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Items: 1 to 50 of 379

1.

Central EP3 (E Prostanoid 3) Receptors Mediate Salt-Sensitive Hypertension and Immune Activation.

Xiao L, Itani HA, do Carmo LS, Carver LS, Breyer RM, Harrison DG.

Hypertension. 2019 Dec;74(6):1507-1515. doi: 10.1161/HYPERTENSIONAHA.119.13850. Epub 2019 Nov 4.

PMID:
31679420
2.

Isolevuglandins as mediators of disease and the development of dicarbonyl scavengers as pharmaceutical interventions.

Davies SS, May-Zhang LS, Boutaud O, Amarnath V, Kirabo A, Harrison DG.

Pharmacol Ther. 2019 Oct 16:107418. doi: 10.1016/j.pharmthera.2019.107418. [Epub ahead of print] Review.

PMID:
31629006
3.

New Insight Sheds Light as to how Nitrite Might Reduce Blood Pressure Height: Is this Alright?

Van Beusecum JP, Harrison DG.

Cardiovasc Res. 2019 Oct 9. pii: cvz248. doi: 10.1093/cvr/cvz248. [Epub ahead of print] No abstract available.

PMID:
31598636
4.

High Salt Activates CD11c+ Antigen-Presenting Cells via SGK (Serum Glucocorticoid Kinase) 1 to Promote Renal Inflammation and Salt-Sensitive Hypertension.

Van Beusecum JP, Barbaro NR, McDowell Z, Aden LA, Xiao L, Pandey AK, Itani HA, Himmel LE, Harrison DG, Kirabo A.

Hypertension. 2019 Sep;74(3):555-563. doi: 10.1161/HYPERTENSIONAHA.119.12761. Epub 2019 Jul 8.

PMID:
31280647
5.

Solving Baroreceptor Mystery: Role of PIEZO Ion Channels.

Burke SD, Jordan J, Harrison DG, Karumanchi SA.

J Am Soc Nephrol. 2019 Jun;30(6):911-913. doi: 10.1681/ASN.2019020160. Epub 2019 May 1. No abstract available.

PMID:
31043433
6.

Scientists on the Spot: Inflammation and translational research-what have we learned from the CIRT trial?

Antoniades C, Harrison DG.

Cardiovasc Res. 2019 Mar 15;115(4):e44-e45. doi: 10.1093/cvr/cvz047. No abstract available.

PMID:
30907415
7.

NOX5 as a therapeutic target in cerebral ischemic injury.

Carmo LSD, Berk BC, Harrison DG.

J Clin Invest. 2019 Mar 18;130:1530-1532. doi: 10.1172/JCI127682. eCollection 2019 Mar 18.

8.

Markers or Makers: Inflammatory Cytokines in Treatment-Resistant Hypertension

Barbaro NR, Harrison DG.

Hypertension. 2019 Apr;73(4):767-769. doi: 10.1161/HYPERTENSIONAHA.119.12604. No abstract available.

PMID:
30776975
9.

What matters in Cardiovascular Research? Scientific discovery driving clinical delivery.

Guzik TJ, Antoniades C, Baker AH, Harrison DG, Loughrey CM, Maffia P, Murphy E, Nicklin SA, Peter K, Pearson J, Casadei B.

Cardiovasc Res. 2018 Oct 1;114(12):1565-1568. doi: 10.1093/cvr/cvy214. No abstract available.

10.

Tobacco smoking induces cardiovascular mitochondrial oxidative stress, promotes endothelial dysfunction, and enhances hypertension.

Dikalov S, Itani H, Richmond B, Vergeade A, Rahman SMJ, Boutaud O, Blackwell T, Massion PP, Harrison DG, Dikalova A.

Am J Physiol Heart Circ Physiol. 2019 Mar 1;316(3):H639-H646. doi: 10.1152/ajpheart.00595.2018. Epub 2019 Jan 4. Erratum in: Am J Physiol Heart Circ Physiol. 2019 Apr 1;316(4):H939.

PMID:
30608177
11.

Ronald G. Victor.

Harrison DG.

Hypertension. 2019 Jan;73(1):13-14. doi: 10.1161/HYPERTENSIONAHA.118.12331. No abstract available.

PMID:
30571574
12.

