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Items: 1 to 50 of 328

1.

An example of medical device-based projection of clinical trial enrollment: Use of electrocardiographic data to identify candidates for a trial in acute coronary syndromes.

Selker HP, Kwong M, Ruthazer R, Gorman S, Green G, Patchen E, Udelson JE, Smithline HA, Baumann MR, Harris PA, Shah RU, Nelson SJ, Cohen T, Jones EB, Barnewolt BA, Williams AE.

J Clin Transl Sci. 2018 Dec;2(6):377-383. doi: 10.1017/cts.2019.365.

2.

Identification of a RIP1 Kinase Inhibitor Clinical Candidate (GSK3145095) for the Treatment of Pancreatic Cancer.

Harris PA, Marinis JM, Lich JD, Berger SB, Chirala A, Cox JA, Eidam PM, Finger JN, Gough PJ, Jeong JU, Kang J, Kasparcova V, Leister LK, Mahajan MK, Miller G, Nagilla R, Ouellette MT, Reilly MA, Rendina AR, Rivera EJ, Sun HH, Thorpe JH, Totoritis RD, Wang W, Wu D, Zhang D, Bertin J, Marquis RW.

ACS Med Chem Lett. 2019 May 9;10(6):857-862. doi: 10.1021/acsmedchemlett.9b00108. eCollection 2019 Jun 13.

3.

The REDCap consortium: Building an international community of software platform partners.

Harris PA, Taylor R, Minor BL, Elliott V, Fernandez M, O'Neal L, McLeod L, Delacqua G, Delacqua F, Kirby J, Duda SN; REDCap Consortium.

J Biomed Inform. 2019 Jul;95:103208. doi: 10.1016/j.jbi.2019.103208. Epub 2019 May 9.

PMID:
31078660
4.

We're not all cut from the same cloth: TAILORing treatments for children with chronic conditions.

Jerome RN, Pulley JM, Edwards TL, Dickerson AB, Conway D, Van Driest SL, Bernard GR, Harris PA.

J Patient Rep Outcomes. 2019 Apr 29;3(1):25. doi: 10.1186/s41687-019-0117-2.

5.

Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase.

Harris PA, Faucher N, George N, Eidam PM, King BW, White GV, Anderson NA, Bandyopadhyay D, Beal AM, Beneton V, Berger SB, Campobasso N, Campos S, Capriotti CA, Cox JA, Daugan A, Donche F, Fouchet MH, Finger JN, Geddes B, Gough PJ, Grondin P, Hoffman BL, Hoffman SJ, Hutchinson SE, Jeong JU, Jigorel E, Lamoureux P, Leister LK, Lich JD, Mahajan MK, Meslamani J, Mosley JE, Nagilla R, Nassau PM, Ng SL, Ouellette MT, Pasikanti KK, Potvain F, Reilly MA, Rivera EJ, Sautet S, Schaeffer MC, Sehon CA, Sun H, Thorpe JH, Totoritis RD, Ward P, Wellaway N, Wisnoski DD, Woolven JM, Bertin J, Marquis RW.

J Med Chem. 2019 May 23;62(10):5096-5110. doi: 10.1021/acs.jmedchem.9b00318. Epub 2019 May 2.

PMID:
31013427
6.

A collaborative, academic approach to optimizing the national clinical research infrastructure: The first year of the Trial Innovation Network.

Bernard GR, Harris PA, Pulley JM, Benjamin DK, Michael J, Ford DE, Hanley DF, Selker HP, Wilkins CH.

J Clin Transl Sci. 2018 Aug;2(4):187-192. doi: 10.1017/cts.2018.319. Epub 2018 Nov 27.

7.

Understanding What Information Is Valued By Research Participants, And Why.

Wilkins CH, Mapes BM, Jerome RN, Villalta-Gil V, Pulley JM, Harris PA.

Health Aff (Millwood). 2019 Mar;38(3):399-407. doi: 10.1377/hlthaff.2018.05046.

PMID:
30830824
8.

