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Antisense oligonucleotide treatment ameliorates IFN-γ-induced proteinuria in APOL1-transgenic mice.

Aghajan M, Booten SL, Althage M, Hart CE, Ericsson A, Maxvall I, Ochaba J, Menschik-Lundin A, Hartleib J, Kuntz S, Gattis D, Ahlström C, Watt AT, Engelhardt JA, Monia BP, Magnone MC, Guo S.

JCI Insight. 2019 Jun 20;4(12). pii: 126124. doi: 10.1172/jci.insight.126124. eCollection 2019 Jun 20.


Chemical modification of PS-ASO therapeutics reduces cellular protein-binding and improves the therapeutic index.

Shen W, De Hoyos CL, Migawa MT, Vickers TA, Sun H, Low A, Bell TA 3rd, Rahdar M, Mukhopadhyay S, Hart CE, Bell M, Riney S, Murray SF, Greenlee S, Crooke RM, Liang XH, Seth PP, Crooke ST.

Nat Biotechnol. 2019 Jun;37(6):640-650. doi: 10.1038/s41587-019-0106-2. Epub 2019 Apr 29.


A modular analysis of microglia gene expression, insights into the aged phenotype.

Cho CE, Damle SS, Wancewicz EV, Mukhopadhyay S, Hart CE, Mazur C, Swayze EE, Kamme F.

BMC Genomics. 2019 Feb 28;20(1):164. doi: 10.1186/s12864-019-5549-9.


Repeated rectal application of a hyperosmolar lubricant is associated with microbiota shifts but does not affect PrEP drug concentrations: results from a randomized trial in men who have sex with men.

Haaland RE, Fountain J, Hu Y, Holder A, Dinh C, Hall L, Pescatore NA, Heeke S, Hart CE, Xu J, Hu YJ, Kelley CF.

J Int AIDS Soc. 2018 Oct;21(10):e25199. doi: 10.1002/jia2.25199.


Blood biochemistry of olive ridley (Lepidochelys olivacea) sea turtles foraging in northern Sinaloa, Mexico.

Espinoza-Romo BA, Sainz-Hernández JC, Ley-Quiñónez CP, Hart CE, Leal-Moreno R, Aguirre AA, Zavala-Norzagaray AA.

PLoS One. 2018 Jul 25;13(7):e0199825. doi: 10.1371/journal.pone.0199825. eCollection 2018.


Natal foraging philopatry in eastern Pacific hawksbill turtles.

Gaos AR, Lewison RL, Jensen MP, Liles MJ, Henriquez A, Chavarria S, Pacheco CM, Valle M, Melero D, Gadea V, Altamirano E, Torres P, Vallejo F, Miranda C, LeMarie C, Lucero J, Oceguera K, Chácon D, Fonseca L, Abrego M, Seminoff JA, Flores EE, Llamas I, Donadi R, Peña B, Muñoz JP, Ruales DA, Chaves JA, Otterstrom S, Zavala A, Hart CE, Brittain R, Alfaro-Shigueto J, Mangel J, Yañez IL, Dutton PH.

R Soc Open Sci. 2017 Aug 23;4(8):170153. doi: 10.1098/rsos.170153. eCollection 2017 Aug.


Zika virus alters the microRNA expression profile and elicits an RNAi response in Aedes aegypti mosquitoes.

Saldaña MA, Etebari K, Hart CE, Widen SG, Wood TG, Thangamani S, Asgari S, Hughes GL.

PLoS Negl Trop Dis. 2017 Jul 17;11(7):e0005760. doi: 10.1371/journal.pntd.0005760. eCollection 2017 Jul.


An Overview of Animal Models for Arthropod-Borne Viruses.

Reynolds ES, Hart CE, Hermance ME, Brining DL, Thangamani S.

Comp Med. 2017 Jun 1;67(3):232-241. Review.


Associations between trace elements and clinical health parameters in the North Pacific loggerhead sea turtle (Caretta caretta) from Baja California Sur, Mexico.

Ley-Quiñónez CP, Rossi-Lafferriere NA, Espinoza-Carreon TL, Hart CE, Peckham SH, Aguirre AA, Zavala-Norzagaray AA.