Th1-type immune responses to Porphyromonas gingivalis antigens exacerbate angiotensin II-dependent hypertension and vascular dysfunction.

Czesnikiewicz-Guzik M, Nosalski R, Mikolajczyk TP, Vidler F, Dohnal T, Dembowska E, Graham D, Harrison DG, Guzik TJ.

Br J Pharmacol. 2019 Jun;176(12):1922-1931. doi: 10.1111/bph.14536. Epub 2018 Dec 26.

13.

Glucose metabolism controls disease-specific signatures of macrophage effector functions.

Watanabe R, Hilhorst M, Zhang H, Zeisbrich M, Berry GJ, Wallis BB, Harrison DG, Giacomini JC, Goronzy JJ, Weyand CM.

JCI Insight. 2018 Oct 18;3(20). pii: 123047. doi: 10.1172/jci.insight.123047.

14.

Nocturnal noise knocks NOS by Nox: mechanisms underlying cardiovascular dysfunction in response to noise pollution.

Patrick DM, Harrison DG.

Eur Heart J. 2018 Oct 7;39(38):3540-3542. doi: 10.1093/eurheartj/ehy431. No abstract available.

15.

Oxidative stress induces BH4 deficiency in male, but not female, SHR.

Gillis EE, Brinson KN, Rafikova O, Chen W, Musall JB, Harrison DG, Sullivan JC.

Biosci Rep. 2018 Jul 2;38(4). pii: BSR20180111. doi: 10.1042/BSR20180111. Print 2018 Aug 31.

16.

Hypertension and increased endothelial mechanical stretch promote monocyte differentiation and activation: roles of STAT3, interleukin 6 and hydrogen peroxide.

Loperena R, Van Beusecum JP, Itani HA, Engel N, Laroumanie F, Xiao L, Elijovich F, Laffer CL, Gnecco JS, Noonan J, Maffia P, Jasiewicz-Honkisz B, Czesnikiewicz-Guzik M, Mikolajczyk T, Sliwa T, Dikalov S, Weyand CM, Guzik TJ, Harrison DG.

Cardiovasc Res. 2018 Sep 1;114(11):1547-1563. doi: 10.1093/cvr/cvy112.

17.

The nerve of the spleen! Causing hypertension by placental growth factor.

Van Beusecum JP, Harrison DG.

Cardiovasc Res. 2018 Mar 1;114(3):356-357. doi: 10.1093/cvr/cvy029. No abstract available.

18.

Reactive species balance via GTP cyclohydrolase I regulates glioblastoma growth and tumor initiating cell maintenance.

Tran AN, Walker K, Harrison DG, Chen W, Mobley J, Hocevar L, Hackney JR, Sedaka RS, Pollock JS, Goldberg MS, Hambardzumyan D, Cooper SJ, Gillespie Y, Hjelmeland AB.

Neuro Oncol. 2018 Jul 5;20(8):1055-1067. doi: 10.1093/neuonc/noy012.

19.

Correction: The immunology of hypertension.

Norlander AE, Madhur MS, Harrison DG.

J Exp Med. 2018 Feb 5;215(2):719. doi: 10.1084/jem.2017177301022018c. Epub 2018 Jan 5. No abstract available.

20.

Mechanisms of VEGF (Vascular Endothelial Growth Factor) Inhibitor-Associated Hypertension and Vascular Disease.

Pandey AK, Singhi EK, Arroyo JP, Ikizler TA, Gould ER, Brown J, Beckman JA, Harrison DG, Moslehi J.

Hypertension. 2018 Feb;71(2):e1-e8. doi: 10.1161/HYPERTENSIONAHA.117.10271. Epub 2017 Dec 26. Review. No abstract available.

21.

The immunology of hypertension.

Norlander AE, Madhur MS, Harrison DG.

J Exp Med. 2018 Jan 2;215(1):21-33. doi: 10.1084/jem.20171773. Epub 2017 Dec 15. Review. Erratum in: J Exp Med. 2018 Jan 5;:.

22.

A Special Report on the NHLBI Initiative to Study Cellular and Molecular Mechanisms of Arterial Stiffness and Its Association With Hypertension.

