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Items: 1 to 50 of 86

1.

Regioisomer-independent quantification of fatty acid oxidation products by HPLC-ESI-MS/MS analysis of sodium adducts.

Ahern KW, Serbulea V, Wingrove CL, Palas ZT, Leitinger N, Harris TE.

Sci Rep. 2019 Aug 1;9(1):11197. doi: 10.1038/s41598-019-47693-5.

2.

Casein kinase II-mediated phosphorylation of lipin 1β phosphatidate phosphatase at Ser-285 and Ser-287 regulates its interaction with 14-3-3β protein.

Hennessy M, Granade ME, Hassaninasab A, Wang D, Kwiatek JM, Han GS, Harris TE, Carman GM.

J Biol Chem. 2019 Feb 15;294(7):2365-2374. doi: 10.1074/jbc.RA118.007246. Epub 2019 Jan 7.

PMID:
30617183
3.

Purification of Lipin and Measurement of Phosphatidic Acid Phosphatase Activity from Liposomes.

Granade ME, Harris TE.

Methods Enzymol. 2018;607:373-388. doi: 10.1016/bs.mie.2018.04.028. Epub 2018 Jun 19.

PMID:
30149866
4.

Loss of lipin 1-mediated phosphatidic acid phosphohydrolase activity in muscle leads to skeletal myopathy in mice.

Schweitzer GG, Collier SL, Chen Z, McCommis KS, Pittman SK, Yoshino J, Matkovich SJ, Hsu FF, Chrast R, Eaton JM, Harris TE, Weihl CC, Finck BN.

FASEB J. 2019 Jan;33(1):652-667. doi: 10.1096/fj.201800361R. Epub 2018 Jul 20.

PMID:
30028636
5.

STAT3 suppresses Wnt/β-catenin signaling during the induction phase of primary Myf5+ brown adipogenesis.

Cantwell MT, Farrar JS, Lownik JC, Meier JA, Hyun M, Raje V, Waters MR, Celi FS, Conrad DH, Harris TE, Larner AC.

Cytokine. 2018 Nov;111:434-444. doi: 10.1016/j.cyto.2018.05.023. Epub 2018 Jun 19.

PMID:
29934048
6.

Klf4 has an unexpected protective role in perivascular cells within the microvasculature.

Haskins RM, Nguyen AT, Alencar GF, Billaud M, Kelly-Goss MR, Good ME, Bottermann K, Klibanov AL, French BA, Harris TE, Peirce SM, Isakson BE, Owens GK.

Am J Physiol Heart Circ Physiol. 2018 Aug 1;315(2):H402-H414. doi: 10.1152/ajpheart.00084.2018. Epub 2018 Apr 6.

7.

Modulation of GSK3β autoinhibition by Thr-7 and Thr-8.

Tong Y, Park S, Wu D, Harris TE, Moskaluk CA, Brautigan DL, Fu Z.

FEBS Lett. 2018 Feb;592(4):537-546. doi: 10.1002/1873-3468.12990. Epub 2018 Feb 8.

8.

Deconstructing Lipid Kinase Inhibitors by Chemical Proteomics.

McCloud RL, Franks CE, Campbell ST, Purow BW, Harris TE, Hsu KL.

Biochemistry. 2018 Jan 16;57(2):231-236. doi: 10.1021/acs.biochem.7b00962. Epub 2017 Nov 22.

9.

Macrophages sensing oxidized DAMPs reprogram their metabolism to support redox homeostasis and inflammation through a TLR2-Syk-ceramide dependent mechanism.

Serbulea V, Upchurch CM, Ahern KW, Bories G, Voigt P, DeWeese DE, Meher AK, Harris TE, Leitinger N.

Mol Metab. 2018 Jan;7:23-34. doi: 10.1016/j.molmet.2017.11.002. Epub 2017 Nov 7.

10.

Targeting the mesenchymal subtype in glioblastoma and other cancers via inhibition of diacylglycerol kinase alpha.

Olmez I, Love S, Xiao A, Manigat L, Randolph P, McKenna BD, Neal BP, Boroda S, Li M, Brenneman B, Abounader R, Floyd D, Lee J, Nakano I, Godlewski J, Bronisz A, Sulman EP, Mayo M, Gioeli D, Weber M, Harris TE, Purow B.

