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First-in-Human Pilot Study of Implantation of a Scaffold-Free Tissue-Engineered Construct Generated From Autologous Synovial Mesenchymal Stem Cells for Repair of Knee Chondral Lesions.

Shimomura K, Yasui Y, Koizumi K, Chijimatsu R, Hart DA, Yonetani Y, Ando W, Nishii T, Kanamoto T, Horibe S, Yoshikawa H, Nakamura N, Sakaue M, Sugita N, Moriguchi Y.

Am J Sports Med. 2018 Jun 1:363546518781825. doi: 10.1177/0363546518781825. [Epub ahead of print]


Achilles tendon structure is negatively correlated with body mass index, but not influenced by statin use: A cross-sectional study using ultrasound tissue characterization.

de Sá A, Hart DA, Khan K, Scott A.

PLoS One. 2018 Jun 21;13(6):e0199645. doi: 10.1371/journal.pone.0199645. eCollection 2018.


High-fat/high-sucrose diet-induced obesity results in joint-specific development of osteoarthritis-like degeneration in a rat model.

Collins KH, Hart DA, Seerattan RA, Reimer RA, Herzog W.

Bone Joint Res. 2018 May 5;7(4):274-281. doi: 10.1302/2046-3758.74.BJR-2017-0201.R2. eCollection 2018 Apr.


Three Novel Escherichia coli Vectors for Convenient and Efficient Molecular Biological Manipulations.

Gao H, Qi X, Hart DJ, Gao S, Wang H, Xu S, Zhang Y, Liu X, Liu Y, An Y.

J Agric Food Chem. 2018 Jun 20;66(24):6123-6131. doi: 10.1021/acs.jafc.8b01960. Epub 2018 Jun 11.


Surplus fat rapidly increases fat oxidation and insulin resistance in lipodystrophic mice.

Girousse A, Virtue S, Hart D, Vidal-Puig A, Murgatroyd PR, Mouisel E, Sengenès C, Savage DB.

Mol Metab. 2018 Jul;13:24-29. doi: 10.1016/j.molmet.2018.05.006. Epub 2018 May 16.


Correlation between translational and rotational kinematic abnormalities and osteoarthritis-like damage in two in vivo sheep injury models.

Shekarforoush M, Beveridge JE, Hart DA, Frank CB, Shrive NG.

J Biomech. 2018 Jun 25;75:67-76. doi: 10.1016/j.jbiomech.2018.04.046. Epub 2018 May 16.


Optimization of pre-analytical heat treatment for inhibitor detection in haemophilia A.

Batty P, Hart DP, Platton S.

Int J Lab Hematol. 2018 May 18. doi: 10.1111/ijlh.12862. [Epub ahead of print]


One-Pot Synthesis of Four Chlorin Derivatives by a Divergent Ylide.

Gonzales J, Bhupathiraju NVSDK, Hart D, Yuen M, Sifuentes MP, Samarxhiu B, Maranan M, Berisha N, Batteas J, Drain CM.

J Org Chem. 2018 Jun 15;83(12):6307-6314. doi: 10.1021/acs.joc.8b00169. Epub 2018 May 29.


Production of Adult Human Synovial Fluid-Derived Mesenchymal Stem Cells in Stirred-Suspension Culture.

Jorgenson KD, Hart DA, Krawetz R, Sen A.

Stem Cells Int. 2018 Mar 27;2018:8431053. doi: 10.1155/2018/8431053. eCollection 2018.


Correction to: A zebrafish model of foxe3 deficiency demonstrates lens and eye defects with dysregulation of key genes involved in cataract formation in humans.

Krall M, Htun S, Anand D, Hart D, Lachke SA, Slavotinek AM.

Hum Genet. 2018 May 11. doi: 10.1007/s00439-018-1890-3. [Epub ahead of print]


A zebrafish model of foxe3 deficiency demonstrates lens and eye defects with dysregulation of key genes involved in cataract formation in humans.

Krall M, Htun S, Anand D, Hart D, Lachke SA, Slavotinek AM.