Oh YS, Berkowitz DE, Cohen RA, Figueroa CA, Harrison DG, Humphrey JD, Larson DF, Leopold JA, Mecham RP, Ruiz-Opazo N, Santhanam L, Seta F, Shyy JYJ, Sun Z, Tsao PS, Wagenseil JE, Galis ZS.

Circ Res. 2017 Nov 10;121(11):1216-1218. doi: 10.1161/CIRCRESAHA.117.311703. Review. No abstract available.

23.

Differential cell-matrix mechanoadaptations and inflammation drive regional propensities to aortic fibrosis, aneurysm or dissection in hypertension.

Bersi MR, Khosravi R, Wujciak AJ, Harrison DG, Humphrey JD.

J R Soc Interface. 2017 Nov;14(136). pii: 20170327. doi: 10.1098/rsif.2017.0327.

24.

Dendritic Cell Amiloride-Sensitive Channels Mediate Sodium-Induced Inflammation and Hypertension.

Barbaro NR, Foss JD, Kryshtal DO, Tsyba N, Kumaresan S, Xiao L, Mernaugh RL, Itani HA, Loperena R, Chen W, Dikalov S, Titze JM, Knollmann BC, Harrison DG, Kirabo A.

Cell Rep. 2017 Oct 24;21(4):1009-1020. doi: 10.1016/j.celrep.2017.10.002.

25.

The role of infiltrating immune cells in dysfunctional adipose tissue.

Guzik TJ, Skiba DS, Touyz RM, Harrison DG.

Cardiovasc Res. 2017 Jul 1;113(9):1009-1023. doi: 10.1093/cvr/cvx108. Review.

26.

Sirt3 Impairment and SOD2 Hyperacetylation in Vascular Oxidative Stress and Hypertension.

Dikalova AE, Itani HA, Nazarewicz RR, McMaster WG, Flynn CR, Uzhachenko R, Fessel JP, Gamboa JL, Harrison DG, Dikalov SI.

Circ Res. 2017 Aug 18;121(5):564-574. doi: 10.1161/CIRCRESAHA.117.310933. Epub 2017 Jul 6.

27.

A salt-sensing kinase in T lymphocytes, SGK1, drives hypertension and hypertensive end-organ damage.

Norlander AE, Saleh MA, Pandey AK, Itani HA, Wu J, Xiao L, Kang J, Dale BL, Goleva SB, Laroumanie F, Du L, Harrison DG, Madhur MS.

JCI Insight. 2017 Jul 6;2(13). pii: 92801. doi: 10.1172/jci.insight.92801. eCollection 2017 Jul 6.

28.

Pyruvate controls the checkpoint inhibitor PD-L1 and suppresses T cell immunity.

Watanabe R, Shirai T, Namkoong H, Zhang H, Berry GJ, Wallis BB, Schaefgen B, Harrison DG, Tremmel JA, Giacomini JC, Goronzy JJ, Weyand CM.

J Clin Invest. 2017 Jun 30;127(7):2725-2738. doi: 10.1172/JCI92167. Epub 2017 Jun 12.

29.

A New Role of Mister (MR) T in Hypertension: Mineralocorticoid Receptor, Immune System, and Hypertension.

Barbaro NR, Kirabo A, Harrison DG.

Circ Res. 2017 May 12;120(10):1527-1529. doi: 10.1161/CIRCRESAHA.117.310985. No abstract available.

30.

High salt intake reprioritizes osmolyte and energy metabolism for body fluid conservation.

Kitada K, Daub S, Zhang Y, Klein JD, Nakano D, Pedchenko T, Lantier L, LaRocque LM, Marton A, Neubert P, Schröder A, Rakova N, Jantsch J, Dikalova AE, Dikalov SI, Harrison DG, Müller DN, Nishiyama A, Rauh M, Harris RC, Luft FC, Wassermann DH, Sands JM, Titze J.

J Clin Invest. 2017 May 1;127(5):1944-1959. doi: 10.1172/JCI88532. Epub 2017 Apr 17.

31.

PETMiner-A Visual Analysis Tool for Petrophysical Properties of Core Sample Data.

Harrison DG, Efford ND, Fisher QJ, Ruddle RA.

IEEE Trans Vis Comput Graph. 2018 May;24(5):1728-1741. doi: 10.1109/TVCG.2017.2682865. Epub 2017 Mar 15.

32.