Neuro Oncol. 2018 Jan 22;20(2):192-202. doi: 10.1093/neuonc/nox119.

11.

The phosphatidic acid-binding, polybasic domain is responsible for the differences in the phosphoregulation of lipins 1 and 3.

Boroda S, Takkellapati S, Lawrence RT, Entwisle SW, Pearson JM, Granade ME, Mullins GR, Eaton JM, Villén J, Harris TE.

J Biol Chem. 2017 Dec 15;292(50):20481-20493. doi: 10.1074/jbc.M117.786574. Epub 2017 Oct 5.

12.

The protein kinase C super-family member PKN is regulated by mTOR and influences differentiation during prostate cancer progression.

Yang CS, Melhuish TA, Spencer A, Ni L, Hao Y, Jividen K, Harris TE, Snow C, Frierson HF Jr, Wotton D, Paschal BM.

Prostate. 2017 Nov;77(15):1452-1467. doi: 10.1002/pros.23400. Epub 2017 Sep 6.

13.

The Ligand Binding Landscape of Diacylglycerol Kinases.

Franks CE, Campbell ST, Purow BW, Harris TE, Hsu KL.

Cell Chem Biol. 2017 Jul 20;24(7):870-880.e5. doi: 10.1016/j.chembiol.2017.06.007. Epub 2017 Jul 14.

14.

Lipin-1 regulation of phospholipid synthesis maintains endoplasmic reticulum homeostasis and is critical for triple-negative breast cancer cell survival.

He J, Zhang F, Tay LWR, Boroda S, Nian W, Levental KR, Levental I, Harris TE, Chang JT, Du G.

FASEB J. 2017 Jul;31(7):2893-2904. doi: 10.1096/fj.201601353R. Epub 2017 Mar 27.

15.

Lysophosphatidic acid counteracts glucagon-induced hepatocyte glucose production via STAT3.

Taddeo EP, Hargett SR, Lahiri S, Nelson ME, Liao JA, Li C, Slack-Davis JK, Tomsig JL, Lynch KR, Yan Z, Harris TE, Hoehn KL.

Sci Rep. 2017 Mar 9;7(1):127. doi: 10.1038/s41598-017-00210-y.

16.

Activation of murine pre-proglucagon-producing neurons reduces food intake and body weight.

Gaykema RP, Newmyer BA, Ottolini M, Raje V, Warthen DM, Lambeth PS, Niccum M, Yao T, Huang Y, Schulman IG, Harris TE, Patel MK, Williams KW, Scott MM.

J Clin Invest. 2017 Mar 1;127(3):1031-1045. doi: 10.1172/JCI81335. Epub 2017 Feb 20.

17.

Dual activities of ritanserin and R59022 as DGKα inhibitors and serotonin receptor antagonists.

Boroda S, Niccum M, Raje V, Purow BW, Harris TE.

Biochem Pharmacol. 2017 Jan 1;123:29-39. doi: 10.1016/j.bcp.2016.10.011. Epub 2016 Oct 28.

18.

SEIPIN Regulates Lipid Droplet Expansion and Adipocyte Development by Modulating the Activity of Glycerol-3-phosphate Acyltransferase.

Pagac M, Cooper DE, Qi Y, Lukmantara IE, Mak HY, Wu Z, Tian Y, Liu Z, Lei M, Du X, Ferguson C, Kotevski D, Sadowski P, Chen W, Boroda S, Harris TE, Liu G, Parton RG, Huang X, Coleman RA, Yang H.

Cell Rep. 2016 Nov 1;17(6):1546-1559. doi: 10.1016/j.celrep.2016.10.037.

19.

Kinase Inactive Tyrosine Kinase (Tyk2) Supports Differentiation of Brown Fat Cells.

Raje V, Derecka M, Cantwell M, Meier J, Szczepanek K, Sisler JD, Strobl B, Gamero A, Harris TE, Larner AC.

Endocrinology. 2017 Jan 1;158(1):148-157. doi: 10.1210/en.2015-2048.

20.