Sustainability considerations for clinical and translational research informatics infrastructure.

Obeid JS, Tarczy-Hornoch P, Harris PA, Barnett WK, Anderson NR, Embi PJ, Hogan WR, Bell DS, McIntosh LD, Knosp B, Tachinardi U, Cimino JJ, Wehbe FH.

J Clin Transl Sci. 2018 Oct;2(5):267-275. doi: 10.1017/cts.2018.332. Epub 2018 Dec 5.

9.

Connecting the public with clinical trial options: The ResearchMatch Trials Today tool.

Pulley JM, Jerome RN, Bernard GR, Olson EJ, Tan J, Wilkins CH, Harris PA.

J Clin Transl Sci. 2018 Aug;2(4):253-257. doi: 10.1017/cts.2018.327.

10.

RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation.

Liccardi G, Ramos Garcia L, Tenev T, Annibaldi A, Legrand AJ, Robertson D, Feltham R, Anderton H, Darding M, Peltzer N, Dannappel M, Schünke H, Fava LL, Haschka MD, Glatter T, Nesvizhskii A, Schmidt A, Harris PA, Bertin J, Gough PJ, Villunger A, Silke J, Pasparakis M, Bianchi K, Meier P.

Mol Cell. 2019 Feb 7;73(3):413-428.e7. doi: 10.1016/j.molcel.2018.11.010. Epub 2018 Dec 28.

11.

The Equine Gastrointestinal Microbiome: Impacts of Age and Obesity.

Morrison PK, Newbold CJ, Jones E, Worgan HJ, Grove-White DH, Dugdale AH, Barfoot C, Harris PA, Argo CM.

Front Microbiol. 2018 Dec 7;9:3017. doi: 10.3389/fmicb.2018.03017. eCollection 2018.

12.

Influence of dietary restriction and low-intensity exercise on weight loss and insulin sensitivity in obese equids.

Bamford NJ, Potter SJ, Baskerville CL, Harris PA, Bailey SR.

J Vet Intern Med. 2019 Jan;33(1):280-286. doi: 10.1111/jvim.15374. Epub 2018 Dec 5.

13.

The effect of insulin on equine lamellar basal epithelial cells mediated by the insulin-like growth factor-1 receptor.

Baskerville CL, Chockalingham S, Harris PA, Bailey SR.

PeerJ. 2018 Nov 29;6:e5945. doi: 10.7717/peerj.5945. eCollection 2018.

14.

RIP1 Kinase Drives Macrophage-Mediated Adaptive Immune Tolerance in Pancreatic Cancer.

Wang W, Marinis JM, Beal AM, Savadkar S, Wu Y, Khan M, Taunk PS, Wu N, Su W, Wu J, Ahsan A, Kurz E, Chen T, Yaboh I, Li F, Gutierrez J, Diskin B, Hundeyin M, Reilly M, Lich JD, Harris PA, Mahajan MK, Thorpe JH, Nassau P, Mosley JE, Leinwand J, Kochen Rossi JA, Mishra A, Aykut B, Glacken M, Ochi A, Verma N, Kim JI, Vasudevaraja V, Adeegbe D, Almonte C, Bagdatlioglu E, Cohen DJ, Wong KK, Bertin J, Miller G.

Cancer Cell. 2018 Nov 12;34(5):757-774.e7. doi: 10.1016/j.ccell.2018.10.006.

PMID:
30423296
15.

Patient and healthcare provider views on a patient-reported outcomes portal.

Cronin RM, Conway D, Condon D, Jerome RN, Byrne DW, Harris PA.

J Am Med Inform Assoc. 2018 Nov 1;25(11):1470-1480. doi: 10.1093/jamia/ocy111.

PMID:
30239733
16.

Elevated A20 promotes TNF-induced and RIPK1-dependent intestinal epithelial cell death.

Garcia-Carbonell R, Wong J, Kim JY, Close LA, Boland BS, Wong TL, Harris PA, Ho SB, Das S, Ernst PB, Sasik R, Sandborn WJ, Bertin J, Gough PJ, Chang JT, Kelliher M, Boone D, Guma M, Karin M.

