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Genomic identification of cryptic susceptibility to penicillins and β-lactamase inhibitors in methicillin-resistant Staphylococcus aureus.

Harrison EM, Ba X, Coll F, Blane B, Restif O, Carvell H, Köser CU, Jamrozy D, Reuter S, Lovering A, Gleadall N, Bellis KL, Uhlemann AC, Lowy FD, Massey RC, Grilo IR, Sobral R, Larsen J, Rhod Larsen A, Vingsbo Lundberg C, Parkhill J, Paterson GK, Holden MTG, Peacock SJ, Holmes MA.

Nat Microbiol. 2019 Jun 24. doi: 10.1038/s41564-019-0471-0. [Epub ahead of print]


Staphylococcus pseudoxylosus sp. nov., isolated from bovine mastitis.

MacFadyen AC, Leroy S, Harrison EM, Parkhill J, Holmes MA, Paterson GK.

Int J Syst Evol Microbiol. 2019 Jun 21. doi: 10.1099/ijsem.0.003416. [Epub ahead of print]


Reported light in the sleep environment: enhancement of the sleep diary.

Harrison EM, Yablonsky AM, Powell AL, Ancoli-Israel S, Glickman GL.

Nat Sci Sleep. 2019 Mar 25;11:11-26. doi: 10.2147/NSS.S193902. eCollection 2019.



Harrison EM, Thomas HS, Weiser TG.

Br J Surg. 2019 May;106(6):802-803. doi: 10.1002/bjs.11194. No abstract available.


Gallstone Disease and the Risk of Cardiovascular Disease.

Fairfield CJ, Wigmore SJ, Harrison EM.

Sci Rep. 2019 Apr 9;9(1):5830. doi: 10.1038/s41598-019-42327-2.


Use of a modified Delphi approach to develop research priorities in HPB surgery across the United Kingdom.

Knight SR, Pathak S, Christie A, Jones L, Rees J, Davies H, Wilson MSJ, Vaughan-Shaw P, Roberts K, Toogood G, Harrison EM, Taylor MA.

HPB (Oxford). 2019 Apr 4. pii: S1365-182X(19)30472-1. doi: 10.1016/j.hpb.2019.03.352. [Epub ahead of print]


Multicentre study of multidisciplinary team assessment of pancreatic cancer resectability and treatment allocation.

Kirkegård J, Aahlin EK, Al-Saiddi M, Bratlie SO, Coolsen M, de Haas RJ, den Dulk M, Fristrup C, Harrison EM, Mortensen MB, Nijkamp MW, Persson J, Søreide JA, Wigmore SJ, Wik T, Mortensen FV.

Br J Surg. 2019 May;106(6):756-764. doi: 10.1002/bjs.11093. Epub 2019 Mar 4.


Characterization of mecC gene-carrying coagulase-negative Staphylococcus spp. isolated from various animals.

Loncaric I, Kübber-Heiss A, Posautz A, Ruppitsch W, Lepuschitz S, Schauer B, Feßler AT, Krametter-Frötscher R, Harrison EM, Holmes MA, Künzel F, Szostak MP, Hauschild T, Desvars-Larrive A, Misic D, Rosengarten R, Walzer C, Slickers P, Monecke S, Ehricht R, Schwarz S, Spergser J.

Vet Microbiol. 2019 Mar;230:138-144. doi: 10.1016/j.vetmic.2019.02.014. Epub 2019 Feb 6.


The effect of liver transplantation on patient-centred outcomes: a propensity-score matched analysis.

McLean KA, Drake TM, Sgrò A, Camilleri-Brennan J, Knight SR, Ots R, Adair A, Wigmore SJ, Harrison EM.

Transpl Int. 2019 Feb 21. doi: 10.1111/tri.13416. [Epub ahead of print]


Truncation of GdpP mediates β-lactam resistance in clinical isolates of Staphylococcus aureus.

Ba X, Kalmar L, Hadjirin NF, Kerschner H, Apfalter P, Morgan FJ, Paterson GK, Girvan SL, Zhou R, Harrison EM, Holmes MA.

J Antimicrob Chemother. 2019 Feb 12. doi: 10.1093/jac/dkz013. [Epub ahead of print]


Prospective genomic surveillance of methicillin-resistant Staphylococcus aureus (MRSA) associated with bloodstream infection, England, 1 October 2012 to 30 September 2013.

Toleman MS, Reuter S, Jamrozy D, Wilson HJ, Blane B, Harrison EM, Coll F, Hope RJ, Kearns A, Parkhill J, Peacock SJ, Török ME.

Euro Surveill. 2019 Jan;24(4). doi: 10.2807/1560-7917.ES.2019.24.4.1800215.


Systematic review of the use of big data to improve surgery in low- and middle-income countries.