Environ Sci Pollut Res Int. 2017 Apr;24(10):9530-9537. doi: 10.1007/s11356-017-8556-x. Epub 2017 Feb 25.


Levels of Intracellular Phosphorylated Tenofovir and Emtricitabine Correlate With Natural Substrate Concentrations in Peripheral Blood Mononuclear Cells of Persons Prescribed Daily Oral Truvada for HIV Pre-exposure Prophylaxis.

Haaland RE, Holder A, Pau CP, Swaims-Kohlmeier A, Dawson C, Smith DK, Segolodi TM, Thigpen MC, Paxton LA, Parsons TL, Hendrix CW, Hart CE.

J Acquir Immune Defic Syndr. 2017 Jul 1;75(3):e86-e88. doi: 10.1097/QAI.0000000000001324. No abstract available.


Zika Virus Vector Competency of Mosquitoes, Gulf Coast, United States.

Hart CE, Roundy CM, Azar SR, Huang JH, Yun R, Reynolds E, Leal G, Nava MR, Vela J, Stark PM, Debboun M, Rossi S, Vasilakis N, Thangamani S, Weaver SC.

Emerg Infect Dis. 2017 Mar;23(3):559-560. doi: 10.3201/eid2303.161636. Epub 2017 Mar 15.


Vertical Transmission of Zika Virus in Aedes aegypti Mosquitoes.

Thangamani S, Huang J, Hart CE, Guzman H, Tesh RB.

Am J Trop Med Hyg. 2016 Nov 2;95(5):1169-1173. doi: 10.4269/ajtmh.16-0448. Epub 2016 Aug 29.


Effect of 4-nonylphenol on the immune response of the Pacific oyster Crassostrea gigas following bacterial infection with Vibrio campbellii.

Hart CE, Lauth MJ, Hunter CS, Krasny BR, Hardy KM.

Fish Shellfish Immunol. 2016 Nov;58:449-461. doi: 10.1016/j.fsi.2016.09.054. Epub 2016 Sep 28.


Integrated Safety Assessment of 2'-O-Methoxyethyl Chimeric Antisense Oligonucleotides in NonHuman Primates and Healthy Human Volunteers.

Crooke ST, Baker BF, Kwoh TJ, Cheng W, Schulz DJ, Xia S, Salgado N, Bui HH, Hart CE, Burel SA, Younis HS, Geary RS, Henry SP, Bhanot S.

Mol Ther. 2016 Oct;24(10):1771-1782. doi: 10.1038/mt.2016.136. Epub 2016 Jun 30.


Progesterone Levels Associate with a Novel Population of CCR5+CD38+ CD4 T Cells Resident in the Genital Mucosa with Lymphoid Trafficking Potential.

Swaims-Kohlmeier A, Haaland RE, Haddad LB, Sheth AN, Evans-Strickfaden T, Lupo LD, Cordes S, Aguirre AJ, Lupoli KA, Chen CY, Ofotukun I, Hart CE, Kohlmeier JE.

J Immunol. 2016 Jul 1;197(1):368-76. doi: 10.4049/jimmunol.1502628. Epub 2016 May 27.


Viable RNaseH1 knockout mice show RNaseH1 is essential for R loop processing, mitochondrial and liver function.

Lima WF, Murray HM, Damle SS, Hart CE, Hung G, De Hoyos CL, Liang XH, Crooke ST.

Nucleic Acids Res. 2016 Jun 20;44(11):5299-312. doi: 10.1093/nar/gkw350. Epub 2016 Apr 29.


Hawksbill turtle terra incognita: conservation genetics of eastern Pacific rookeries.

Gaos AR, Lewison RL, Liles MJ, Gadea V, Altamirano E, Henríquez AV, Torres P, Urteaga J, Vallejo F, Baquero A, LeMarie C, Muñoz JP, Chaves JA, Hart CE, Peña de Niz A, Chácon D, Fonseca L, Otterstrom S, Yañez IL, LaCasella EL, Frey A, Jensen MP, Dutton PH.

Ecol Evol. 2016 Jan 28;6(4):1251-64. doi: 10.1002/ece3.1897. eCollection 2016 Feb.


