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Persistence of tumor necrosis factor inhibitor or conventional synthetic disease-modifying antirheumatic drug monotherapy or combination therapy in psoriatic arthritis in a real-world setting.

Mease PJ, Accortt NA, Rebello S, Etzel CJ, Harrison RW, Aras GA, Gharaibeh MMF, Greenberg JD, Collier DH.

Rheumatol Int. 2019 Sep;39(9):1547-1558. doi: 10.1007/s00296-019-04345-1. Epub 2019 Jul 18.


Highly Drug-Resistant HIV-1 Protease Mutant PRS17 Shows Enhanced Binding to Substrate Analogues.

Agniswamy J, Kneller DW, Brothers R, Wang YF, Harrison RW, Weber IT.

ACS Omega. 2019 May 31;4(5):8707-8719. doi: 10.1021/acsomega.9b00683. Epub 2019 May 17.


Response to "Be alert to leukocyte antibodies when prescribing granulocyte transfusions".

Price TH, McCullough J, Strauss RG, Ness PM, Hamza TH, Harrison RW, Assmann SF.

Transfusion. 2019 Jun;59(6):2174-2175. doi: 10.1111/trf.15258. No abstract available.


Structural studies of antiviral inhibitor with HIV-1 protease bearing drug resistant substitutions of V32I, I47V and V82I.

Pawar S, Wang YF, Wong-Sam A, Agniswamy J, Ghosh AK, Harrison RW, Weber IT.

Biochem Biophys Res Commun. 2019 Jun 30;514(3):974-978. doi: 10.1016/j.bbrc.2019.05.064. Epub 2019 May 12.


Rivaroxaban in Acute Coronary Syndromes: We Have a Compass and an Atlas, But Where Are We Headed?

Harrison RW, Newby LK.

J Am Heart Assoc. 2019 Mar 5;8(5):e012014. doi: 10.1161/JAHA.119.012014.


Frequency, Regional Variation, and Predictors of Undetermined Cause of Death in Cardiometabolic Clinical Trials: A Pooled Analysis of 9259 Deaths in 9 Trials.

Fanaroff AC, Clare R, Pieper KS, Mahaffey KW, Melloni C, Green JB, Alexander JH, Jones WS, Harrison RW, Mehta RH, Povsic TJ, Moreira HG, Al-Khatib SM, Roe MT, Kong DF, Mathews R, Tricoci P, Holman RR, Wallentin L, Held C, Califf RM, Alexander KP, Lopes RD.

Circulation. 2019 Feb 12;139(7):863-873. doi: 10.1161/CIRCULATIONAHA.118.037202.


Enhanced Radiation Tolerance of Tungsten Nanoparticles to He Ion Irradiation.

Aradi E, Lewis-Fell J, Harrison RW, Greaves G, Mir AH, Donnelly SE, Hinks JA.

Nanomaterials (Basel). 2018 Dec 14;8(12). pii: E1052. doi: 10.3390/nano8121052.


Analysis of drug resistance in HIV protease.

Pawar SD, Freas C, Weber IT, Harrison RW.

BMC Bioinformatics. 2018 Oct 22;19(Suppl 11):362. doi: 10.1186/s12859-018-2331-y.


The East-West late lumen loss study: Comparison of angiographic late lumen loss between Eastern and Western drug-eluting stent study cohorts.

Harrison RW, Radhakrishnan V, Allen JC Jr, Lam PS, Allocco DJ, Brar S, Fahy M, Zhang Z, Fisher R, Ikeno F, Généreux P, Kimura T, Liu M, Lye WK, Nagai H, Suzuki Y, White R, Krucoff MW.

Am Heart J. 2018 Dec;206:61-71. doi: 10.1016/j.ahj.2018.08.017. Epub 2018 Sep 7.


Drug Resistance Mutation L76V Alters Nonpolar Interactions at the Flap-Core Interface of HIV-1 Protease.

Wong-Sam A, Wang YF, Zhang Y, Ghosh AK, Harrison RW, Weber IT.

ACS Omega. 2018 Sep 30;3(9):12132-12140. doi: 10.1021/acsomega.8b01683. Epub 2018 Sep 27.


Ion-beam-induced bending of semiconductor nanowires.

Hanif I, Camara O, Tunes MA, Harrison RW, Greaves G, Donnelly SE, Hinks JA.

Nanotechnology. 2018 Aug 17;29(33):335701. doi: 10.1088/1361-6528/aac659. Epub 2018 May 21.


WBC alloimmunization: effects on the laboratory and clinical endpoints of therapeutic granulocyte transfusions.

