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Items: 1 to 50 of 71

1.

Use of Human Induced Pluripotent Stem Cells and Kidney Organoids To Develop a Cysteamine/mTOR Inhibition Combination Therapy for Cystinosis.

Hollywood JA, Przepiorski A, D'Souza RF, Sreebhavan S, Wolvetang EJ, Harrison PT, Davidson AJ, Holm TM.

J Am Soc Nephrol. 2020 Mar 20. pii: ASN.2019070712. doi: 10.1681/ASN.2019070712. [Epub ahead of print]

PMID:
32198276
2.

Evaluating the risk to humans from mineral oils in foods: Current state of the evidence.

Bevan R, Harrison PTC, Jeffery B, Mitchell D.

Food Chem Toxicol. 2020 Feb;136:110966. doi: 10.1016/j.fct.2019.110966. Epub 2019 Nov 18. Review.

PMID:
31751646
3.

Rare epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer.

Harrison PT, Vyse S, Huang PH.

Semin Cancer Biol. 2020 Apr;61:167-179. doi: 10.1016/j.semcancer.2019.09.015. Epub 2019 Sep 25. Review.

4.

Gene and Base Editing as a Therapeutic Option for Cystic Fibrosis-Learning from Other Diseases.

Mention K, Santos L, Harrison PT.

Genes (Basel). 2019 May 21;10(5). pii: E387. doi: 10.3390/genes10050387. Review.

5.

Corrigendum to "Spatial localisation of Discoidin Domain Receptor 2 (DDR2) signalling is dependent on its collagen binding and kinase activity" [Biochem. Biophys. Res. Commun. 501 (1) (18 June 2018) 124-130].

Luczynski MT, Harrison PT, Lima N, Krasny L, Paul A, Huang PH.

Biochem Biophys Res Commun. 2018 Sep 26;504(1):360. doi: 10.1016/j.bbrc.2018.08.051. Epub 2018 Aug 22. No abstract available.

6.

Exploiting vulnerabilities in cancer signalling networks to combat targeted therapy resistance.

Harrison PT, Huang PH.

Essays Biochem. 2018 Oct 26;62(4):583-593. doi: 10.1042/EBC20180016. Print 2018 Oct 26. Review.

7.

Spatial localisation of Discoidin Domain Receptor 2 (DDR2) signalling is dependent on its collagen binding and kinase activity.

Luczynski MT, Harrison PT, Lima N, Krasny L, Paul A, Huang PH.

Biochem Biophys Res Commun. 2018 Jun 18;501(1):124-130. doi: 10.1016/j.bbrc.2018.04.191. Epub 2018 May 3. Erratum in: Biochem Biophys Res Commun. 2018 Sep 26;504(1):360.

8.

The Regulation of Monoamine Oxidase A Gene Expression by Distinct Variable Number Tandem Repeats.

Manca M, Pessoa V, Lopez AI, Harrison PT, Miyajima F, Sharp H, Pickles A, Hill J, Murgatroyd C, Bubb VJ, Quinn JP.

J Mol Neurosci. 2018 Mar;64(3):459-470. doi: 10.1007/s12031-018-1044-z. Epub 2018 Mar 14.

9.

A beginner's guide to gene editing.

Harrison PT, Hart S.

Exp Physiol. 2018 Apr 1;103(4):439-448. doi: 10.1113/EP086047. Epub 2018 Jan 25. Review.

10.

Gene editing & stem cells.

Harrison PT, Hoppe N, Martin U.

J Cyst Fibros. 2018 Jan;17(1):10-16. doi: 10.1016/j.jcf.2017.11.018. Epub 2017 Dec 9. Review. No abstract available.

PMID:
29233638
11.

Genetic therapies for cystic fibrosis lung disease.

Hart SL, Harrison PT.

Curr Opin Pharmacol. 2017 Jun;34:119-124. doi: 10.1016/j.coph.2017.10.006. Epub 2017 Nov 5. Review.

PMID:
29107808
12.

Cas9/gRNA targeted excision of cystic fibrosis-causing deep-intronic splicing mutations restores normal splicing of CFTR mRNA.

Sanz DJ, Hollywood JA, Scallan MF, Harrison PT.

PLoS One. 2017 Sep 1;12(9):e0184009. doi: 10.1371/journal.pone.0184009. eCollection 2017.

13.

Double TALEN-edited T-cells kick B-ALL into touch.

Harrison PT.

Gene Ther. 2017 Mar;24(3):122. doi: 10.1038/gt.2017.17. No abstract available.

PMID:
28356600
14.

Threshold and non-threshold chemical carcinogens: A survey of the present regulatory landscape.

Bevan RJ, Harrison PTC.