Knight SR, Ots R, Maimbo M, Drake TM, Fairfield CJ, Harrison EM.

Br J Surg. 2019 Jan;106(2):e62-e72. doi: 10.1002/bjs.11052. Review.


A mecC allotype, mecC3, in the CoNS Staphylococcus caeli, encoded within a variant SCCmecC.

MacFadyen AC, Harrison EM, Drigo I, Parkhill J, Holmes MA, Paterson GK.

J Antimicrob Chemother. 2019 Mar 1;74(3):547-552. doi: 10.1093/jac/dky502.


Systematic review of management of incidental gallbladder cancer after cholecystectomy.

Søreide K, Guest RV, Harrison EM, Kendall TJ, Garden OJ, Wigmore SJ.

Br J Surg. 2019 Jan;106(1):32-45. doi: 10.1002/bjs.11035.


Evaluating the collection, comparability and findings of six global surgery indicators.

Holmer H, Bekele A, Hagander L, Harrison EM, Kamali P, Ng-Kamstra JS, Khan MA, Knowlton L, Leather AJM, Marks IH, Meara JG, Shrime MG, Smith M, Søreide K, Weiser TG, Davies J.

Br J Surg. 2019 Jan;106(2):e138-e150. doi: 10.1002/bjs.11061. Epub 2018 Dec 20.


Staphylococcus caeli sp. nov., isolated from air sampling in an industrial rabbit holding.

MacFadyen AC, Drigo I, Harrison EM, Parkhill J, Holmes MA, Paterson GK.

Int J Syst Evol Microbiol. 2019 Jan;69(1):82-86. doi: 10.1099/ijsem.0.003098. Epub 2018 Nov 14.


Nasal carriage of Staphylococcus pseudintermedius in patients with granulomatosis with polyangiitis.

Kronbichler A, Blane B, Holmes MA, Wagner J, Parkhill J, Peacock SJ, Jayne DRW, Harrison EM.

Rheumatology (Oxford). 2019 Mar 1;58(3):548-550. doi: 10.1093/rheumatology/key317. No abstract available.


Counting the cost of cancelled surgery: a system wide approach is needed.

Gillies MA, Wijeysundera DN, Harrison EM.

Br J Anaesth. 2018 Oct;121(4):691-694. doi: 10.1016/j.bja.2018.08.002. Epub 2018 Sep 7. No abstract available.


Global Inequities in Precision Medicine and Molecular Cancer Research.

Drake TM, Knight SR, Harrison EM, Søreide K.

Front Oncol. 2018 Sep 4;8:346. doi: 10.3389/fonc.2018.00346. eCollection 2018. Review.


A highly conserved mecC-encoding SCCmec type XI in a bovine isolate of methicillin-resistant Staphylococcus xylosus.

MacFadyen AC, Harrison EM, Ellington MJ, Parkhill J, Holmes MA, Paterson GK.

J Antimicrob Chemother. 2018 Dec 1;73(12):3516-3518. doi: 10.1093/jac/dky333. No abstract available.


Circadian rhythm bifurcation induces flexible phase resetting by reducing circadian amplitude.

Noguchi T, Harrison EM, Sun J, May D, Ng A, Welsh DK, Gorman MR.

Eur J Neurosci. 2018 Jul 25. doi: 10.1111/ejn.14086. [Epub ahead of print]


Gene exchange drives the ecological success of a multi-host bacterial pathogen.

Richardson EJ, Bacigalupe R, Harrison EM, Weinert LA, Lycett S, Vrieling M, Robb K, Hoskisson PA, Holden MTG, Feil EJ, Paterson GK, Tong SYC, Shittu A, van Wamel W, Aanensen DM, Parkhill J, Peacock SJ, Corander J, Holmes M, Fitzgerald JR.

Nat Ecol Evol. 2018 Sep;2(9):1468-1478. doi: 10.1038/s41559-018-0617-0. Epub 2018 Jul 23.


Examining the impact of audience response systems on student performance in anatomy education: a randomised controlled trial.

Fergusson SJ, Aka JJ, Hennessy CM, Wilson AJ, Parson SH, Harrison EM, Finn GM, Gillingwater TH.

Scott Med J. 2018 Feb;63(1):16-21. doi: 10.1177/0036933017741409. Epub 2018 Jun 17.


Research gaps and unanswered questions in gallbladder cancer.

Søreide K, Harrison EM, Wigmore SJ.

HPB (Oxford). 2018 Aug;20(8):685-686. doi: 10.1016/j.hpb.2018.03.006. Epub 2018 May 18. No abstract available.


Two complement receptor one alleles have opposing associations with cerebral malaria and interact with α+thalassaemia.

