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Items: 1 to 50 of 81

1.

Identification of RIPK3 Type II Inhibitors Using High-Throughput Mechanistic Studies in Hit Triage.

Hart AC, Abell L, Guo J, Mertzman ME, Padmanabha R, Macor JE, Chaudhry C, Lu H, O'Malley K, Shaw PJ, Weigelt C, Pokross M, Kish K, Kim KS, Cornelius L, Douglas AE, Calambur D, Zhang P, Carpenter B, Pitts WJ.

ACS Med Chem Lett. 2019 May 6;11(3):266-271. doi: 10.1021/acsmedchemlett.9b00065. eCollection 2020 Mar 12.

PMID:
32184955
2.

Heat-Triggered Remote Control of CRISPR-dCas9 for Tunable Transcriptional Modulation.

Gamboa L, Phung EV, Li H, Meyers JP, Hart AC, Miller IC, Kwong GA.

ACS Chem Biol. 2020 Feb 21;15(2):533-542. doi: 10.1021/acschembio.9b01005. Epub 2020 Jan 13.

3.

WormCat: An Online Tool for Annotation and Visualization of Caenorhabditis elegans Genome-Scale Data.

Holdorf AD, Higgins DP, Hart AC, Boag PR, Pazour GJ, Walhout AJM, Walker AK.

Genetics. 2020 Feb;214(2):279-294. doi: 10.1534/genetics.119.302919. Epub 2019 Dec 6.

PMID:
31810987
4.

A pilot prospective study of sleep patterns and DNA methylation-characterized epigenetic aging in young adults.

Carskadon MA, Chappell KR, Barker DH, Hart AC, Dwyer K, Gredvig-Ardito C, Starr C, McGeary JE.

BMC Res Notes. 2019 Sep 16;12(1):583. doi: 10.1186/s13104-019-4633-1.

5.

Meta-analysis of Genetic Modifiers Reveals Candidate Dysregulated Pathways in Amyotrophic Lateral Sclerosis.

Yanagi KS, Wu Z, Amaya J, Chapkis N, Duffy AM, Hajdarovic KH, Held A, Mathur AD, Russo K, Ryan VH, Steinert BL, Whitt JP, Fallon JR, Fawzi NL, Lipscombe D, Reenan RA, Wharton KA, Hart AC.

Neuroscience. 2019 Jan 1;396:A3-A20. doi: 10.1016/j.neuroscience.2018.10.033.

6.

Gap Junctions and NCA Cation Channels Are Critical for Developmentally Timed Sleep and Arousal in Caenorhabditis elegans.

Huang H, Hayden DJ, Zhu CT, Bennett HL, Venkatachalam V, Skuja LL, Hart AC.

Genetics. 2018 Dec;210(4):1369-1381. doi: 10.1534/genetics.118.301551. Epub 2018 Oct 15.

7.

Single copy/knock-in models of ALS SOD1 in C. elegans suggest loss and gain of function have different contributions to cholinergic and glutamatergic neurodegeneration.

Baskoylu SN, Yersak J, O'Hern P, Grosser S, Simon J, Kim S, Schuch K, Dimitriadi M, Yanagi KS, Lins J, Hart AC.

PLoS Genet. 2018 Oct 8;14(10):e1007682. doi: 10.1371/journal.pgen.1007682. eCollection 2018 Oct.

8.

A V-to-F substitution in SK2 channels causes Ca2+ hypersensitivity and improves locomotion in a C. elegans ALS model.

Nam YW, Baskoylu SN, Gazgalis D, Orfali R, Cui M, Hart AC, Zhang M.

Sci Rep. 2018 Jul 16;8(1):10749. doi: 10.1038/s41598-018-28783-2.

9.

LIN-12/Notch Regulates GABA Signaling at the Caenorhabditis elegans Neuromuscular Junction.

Sorkaç A, DiIorio MA, O'Hern PJ, Baskoylu SN, Graham HK, Hart AC.

G3 (Bethesda). 2018 Jul 31;8(8):2825-2832. doi: 10.1534/g3.118.200202.

10.

Normal sleep bouts are not essential for C. elegans survival and FoxO is important for compensatory changes in sleep.