Regul Toxicol Pharmacol. 2017 Aug;88:291-302. doi: 10.1016/j.yrtph.2017.01.003. Epub 2017 Jan 21.

PMID:
28119000
15.

Genetic medicines for CF: Hype versus reality.

Alton EW, Boyd AC, Davies JC, Gill DR, Griesenbach U, Harrison PT, Henig N, Higgins T, Hyde SC, Innes JA, Korman MS.

Pediatr Pulmonol. 2016 Oct;51(S44):S5-S17. doi: 10.1002/ppul.23543. Review.

16.

Analysis of gene repair tracts from Cas9/gRNA double-stranded breaks in the human CFTR gene.

Hollywood JA, Lee CM, Scallan MF, Harrison PT.

Sci Rep. 2016 Aug 25;6:32230. doi: 10.1038/srep32230.

17.

Impact of gene editing on the study of cystic fibrosis.

Harrison PT, Sanz DJ, Hollywood JA.

Hum Genet. 2016 Sep;135(9):983-92. doi: 10.1007/s00439-016-1693-3. Epub 2016 Jun 21. Review.

PMID:
27325484
18.

Pollutant exposures and health symptoms in aircrew and office workers: Is there a link?

Wolkoff P, Crump DR, Harrison PT.

Environ Int. 2016 Feb;87:74-84. doi: 10.1016/j.envint.2015.11.008. Epub 2015 Nov 28. Review.

19.

Lack of marked cyto- and genotoxicity of cristobalite in devitrified (heated) alkaline earth silicate wools in short-term assays with cultured primary rat alveolar macrophages.

Ziemann C, Harrison PT, Bellmann B, Brown RC, Zoitos BK, Class P.

Inhal Toxicol. 2014 Feb;26(2):113-27. doi: 10.3109/08958378.2013.863411.

PMID:
24495247
20.

Crystalline silica in heated man-made vitreous fibres: a review.

Brown TP, Harrison PT.

Regul Toxicol Pharmacol. 2014 Feb;68(1):152-9. doi: 10.1016/j.yrtph.2013.11.014. Epub 2013 Dec 1. Review.

21.

Assessing and controlling risks from the emission of organic chemicals from construction products into indoor environments.

Brown VM, Crump DR, Harrison PT.

Environ Sci Process Impacts. 2013 Dec;15(12):2164-77. doi: 10.1039/c3em00413a.

PMID:
24190361
22.

Correction of the ΔF508 Mutation in the Cystic Fibrosis Transmembrane Conductance Regulator Gene by Zinc-Finger Nuclease Homology-Directed Repair.

Lee CM, Flynn R, Hollywood JA, Scallan MF, Harrison PT.

Biores Open Access. 2012 Jun;1(3):99-108. doi: 10.1089/biores.2012.0218.

23.

Alkaline earth silicate wools - A new generation of high temperature insulation.

Brown RC, Harrison PT.

Regul Toxicol Pharmacol. 2012 Nov;64(2):296-304. doi: 10.1016/j.yrtph.2012.08.020. Epub 2012 Sep 3. Review.

PMID:
22975085
24.

Devitrification of artificial fibres.

Harrison PT, Brown RC.

Ann Occup Hyg. 2011 Aug;55(7):823-4; author reply 825-6. doi: 10.1093/annhyg/mer061. No abstract available.

PMID:
21831851
25.

AAV2-mediated in vivo immune gene therapy of solid tumours.

Collins SA, Buhles A, Scallan MF, Harrison PT, O'Hanlon DM, O'Sullivan GC, Tangney M.

Genet Vaccines Ther. 2010 Dec 20;8:8. doi: 10.1186/1479-0556-8-8.

26.

Effects of GDF5 overexpression on embryonic rat dopaminergic neurones in vitro and in vivo.

O'Sullivan DB, Harrison PT, Sullivan AM.

J Neural Transm (Vienna). 2010 May;117(5):559-72. doi: 10.1007/s00702-010-0392-9. Epub 2010 Mar 27.

PMID:
20349094
27.

Assessment of the environmental toxicity and carcinogenicity of tungsten-based shot.

Thomas VG, Roberts MJ, Harrison PT.

Ecotoxicol Environ Saf. 2009 May;72(4):1031-7. doi: 10.1016/j.ecoenv.2009.01.001. Epub 2009 Feb 20. Review.

PMID:
19232723
28.

Application of gene therapy in diabetes care.

Harrison PT.

Infect Disord Drug Targets. 2008 Jun;8(2):129-33. Review.

PMID:
18537708
29.

Viral vectors in cancer immunotherapy: which vector for which strategy?

Collins SA, Guinn BA, Harrison PT, Scallan MF, O'Sullivan GC, Tangney M.

Curr Gene Ther. 2008 Apr;8(2):66-78. Review.