Do high-salt microenvironments drive hypertensive inflammation?

Foss JD, Kirabo A, Harrison DG.

Am J Physiol Regul Integr Comp Physiol. 2017 Jan 1;312(1):R1-R4. doi: 10.1152/ajpregu.00414.2016. Epub 2016 Nov 30. Review.

33.

Oxidative Stress and Hypertensive Diseases.

Loperena R, Harrison DG.

Med Clin North Am. 2017 Jan;101(1):169-193. doi: 10.1016/j.mcna.2016.08.004. Epub 2016 Oct 27. Review.

34.

Macrophages come to mind as keys to cognitive decline.

Harrison DG, Guzik TJ.

J Clin Invest. 2016 Dec 1;126(12):4393-4395. doi: 10.1172/JCI91277. Epub 2016 Nov 14. Review.

35.

Is Hypertension a Bone Marrow Disease?

Montaniel KR, Harrison DG.

Circulation. 2016 Nov 1;134(18):1369-1372. Epub 2016 Sep 27. No abstract available.

36.

Association of T Cell and Macrophage Activation with Arterial Vascular Health in HIV.

Grome HN, Barnett L, Hagar CC, Harrison DG, Kalams SA, Koethe JR.

AIDS Res Hum Retroviruses. 2017 Feb;33(2):181-186. doi: 10.1089/AID.2016.0113. Epub 2016 Sep 14.

37.

Measurement of Reactive Oxygen Species, Reactive Nitrogen Species, and Redox-Dependent Signaling in the Cardiovascular System: A Scientific Statement From the American Heart Association.

Griendling KK, Touyz RM, Zweier JL, Dikalov S, Chilian W, Chen YR, Harrison DG, Bhatnagar A; American Heart Association Council on Basic Cardiovascular Sciences.

Circ Res. 2016 Aug 19;119(5):e39-75. doi: 10.1161/RES.0000000000000110. Epub 2016 Jul 14. Review.

38.

National Heart, Lung, and Blood Institute Working Group Report on Salt in Human Health and Sickness: Building on the Current Scientific Evidence.

Oh YS, Appel LJ, Galis ZS, Hafler DA, He J, Hernandez AL, Joe B, Karumanchi SA, Maric-Bilkan C, Mattson D, Mehta NN, Randolph G, Ryan M, Sandberg K, Titze J, Tolunay E, Toney GM, Harrison DG.

Hypertension. 2016 Aug;68(2):281-8. doi: 10.1161/HYPERTENSIONAHA.116.07415. Epub 2016 Jun 20. Review. No abstract available.

39.

BMP Antagonist Gremlin 2 Limits Inflammation After Myocardial Infarction.

Sanders LN, Schoenhard JA, Saleh MA, Mukherjee A, Ryzhov S, McMaster WG Jr, Nolan K, Gumina RJ, Thompson TB, Magnuson MA, Harrison DG, Hatzopoulos AK.

Circ Res. 2016 Jul 22;119(3):434-49. doi: 10.1161/CIRCRESAHA.116.308700. Epub 2016 Jun 9.

40.

Activation of Human T Cells in Hypertension: Studies of Humanized Mice and Hypertensive Humans.

Itani HA, McMaster WG Jr, Saleh MA, Nazarewicz RR, Mikolajczyk TP, Kaszuba AM, Konior A, Prejbisz A, Januszewicz A, Norlander AE, Chen W, Bonami RH, Marshall AF, Poffenberger G, Weyand CM, Madhur MS, Moore DJ, Harrison DG, Guzik TJ.

Hypertension. 2016 Jul;68(1):123-32. doi: 10.1161/HYPERTENSIONAHA.116.07237. Epub 2016 May 23.

41.

Mitochondrial Cyclophilin D in Vascular Oxidative Stress and Hypertension.

Itani HA, Dikalova AE, McMaster WG, Nazarewicz RR, Bikineyeva AT, Harrison DG, Dikalov SI.

Hypertension. 2016 Jun;67(6):1218-27. doi: 10.1161/HYPERTENSIONAHA.115.07085. Epub 2016 Apr 11.

42.

Immune activation caused by vascular oxidation promotes fibrosis and hypertension.