Proc Natl Acad Sci U S A. 2018 Sep 25;115(39):E9192-E9200. doi: 10.1073/pnas.1810584115. Epub 2018 Sep 12.

17.

Characterization of insulin and IGF-1 receptor binding in equine liver and lamellar tissue: implications for endocrinopathic laminitis.

Nanayakkara SN, Rahnama S, Harris PA, Anderson ST, de Laat MA, Bailey S, Sillence MN.

Domest Anim Endocrinol. 2019 Jan;66:21-26. doi: 10.1016/j.domaniend.2018.05.008. Epub 2018 Jun 7.

PMID:
30205269
18.

Cell specific microvesicles vary with season and disease predisposition in healthy and previously laminitic ponies.

Finding EJT, Lawson C, Elliott J, Harris PA, Menzies-Gow NJ.

Vet Immunol Immunopathol. 2018 Aug;202:85-92. doi: 10.1016/j.vetimm.2018.06.001. Epub 2018 Jun 23.

PMID:
30078603
19.

Comparison of Immediate versus Delayed DIEP Flap Reconstruction in Women Who Require Postmastectomy Radiotherapy.

O'Connell RL, Di Micco R, Khabra K, Kirby AM, Harris PA, James SE, Power K, Ramsey KWD, Rusby JE.

Plast Reconstr Surg. 2018 Sep;142(3):594-605. doi: 10.1097/PRS.0000000000004676.

20.

A content analysis of Clinical and Translational Science Award (CTSA) strategies for communicating about clinical research participation online.

Flood-Grady E, Paige SR, Karimipour N, Harris PA, Cottler LB, Krieger JL.

J Clin Transl Sci. 2017 Dec;1(6):340-351. doi: 10.1017/cts.2018.2.

21.

Effect of varying the dose of corn syrup on the insulin and glucose response to the oral sugar test.

Jocelyn NA, Harris PA, Menzies-Gow NJ.

Equine Vet J. 2018 Nov;50(6):836-841. doi: 10.1111/evj.12826. Epub 2018 Mar 22.

PMID:
29504630
22.

Genetically modified lentiviruses that preserve microvascular function protect against late radiation damage in normal tissues.

Khan AA, Paget JT, McLaughlin M, Kyula JN, Wilkinson MJ, Pencavel T, Mansfield D, Roulstone V, Seth R, Halle M, Somaiah N, Boult JKR, Robinson SP, Pandha HS, Vile RG, Melcher AA, Harris PA, Harrington KJ.

Sci Transl Med. 2018 Jan 24;10(425). pii: eaar2041. doi: 10.1126/scitranslmed.aar2041.

23.

Effects of age and diet on glucose and insulin dynamics in the horse.

Rapson JL, Schott HC 2nd, Nielsen BD, McCutcheon LJ, Harris PA, Geor RJ.

Equine Vet J. 2018 Sep;50(5):690-696. doi: 10.1111/evj.12812. Epub 2018 Feb 21.

PMID:
29356053
24.

Plasma adrenocorticotropic hormone (ACTH) concentrations in ponies measured by two different assays suggests seasonal cross-reactivity or interference.

Knowles EJ, Moreton-Clack MC, Shaw S, Harris PA, Elliott J, Menzies-Gow NJ.

Equine Vet J. 2018 Sep;50(5):672-677. doi: 10.1111/evj.12797. Epub 2018 Feb 6.

PMID:
29247453
25.

Randomized clinical study of safety, pharmacokinetics, and pharmacodynamics of RIPK1 inhibitor GSK2982772 in healthy volunteers.

Weisel K, Scott NE, Tompson DJ, Votta BJ, Madhavan S, Povey K, Wolstenholme A, Simeoni M, Rudo T, Richards-Peterson L, Sahota T, Wang JG, Lich J, Finger J, Verticelli A, Reilly M, Gough PJ, Harris PA, Bertin J, Wang ML.