Opi DH, Swann O, Macharia A, Uyoga S, Band G, Ndila CM, Harrison EM, Thera MA, Kone AK, Diallo DA, Doumbo OK, Lyke KE, Plowe CV, Moulds JM, Shebbe M, Mturi N, Peshu N, Maitland K, Raza A, Kwiatkowski DP, Rockett KA, Williams TN, Rowe JA.

Elife. 2018 Apr 25;7. pii: e31579. doi: 10.7554/eLife.31579.


Glucocorticosteroid-free versus glucocorticosteroid-containing immunosuppression for liver transplanted patients.

Fairfield C, Penninga L, Powell J, Harrison EM, Wigmore SJ.

Cochrane Database Syst Rev. 2018 Apr 9;4:CD007606. doi: 10.1002/14651858.CD007606.pub4. Review.


Identification of a staphylococcal complement inhibitor with broad host specificity in equid Staphylococcus aureus strains.

de Jong NWM, Vrieling M, Garcia BL, Koop G, Brettmann M, Aerts PC, Ruyken M, van Strijp JAG, Holmes M, Harrison EM, Geisbrecht BV, Rooijakkers SHM.

J Biol Chem. 2018 Mar 23;293(12):4468-4477. doi: 10.1074/jbc.RA117.000599. Epub 2018 Feb 5.


No Evidence that Knops Blood Group Polymorphisms Affect Complement Receptor 1 Clustering on Erythrocytes.

Swann OV, Harrison EM, Opi DH, Nyatichi E, Macharia A, Uyoga S, Williams TN, Rowe JA.

Sci Rep. 2017 Dec 19;7(1):17825. doi: 10.1038/s41598-017-17664-9.


Duplicate publication bias weakens the validity of meta-analysis of immunosuppression after transplantation.

Fairfield CJ, Harrison EM, Wigmore SJ.

World J Gastroenterol. 2017 Oct 21;23(39):7198-7200. doi: 10.3748/wjg.v23.i39.7198.


Investigation of a Cluster of Sequence Type 22 Methicillin-Resistant Staphylococcus aureus Transmission in a Community Setting.

Toleman MS, Watkins ER, Williams T, Blane B, Sadler B, Harrison EM, Coll F, Parkhill J, Nazareth B, Brown NM, Peacock SJ.

Clin Infect Dis. 2017 Nov 29;65(12):2069-2077. doi: 10.1093/cid/cix539.


Longitudinal genomic surveillance of MRSA in the UK reveals transmission patterns in hospitals and the community.

Coll F, Harrison EM, Toleman MS, Reuter S, Raven KE, Blane B, Palmer B, Kappeler ARM, Brown NM, Török ME, Parkhill J, Peacock SJ.

Sci Transl Med. 2017 Oct 25;9(413). pii: eaak9745. doi: 10.1126/scitranslmed.aak9745. Epub 2017 Oct 25.


Evolution of mobile genetic element composition in an epidemic methicillin-resistant Staphylococcus aureus: temporal changes correlated with frequent loss and gain events.

Jamrozy D, Coll F, Mather AE, Harris SR, Harrison EM, MacGowan A, Karas A, Elston T, Estée Török M, Parkhill J, Peacock SJ.

BMC Genomics. 2017 Sep 4;18(1):684. doi: 10.1186/s12864-017-4065-z.


Frequency of surgical treatment and related hospital procedures in the UK: a national ecological study using hospital episode statistics.

Abbott TEF, Fowler AJ, Dobbs TD, Harrison EM, Gillies MA, Pearse RM.

Br J Anaesth. 2017 Aug 1;119(2):249-257. doi: 10.1093/bja/aex137.


Genomic surveillance reveals low prevalence of livestock-associated methicillin-resistant Staphylococcus aureus in the East of England.

Harrison EM, Coll F, Toleman MS, Blane B, Brown NM, Török ME, Parkhill J, Peacock SJ.

Sci Rep. 2017 Aug 7;7(1):7406. doi: 10.1038/s41598-017-07662-2.


The efficiency, accuracy and acceptability of smartphone-delivered data collection in a low-resource setting - A prospective study.

Raza A, Raza I, Drake TM, Sadar AB, Adil M, Baluch F, Qureshi AU, Harrison EM; GlobalSurg Collaborative.

Int J Surg. 2017 Aug;44:252-254. doi: 10.1016/j.ijsu.2017.06.081. Epub 2017 Jul 1.


Patient experience and overall satisfaction after emergency abdominal surgery.

Jones CH, O'Neill S, McLean KA, Wigmore SJ, Harrison EM.

BMC Surg. 2017 Jul 1;17(1):76. doi: 10.1186/s12893-017-0271-5.


Lifebox pulse oximeter implementation in Malawi: evaluation of educational outcomes and impact on oxygen desaturation episodes during anaesthesia.