Two consecutive partial liver transplants in a patient with Classic Maple Syrup Urine Disease.

Chin HL, Aw MM, Quak SH, Huang J, Hart CE, Prabhakaran K, Goh DL.

Mol Genet Metab Rep. 2015 Jul 12;4:49-52. doi: 10.1016/j.ymgmr.2015.06.003. eCollection 2015 Sep.


Hepatotoxicity of high affinity gapmer antisense oligonucleotides is mediated by RNase H1 dependent promiscuous reduction of very long pre-mRNA transcripts.

Burel SA, Hart CE, Cauntay P, Hsiao J, Machemer T, Katz M, Watt A, Bui HH, Younis H, Sabripour M, Freier SM, Hung G, Dan A, Prakash TP, Seth PP, Swayze EE, Bennett CF, Crooke ST, Henry SP.

Nucleic Acids Res. 2016 Mar 18;44(5):2093-109. doi: 10.1093/nar/gkv1210. Epub 2015 Nov 8.


Partial Hepatectomy Induced Long Noncoding RNA Inhibits Hepatocyte Proliferation during Liver Regeneration.

Huang L, Damle SS, Booten S, Singh P, Sabripour M, Hsu J, Jo M, Katz M, Watt A, Hart CE, Freier SM, Monia BP, Guo S.

PLoS One. 2015 Jul 24;10(7):e0132798. doi: 10.1371/journal.pone.0132798. eCollection 2015.


Multinational tagging efforts illustrate regional scale of distribution and threats for east pacific green turtles (Chelonia mydas agassizii).

Hart CE, Blanco GS, Coyne MS, Delgado-Trejo C, Godley BJ, Jones TT, Resendiz A, Seminoff JA, Witt MJ, Nichols WJ.

PLoS One. 2015 Feb 3;10(2):e0116225. doi: 10.1371/journal.pone.0116225. eCollection 2015.


Synthesis, biophysical properties and biological activity of second generation antisense oligonucleotides containing chiral phosphorothioate linkages.

Wan WB, Migawa MT, Vasquez G, Murray HM, Nichols JG, Gaus H, Berdeja A, Lee S, Hart CE, Lima WF, Swayze EE, Seth PP.

Nucleic Acids Res. 2014 Dec 16;42(22):13456-68. doi: 10.1093/nar/gku1115. Epub 2014 Nov 14.


Trace elements in blood of sea turtles Lepidochelys olivacea in the Gulf of California, Mexico.

Zavala-Norzagaray AA, Ley-Quiñónez CP, Espinosa-Carreón TL, Canizalez-Román A, Hart CE, Aguirre AA.

Bull Environ Contam Toxicol. 2014 Nov;93(5):536-41. doi: 10.1007/s00128-014-1320-8. Epub 2014 Jun 24.


Selected heavy metals and selenium in the blood of black sea turtle (Chelonia mydas agasiizzi) from Sonora, Mexico.

Ley-Quiñónez CP, Zavala-Norzagaray AA, Réndon-Maldonado JG, Espinosa-Carreón TL, Canizales-Román A, Escobedo-Urías DC, Leal-Acosta ML, Hart CE, Aguirre AA.

Bull Environ Contam Toxicol. 2013 Dec;91(6):645-51. doi: 10.1007/s00128-013-1114-4. Epub 2013 Sep 27.


Transfection of siRNAs can alter miRNA levels and trigger non-specific protein degradation in mammalian cells.

Liang XH, Hart CE, Crooke ST.

Biochim Biophys Acta. 2013 May;1829(5):455-68. doi: 10.1016/j.bbagrm.2013.01.011. Epub 2013 Feb 8.


Carrageenan-based gel retains limited anti-HIV-1 activity 8-24 hours after vaginal application by HIV-infected Thai women enrolled in a phase I safety trial.

Haaland RE, Chaowanachan T, Evans-Strickfaden T, van de Wijgert JH, Kilmarx PH, McLean CA, Hart CE.

J Acquir Immune Defic Syndr. 2012 Dec 15;61(5):e71-3. doi: 10.1097/QAI.0b013e318271c8f9. No abstract available.