Pharmacol Res Perspect. 2017 Dec;5(6). doi: 10.1002/prp2.365.

26.

Identification of an antibody-based immunoassay for measuring direct target binding of RIPK1 inhibitors in cells and tissues.

Finger JN, Brusq JM, Campobasso N, Cook MN, Deutsch J, Haag H, Harris PA, Jenkins EL, Joglekar D, Lich JD, Maguire S, Nagilla R, Rivera EJ, Sun H, Votta BJ, Bertin J, Gough PJ.

Pharmacol Res Perspect. 2017 Dec;5(6). doi: 10.1002/prp2.377.

27.

Effect of dietary carbohydrates and time of year on ACTH and cortisol concentrations in adult and aged horses.

Jacob SI, Geor RJ, Weber PSD, Harris PA, McCue ME.

Domest Anim Endocrinol. 2018 Apr;63:15-22. doi: 10.1016/j.domaniend.2017.10.005. Epub 2017 Nov 1.

PMID:
29195115
28.

A single-centre, retrospective proof-of-concept review of salvage of infected or exposed implant breast reconstructions with explantation and one-stage free flap replacement.

Bramhall RJ, Hernan I, Harris PA.

J Plast Reconstr Aesthet Surg. 2018 Feb;71(2):194-200. doi: 10.1016/j.bjps.2017.10.009. Epub 2017 Oct 18.

PMID:
29122498
29.

Autophagy protein ATG16L1 prevents necroptosis in the intestinal epithelium.

Matsuzawa-Ishimoto Y, Shono Y, Gomez LE, Hubbard-Lucey VM, Cammer M, Neil J, Dewan MZ, Lieberman SR, Lazrak A, Marinis JM, Beal A, Harris PA, Bertin J, Liu C, Ding Y, van den Brink MRM, Cadwell K.

J Exp Med. 2017 Dec 4;214(12):3687-3705. doi: 10.1084/jem.20170558. Epub 2017 Oct 31.

30.

Incidence of laminitis and survey of dietary and management practices in pleasure horses and ponies in south-eastern Australia.

Potter SJ, Bamford NJ, Harris PA, Bailey SR.

Aust Vet J. 2017 Oct;95(10):370-374. doi: 10.1111/avj.12635.

PMID:
28948628
31.

Changes in the Total Fecal Bacterial Population in Individual Horses Maintained on a Restricted Diet Over 6 Weeks.

Dougal K, Harris PA, Girdwood SE, Creevey CJ, Curtis GC, Barfoot CF, Argo CM, Newbold CJ.

Front Microbiol. 2017 Aug 11;8:1502. doi: 10.3389/fmicb.2017.01502. eCollection 2017.

32.

Effect of age and dietary carbohydrate profiles on glucose and insulin dynamics in horses.

Jacob SI, Geor RJ, Weber PSD, Harris PA, McCue ME.

Equine Vet J. 2018 Mar;50(2):249-254. doi: 10.1111/evj.12745. Epub 2017 Sep 13.

PMID:
28833406
33.

Recruitment methods for survey research: Findings from the Mid-South Clinical Data Research Network.

Heerman WJ, Jackson N, Roumie CL, Harris PA, Rosenbloom ST, Pulley J, Wilkins CH, Williams NA, Crenshaw D, Leak C, Scherdin J, Muñoz D, Bachmann J, Rothman RL, Kripalani S.

Contemp Clin Trials. 2017 Nov;62:50-55. doi: 10.1016/j.cct.2017.08.006. Epub 2017 Aug 17.

PMID:
28823925
34.

Monitoring Anesthesia Care Delivery and Perioperative Mortality in Kenya Utilizing a Provider-driven Novel Data Collection Tool.

Sileshi B, Newton MW, Kiptanui J, Shotwell MS, Wanderer JP, Mungai M, Scherdin J, Harris PA, Vermund SH, Sandberg WS, McEvoy MD.

Anesthesiology. 2017 Aug;127(2):250-271. doi: 10.1097/ALN.0000000000001713.