Price TH, McCullough J, Strauss RG, Ness PM, Hamza TH, Harrison RW, Assmann SF.

Transfusion. 2018 May;58(5):1280-1288. doi: 10.1111/trf.14551. Epub 2018 Mar 1.


No Obesity Paradox in Pediatric Patients With Dilated Cardiomyopathy.

Castleberry CD, Jefferies JL, Shi L, Wilkinson JD, Towbin JA, Harrison RW, Rossano JW, Pahl E, Lee TM, Addonizio LJ, Everitt MD, Godown J, Mahgerefteh J, Rusconi P, Canter CE, Colan SD, Kantor PF, Razoky H, Lipshultz SE, Miller TL.

JACC Heart Fail. 2018 Mar;6(3):222-230. doi: 10.1016/j.jchf.2017.11.015. Epub 2018 Feb 7.


Engineering self-organising helium bubble lattices in tungsten.

Harrison RW, Greaves G, Hinks JA, Donnelly SE.

Sci Rep. 2017 Aug 10;7(1):7724. doi: 10.1038/s41598-017-07711-w.


Decoding HIV resistance: from genotype to therapy.

Weber IT, Harrison RW.

Future Med Chem. 2017 Sep;9(13):1529-1538. doi: 10.4155/fmc-2017-0048. Epub 2017 Aug 9. Review.


Laboratory predictors of bleeding and the effect of platelet and RBC transfusions on bleeding outcomes in the PLADO trial.

Uhl L, Assmann SF, Hamza TH, Harrison RW, Gernsheimer T, Slichter SJ.

Blood. 2017 Sep 7;130(10):1247-1258. doi: 10.1182/blood-2017-01-757930. Epub 2017 Jul 5.


Levosimendan in Patients with Left Ventricular Dysfunction Undergoing Cardiac Surgery.

Mehta RH, Leimberger JD, van Diepen S, Meza J, Wang A, Jankowich R, Harrison RW, Hay D, Fremes S, Duncan A, Soltesz EG, Luber J, Park S, Argenziano M, Murphy E, Marcel R, Kalavrouziotis D, Nagpal D, Bozinovski J, Toller W, Heringlake M, Goodman SG, Levy JH, Harrington RA, Anstrom KJ, Alexander JH; LEVO-CTS Investigators.

N Engl J Med. 2017 May 25;376(21):2032-2042. doi: 10.1056/NEJMoa1616218. Epub 2017 Mar 19.


Tackling the problem of HIV drug resistance.

Weber IT, Harrison RW.

Postepy Biochem. 2016;62(3):273-279. Review.


Structural Studies of a Rationally Selected Multi-Drug Resistant HIV-1 Protease Reveal Synergistic Effect of Distal Mutations on Flap Dynamics.

Agniswamy J, Louis JM, Roche J, Harrison RW, Weber IT.

PLoS One. 2016 Dec 16;11(12):e0168616. doi: 10.1371/journal.pone.0168616. eCollection 2016.


Levosimendan in patients with left ventricular systolic dysfunction undergoing cardiac surgery on cardiopulmonary bypass: Rationale and study design of the Levosimendan in Patients with Left Ventricular Systolic Dysfunction Undergoing Cardiac Surgery Requiring Cardiopulmonary Bypass (LEVO-CTS) trial.

Mehta RH, Van Diepen S, Meza J, Bokesch P, Leimberger JD, Tourt-Uhlig S, Swartz M, Parrotta J, Jankowich R, Hay D, Harrison RW, Fremes S, Goodman SG, Luber J, Toller W, Heringlake M, Anstrom KJ, Levy JH, Harrington RA, Alexander JH; LEVO-CTS Investigators.

Am Heart J. 2016 Dec;182:62-71. doi: 10.1016/j.ahj.2016.09.001. Epub 2016 Sep 9.


Rationale and design of the East-West late lumen loss study: Comparison of late lumen loss between Eastern and Western drug-eluting stent study cohorts.

Harrison RW, Radhakrishnan V, Lam PS, Allocco DJ, Brar S, Fahy M, Fisher R, Ikeno F, Généreux P, Kimura T, Liu M, Lye WK, Mintz GS, Nagai H, Suzuki Y, White R, Allen JC Jr, Krucoff MW.

Am Heart J. 2016 Dec;182:103-110. doi: 10.1016/j.ahj.2016.07.011. Epub 2016 Aug 3.


Trends in Bare-Metal Stent Use in the United States in Patients Aged ≥65 Years (from the CathPCI Registry).

Rymer JA, Harrison RW, Dai D, Roe MT, Messenger JC, Anderson HV, Peterson ED, Wang TY.