Bennett HL, Khoruzhik Y, Hayden D, Huang H, Sanders J, Walsh MB, Biron D, Hart AC.

BMC Neurosci. 2018 Mar 9;19(1):10. doi: 10.1186/s12868-018-0408-1.

11.

Development of a series of novel o-phenylenediamine-based indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors.

Williams DK, Markwalder JA, Balog AJ, Chen B, Chen L, Donnell J, Haque L, Hart AC, Mandal SK, Nation A, Shan W, Vite GD, Covello K, Hunt JT, Jure-Kunkel MN, Seitz SP.

Bioorg Med Chem Lett. 2018 Feb 15;28(4):732-736. doi: 10.1016/j.bmcl.2018.01.010. Epub 2018 Jan 11.

PMID:
29398543
12.

Macrophage activation syndrome and post-transplant microangiopathy following haploidentical bone marrow transplantation for sickle cell anemia.

Davies JOJ, Hart AC, De La Fuente J, Bain BJ.

Am J Hematol. 2018 Aug;93(4):588-589. doi: 10.1002/ajh.24995. Epub 2017 Dec 18. No abstract available.

13.

Measuring Caenorhabditis elegans Sleep During the Transition to Adulthood Using a Microfluidics-based System.

Huang H, Singh K, Hart AC.

Bio Protoc. 2017 Mar 20;7(6). pii: e2174. doi: 10.21769/BioProtoc.2174.

14.

Genome-Wide Screen for Genes Involved in Caenorhabditis elegans Developmentally Timed Sleep.

Huang H, Zhu CT, Skuja LL, Hayden DJ, Hart AC.

G3 (Bethesda). 2017 Sep 7;7(9):2907-2917. doi: 10.1534/g3.117.300071.

15.

Decreased microRNA levels lead to deleterious increases in neuronal M2 muscarinic receptors in Spinal Muscular Atrophy models.

O'Hern PJ, do Carmo G Gonçalves I, Brecht J, López Soto EJ, Simon J, Chapkis N, Lipscombe D, Kye MJ, Hart AC.

Elife. 2017 May 2;6. pii: e20752. doi: 10.7554/eLife.20752.

16.

Combining Human Epigenetics and Sleep Studies in Caenorhabditis elegans: A Cross-Species Approach for Finding Conserved Genes Regulating Sleep.

Huang H, Zhu Y, Eliot MN, Knopik VS, McGeary JE, Carskadon MA, Hart AC.

Sleep. 2017 Jun 1;40(6). doi: 10.1093/sleep/zsx063.

17.

What's Your Position? Strategies for Safely Reaching Patient Comfort Goals After Cardiac Catheterization via Femoral Approach.

Suggs PM, Lewis R, Hart AC, Troutman-Jordan M, Hardin SR.

Dimens Crit Care Nurs. 2017 Mar/Apr;36(2):87-93. doi: 10.1097/DCC.0000000000000232.

PMID:
28151785
18.

Neurocalcin Delta Suppression Protects against Spinal Muscular Atrophy in Humans and across Species by Restoring Impaired Endocytosis.

Riessland M, Kaczmarek A, Schneider S, Swoboda KJ, Löhr H, Bradler C, Grysko V, Dimitriadi M, Hosseinibarkooie S, Torres-Benito L, Peters M, Upadhyay A, Biglari N, Kröber S, Hölker I, Garbes L, Gilissen C, Hoischen A, Nürnberg G, Nürnberg P, Walter M, Rigo F, Bennett CF, Kye MJ, Hart AC, Hammerschmidt M, Kloppenburg P, Wirth B.

Am J Hum Genet. 2017 Feb 2;100(2):297-315. doi: 10.1016/j.ajhg.2017.01.005. Epub 2017 Jan 26.

19.

In Vivo Modelling of ATP1A3 G316S-Induced Ataxia in C. elegans Using CRISPR/Cas9-Mediated Homologous Recombination Reveals Dominant Loss of Function Defects.

Sorkaç A, Alcantara IC, Hart AC.