PMID:
18393828
30.

The impact of the European Environment and Health Process on UK environment and health policy, plans and practice: what difference has it made?

Capleton AC, Stevens J, Harrison PT.

Eur J Public Health. 2005 Oct;15(5):546-51. Epub 2005 Jul 21.

PMID:
16037078
31.

Endocrine disrupters and menopausal health.

Holmes P, Rumsby P, Harrison PT.

J Br Menopause Soc. 2004 Jun;10(2):54-9. Review.

PMID:
15207025
32.

FcgammaRIIa expression with FcgammaRI results in C-reactive protein- and IgG-mediated phagocytosis.

Bodman-Smith KB, Gregory RE, Harrison PT, Raynes JG.

J Leukoc Biol. 2004 Jun;75(6):1029-35. Epub 2004 Apr 1.

PMID:
15075346
33.

C-reactive protein-mediated phagocytosis and phospholipase D signalling through the high-affinity receptor for immunoglobulin G (FcgammaRI).

Bodman-Smith KB, Melendez AJ, Campbell I, Harrison PT, Allen JM, Raynes JG.

Immunology. 2002 Oct;107(2):252-60.

34.

Indoor air quality guidelines.

Harrison PT.

Occup Environ Med. 2002 Feb;59(2):73-4. No abstract available.

35.

Scientific analysis of the proposed uses of the T25 dose descriptor in chemical carcinogen regulation.

Roberts RA, Crump KS, Lutz WK, Wiegand HJ, Williams GM, Harrison PT, Purchase IF.

Arch Toxicol. 2001 Nov;75(9):507-12.

PMID:
11760810
36.

Endocrine disrupters and human health.

Harrison PT.

BMJ. 2001 Dec 8;323(7325):1317-8. No abstract available.

37.

Protecting environmental quality and human health: strategies for harmonisation.

Green E, Short SD, Stutt E, Harrison PT.

Sci Total Environ. 2000 Jul 10;256(2-3):205-13.

PMID:
10902847
38.

Links between environment and health: possible future directions.

Harrison PT.

Sci Total Environ. 2000 Apr 17;249(1-3):103-5.

PMID:
10813450
39.

Hyperplastic and Neoplastic Changes in the Lungs of Rats Treated Concurrently with Chrysotile Asbestos and N-Nitrosoheptamethyleneimine.

Harrison PT, Hoskins JA, Brown RC, Pigott GH, Hext PM, Mugglestone MA.

Inhal Toxicol. 2000 Jan;12 Suppl 3:167-72. doi: 10.1080/08958378.2000.11463210.

PMID:
26368613
40.
41.

A research strategy for investigating the ecological significance of endocrine disruption: report of a UK workshop.

Taylor MR, Holmes P, Duarte-Davidson R, Humfrey CD, Harrison PT.

Sci Total Environ. 1999 Aug 15;233(1-3):181-91.

PMID:
10492904
42.

Ecological effects of endocrine disruption: current evidence and research priorities.

Taylor MR, Harrison PT.

Chemosphere. 1999 Oct;39(8):1237-48. Review.

PMID:
10467718
43.

Comparative hazards of chrysotile asbestos and its substitutes: A European perspective.

Harrison PT, Levy LS, Patrick G, Pigott GH, Smith LL.

Environ Health Perspect. 1999 Aug;107(8):607-11.

44.

Creature comforts--living with mites and moulds.

Harrison PT.

Clin Exp Allergy. 1999 Feb;29(2):148-9. Review. No abstract available.

PMID:
10051715
45.

Lysosomal routing of Fc gamma RI from early endosomes requires recruitment of tyrosine kinases.

Norman JC, Harrison PT, Davis W, Floto RA, Allen JM.

Immunology. 1998 May;94(1):48-55.

47.

Use of GPI-anchored proteins to study biomolecular interactions by surface plasmon resonance.

Harrison PT, Campbell IW, Allen JM.

FEBS Lett. 1998 Feb 6;422(3):301-6.

48.

Reproductive health in humans and wildlife: are adverse trends associated with environmental chemical exposure?

Harrison PT, Holmes P, Humfrey CD.

Sci Total Environ. 1997 Oct 20;205(2-3):97-106.

PMID:
9372623
49.

Scanning alanine mutagenesis of the second Ig domain of Fc gamma RI indicates critical residues for ligand recognition.

McCarthy-Troke MH, Harrison PT, Campbell I, Allen JM.

Biochem Soc Trans. 1997 May;25(2):361S. No abstract available.

PMID:
9191406
50.

Protein:protein interactions in the lipid bilayer (review).

Harrison PT.

Mol Membr Biol. 1996 Apr-Jun;13(2):67-79. Review.

PMID:
8839450

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