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Alcohol Consumption during Adolescence in a Mouse Model of Binge Drinking Alters the Intrinsic Excitability and Function of the Prefrontal Cortex through a Reduction in the Hyperpolarization-Activated Cation Current.

Salling MC, Skelly MJ, Avegno E, Regan S, Zeric T, Nichols E, Harrison NL.

J Neurosci. 2018 Jul 4;38(27):6207-6222. doi: 10.1523/JNEUROSCI.0550-18.2018. Epub 2018 Jun 18.


The quality of assessments for childhood psychopathology within a regional medical center.

Sattler AF, Leffler JM, Harrison NL, Bieber ED, Kosmach JJ, Sim LA, Whiteside SPH.

Psychol Serv. 2019 Nov;16(4):596-604. doi: 10.1037/ser0000241. Epub 2018 May 17.


Glycine receptor α3 and α2 subunits mediate tonic and exogenous agonist-induced currents in forebrain.

McCracken LM, Lowes DC, Salling MC, Carreau-Vollmer C, Odean NN, Blednov YA, Betz H, Harris RA, Harrison NL.

Proc Natl Acad Sci U S A. 2017 Aug 22;114(34):E7179-E7186. doi: 10.1073/pnas.1703839114. Epub 2017 Aug 7.


Effects of acute alcohol on excitability in the CNS.

Harrison NL, Skelly MJ, Grosserode EK, Lowes DC, Zeric T, Phister S, Salling MC.

Neuropharmacology. 2017 Aug 1;122:36-45. doi: 10.1016/j.neuropharm.2017.04.007. Epub 2017 May 4. Review.


GABAA receptor α4-subunit knockout enhances lung inflammation and airway reactivity in a murine asthma model.

Yocum GT, Turner DL, Danielsson J, Barajas MB, Zhang Y, Xu D, Harrison NL, Homanics GE, Farber DL, Emala CW.

Am J Physiol Lung Cell Mol Physiol. 2017 Aug 1;313(2):L406-L415. doi: 10.1152/ajplung.00107.2017. Epub 2017 May 4.


Voluntary adolescent drinking enhances excitation by low levels of alcohol in a subset of dopaminergic neurons in the ventral tegmental area.

Avegno EM, Salling MC, Borgkvist A, Mrejeru A, Whitebirch AC, Margolis EB, Sulzer D, Harrison NL.

Neuropharmacology. 2016 Nov;110(Pt A):386-395. doi: 10.1016/j.neuropharm.2016.07.031. Epub 2016 Jul 27.


Maternal immune activation does not alter the number of perisomatic parvalbumin-positive boutons in the offspring prefrontal cortex.

Canetta S, Bolkan S, Padilla-Coreano N, Song LJ, Sahn R, Harrison NL, Gordon JA, Brown A, Kellendonk C.

Mol Psychiatry. 2016 Jul;21(7):857. doi: 10.1038/mp.2016.92. No abstract available.


Maternal immune activation leads to selective functional deficits in offspring parvalbumin interneurons.

Canetta S, Bolkan S, Padilla-Coreano N, Song LJ, Sahn R, Harrison NL, Gordon JA, Brown A, Kellendonk C.

Mol Psychiatry. 2016 Jul;21(7):956-68. doi: 10.1038/mp.2015.222. Epub 2016 Feb 2.


Downregulation of Gabra4 expression during alcohol withdrawal is mediated by specific microRNAs in cultured mouse cortical neurons.

Bekdash RA, Harrison NL.

Brain Behav. 2015 Aug;5(8):e00355. doi: 10.1002/brb3.355. Epub 2015 Jun 2.


Zolpidem and eszopiclone prime α1β2γ2 GABAA receptors for longer duration of activity.

Dixon CL, Harrison NL, Lynch JW, Keramidas A.

Br J Pharmacol. 2015 Jul;172(14):3522-36. doi: 10.1111/bph.13142. Epub 2015 May 11.


Acetaldehyde, not ethanol, impairs myelin formation and viability in primary mouse oligodendrocytes.

Coutts DJ, Harrison NL.

Alcohol Clin Exp Res. 2015 Mar;39(3):455-62. doi: 10.1111/acer.12642. Epub 2015 Feb 19.