PLoS One. 2016 Dec 9;11(12):e0167963. doi: 10.1371/journal.pone.0167963. eCollection 2016.

20.

Decreased function of survival motor neuron protein impairs endocytic pathways.

Dimitriadi M, Derdowski A, Kalloo G, Maginnis MS, O'Hern P, Bliska B, Sorkaç A, Nguyen KC, Cook SJ, Poulogiannis G, Atwood WJ, Hall DH, Hart AC.

Proc Natl Acad Sci U S A. 2016 Jul 26;113(30):E4377-86. doi: 10.1073/pnas.1600015113. Epub 2016 Jul 11.

21.

C. elegans lifespan extension by osmotic stress requires FUdR, base excision repair, FOXO, and sirtuins.

Anderson EN, Corkins ME, Li JC, Singh K, Parsons S, Tucey TM, Sorkaç A, Huang H, Dimitriadi M, Sinclair DA, Hart AC.

Mech Ageing Dev. 2016 Mar;154:30-42. doi: 10.1016/j.mad.2016.01.004. Epub 2016 Feb 22.

22.

A Conserved GEF for Rho-Family GTPases Acts in an EGF Signaling Pathway to Promote Sleep-like Quiescence in Caenorhabditis elegans.

Fry AL, Laboy JT, Huang H, Hart AC, Norman KR.

Genetics. 2016 Mar;202(3):1153-66. doi: 10.1534/genetics.115.183038. Epub 2016 Jan 22.

23.

Discovery of a Highly Selective JAK2 Inhibitor, BMS-911543, for the Treatment of Myeloproliferative Neoplasms.

Wan H, Schroeder GM, Hart AC, Inghrim J, Grebinski J, Tokarski JS, Lorenzi MV, You D, Mcdevitt T, Penhallow B, Vuppugalla R, Zhang Y, Gu X, Iyer R, Lombardo LJ, Trainor GL, Ruepp S, Lippy J, Blat Y, Sack JS, Khan JA, Stefanski K, Sleczka B, Mathur A, Sun JH, Wong MK, Wu DR, Li P, Gupta A, Arunachalam PN, Pragalathan B, Narayanan S, K C N, Kuppusamy P, Purandare AV.

ACS Med Chem Lett. 2015 Jul 12;6(8):850-5. doi: 10.1021/acsmedchemlett.5b00226. eCollection 2015 Aug 13.

24.

Structure-Based Design of Selective Janus Kinase 2 Imidazo[4,5-d]pyrrolo[2,3-b]pyridine Inhibitors.

Hart AC, Schroeder GM, Wan H, Grebinski J, Inghrim J, Kempson J, Guo J, Pitts WJ, Tokarski JS, Sack JS, Khan JA, Lippy J, Lorenzi MV, You D, McDevitt T, Vuppugalla R, Zhang Y, Lombardo LJ, Trainor GL, Purandare AV.

ACS Med Chem Lett. 2015 Jul 10;6(8):845-9. doi: 10.1021/acsmedchemlett.5b00225. eCollection 2015 Aug 13.

25.

Dietary restriction involves NAD⁺ -dependent mechanisms and a shift toward oxidative metabolism.

Moroz N, Carmona JJ, Anderson E, Hart AC, Sinclair DA, Blackwell TK.

Aging Cell. 2014 Dec;13(6):1075-85. doi: 10.1111/acel.12273. Epub 2014 Sep 25.

26.

Deep conservation of genes required for both Drosphila melanogaster and Caenorhabditis elegans sleep includes a role for dopaminergic signaling.

Singh K, Ju JY, Walsh MB, DiIorio MA, Hart AC.

Sleep. 2014 Sep 1;37(9):1439-51. doi: 10.5665/sleep.3990.

27.

Assaying mechanosensation.

Chalfie M, Hart AC, Rankin CH, Goodman MB.

WormBook. 2014 Jul 31. doi: 10.1895/wormbook.1.172.1. Review.

28.

Enhanced field emission properties from CNT arrays synthesized on Inconel superalloy.

Sridhar S, Ge L, Tiwary CS, Hart AC, Ozden S, Kalaga K, Lei S, Sridhar SV, Sinha RK, Harsh H, Kordas K, Ajayan PM, Vajtai R.