Staphylococcal Cassette Chromosome mec type and antibiotic susceptibility profiles of vaginal and nonvaginal MRSA clinical isolates.

Chadwick SG, Hart CE, Mordechai E, Adelson ME, Gygax SE.

Diagn Microbiol Infect Dis. 2012 Oct;74(2):210-2. doi: 10.1016/j.diagmicrobio.2012.06.016. Epub 2012 Aug 4.


Dermagraft: Use in the Treatment of Chronic Wounds.

Hart CE, Loewen-Rodriguez A, Lessem J.

Adv Wound Care (New Rochelle). 2012 Jun;1(3):138-141.


Bikram yoga training and physical fitness in healthy young adults.

Tracy BL, Hart CE.

J Strength Cond Res. 2013 Mar;27(3):822-30. doi: 10.1519/JSC.0b013e31825c340f.


UC781 microbicide gel retains anti-HIV activity in cervicovaginal lavage fluids collected following twice-daily vaginal application.

Haaland RE, Evans-Strickfaden T, Holder A, Pau CP, McNicholl JM, Chaikummao S, Chonwattana W, Hart CE.

Antimicrob Agents Chemother. 2012 Jul;56(7):3592-6. doi: 10.1128/AAC.00452-12. Epub 2012 Apr 16.


Female genital tract shedding of CXCR4-tropic HIV Type 1 is associated with a majority population of CXCR4-tropic HIV Type 1 in blood and declining CD4(+) cell counts.

Haaland RE, Sullivan ST, Evans-Strickfaden T, Lennox JL, Hart CE.

AIDS Res Hum Retroviruses. 2012 Nov;28(11):1524-32. doi: 10.1089/AID.2012.0004. Epub 2012 Mar 23.


Role of donor genital tract HIV-1 diversity in the transmission bottleneck.

Boeras DI, Hraber PT, Hurlston M, Evans-Strickfaden T, Bhattacharya T, Giorgi EE, Mulenga J, Karita E, Korber BT, Allen S, Hart CE, Derdeyn CA, Hunter E.

Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):E1156-63. doi: 10.1073/pnas.1103764108. Epub 2011 Nov 7.


HIV-1 RNA rectal shedding is reduced in men with low plasma HIV-1 RNA viral loads and is not enhanced by sexually transmitted bacterial infections of the rectum.

Kelley CF, Haaland RE, Patel P, Evans-Strickfaden T, Farshy C, Hanson D, Mayer K, Lennox JL, Brooks JT, Hart CE.

J Infect Dis. 2011 Sep 1;204(5):761-7. doi: 10.1093/infdis/jir400.


Helicos single-molecule sequencing of bacterial genomes.

Steinmann KE, Hart CE, Thompson JF, Milos PM.

Methods Mol Biol. 2011;733:3-24. doi: 10.1007/978-1-61779-089-8_1.


Preclinical Toxicology Studies of Recombinant Human Platelet-Derived Growth Factor-BB Either Alone or in Combination with Beta-Tricalcium Phosphate and Type I Collagen.

Young CS, Bradica G, Hart CE, Karunanidhi A, Street RM, Schutte L, Hollinger JO.

J Tissue Eng. 2011 Jan 10;2010:246215. doi: 10.4061/2010/246215.


Paternally induced transgenerational environmental reprogramming of metabolic gene expression in mammals.

Carone BR, Fauquier L, Habib N, Shea JM, Hart CE, Li R, Bock C, Li C, Gu H, Zamore PD, Meissner A, Weng Z, Hofmann HA, Friedman N, Rando OJ.

Cell. 2010 Dec 23;143(7):1084-96. doi: 10.1016/j.cell.2010.12.008.


Field experience in implementing ISO 15189 in Kisumu, Kenya.

Zeh CE, Inzaule SC, Magero VO, Thomas TK, Laserson KF, Hart CE, Nkengasong JN; KEMRI/CDC HIV Research Laboratory.

Am J Clin Pathol. 2010 Sep;134(3):410-8. doi: 10.1309/AJCPZIRKDUS5LK2D.