Hum Genet. 2018 Apr;137(4):315-328. doi: 10.1007/s00439-018-1884-1. Epub 2018 Apr 30. Erratum in: Hum Genet. 2018 May 11;:.


Perioperative replacement therapy in haemophilia B: An appeal to "B" more precise.

Hazendonk HCAM, Preijers T, Liesner R, Chowdary P, Hart D, Keeling D, Driessens MHE, Laros-van Gorkom BAP, van der Meer FJM, Meijer K, Fijnvandraat K, Leebeek FWG, Mathôt RAA, Collins PW, Cnossen MH.

Haemophilia. 2018 Apr 29. doi: 10.1111/hae.13469. [Epub ahead of print]


Posttraumatic Osteoarthritis Development and Progression in an Ovine Model of Partial Anterior Cruciate Ligament Transection and Effect of Repeated Intra-articular Methylprednisolone Acetate Injections on Early Disease.

Barton KI, Heard BJ, Sevick JL, Martin CR, Shekarforoush SMM, Chung M, Achari Y, Frank CB, Shrive NG, Hart DA.

Am J Sports Med. 2018 Jun;46(7):1596-1605. doi: 10.1177/0363546518765098. Epub 2018 Apr 18.


Fibril deformation under load of the rabbit Achilles tendon and medial collateral ligament femoral entheses.

Sevick JL, Abusara Z, Andrews SH, Xu M, Khurshid S, Chatha J, Hart DA, Shrive NG.

J Orthop Res. 2018 Apr 10. doi: 10.1002/jor.23912. [Epub ahead of print]


Quality and Correlates of Peer Relationships in Youths with Chronic Pain.

La Buissonnière-Ariza V, Hart D, Schneider SC, McBride NM, Cepeda SL, Haney B, Tauriello S, Glenn S, Ung D, Huszar P, Tetreault L, Petti E, Winesett SP, Storch EA.

Child Psychiatry Hum Dev. 2018 Apr 10. doi: 10.1007/s10578-018-0802-z. [Epub ahead of print]


A blood dendritic cell vaccine for acute myeloid leukemia expands anti-tumor T cell responses at remission.

Hsu JL, Bryant CE, Papadimitrious MS, Kong B, Gasiorowski RE, Orellana D, McGuire HM, Groth BFS, Joshua DE, Ho PJ, Larsen S, Iland HJ, Gibson J, Clark GJ, Fromm PD, Hart DN.

Oncoimmunology. 2018 Jan 25;7(4):e1419114. doi: 10.1080/2162402X.2017.1419114. eCollection 2018.


Quantifying the Effects of Different Treadmill Training Speeds and Durations on the Health of Rat Knee Joints.

Rios JL, Boldt KR, Mather JW, Seerattan RA, Hart DA, Herzog W.

Sports Med Open. 2018 Apr 2;4(1):15. doi: 10.1186/s40798-018-0127-2.


Connexin 43 regulates the expression of wound healing-related genes in human gingival and skin fibroblasts.

Tarzemany R, Jiang G, Jiang JX, Gallant-Behm C, Wiebe C, Hart DA, Larjava H, Häkkinen L.

Exp Cell Res. 2018 Jun 15;367(2):150-161. doi: 10.1016/j.yexcr.2018.03.031. Epub 2018 Mar 27.


Definitive Zygosity Scores in the Peas in the Pod Questionnaire is a Sensitive and Accurate Assessment of the Zygosity of Adult Twins.

Jarrar ZA, Ward KJ, Mangino M, Cherkas LF, Gill R, Gillham-Nasenya I, Yarand D, Hart D, Hammond CJ, Spector TD.

Twin Res Hum Genet. 2018 Apr;21(2):146-154. doi: 10.1017/thg.2018.9.


Individualized PK-based prophylaxis in severe haemophilia.

Dargaud Y, Delavenne X, Hart DP, Meunier S, Mismetti P.

Haemophilia. 2018 Mar;24 Suppl 2:3-17. doi: 10.1111/hae.13397. Review.


Gene-expression changes in knee-joint tissues with aging and menopause: implications for the joint as an organ.