ACS Appl Mater Interfaces. 2014 Feb 12;6(3):1986-91. doi: 10.1021/am405026y. Epub 2014 Jan 13.

PMID:
24417432
29.

Genetic circuitry of Survival motor neuron, the gene underlying spinal muscular atrophy.

Sen A, Dimlich DN, Guruharsha KG, Kankel MW, Hori K, Yokokura T, Brachat S, Richardson D, Loureiro J, Sivasankaran R, Curtis D, Davidow LS, Rubin LL, Hart AC, Van Vactor D, Artavanis-Tsakonas S.

Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):E2371-80. doi: 10.1073/pnas.1301738110. Epub 2013 Jun 11.

30.

The E3 ubiquitin ligase mind bomb 1 ubiquitinates and promotes the degradation of survival of motor neuron protein.

Kwon DY, Dimitriadi M, Terzic B, Cable C, Hart AC, Chitnis A, Fischbeck KH, Burnett BG.

Mol Biol Cell. 2013 Jun;24(12):1863-71. doi: 10.1091/mbc.E13-01-0042. Epub 2013 Apr 24.

31.

The neuroprotective drug riluzole acts via small conductance Ca2+-activated K+ channels to ameliorate defects in spinal muscular atrophy models.

Dimitriadi M, Kye MJ, Kalloo G, Yersak JM, Sahin M, Hart AC.

J Neurosci. 2013 Apr 10;33(15):6557-62. doi: 10.1523/JNEUROSCI.1536-12.2013.

32.

Do C. elegans sleep? A closer look.

Singh K, Huang H, Hart AC.

Sleep. 2013 Mar 1;36(3):307-8. doi: 10.5665/sleep.2436. No abstract available.

33.

Local RNA translation at the synapse and in disease.

Liu-Yesucevitz L, Bassell GJ, Gitler AD, Hart AC, Klann E, Richter JD, Warren ST, Wolozin B.

J Neurosci. 2011 Nov 9;31(45):16086-93. doi: 10.1523/JNEUROSCI.4105-11.2011. Review.

34.

A conserved SREBP-1/phosphatidylcholine feedback circuit regulates lipogenesis in metazoans.

Walker AK, Jacobs RL, Watts JL, Rottiers V, Jiang K, Finnegan DM, Shioda T, Hansen M, Yang F, Niebergall LJ, Vance DE, Tzoneva M, Hart AC, Näär AM.

Cell. 2011 Nov 11;147(4):840-52. doi: 10.1016/j.cell.2011.09.045. Epub 2011 Oct 27.

35.

From Odors to Behaviors in Caenorhabditis elegans.

Hart AC, Chao MY.

In: Menini A, editor. The Neurobiology of Olfaction. Boca Raton (FL): CRC Press/Taylor & Francis; 2010. Chapter 1.

36.

C. elegans Notch signaling regulates adult chemosensory response and larval molting quiescence.

Singh K, Chao MY, Somers GA, Komatsu H, Corkins ME, Larkins-Ford J, Tucey T, Dionne HM, Walsh MB, Beaumont EK, Hart DP, Lockery SR, Hart AC.

Curr Biol. 2011 May 24;21(10):825-34. doi: 10.1016/j.cub.2011.04.010. Epub 2011 May 5.

37.

PKC-1 acts with the ERK MAPK signaling pathway to regulate Caenorhabditis elegans mechanosensory response.

Hyde R, Corkins ME, Somers GA, Hart AC.

Genes Brain Behav. 2011 Apr;10(3):286-98. doi: 10.1111/j.1601-183X.2010.00667.x. Epub 2011 Jan 10.

38.

Conserved genes act as modifiers of invertebrate SMN loss of function defects.

Dimitriadi M, Sleigh JN, Walker A, Chang HC, Sen A, Kalloo G, Harris J, Barsby T, Walsh MB, Satterlee JS, Li C, Van Vactor D, Artavanis-Tsakonas S, Hart AC.

PLoS Genet. 2010 Oct 28;6(10):e1001172. doi: 10.1371/journal.pgen.1001172.