A subset of ventral tegmental area dopamine neurons responds to acute ethanol.

Mrejeru A, Martí-Prats L, Avegno EM, Harrison NL, Sulzer D.

Neuroscience. 2015 Apr 2;290:649-58. doi: 10.1016/j.neuroscience.2014.12.081. Epub 2015 Feb 7.


Upregulation of dopamine D2 receptors in the nucleus accumbens indirect pathway increases locomotion but does not reduce alcohol consumption.

Gallo EF, Salling MC, Feng B, Morón JA, Harrison NL, Javitch JA, Kellendonk C.

Neuropsychopharmacology. 2015 Jun;40(7):1609-18. doi: 10.1038/npp.2015.11. Epub 2015 Jan 12.


Strychnine-sensitive glycine receptors on pyramidal neurons in layers II/III of the mouse prefrontal cortex are tonically activated.

Salling MC, Harrison NL.

J Neurophysiol. 2014 Sep 1;112(5):1169-78. doi: 10.1152/jn.00714.2013. Epub 2014 May 28.


HSF1 transcriptional activity mediates alcohol induction of Vamp2 expression and GABA release.

Varodayan FP, Harrison NL.

Front Integr Neurosci. 2013 Dec 11;7:89. doi: 10.3389/fnint.2013.00089. eCollection 2013.


Brief alcohol exposure alters transcription in astrocytes via the heat shock pathway.

Pignataro L, Varodayan FP, Tannenholz LE, Protiva P, Harrison NL.

Brain Behav. 2013 Mar;3(2):114-33. doi: 10.1002/brb3.125. Epub 2013 Feb 6.


Anesthetics interfere with axon guidance in developing mouse neocortical neurons in vitro via a γ-aminobutyric acid type A receptor mechanism.

Mintz CD, Barrett KM, Smith SC, Benson DL, Harrison NL.

Anesthesiology. 2013 Apr;118(4):825-33. doi: 10.1097/ALN.0b013e318287b850.


Striatal D2 receptors regulate dendritic morphology of medium spiny neurons via Kir2 channels.

Cazorla M, Shegda M, Ramesh B, Harrison NL, Kellendonk C.

J Neurosci. 2012 Feb 15;32(7):2398-409. doi: 10.1523/JNEUROSCI.6056-11.2012.


Alcohol induces synaptotagmin 1 expression in neurons via activation of heat shock factor 1.

Varodayan FP, Pignataro L, Harrison NL.

Neuroscience. 2011 Oct 13;193:63-71. doi: 10.1016/j.neuroscience.2011.07.035. Epub 2011 Jul 27.


Loss of ethanol conditioned taste aversion and motor stimulation in knockin mice with ethanol-insensitive α2-containing GABA(A) receptors.

Blednov YA, Borghese CM, McCracken ML, Benavidez JM, Geil CR, Osterndorff-Kahanek E, Werner DF, Iyer S, Swihart A, Harrison NL, Homanics GE, Harris RA.

J Pharmacol Exp Ther. 2011 Jan;336(1):145-54. doi: 10.1124/jpet.110.171645. Epub 2010 Sep 27.


Inhaled anesthetic responses of recombinant receptors and knockin mice harboring α2(S270H/L277A) GABA(A) receptor subunits that are resistant to isoflurane.

Werner DF, Swihart A, Rau V, Jia F, Borghese CM, McCracken ML, Iyer S, Fanselow MS, Oh I, Sonner JM, Eger EI 2nd, Harrison NL, Harris RA, Homanics GE.

J Pharmacol Exp Ther. 2011 Jan;336(1):134-44. doi: 10.1124/jpet.110.170431. Epub 2010 Aug 31.


The activation mechanism of alpha1beta2gamma2S and alpha3beta3gamma2S GABAA receptors.

Keramidas A, Harrison NL.

J Gen Physiol. 2010 Jan;135(1):59-75. doi: 10.1085/jgp.200910317.


Extrasynaptic GABAA receptors: form, pharmacology, and function.

Belelli D, Harrison NL, Maguire J, Macdonald RL, Walker MC, Cope DW.

J Neurosci. 2009 Oct 14;29(41):12757-63. doi: 10.1523/JNEUROSCI.3340-09.2009. Review.