Rollick NC, Lemmex DB, Ono Y, Reno CR, Hart DA, Lo IK, Thornton GM.

Clin Interv Aging. 2018 Mar 1;13:365-375. doi: 10.2147/CIA.S151453. eCollection 2018.


Obesity, Metabolic Syndrome, and Musculoskeletal Disease: Common Inflammatory Pathways Suggest a Central Role for Loss of Muscle Integrity.

Collins KH, Herzog W, MacDonald GZ, Reimer RA, Rios JL, Smith IC, Zernicke RF, Hart DA.

Front Physiol. 2018 Feb 23;9:112. doi: 10.3389/fphys.2018.00112. eCollection 2018. Review.


The cell surface phenotype of human dendritic cells.

Clark GJ, Silveira PA, Hogarth PM, Hart DNJ.

Semin Cell Dev Biol. 2018 Mar 27. pii: S1084-9521(17)30494-9. doi: 10.1016/j.semcdb.2018.02.013. [Epub ahead of print] Review.


Ending AIDS by 2030: the importance of an interlinked approach and meaningful youth leadership.

Gleeson HS, Oliveras Rodriguez CA, Hatane L, Hart D.

J Int AIDS Soc. 2018 Feb;21 Suppl 1. doi: 10.1002/jia2.25061.


Dendritic cells as cancer therapeutics.

Bryant CE, Sutherland S, Kong B, Papadimitrious MS, Fromm PD, Hart DNJ.

Semin Cell Dev Biol. 2018 Mar 21. pii: S1084-9521(17)30495-0. doi: 10.1016/j.semcdb.2018.02.015. [Epub ahead of print] Review.


A universal mini-vector and an annealing of PCR products (APP)-based cloning strategy for convenient molecular biological manipulations.

Liu X, Li T, Hart DJ, Gao S, Wang H, Gao H, Xu S, Zhang Y, Liu Y, An Y.

Biochem Biophys Res Commun. 2018 Mar 18;497(4):978-982. doi: 10.1016/j.bbrc.2018.02.099. Epub 2018 Feb 12.


CD83 is a new potential biomarker and therapeutic target for Hodgkin lymphoma.

Li Z, Ju X, Lee K, Clarke C, Hsu JL, Abadir E, Bryant CE, Pears S, Sunderland N, Heffernan S, Hennessy A, Lo TH, Pietersz GA, Kupresanin F, Fromm PD, Silveira PA, Tsonis C, Cooper WA, Cunningham I, Brown C, Clark GJ, Hart DNJ.

Haematologica. 2018 Apr;103(4):655-665. doi: 10.3324/haematol.2017.178384. Epub 2018 Jan 19.


Inactivating mutations in Drosha mediate vascular abnormalities similar to hereditary hemorrhagic telangiectasia.

Jiang X, Wooderchak-Donahue WL, McDonald J, Ghatpande P, Baalbaki M, Sandoval M, Hart D, Clay H, Coughlin S, Lagna G, Bayrak-Toydemir P, Hata A.

Sci Signal. 2018 Jan 16;11(513). pii: eaan6831. doi: 10.1126/scisignal.aan6831.


Scaffold-free tissue engineering for injured joint surface restoration.

Shimomura K, Ando W, Fujie H, Hart DA, Yoshikawa H, Nakamura N.

J Exp Orthop. 2018 Jan 5;5(1):2. doi: 10.1186/s40634-017-0118-0. Review.


Utilization of Nerve Integrity Monitor for Promontory Stimulation Testing Prior to Cochlear Implant.

Kelly EA, Levine S, Gravel KE, Hart DL, Huang T.

Otol Neurotol. 2018 Feb;39(2):e60-e62. doi: 10.1097/MAO.0000000000001669.


Time-Dependent Recovery of Human Synovial Membrane Mesenchymal Stem Cell Function After High-Dose Steroid Therapy: Case Report and Laboratory Study.

Yasui Y, Hart DA, Sugita N, Chijimatsu R, Koizumi K, Ando W, Moriguchi Y, Shimomura K, Myoui A, Yoshikawa H, Nakamura N.