Lack of effect of compartmentalized drug resistance mutations on HIV-1 pol divergence in antiretroviral-experienced women.

Kelley CF, Sullivan ST, Lennox JL, Evans-Strickfaden T, Hart CE.

AIDS. 2010 Jun 1;24(9):1361-6. doi: 10.1097/QAD.0b013e3283394f3f.


Use of an alarm pheromone against ants for gaining access to aphid/scale prey by the red velvet mite Balaustium sp. (Erythraeidae) in a honeydew-rich environment.

Yoder JA, Condon MR, Hart CE, Collier MH, Patrick KR, Benoit JB.

J Exp Biol. 2010 Feb 1;213(3):386-92. doi: 10.1242/jeb.035642.


Recombinant human platelet-derived growth factor-BB augmentation of new-bone formation in a rat model of distraction osteogenesis.

Moore DC, Ehrlich MG, McAllister SC, Machan JT, Hart CE, Voigt C, Lesieur-Brooks AM, Weber EW.

J Bone Joint Surg Am. 2009 Aug;91(8):1973-84. doi: 10.2106/JBJS.H.00540.


Release, biological potency, and biochemical integrity of recombinant human platelet-derived growth factor-BB (rhPDGF-BB) combined with Augment(TM) Bone Graft or GEM 21S beta-tricalcium phosphate (beta-TCP).

Young CS, Ladd PA, Browning CF, Thompson A, Bonomo J, Shockley K, Hart CE.

J Control Release. 2009 Dec 16;140(3):250-5. doi: 10.1016/j.jconrel.2009.06.030. Epub 2009 Jul 3.


Recombinant human platelet-derived growth factor BB (rhPDGF-BB) and beta-tricalcium phosphate/collagen matrix enhance fracture healing in a diabetic rat model.

Al-Zube L, Breitbart EA, O'Connor JP, Parsons JR, Bradica G, Hart CE, Lin SS.

J Orthop Res. 2009 Aug;27(8):1074-81. doi: 10.1002/jor.20842.


Yoga as steadiness training: effects on motor variability in young adults.

Hart CE, Tracy BL.

J Strength Cond Res. 2008 Sep;22(5):1659-69. doi: 10.1519/JSC.0b013e31818200dd.


Recombinant human platelet-derived growth factor: biology and clinical applications.

Hollinger JO, Hart CE, Hirsch SN, Lynch S, Friedlaender GE.

J Bone Joint Surg Am. 2008 Feb;90 Suppl 1:48-54. doi: 10.2106/JBJS.G.01231. Review.


Carraguard Vaginal Gel Safety in HIV-Positive Women and Men in South Africa.

van de Wijgert JH, Braunstein SL, Morar NS, Jones HE, Madurai L, Strickfaden TT, Moodley M, Aboobaker J, Ndlovu G, Ferguson TM, Friedland BA, Hart CE, Ramjee G.

J Acquir Immune Defic Syndr. 2007 Dec 15;46(5):538-46.


Phosphoserine aminotransferase deficiency: a novel disorder of the serine biosynthesis pathway.

Hart CE, Race V, Achouri Y, Wiame E, Sharrard M, Olpin SE, Watkinson J, Bonham JR, Jaeken J, Matthijs G, Van Schaftingen E.

Am J Hum Genet. 2007 May;80(5):931-7. Epub 2007 Mar 30.


Connectivity in the yeast cell cycle transcription network: inferences from neural networks.

Hart CE, Mjolsness E, Wold BJ.

PLoS Comput Biol. 2006 Dec 22;2(12):e169. Epub 2006 Oct 30.


Mucosal innate immune factors in the female genital tract are associated with vaginal HIV-1 shedding independent of plasma viral load.

Cummins JE, Christensen L, Lennox JL, Bush TJ, Wu Z, Malamud D, Evans-Strickfaden T, Siddig A, Caliendo AM, Hart CE, Dezzutti CS.

AIDS Res Hum Retroviruses. 2006 Aug;22(8):788-95.


Mining gene expression data by interpreting principal components.

Roden JC, King BW, Trout D, Mortazavi A, Wold BJ, Hart CE.

BMC Bioinformatics. 2006 Apr 7;7:194.

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