Wu J, Saleh MA, Kirabo A, Itani HA, Montaniel KR, Xiao L, Chen W, Mernaugh RL, Cai H, Bernstein KE, Goronzy JJ, Weyand CM, Curci JA, Barbaro NR, Moreno H, Davies SS, Roberts LJ 2nd, Madhur MS, Harrison DG.

J Clin Invest. 2016 Apr 1;126(4):1607. doi: 10.1172/JCI87425. Epub 2016 Apr 1. No abstract available.

43.

Excessive Adventitial Remodeling Leads to Early Aortic Maladaptation in Angiotensin-Induced Hypertension.

Bersi MR, Bellini C, Wu J, Montaniel KRC, Harrison DG, Humphrey JD.

Hypertension. 2016 May;67(5):890-896. doi: 10.1161/HYPERTENSIONAHA.115.06262. Epub 2016 Mar 21.

44.

CD70 Exacerbates Blood Pressure Elevation and Renal Damage in Response to Repeated Hypertensive Stimuli.

Itani HA, Xiao L, Saleh MA, Wu J, Pilkinton MA, Dale BL, Barbaro NR, Foss JD, Kirabo A, Montaniel KR, Norlander AE, Chen W, Sato R, Navar LG, Mallal SA, Madhur MS, Bernstein KE, Harrison DG.

Circ Res. 2016 Apr 15;118(8):1233-43. doi: 10.1161/CIRCRESAHA.115.308111. Epub 2016 Mar 17.

45.

Novel methods for microCT-based analyses of vasculature in the renal cortex reveal a loss of perfusable arterioles and glomeruli in eNOS-/- mice.

Perrien DS, Saleh MA, Takahashi K, Madhur MS, Harrison DG, Harris RC, Takahashi T.

BMC Nephrol. 2016 Mar 2;17:24. doi: 10.1186/s12882-016-0235-5.

46.

The glycolytic enzyme PKM2 bridges metabolic and inflammatory dysfunction in coronary artery disease.

Shirai T, Nazarewicz RR, Wallis BB, Yanes RE, Watanabe R, Hilhorst M, Tian L, Harrison DG, Giacomini JC, Assimes TL, Goronzy JJ, Weyand CM.

J Exp Med. 2016 Mar 7;213(3):337-54. doi: 10.1084/jem.20150900. Epub 2016 Feb 29.

47.

Role of chemokine RANTES in the regulation of perivascular inflammation, T-cell accumulation, and vascular dysfunction in hypertension.

Mikolajczyk TP, Nosalski R, Szczepaniak P, Budzyn K, Osmenda G, Skiba D, Sagan A, Wu J, Vinh A, Marvar PJ, Guzik B, Podolec J, Drummond G, Lob HE, Harrison DG, Guzik TJ.

FASEB J. 2016 May;30(5):1987-99. doi: 10.1096/fj.201500088R. Epub 2016 Feb 12.

48.

Central Artery Stiffness in Hypertension and Aging: A Problem With Cause and Consequence.

Humphrey JD, Harrison DG, Figueroa CA, Lacolley P, Laurent S.

Circ Res. 2016 Feb 5;118(3):379-81. doi: 10.1161/CIRCRESAHA.115.307722. No abstract available.

49.

Origin of Matrix-Producing Cells That Contribute to Aortic Fibrosis in Hypertension.

Wu J, Montaniel KR, Saleh MA, Xiao L, Chen W, Owens GK, Humphrey JD, Majesky MW, Paik DT, Hatzopoulos AK, Madhur MS, Harrison DG.

Hypertension. 2016 Feb;67(2):461-8. doi: 10.1161/HYPERTENSIONAHA.115.06123. Epub 2015 Dec 22.

50.

Immune activation caused by vascular oxidation promotes fibrosis and hypertension.

Wu J, Saleh MA, Kirabo A, Itani HA, Montaniel KR, Xiao L, Chen W, Mernaugh RL, Cai H, Bernstein KE, Goronzy JJ, Weyand CM, Curci JA, Barbaro NR, Moreno H, Davies SS, Roberts LJ 2nd, Madhur MS, Harrison DG.

J Clin Invest. 2016 Jan;126(1):50-67. doi: 10.1172/JCI80761. Epub 2015 Nov 23. Erratum in: J Clin Invest. 2016 Apr 1;126(4):1607.

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