Am J Sports Med. 2018 Mar;46(3):695-701. doi: 10.1177/0363546517741307. Epub 2017 Dec 11.


The vaccinia virus DNA polymerase structure provides insights into the mode of processivity factor binding.

Tarbouriech N, Ducournau C, Hutin S, Mas PJ, Man P, Forest E, Hart DJ, Peyrefitte CN, Burmeister WP, Iseni F.

Nat Commun. 2017 Nov 13;8(1):1455. doi: 10.1038/s41467-017-01542-z.


Training and Assessing Critical Airway, Breathing, and Hemorrhage Control Procedures for Trauma Care: Live Tissue Versus Synthetic Models.

Hart D, Rush R, Rule G, Clinton J, Beilman G, Anders S, Brown R, McNeil MA, Reihsen T, Chipman J, Sweet R; on behalf of the University of Minnesota Combat Casualty Training Consortium (UMN CCTC).

Acad Emerg Med. 2018 Feb;25(2):148-167. doi: 10.1111/acem.13340. Epub 2017 Dec 14.


Diet-induced obesity leads to pro-inflammatory alterations to the vitreous humour of the eye in a rat model.

Collins KH, Herzog W, Reimer RA, Reno CR, Heard BJ, Hart DA.

Inflamm Res. 2018 Feb;67(2):139-146. doi: 10.1007/s00011-017-1102-y. Epub 2017 Oct 26.


Simulation-based Education to Ensure Provider Competency Within the Health Care System.

Griswold S, Fralliccardi A, Boulet J, Moadel T, Franzen D, Auerbach M, Hart D, Goswami V, Hui J, Gordon JA.

Acad Emerg Med. 2018 Feb;25(2):168-176. doi: 10.1111/acem.13322. Epub 2017 Nov 8.


In chemico, in vitro and in vivo comparison of the skin sensitizing potential of eight unsaturated and one saturated lipid compounds.

Kreiling R, Gehrke H, Broschard TH, Dreeßen B, Eigler D, Hart D, Höpflinger V, Kleber M, Kupny J, Li Q, Ungeheuer P, Sauer UG.

Regul Toxicol Pharmacol. 2017 Nov;90:262-276. doi: 10.1016/j.yrtph.2017.09.023. Epub 2017 Sep 27.


Artificial stone-associated silicosis: a rapidly emerging occupational lung disease.

Hoy RF, Baird T, Hammerschlag G, Hart D, Johnson AR, King P, Putt M, Yates DH.

Occup Environ Med. 2018 Jan;75(1):3-5. doi: 10.1136/oemed-2017-104428. Epub 2017 Sep 7.


Genome-wide association and functional studies identify a role for matrix Gla protein in osteoarthritis of the hand.

den Hollander W, Boer CG, Hart DJ, Yau MS, Ramos YFM, Metrustry S, Broer L, Deelen J, Cupples LA, Rivadeneira F, Kloppenburg M, Peters M, Spector TD, Hofman A, Slagboom PE, Nelissen RGHH, Uitterlinden AG, Felson DT, Valdes AM, Meulenbelt I, van Meurs JJB.

Ann Rheum Dis. 2017 Dec;76(12):2046-2053. doi: 10.1136/annrheumdis-2017-211214. Epub 2017 Aug 30.


Simulation for Assessment of Milestones in Emergency Medicine Residents.

Hart D, Bond W, Siegelman JN, Miller D, Cassara M, Barker L, Anders S, Ahn J, Huang H, Strother C, Hui J.

Acad Emerg Med. 2018 Feb;25(2):205-220. doi: 10.1111/acem.13296. Epub 2017 Nov 9.


Messenger RNA profiling of rabbit quadriceps femoris after repeat injections of botulinum toxin: Evidence for a dynamic pattern without further structural alterations.

Hart DA, Fortuna R, Herzog W.

Muscle Nerve. 2018 Mar;57(3):487-493. doi: 10.1002/mus.25775. Epub 2017 Aug 31.