Disabled homolog 2 controls macrophage phenotypic polarization and adipose tissue inflammation.

Adamson SE, Griffiths R, Moravec R, Senthivinayagam S, Montgomery G, Chen W, Han J, Sharma PR, Mullins GR, Gorski SA, Cooper JA, Kadl A, Enfield K, Braciale TJ, Harris TE, Leitinger N.

J Clin Invest. 2016 Apr 1;126(4):1311-22. doi: 10.1172/JCI79590. Epub 2016 Feb 29.

21.

The Signal Transducer and Activator of Transcription 1 (STAT1) Inhibits Mitochondrial Biogenesis in Liver and Fatty Acid Oxidation in Adipocytes.

Sisler JD, Morgan M, Raje V, Grande RC, Derecka M, Meier J, Cantwell M, Szczepanek K, Korzun WJ, Lesnefsky EJ, Harris TE, Croniger CM, Larner AC.

PLoS One. 2015 Dec 21;10(12):e0144444. doi: 10.1371/journal.pone.0144444. eCollection 2015.

22.

Pannexin 1 is required for full activation of insulin-stimulated glucose uptake in adipocytes.

Adamson SE, Meher AK, Chiu YH, Sandilos JK, Oberholtzer NP, Walker NN, Hargett SR, Seaman SA, Peirce-Cottler SM, Isakson BE, McNamara CA, Keller SR, Harris TE, Bayliss DA, Leitinger N.

Mol Metab. 2015 Jul 3;4(9):610-8. doi: 10.1016/j.molmet.2015.06.009. eCollection 2015 Sep.

23.

Rhabdomyolysis-Associated Mutations in Human LPIN1 Lead to Loss of Phosphatidic Acid Phosphohydrolase Activity.

Schweitzer GG, Collier SL, Chen Z, Eaton JM, Connolly AM, Bucelli RC, Pestronk A, Harris TE, Finck BN.

JIMD Rep. 2015;23:113-22. doi: 10.1007/8904_2015_440. Epub 2015 May 13.

24.

Involvement of mTOR in Type 2 CRF Receptor Inhibition of Insulin Signaling in Muscle Cells.

Chao H, Li H, Grande R, Lira V, Yan Z, Harris TE, Li C.

Mol Endocrinol. 2015 Jun;29(6):831-41. doi: 10.1210/me.2014-1245. Epub 2015 Apr 15.

25.

Inhibited insulin signaling in mouse hepatocytes is associated with increased phosphatidic acid but not diacylglycerol.

Zhang C, Hwarng G, Cooper DE, Grevengoed TJ, Eaton JM, Natarajan V, Harris TE, Coleman RA.

J Biol Chem. 2015 Feb 6;290(6):3519-28. doi: 10.1074/jbc.M114.602789. Epub 2014 Dec 15.

26.

Correction to assembly of high molecular weight complexes of lipin on a supported lipid bilayer observed by atomic force microscopy.

Creutz CE, Eaton JM, Harris TE.

Biochemistry. 2014 Dec 16;53(49):7866. doi: 10.1021/bi501457g. Epub 2014 Dec 4. No abstract available.

27.

Catecholamine-induced lipolysis causes mTOR complex dissociation and inhibits glucose uptake in adipocytes.

Mullins GR, Wang L, Raje V, Sherwood SG, Grande RC, Boroda S, Eaton JM, Blancquaert S, Roger PP, Leitinger N, Harris TE.

Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):17450-5. doi: 10.1073/pnas.1410530111. Epub 2014 Nov 24.

28.

Vorticity generation by the instantaneous release of energy near a reflective boundary.

Moresco P, Harris TE, Jodoin V.

Phys Rev E Stat Nonlin Soft Matter Phys. 2014 Aug;90(2):023002. Epub 2014 Aug 8.

PMID:
25215815
29.

Glycerol-3-phosphate acyltransferase-4-deficient mice are protected from diet-induced insulin resistance by the enhanced association of mTOR and rictor.

Zhang C, Cooper DE, Grevengoed TJ, Li LO, Klett EL, Eaton JM, Harris TE, Coleman RA.

Am J Physiol Endocrinol Metab. 2014 Aug 1;307(3):E305-15. doi: 10.1152/ajpendo.00034.2014. Epub 2014 Jun 17.

