integrity.

Collins KH, Herzog W, MacDonald GZ, Reimer RA, Rios JL, Smith IC, Zernicke RF, Hart DA.

Front Physiol. 2018 Feb 23;9:112. doi: 10.3389/fphys.2018.00112. eCollection 2018. Review.


Scaffold-free tissue engineering for injured joint surface restoration.

Shimomura K, Ando W, Fujie H, Hart DA, Yoshikawa H, Nakamura N.

J Exp Orthop. 2018 Jan 5;5(1):2. doi: 10.1186/s40634-017-0118-0. Review.


Time-Dependent Recovery of Human Synovial Membrane Mesenchymal Stem Cell Function After High-Dose Steroid Therapy: Case Report and Laboratory Study.

Yasui Y, Hart DA, Sugita N, Chijimatsu R, Koizumi K, Ando W, Moriguchi Y, Shimomura K, Myoui A, Yoshikawa H, Nakamura N.

Am J Sports Med. 2018 Mar;46(3):695-701. doi: 10.1177/0363546517741307. Epub 2017 Dec 11.


Diet-induced obesity leads to pro-inflammatory alterations to the vitreous humour of the eye in a rat model.

Collins KH, Herzog W, Reimer RA, Reno CR, Heard BJ, Hart DA.

Inflamm Res. 2018 Feb;67(2):139-146. doi: 10.1007/s00011-017-1102-y. Epub 2017 Oct 26.


Messenger RNA profiling of rabbit quadriceps femoris after repeat injections of botulinum toxin: Evidence for a dynamic pattern without further structural alterations.

Hart DA, Fortuna R, Herzog W.

Muscle Nerve. 2018 Mar;57(3):487-493. doi: 10.1002/mus.25775. Epub 2017 Aug 31.


IGF-1 Gene Transfer to Human Synovial MSCs Promotes Their Chondrogenic Differentiation Potential without Induction of the Hypertrophic Phenotype.

Ikeda Y, Sakaue M, Chijimatsu R, Hart DA, Otsubo H, Shimomura K, Madry H, Suzuki T, Yoshikawa H, Yamashita T, Nakamura N.

Stem Cells Int. 2017;2017:5804147. doi: 10.1155/2017/5804147. Epub 2017 Jun 27.


Elevated CD26 Expression by Skin Fibroblasts Distinguishes a Profibrotic Phenotype Involved in Scar Formation Compared to Gingival Fibroblasts.

Mah W, Jiang G, Olver D, Gallant-Behm C, Wiebe C, Hart DA, Koivisto L, Larjava H, Häkkinen L.

Am J Pathol. 2017 Aug;187(8):1717-1735. doi: 10.1016/j.ajpath.2017.04.017. Epub 2017 Jun 20.


Characterization of Mesenchymal Stem Cell-Like Cells Derived From Human iPSCs via Neural Crest Development and Their Application for Osteochondral Repair.

Chijimatsu R, Ikeya M, Yasui Y, Ikeda Y, Ebina K, Moriguchi Y, Shimomura K, Hart DA, Hideki Y, Norimasa N.

Stem Cells Int. 2017;2017:1960965. doi: 10.1155/2017/1960965. Epub 2017 May 10.


Analysis of change in gait in the ovine stifle: normal, injured, and anterior cruciate ligament reconstructed.

Heard BJ, Beveridge JE, Atarod M, O'Brien EJ, Rolian C, Frank CB, Hart DA, Shrive NG.

BMC Musculoskelet Disord. 2017 May 23;18(1):212. doi: 10.1186/s12891-017-1576-3.


Acute and chronic changes in rat soleus muscle after high-fat high-sucrose diet.

Collins KH, Hart DA, Smith IC, Issler AM, Reimer RA, Seerattan RA, Rios JL, Herzog W.

Physiol Rep. 2017 May;5(10):e13270. doi: 10.14814/phy2.13270.


Enumeration and Localization of Mesenchymal Progenitor Cells and Macrophages in Synovium from Normal Individuals and Patients with Pre-Osteoarthritis or Clinically Diagnosed Osteoarthritis.

O'Brien K, Tailor P, Leonard C, DiFrancesco LM, Hart DA, Matyas JR, Frank CB, Krawetz RJ.

Int J Mol Sci. 2017 Apr 5;18(4). pii: E774. doi: 10.3390/ijms18040774.


Comparison of 2 Different Formulations of Artificial Bone for a Hybrid Implant With a Tissue-Engineered Construct Derived From Synovial Mesenchymal Stem Cells: A Study Using a Rabbit Osteochondral Defect Model.

Shimomura K, Moriguchi Y, Nansai R, Fujie H, Ando W, Horibe S, Hart DA, Gobbi A, Yoshikawa H, Nakamura N.

Am J Sports Med. 2017 Mar;45(3):666-675. doi: 10.1177/0363546516668835. Epub 2016 Oct 23.


Serum Mast Cell Tryptase as a Marker of Posttraumatic Joint Contracture in a Rabbit Model.

Kopka M, Monument MJ, Befus AD, Zhang M, Hart DA, Salo PT, Schneider PS, Fan CY, Liang X, Garven A, Hildebrand KA.

J Orthop Trauma. 2017 Mar;31(3):e86-e89. doi: 10.1097/BOT.0000000000000747.


Compromised Neurotrophic and Angiogenic Regenerative Capability during Tendon Healing in a Rat Model of Type-II Diabetes.