Albert V, Mndolo S, Harrison EM, O'Sullivan E, Wilson IH, Walker IA.

Anaesthesia. 2017 Jun;72(6):686-693. doi: 10.1111/anae.13838. Epub 2017 Apr 24.


Effect of day of the week on short- and long-term mortality after emergency general surgery.

Gillies MA, Lone NI, Pearse RM, Haddow C, Smyth L, Parks RW, Walsh TS, Harrison EM.

Br J Surg. 2017 Jun;104(7):936-945. doi: 10.1002/bjs.10507. Epub 2017 Mar 21.


The Influence of Clinical and Patient-Reported Outcomes on Post-surgery Satisfaction in Cholecystectomy Patients.

McLean KA, Sheng Z, O'Neill S, Boyce K, Jones C, Wigmore SJ, Harrison EM.

World J Surg. 2017 Jul;41(7):1752-1761. doi: 10.1007/s00268-017-3917-7.


Assessment of available evidence in the management of gallbladder and bile duct stones: a systematic review of international guidelines.

van Dijk AH, de Reuver PR, Besselink MG, van Laarhoven KJ, Harrison EM, Wigmore SJ, Hugh TJ, Boermeester MA.

HPB (Oxford). 2017 Apr;19(4):297-309. doi: 10.1016/j.hpb.2016.12.011. Epub 2017 Jan 20. Review.


Identification of LukPQ, a novel, equid-adapted leukocidin of Staphylococcus aureus.

Koop G, Vrieling M, Storisteanu DM, Lok LS, Monie T, van Wigcheren G, Raisen C, Ba X, Gleadall N, Hadjirin N, Timmerman AJ, Wagenaar JA, Klunder HM, Fitzgerald JR, Zadoks R, Paterson GK, Torres C, Waller AS, Loeffler A, Loncaric I, Hoet AE, Bergström K, De Martino L, Pomba C, de Lencastre H, Ben Slama K, Gharsa H, Richardson EJ, Chilvers ER, de Haas C, van Kessel K, van Strijp JA, Harrison EM, Holmes MA.

Sci Rep. 2017 Jan 20;7:40660. doi: 10.1038/srep40660.


Intensive care utilization and outcomes after high-risk surgery in Scotland: a population-based cohort study.

Gillies MA, Harrison EM, Pearse RM, Garrioch S, Haddow C, Smyth L, Parks R, Walsh TS, Lone NI.

Br J Anaesth. 2017 Jan;118(1):123-131. doi: 10.1093/bja/aew396.


Decision modeling in donation after circulatory death liver transplantation.

McLean KA, Camilleri-Brennan J, Knight SR, Drake TM, Ots R, Shaw CA, Wigmore SJ, Harrison EM.

Liver Transpl. 2017 May;23(5):594-603. doi: 10.1002/lt.24715.


Recent early clinical drug development for acute kidney injury.

Gallagher KM, O'neill S, Harrison EM, Ross JA, Wigmore SJ, Hughes J.

Expert Opin Investig Drugs. 2017 Feb;26(2):141-154. doi: 10.1080/13543784.2017.1274730. Epub 2016 Dec 27. Review.


Extraordinary behavioral entrainment following circadian rhythm bifurcation in mice.

Harrison EM, Walbeek TJ, Sun J, Johnson J, Poonawala Q, Gorman MR.

Sci Rep. 2016 Dec 8;6:38479. doi: 10.1038/srep38479.


Validation of self-administered nasal swabs and postage for the isolation of Staphylococcus aureus.

Harrison EM, Gleadall NS, Ba X, Danesh J, Peacock SJ, Holmes M.

J Med Microbiol. 2016 Dec;65(12):1434-1437. doi: 10.1099/jmm.0.000381. Epub 2016 Oct 31.


Circadian waveform bifurcation, but not phase-shifting, leaves cued fear memory intact.

Harrison EM, Carmack SA, Block CL, Sun J, Anagnostaras SG, Gorman MR.

Physiol Behav. 2017 Feb 1;169:106-113. doi: 10.1016/j.physbeh.2016.11.033. Epub 2016 Nov 25.


Individual surgeon mortality rates: can outliers be detected? A national utility analysis.

Harrison EM, Drake TM, O'Neill S, Shaw CA, Garden OJ, Wigmore SJ.

BMJ Open. 2016 Oct 31;6(10):e012471. doi: 10.1136/bmjopen-2016-012471.


Transmission of methicillin-resistant Staphylococcus aureus in long-term care facilities and their related healthcare networks.

Harrison EM, Ludden C, Brodrick HJ, Blane B, Brennan G, Morris D, Coll F, Reuter S, Brown NM, Holmes MA, O'Connell B, Parkhill J, Török ME, Cormican M, Peacock SJ.

Genome Med. 2016 Oct 3;8(1):102.

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