30.

Lipin 2 binds phosphatidic acid by the electrostatic hydrogen bond switch mechanism independent of phosphorylation.

Eaton JM, Takkellapati S, Lawrence RT, McQueeney KE, Boroda S, Mullins GR, Sherwood SG, Finck BN, Villén J, Harris TE.

J Biol Chem. 2014 Jun 27;289(26):18055-66. doi: 10.1074/jbc.M114.547604. Epub 2014 May 8.

31.

Opening of the mitochondrial permeability transition pore links mitochondrial dysfunction to insulin resistance in skeletal muscle.

Taddeo EP, Laker RC, Breen DS, Akhtar YN, Kenwood BM, Liao JA, Zhang M, Fazakerley DJ, Tomsig JL, Harris TE, Keller SR, Chow JD, Lynch KR, Chokki M, Molkentin JD, Turner N, James DE, Yan Z, Hoehn KL.

Mol Metab. 2013 Nov 26;3(2):124-34. doi: 10.1016/j.molmet.2013.11.003. eCollection 2014 Apr.

32.

Conserved residues in the N terminus of lipin-1 are required for binding to protein phosphatase-1c, nuclear translocation, and phosphatidate phosphatase activity.

Kok BP, Skene-Arnold TD, Ling J, Benesch MG, Dewald J, Harris TE, Holmes CF, Brindley DN.

J Biol Chem. 2014 Apr 11;289(15):10876-86. doi: 10.1074/jbc.M114.552612. Epub 2014 Feb 20.

33.

Assembly of high molecular weight complexes of lipin on a supported lipid bilayer observed by atomic force microscopy.

Creutz CE, Eaton JM, Harris TE.

Biochemistry. 2013 Jul 30;52(30):5092-102. doi: 10.1021/bi4004765. Epub 2013 Jul 17. Erratum in: Biochemistry. 2014 Dec 16;53(49):7866.

34.

Diacylglycerol kinase α is a critical signaling node and novel therapeutic target in glioblastoma and other cancers.

Dominguez CL, Floyd DH, Xiao A, Mullins GR, Kefas BA, Xin W, Yacur MN, Abounader R, Lee JK, Wilson GM, Harris TE, Purow BW.

Cancer Discov. 2013 Jul;3(7):782-97. doi: 10.1158/2159-8290.CD-12-0215. Epub 2013 Apr 4.

35.

Differential regulation of the expressions of the PGC-1α splice variants, lipins, and PPARα in heart compared to liver.

Kok BP, Dyck JR, Harris TE, Brindley DN.

J Lipid Res. 2013 Jun;54(6):1662-77. doi: 10.1194/jlr.M036624. Epub 2013 Mar 16.

36.

Phosphorylation of lipin 1 and charge on the phosphatidic acid head group control its phosphatidic acid phosphatase activity and membrane association.

Eaton JM, Mullins GR, Brindley DN, Harris TE.

J Biol Chem. 2013 Apr 5;288(14):9933-45. doi: 10.1074/jbc.M112.441493. Epub 2013 Feb 20.

37.

Mice with an adipocyte-specific lipin 1 separation-of-function allele reveal unexpected roles for phosphatidic acid in metabolic regulation.

Mitra MS, Chen Z, Ren H, Harris TE, Chambers KT, Hall AM, Nadra K, Klein S, Chrast R, Su X, Morris AJ, Finck BN.

Proc Natl Acad Sci U S A. 2013 Jan 8;110(2):642-7. doi: 10.1073/pnas.1213493110. Epub 2012 Dec 24.

38.

Tyk2 and Stat3 regulate brown adipose tissue differentiation and obesity.

Derecka M, Gornicka A, Koralov SB, Szczepanek K, Morgan M, Raje V, Sisler J, Zhang Q, Otero D, Cichy J, Rajewsky K, Shimoda K, Poli V, Strobl B, Pellegrini S, Harris TE, Seale P, Russell AP, McAinch AJ, O'Brien PE, Keller SR, Croniger CM, Kordula T, Larner AC.

Cell Metab. 2012 Dec 5;16(6):814-24. doi: 10.1016/j.cmet.2012.11.005.