The regulation of neuronal gene expression by alcohol.

Pignataro L, Varodayan FP, Tannenholz LE, Harrison NL.

Pharmacol Ther. 2009 Dec;124(3):324-35. doi: 10.1016/j.pharmthera.2009.09.002. Epub 2009 Sep 23. Review.


The modulation of synaptic GABA(A) receptors in the thalamus by eszopiclone and zolpidem.

Jia F, Goldstein PA, Harrison NL.

J Pharmacol Exp Ther. 2009 Mar;328(3):1000-6. doi: 10.1124/jpet.108.146084. Epub 2008 Nov 25.


Alcohol-induced tolerance and physical dependence in mice with ethanol insensitive alpha1 GABA A receptors.

Werner DF, Swihart AR, Ferguson C, Lariviere WR, Harrison NL, Homanics GE.

Alcohol Clin Exp Res. 2009 Feb;33(2):289-99. doi: 10.1111/j.1530-0277.2008.00832.x. Epub 2008 Nov 19.


Isoflurane modulates excitability in the mouse thalamus via GABA-dependent and GABA-independent mechanisms.

Ying SW, Werner DF, Homanics GE, Harrison NL, Goldstein PA.

Neuropharmacology. 2009 Feb;56(2):438-47. doi: 10.1016/j.neuropharm.2008.09.015. Epub 2008 Oct 9.


Ethanol modulates synaptic and extrasynaptic GABAA receptors in the thalamus.

Jia F, Chandra D, Homanics GE, Harrison NL.

J Pharmacol Exp Ther. 2008 Aug;326(2):475-82. doi: 10.1124/jpet.108.139303. Epub 2008 May 13.


Agonist-dependent single channel current and gating in alpha4beta2delta and alpha1beta2gamma2S GABAA receptors.

Keramidas A, Harrison NL.

J Gen Physiol. 2008 Feb;131(2):163-81. doi: 10.1085/jgp.200709871.


Molecular modeling and mutagenesis reveals a tetradentate binding site for Zn2+ in GABA(A) alphabeta receptors and provides a structural basis for the modulating effect of the gamma subunit.

Trudell JR, Yue ME, Bertaccini EJ, Jenkins A, Harrison NL.

J Chem Inf Model. 2008 Feb;48(2):344-9. doi: 10.1021/ci700324a. Epub 2008 Jan 16.


Taurine is a potent activator of extrasynaptic GABA(A) receptors in the thalamus.

Jia F, Yue M, Chandra D, Keramidas A, Goldstein PA, Homanics GE, Harrison NL.

J Neurosci. 2008 Jan 2;28(1):106-15. doi: 10.1523/JNEUROSCI.3996-07.2008.


Isoflurane is a potent modulator of extrasynaptic GABA(A) receptors in the thalamus.

Jia F, Yue M, Chandra D, Homanics GE, Goldstein PA, Harrison NL.

J Pharmacol Exp Ther. 2008 Mar;324(3):1127-35. Epub 2007 Dec 19.


Normal acute behavioral responses to moderate/high dose ethanol in GABAA receptor alpha 4 subunit knockout mice.

Chandra D, Werner DF, Liang J, Suryanarayanan A, Harrison NL, Spigelman I, Olsen RW, Homanics GE.

Alcohol Clin Exp Res. 2008 Jan;32(1):10-8. Epub 2007 Dec 12.


Alcohol regulates gene expression in neurons via activation of heat shock factor 1.

Pignataro L, Miller AN, Ma L, Midha S, Protiva P, Herrera DG, Harrison NL.

J Neurosci. 2007 Nov 21;27(47):12957-66.


Mechanisms of sleep induction by GABA(A) receptor agonists.

Harrison NL.

J Clin Psychiatry. 2007;68 Suppl 5:6-12. Review.


GABAA receptors in the thalamus: alpha4 subunit expression and alcohol sensitivity.

Jia F, Pignataro L, Harrison NL.

Alcohol. 2007 May;41(3):177-85. Epub 2007 May 23. Review.


GABAA receptor alpha 4 subunits mediate extrasynaptic inhibition in thalamus and dentate gyrus and the action of gaboxadol.

Chandra D, Jia F, Liang J, Peng Z, Suryanarayanan A, Werner DF, Spigelman I, Houser CR, Olsen RW, Harrison NL, Homanics GE.

Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15230-5. Epub 2006 Sep 27.


Aryl trihydroxyborates: easily isolated discrete species convenient for direct application in coupling reactions.

Cammidge AN, Goddard VH, Gopee H, Harrison NL, Hughes DL, Schubert CJ, Sutton BM, Watts GL, Whitehead AJ.

Org Lett. 2006 Aug 31;8(18):4071-4.


An isoflurane- and alcohol-insensitive mutant GABA(A) receptor alpha(1) subunit with near-normal apparent affinity for GABA: characterization in heterologous systems and production of knockin mice.

Borghese CM, Werner DF, Topf N, Baron NV, Henderson LA, Boehm SL 2nd, Blednov YA, Saad A, Dai S, Pearce RA, Harris RA, Homanics GE, Harrison NL.

J Pharmacol Exp Ther. 2006 Oct;319(1):208-18. Epub 2006 Jun 28.


Knockin mice with ethanol-insensitive alpha1-containing gamma-aminobutyric acid type A receptors display selective alterations in behavioral responses to ethanol.

Werner DF, Blednov YA, Ariwodola OJ, Silberman Y, Logan E, Berry RB, Borghese CM, Matthews DB, Weiner JL, Harrison NL, Harris RA, Homanics GE.

J Pharmacol Exp Ther. 2006 Oct;319(1):219-27. Epub 2006 Jun 19.


The pre-M1 segment of the alpha1 subunit is a transduction element in the activation of the GABAA receptor.

Keramidas A, Kash TL, Harrison NL.

J Physiol. 2006 Aug 15;575(Pt 1):11-22. Epub 2006 Jun 8.


GABA(A)-R alpha1 subunit knockin mutation leads to abnormal EEG and anesthetic-induced seizure-like activity in mice.

Elsen FP, Liljelund P, Werner DF, Olsen RW, Homanics GE, Harrison NL.

Brain Res. 2006 Mar 17;1078(1):60-70. Epub 2006 Feb 21.


Propofol block of I(h) contributes to the suppression of neuronal excitability and rhythmic burst firing in thalamocortical neurons.

Ying SW, Abbas SY, Harrison NL, Goldstein PA.

Eur J Neurosci. 2006 Jan;23(2):465-80. Erratum in: Eur J Neurosci. 2006 Mar;23(5):1403.


An extrasynaptic GABAA receptor mediates tonic inhibition in thalamic VB neurons.

Jia F, Pignataro L, Schofield CM, Yue M, Harrison NL, Goldstein PA.

J Neurophysiol. 2005 Dec;94(6):4491-501. Epub 2005 Sep 14.


Emerging molecular mechanisms of general anesthetic action.

Hemmings HC Jr, Akabas MH, Goldstein PA, Trudell JR, Orser BA, Harrison NL.

Trends Pharmacol Sci. 2005 Oct;26(10):503-10. Review.


Impairment of hyperpolarization-activated, cyclic nucleotide-gated channel function by the intravenous general anesthetic propofol.

Cacheaux LP, Topf N, Tibbs GR, Schaefer UR, Levi R, Harrison NL, Abbott GW, Goldstein PA.

J Pharmacol Exp Ther. 2005 Nov;315(2):517-25. Epub 2005 Jul 20.


Subunit-dependent block by isoflurane of wild-type and mutant alpha(1)S270H GABA(A) receptor currents in Xenopus oocytes.

Hall AC, Stevens RJ, Betts BA, Yeung WY, Kelley JC, Harrison NL.

Neurosci Lett. 2005 Jul 15;382(3):332-7. Epub 2005 Apr 14.


Transmembrane residues define the action of isoflurane at the GABAA receptor alpha-3 subunit.

Schofield CM, Harrison NL.

Brain Res. 2005 Jan 25;1032(1-2):30-5.


A gain-of-function mutation in the GABA receptor produces synaptic and behavioral abnormalities in the mouse.

Homanics GE, Elsen FP, Ying SW, Jenkins A, Ferguson C, Sloat B, Yuditskaya S, Goldstein PA, Kralic JE, Morrow AL, Harrison NL.

Genes Brain Behav. 2005 Feb;4(1):10-9.

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