Am J Cardiol. 2016 Oct 1;118(7):959-66. doi: 10.1016/j.amjcard.2016.06.061. Epub 2016 Jul 18.


Automated prediction of HIV drug resistance from genotype data.

Shen C, Yu X, Harrison RW, Weber IT.

BMC Bioinformatics. 2016 Aug 31;17 Suppl 8:278. doi: 10.1186/s12859-016-1114-6.


Association of hospital myocardial infarction volume with adherence to American College of Cardiology/American Heart Association performance measures: Insights from the National Cardiovascular Data Registry.

Harrison RW, Simon D, Miller AL, de Lemos JA, Peterson ED, Wang TY.

Am Heart J. 2016 Aug;178:95-101. doi: 10.1016/j.ahj.2016.04.002. Epub 2016 Apr 13.


Binding of Clinical Inhibitors to a Model Precursor of a Rationally Selected Multidrug Resistant HIV-1 Protease Is Significantly Weaker Than That to the Released Mature Enzyme.

Park JH, Sayer JM, Aniana A, Yu X, Weber IT, Harrison RW, Louis JM.

Biochemistry. 2016 Apr 26;55(16):2390-400. doi: 10.1021/acs.biochem.6b00012. Epub 2016 Apr 15.


Identifying representative drug resistant mutants of HIV.

Yu X, Weber IT, Harrison RW.

BMC Bioinformatics. 2015;16 Suppl 17:S1. doi: 10.1186/1471-2105-16-S17-S1. Epub 2015 Dec 7.


Lost to Follow-up and Withdrawal of Consent in Contemporary Global Cardiovascular Randomized Clinical Trials.

Rodriguez F, Harrison RW, Wojdyla D, Mahaffey KW.

Crit Pathw Cardiol. 2015 Dec;14(4):150-3. doi: 10.1097/HPC.0000000000000055. Review.


Conformational variation of an extreme drug resistant mutant of HIV protease.

Shen CH, Chang YC, Agniswamy J, Harrison RW, Weber IT.

J Mol Graph Model. 2015 Nov;62:87-96. doi: 10.1016/j.jmgm.2015.09.006. Epub 2015 Sep 8.


Efficacy of transfusion with granulocytes from G-CSF/dexamethasone-treated donors in neutropenic patients with infection.

Price TH, Boeckh M, Harrison RW, McCullough J, Ness PM, Strauss RG, Nichols WG, Hamza TH, Cushing MM, King KE, Young JA, Williams E, McFarland J, Holter Chakrabarty J, Sloan SR, Friedman D, Parekh S, Sachais BS, Kiss JE, Assmann SF.

Blood. 2015 Oct 29;126(18):2153-61. doi: 10.1182/blood-2015-05-645986. Epub 2015 Sep 2.


Platelet aggregation and mental stress induced myocardial ischemia: Results from the Responses of Myocardial Ischemia to Escitalopram Treatment (REMIT) study.

Jiang W, Boyle SH, Ortel TL, Samad Z, Velazquez EJ, Harrison RW, Wilson J, Kuhn C, Williams RB, O'Connor CM, Becker RC.

Am Heart J. 2015 Apr;169(4):496-507.e1. doi: 10.1016/j.ahj.2014.12.002. Epub 2014 Dec 17.


FDT 2.0: Improving scalability of the fuzzy decision tree induction tool - integrating database storage.

Durham EA, Yu X, Harrison RW.

Proc IEEE Symp Comput Intell Healthc Ehealth. 2014 Dec;2014:187-190. doi: 10.1109/CICARE.2014.7007853. Epub 2015 Jan 15.


Prediction of HIV drug resistance from genotype with encoded three-dimensional protein structure.

Yu X, Weber IT, Harrison RW.

BMC Genomics. 2014;15 Suppl 5:S1. doi: 10.1186/1471-2164-15-S5-S1. Epub 2014 Jul 14.


Structures of darunavir-resistant HIV-1 protease mutant reveal atypical binding of darunavir to wide open flaps.

Zhang Y, Chang YC, Louis JM, Wang YF, Harrison RW, Weber IT.

ACS Chem Biol. 2014 Jun 20;9(6):1351-8. doi: 10.1021/cb4008875. Epub 2014 Apr 28.


Effect of levosimendan on survival and adverse events after cardiac surgery: a meta-analysis.

Harrison RW, Hasselblad V, Mehta RH, Levin R, Harrington RA, Alexander JH.

J Cardiothorac Vasc Anesth. 2013 Dec;27(6):1224-32. doi: 10.1053/j.jvca.2013.03.027. Epub 2013 Sep 16. Review.