IGF-1 Gene Transfer to Human Synovial MSCs Promotes Their Chondrogenic Differentiation Potential without Induction of the Hypertrophic Phenotype.

Ikeda Y, Sakaue M, Chijimatsu R, Hart DA, Otsubo H, Shimomura K, Madry H, Suzuki T, Yoshikawa H, Yamashita T, Nakamura N.

Stem Cells Int. 2017;2017:5804147. doi: 10.1155/2017/5804147. Epub 2017 Jun 27.


Elevated CD26 Expression by Skin Fibroblasts Distinguishes a Profibrotic Phenotype Involved in Scar Formation Compared to Gingival Fibroblasts.

Mah W, Jiang G, Olver D, Gallant-Behm C, Wiebe C, Hart DA, Koivisto L, Larjava H, Häkkinen L.

Am J Pathol. 2017 Aug;187(8):1717-1735. doi: 10.1016/j.ajpath.2017.04.017. Epub 2017 Jun 20.


Parental perceptions of hypothermia treatment for neonatal hypoxic-ischaemic encephalopathy.

Thyagarajan B, Baral V, Gunda R, Hart D, Leppard L, Vollmer B.

J Matern Fetal Neonatal Med. 2018 Oct;31(19):2527-2533. doi: 10.1080/14767058.2017.1346074. Epub 2017 Jul 11.


Structural Characterization of the SMRT Corepressor Interacting with Histone Deacetylase 7.

Desravines DC, Serna Martin I, Schneider R, Mas PJ, Aleksandrova N, Jensen MR, Blackledge M, Hart DJ.

Sci Rep. 2017 Jun 16;7(1):3678. doi: 10.1038/s41598-017-03718-5.


Characterization of Mesenchymal Stem Cell-Like Cells Derived From Human iPSCs via Neural Crest Development and Their Application for Osteochondral Repair.

Chijimatsu R, Ikeya M, Yasui Y, Ikeda Y, Ebina K, Moriguchi Y, Shimomura K, Hart DA, Hideki Y, Norimasa N.

Stem Cells Int. 2017;2017:1960965. doi: 10.1155/2017/1960965. Epub 2017 May 10.


Serum Lipid Levels and Risk Of Hand Osteoarthritis: The Chingford Prospective Cohort Study.

Garcia-Gil M, Reyes C, Ramos R, Sanchez-Santos MT, Prieto-Alhambra D, Spector TD, Hart DJ, Arden NK.

Sci Rep. 2017 Jun 9;7(1):3147. doi: 10.1038/s41598-017-03317-4.


Core principles of assessment in competency-based medical education.

Lockyer J, Carraccio C, Chan MK, Hart D, Smee S, Touchie C, Holmboe ES, Frank JR; ICBME Collaborators.

Med Teach. 2017 Jun;39(6):609-616. doi: 10.1080/0142159X.2017.1315082.


Nuclear Pores Regulate Muscle Development and Maintenance by Assembling a Localized Mef2C Complex.

Raices M, Bukata L, Sakuma S, Borlido J, Hernandez LS, Hart DO, D'Angelo MA.

Dev Cell. 2017 Jun 5;41(5):540-554.e7. doi: 10.1016/j.devcel.2017.05.007.


First-line immune tolerance induction for children with severe haemophilia A: A protocol from the UK Haemophilia Centre Doctors' Organisation Inhibitor and Paediatric Working Parties.

Collins P, Chalmers E, Alamelu J, Hay C, Liesner R, Makris M, Mathias M, Payne J, Rangarajan S, Richards M, Talks K, Tunstall O, Williams M, Hart DP.

Haemophilia. 2017 Sep;23(5):654-659. doi: 10.1111/hae.13264. Epub 2017 Jun 2. No abstract available.


Analysis of change in gait in the ovine stifle: normal, injured, and anterior cruciate ligament reconstructed.

Heard BJ, Beveridge JE, Atarod M, O'Brien EJ, Rolian C, Frank CB, Hart DA, Shrive NG.

BMC Musculoskelet Disord. 2017 May 23;18(1):212. doi: 10.1186/s12891-017-1576-3.

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