39.

Caloric restriction in mTORC1 control of intestinal homeostasis.

Harris TE, Thorner MO.

Cell Metab. 2012 Jul 3;16(1):6-8. doi: 10.1016/j.cmet.2012.06.010.

40.

Intestinal cell kinase (ICK) promotes activation of mTOR complex 1 (mTORC1) through phosphorylation of Raptor Thr-908.

Wu D, Chapman JR, Wang L, Harris TE, Shabanowitz J, Hunt DF, Fu Z.

J Biol Chem. 2012 Apr 6;287(15):12510-9. doi: 10.1074/jbc.M111.302117. Epub 2012 Feb 22.

41.

Glycerolipid signals alter mTOR complex 2 (mTORC2) to diminish insulin signaling.

Zhang C, Wendel AA, Keogh MR, Harris TE, Chen J, Coleman RA.

Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):1667-72. doi: 10.1073/pnas.1110730109. Epub 2012 Jan 17.

42.

Multiple site acetylation of Rictor stimulates mammalian target of rapamycin complex 2 (mTORC2)-dependent phosphorylation of Akt protein.

Glidden EJ, Gray LG, Vemuru S, Li D, Harris TE, Mayo MW.

J Biol Chem. 2012 Jan 2;287(1):581-8. doi: 10.1074/jbc.M111.304337. Epub 2011 Nov 14.

43.

mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway.

Peterson TR, Sengupta SS, Harris TE, Carmack AE, Kang SA, Balderas E, Guertin DA, Madden KL, Carpenter AE, Finck BN, Sabatini DM.

Cell. 2011 Aug 5;146(3):408-20. doi: 10.1016/j.cell.2011.06.034.

44.

Role of SRC family kinase in extracellular renal cyclic guanosine 3',5'-monophosphate- and pressure-induced natriuresis.

Nascimento NR, Kemp BA, Howell NL, Gildea JJ, Santos CF, Harris TE, Carey RM.

Hypertension. 2011 Jul;58(1):107-13. doi: 10.1161/HYPERTENSIONAHA.110.168708. Epub 2011 Apr 11.

45.

Dual function lipin proteins and glycerolipid metabolism.

Harris TE, Finck BN.

Trends Endocrinol Metab. 2011 Jun;22(6):226-33. doi: 10.1016/j.tem.2011.02.006. Epub 2011 Apr 4. Review.

46.

Lipin proteins form homo- and hetero-oligomers.

Liu GH, Qu J, Carmack AE, Kim HB, Chen C, Ren H, Morris AJ, Finck BN, Harris TE.

Biochem J. 2010 Nov 15;432(1):65-76. doi: 10.1042/BJ20100584.

47.

cAMP-dependent activation of mammalian target of rapamycin (mTOR) in thyroid cells. Implication in mitogenesis and activation of CDK4.

Blancquaert S, Wang L, Paternot S, Coulonval K, Dumont JE, Harris TE, Roger PP.

Mol Endocrinol. 2010 Jul;24(7):1453-68. doi: 10.1210/me.2010-0087. Epub 2010 May 19.

48.

Lipin 1 represses NFATc4 transcriptional activity in adipocytes to inhibit secretion of inflammatory factors.

Kim HB, Kumar A, Wang L, Liu GH, Keller SR, Lawrence JC Jr, Finck BN, Harris TE.

Mol Cell Biol. 2010 Jun;30(12):3126-39. doi: 10.1128/MCB.01671-09. Epub 2010 Apr 12.

49.

Fat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolism.

Kumar A, Lawrence JC Jr, Jung DY, Ko HJ, Keller SR, Kim JK, Magnuson MA, Harris TE.

Diabetes. 2010 Jun;59(6):1397-406. doi: 10.2337/db09-1061. Epub 2010 Mar 23.

50.

Insulin-stimulated interaction with 14-3-3 promotes cytoplasmic localization of lipin-1 in adipocytes.

Péterfy M, Harris TE, Fujita N, Reue K.

J Biol Chem. 2010 Feb 5;285(6):3857-64. doi: 10.1074/jbc.M109.072488. Epub 2009 Dec 2.

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