Novel P2 tris-tetrahydrofuran group in antiviral compound 1 (GRL-0519) fills the S2 binding pocket of selected mutants of HIV-1 protease.

Zhang H, Wang YF, Shen CH, Agniswamy J, Rao KV, Xu CX, Ghosh AK, Harrison RW, Weber IT.

J Med Chem. 2013 Feb 14;56(3):1074-83. doi: 10.1021/jm301519z. Epub 2013 Jan 23.


Sparse Representation for Prediction of HIV-1 Protease Drug Resistance.

Yu X, Weber IT, Harrison RW.

Proc SIAM Int Conf Data Min. 2013;2013:342-349.


Incidence and outcomes of no-reflow phenomenon during percutaneous coronary intervention among patients with acute myocardial infarction.

Harrison RW, Aggarwal A, Ou FS, Klein LW, Rumsfeld JS, Roe MT, Wang TY; American College of Cardiology National Cardiovascular Data Registry.

Am J Cardiol. 2013 Jan 15;111(2):178-84. doi: 10.1016/j.amjcard.2012.09.015. Epub 2012 Oct 27.


Capturing the reaction pathway in near-atomic-resolution crystal structures of HIV-1 protease.

Shen CH, Tie Y, Yu X, Wang YF, Kovalevsky AY, Harrison RW, Weber IT.

Biochemistry. 2012 Oct 2;51(39):7726-32. doi: 10.1021/bi3008092. Epub 2012 Sep 21.


Reaction intermediates discovered in crystal structures of enzymes.

Weber IT, Agniswamy J, Fu G, Shen CH, Harrison RW.

Adv Protein Chem Struct Biol. 2012;87:57-86. doi: 10.1016/B978-0-12-398312-1.00003-2. Review.


To bridge or not to bridge: these are the questions.

Harrison RW, Ortel TL, Becker RC.

J Thromb Thrombolysis. 2012 Jul;34(1):31-5. doi: 10.1007/s11239-012-0732-8. Review. No abstract available.


Potent antiviral HIV-1 protease inhibitor GRL-02031 adapts to the structures of drug resistant mutants with its P1'-pyrrolidinone ring.

Chang YC, Yu X, Zhang Y, Tie Y, Wang YF, Yashchuk S, Ghosh AK, Harrison RW, Weber IT.

J Med Chem. 2012 Apr 12;55(7):3387-97. doi: 10.1021/jm300072d. Epub 2012 Mar 22.


Dynamic denitrosylation via S-nitrosoglutathione reductase regulates cardiovascular function.

Beigi F, Gonzalez DR, Minhas KM, Sun QA, Foster MW, Khan SA, Treuer AV, Dulce RA, Harrison RW, Saraiva RM, Premer C, Schulman IH, Stamler JS, Hare JM.

Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4314-9. doi: 10.1073/pnas.1113319109. Epub 2012 Feb 24.


Critical differences in HIV-1 and HIV-2 protease specificity for clinical inhibitors.

Tie Y, Wang YF, Boross PI, Chiu TY, Ghosh AK, Tozser J, Louis JM, Harrison RW, Weber IT.

Protein Sci. 2012 Mar;21(3):339-50. doi: 10.1002/pro.2019. Epub 2012 Jan 24.


Clopidogrel and PPI interaction: clinically relevant or not?

Harrison RW, Mahaffey KW.

Curr Cardiol Rep. 2012 Feb;14(1):49-58. doi: 10.1007/s11886-011-0233-y. Review.


Understandable learning machine system design for transmembrane or embedded membrane segments prediction.

Hu HJ, Harrison RW, Tai PC, Pan Y.

Int J Data Min Bioinform. 2011;5(1):38-51.


The L76V drug resistance mutation decreases the dimer stability and rate of autoprocessing of HIV-1 protease by reducing internal hydrophobic contacts.

Louis JM, Zhang Y, Sayer JM, Wang YF, Harrison RW, Weber IT.

Biochemistry. 2011 May 31;50(21):4786-95. doi: 10.1021/bi200033z. Epub 2011 May 3.


A continuous-time, discrete-state method for simulating the dynamics of biochemical systems.

Sabnis A, Harrison RW.

IEEE/ACM Trans Comput Biol Bioinform. 2011 Mar-Apr;8(2):335-41. doi: 10.1109/TCBB.2010.97.


Amprenavir complexes with HIV-1 protease and its drug-resistant mutants altering hydrophobic clusters.

Shen CH, Wang YF, Kovalevsky AY, Harrison RW, Weber IT.

FEBS J. 2010 Sep;277(18):3699-714. doi: 10.1111/j.1742-4658.2010.07771.x. Epub 2010 Aug 2.

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