Ahmed AS, Li J, Abdul AM, Ahmed M, Östenson CG, Salo PT, Hewitt C, Hart DA, Ackermann PW.

PLoS One. 2017 Jan 25;12(1):e0170748. doi: 10.1371/journal.pone.0170748. eCollection 2017.


Location and gene-specific effects of methylprednisolone acetate on mitigating IL1β-induced inflammation in mature ovine explant knee tissue.

Barton KI, Heard BJ, Chung M, Sevick JL, Martin CR, Achari Y, Frank CB, Shrive NG, Hart DA.

Inflamm Res. 2017 Mar;66(3):239-248. doi: 10.1007/s00011-016-1009-z. Epub 2016 Nov 16.


A High-Fat High-Sucrose Diet Rapidly Alters Muscle Integrity, Inflammation and Gut Microbiota in Male Rats.

Collins KH, Paul HA, Hart DA, Reimer RA, Smith IC, Rios JL, Seerattan RA, Herzog W.

Sci Rep. 2016 Nov 17;6:37278. doi: 10.1038/srep37278.


Optimization of human mesenchymal stem cell isolation from synovial membrane: Implications for subsequent tissue engineering effectiveness.

Sugita N, Moriguchi Y, Sakaue M, Hart DA, Yasui Y, Koizumi K, Chijimatsu R, Shimomura S, Ikeda Y, Yoshikawa H, Nakamura N.

Regen Ther. 2016 Sep 29;5:79-85. doi: 10.1016/j.reth.2016.09.002. eCollection 2016 Dec.


PXL01 in sodium hyaluronate results in increased PRG4 expression: a potential mechanism for anti-adhesion.

Edsfeldt S, Holm B, Mahlapuu M, Reno C, Hart DA, Wiig M.

Ups J Med Sci. 2017 Mar;122(1):28-34. doi: 10.1080/03009734.2016.1230157. Epub 2016 Sep 23.


General Overview and Summary of Concepts Regarding Tendon Disease Topics Addressed Related to Metabolic Disorders.

Ackermann PW, Hart DA.

Adv Exp Med Biol. 2016;920:293-8. doi: 10.1007/978-3-319-33943-6_28. Review.


Tendon Innervation.

Ackermann PW, Salo P, Hart DA.

Adv Exp Med Biol. 2016;920:35-51. doi: 10.1007/978-3-319-33943-6_4. Review.


Use of pre-clinical surgically induced models to understand biomechanical and biological consequences of PTOA development.

Barton KI, Shekarforoush M, Heard BJ, Sevick JL, Vakil P, Atarod M, Martin R, Achari Y, Hart DA, Frank CB, Shrive NG.

J Orthop Res. 2017 Mar;35(3):454-465. doi: 10.1002/jor.23322. Epub 2017 Mar 2. Review.


High-fat high-sucrose diet leads to dynamic structural and inflammatory alterations in the rat vastus lateralis muscle.

Collins KH, Hart DA, Reimer RA, Seerattan RA, Waters-Banker C, Sibole SC, Herzog W.

J Orthop Res. 2016 Dec;34(12):2069-2078. doi: 10.1002/jor.23230. Epub 2016 Apr 6.


Preparation of Scaffold-Free Tissue-Engineered Constructs Derived from Human Synovial Mesenchymal Stem Cells Under Low Oxygen Tension Enhances Their Chondrogenic Differentiation Capacity.

Yasui Y, Chijimatsu R, Hart DA, Koizumi K, Sugita N, Shimomura K, Myoui A, Yoshikawa H, Nakamura N.

Tissue Eng Part A. 2016 Mar;22(5-6):490-500. doi: 10.1089/ten.tea.2015.0458. Epub 2016 Mar 14.


Synovial mesenchymal stem cells from osteo- or rheumatoid arthritis joints exhibit good potential for cartilage repair using a scaffold-free tissue engineering approach.

Koizumi K, Ebina K, Hart DA, Hirao M, Noguchi T, Sugita N, Yasui Y, Chijimatsu R, Yoshikawa H, Nakamura N.

Osteoarthritis Cartilage. 2016 Aug;24(8):1413-22. doi: 10.1016/j.joca.2016.03.006. Epub 2016 Mar 10.


The infrapatellar fat pad is affected by injury induced inflammation in the rabbit knee: use of dexamethasone to mitigate damage.

Heard BJ, Solbak NM, Chung M, Achari Y, Shrive NG, Frank CB, Hart DA.

Inflamm Res. 2016 Jun;65(6):459-70. doi: 10.1007/s00011-016-0928-z. Epub 2016 Feb 22.


Joint instability leads to long-term alterations to knee synovium and osteoarthritis in a rabbit model.

Egloff C, Hart DA, Hewitt C, Vavken P, Valderrabano V, Herzog W.

Osteoarthritis Cartilage. 2016 Jun;24(6):1054-60. doi: 10.1016/j.joca.2016.01.341. Epub 2016 Feb 2.


Increased lubricin/proteoglycan 4 gene expression and decreased modulus in medial collateral ligaments following ovariohysterectomy in the adult rabbit: Evidence consistent with aging.

Lemmex DB, Ono Y, Reno CR, Hart DA, Lo IK, Thornton GM.

J Biomech. 2016 Feb 8;49(3):382-7. doi: 10.1016/j.jbiomech.2015.12.026. Epub 2015 Dec 29.

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