39.

Motoneurons dedicated to either forward or backward locomotion in the nematode Caenorhabditis elegans.

Haspel G, O'Donovan MJ, Hart AC.

J Neurosci. 2010 Aug 18;30(33):11151-6. doi: 10.1523/JNEUROSCI.2244-10.2010.

40.

Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP.

Walker AK, Yang F, Jiang K, Ji JY, Watts JL, Purushotham A, Boss O, Hirsch ML, Ribich S, Smith JJ, Israelian K, Westphal CH, Rodgers JT, Shioda T, Elson SL, Mulligan P, Najafi-Shoushtari H, Black JC, Thakur JK, Kadyk LC, Whetstine JR, Mostoslavsky R, Puigserver P, Li X, Dyson NJ, Hart AC, Näär AM.

Genes Dev. 2010 Jul 1;24(13):1403-17. doi: 10.1101/gad.1901210.

41.

Neurodegenerative disorders: insights from the nematode Caenorhabditis elegans.

Dimitriadi M, Hart AC.

Neurobiol Dis. 2010 Oct;40(1):4-11. doi: 10.1016/j.nbd.2010.05.012. Epub 2010 May 19. Review.

42.

Estimating Individual-Level Risk in Spatial Epidemiology Using Spatially Aggregated Information on the Population at Risk.

Diggle PJ, Guan Y, Hart AC, Paize F, Stanton M.

J Am Stat Assoc. 2010;105(492):1394-1402. Epub 2012 Jan 1.

43.

Optical interrogation of neural circuits in Caenorhabditis elegans.

Guo ZV, Hart AC, Ramanathan S.

Nat Methods. 2009 Dec;6(12):891-6. doi: 10.1038/nmeth.1397. Epub 2009 Nov 8.

44.

Acetylation targets mutant huntingtin to autophagosomes for degradation.

Jeong H, Then F, Melia TJ Jr, Mazzulli JR, Cui L, Savas JN, Voisine C, Paganetti P, Tanese N, Hart AC, Yamamoto A, Krainc D.

Cell. 2009 Apr 3;137(1):60-72. doi: 10.1016/j.cell.2009.03.018.

45.

Modeling spinal muscular atrophy in Drosophila.

Chang HC, Dimlich DN, Yokokura T, Mukherjee A, Kankel MW, Sen A, Sridhar V, Fulga TA, Hart AC, Van Vactor D, Artavanis-Tsakonas S.

PLoS One. 2008 Sep 15;3(9):e3209. doi: 10.1371/journal.pone.0003209.

46.

OSM-11 facilitates LIN-12 Notch signaling during Caenorhabditis elegans vulval development.

Komatsu H, Chao MY, Larkins-Ford J, Corkins ME, Somers GA, Tucey T, Dionne HM, White JQ, Wani K, Boxem M, Hart AC.

PLoS Biol. 2008 Aug 12;6(8):e196. doi: 10.1371/journal.pbio.0060196.

47.

Inhibitors of metabolism rescue cell death in Huntington's disease models.

Varma H, Cheng R, Voisine C, Hart AC, Stockwell BR.

Proc Natl Acad Sci U S A. 2007 Sep 4;104(36):14525-30. Epub 2007 Aug 28.

48.

Identification of potential therapeutic drugs for huntington's disease using Caenorhabditis elegans.

Voisine C, Varma H, Walker N, Bates EA, Stockwell BR, Hart AC.

PLoS One. 2007 Jun 6;2(6):e504.

49.

C. elegans G protein regulator RGS-3 controls sensitivity to sensory stimuli.

Ferkey DM, Hyde R, Haspel G, Dionne HM, Hess HA, Suzuki H, Schafer WR, Koelle MR, Hart AC.

Neuron. 2007 Jan 4;53(1):39-52.

50.

Selective inhibitors of death in mutant huntingtin cells.

Varma H, Voisine C, DeMarco CT, Cattaneo E, Lo DC, Hart AC, Stockwell BR.

Nat Chem Biol. 2007 Feb;3(2):99-100. Epub 2006 Dec 31.

PMID:
17195849

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