35.

Comparison and validation of ELISA assays for plasma insulin-like growth factor-1 in the horse.

Baskerville CL, Bamford NJ, Harris PA, Bailey SR.

Open Vet J. 2017;7(1):75-80. doi: 10.4314/ovj.v7i1.12. Epub 2017 Mar 31.

36.

Intra-operative techniques to reduce the risk of capsular contracture in patients undergoing aesthetic breast augmentation - A review.

Horsnell JD, Searle AE, Harris PA.

Surgeon. 2017 Oct;15(5):282-289. doi: 10.1016/j.surge.2017.03.001. Epub 2017 May 2. Review.

PMID:
28476310
37.

Exogenous lactobacilli mitigate microbial changes associated with grain fermentation (corn, oats, and wheat) by equine fecal microflora ex vivo.

Harlow BE, Lawrence LM, Harris PA, Aiken GE, Flythe MD.

PLoS One. 2017 Mar 30;12(3):e0174059. doi: 10.1371/journal.pone.0174059. eCollection 2017.

38.

EQUIFAT: A novel scoring system for the semi-quantitative evaluation of regional adipose tissues in Equidae.

Morrison PK, Harris PA, Maltin CA, Grove-White D, Argo CM.

PLoS One. 2017 Mar 15;12(3):e0173753. doi: 10.1371/journal.pone.0173753. eCollection 2017.

39.

Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases.

Harris PA, Berger SB, Jeong JU, Nagilla R, Bandyopadhyay D, Campobasso N, Capriotti CA, Cox JA, Dare L, Dong X, Eidam PM, Finger JN, Hoffman SJ, Kang J, Kasparcova V, King BW, Lehr R, Lan Y, Leister LK, Lich JD, MacDonald TT, Miller NA, Ouellette MT, Pao CS, Rahman A, Reilly MA, Rendina AR, Rivera EJ, Schaeffer MC, Sehon CA, Singhaus RR, Sun HH, Swift BA, Totoritis RD, Vossenkämper A, Ward P, Wisnoski DD, Zhang D, Marquis RW, Gough PJ, Bertin J.

J Med Chem. 2017 Feb 23;60(4):1247-1261. doi: 10.1021/acs.jmedchem.6b01751. Epub 2017 Feb 10.

PMID:
28151659
40.

Review: Feeding conserved forage to horses: recent advances and recommendations.

Harris PA, Ellis AD, Fradinho MJ, Jansson A, Julliand V, Luthersson N, Santos AS, Vervuert I.

Animal. 2017 Jun;11(6):958-967. doi: 10.1017/S1751731116002469. Epub 2016 Nov 24. Review.

PMID:
27881201
41.

Prevalence of obesity and owners' perceptions of body condition in pleasure horses and ponies in south-eastern Australia.

Potter SJ, Bamford NJ, Harris PA, Bailey SR.

Aust Vet J. 2016 Nov;94(11):427-432. doi: 10.1111/avj.12506.

PMID:
27785793
42.

Effect of increased adiposity on insulin sensitivity and adipokine concentrations in different equine breeds adapted to cereal-rich or fat-rich meals.

Bamford NJ, Potter SJ, Baskerville CL, Harris PA, Bailey SR.

Vet J. 2016 Aug;214:14-20. doi: 10.1016/j.tvjl.2016.02.002. Epub 2016 Feb 12.

PMID:
27387720
43.

Use of the oral sugar test in ponies when performed with or without prior fasting.

Knowles EJ, Harris PA, Elliott J, Menzies-Gow NJ.

Equine Vet J. 2017 Jul;49(4):519-524. doi: 10.1111/evj.12607. Epub 2016 Sep 5.

PMID:
27381044
44.

Prospective cohort study evaluating risk factors for the development of pasture-associated laminitis in the United Kingdom.

Menzies-Gow NJ, Harris PA, Elliott J.

Equine Vet J. 2017 May;49(3):300-306. doi: 10.1111/evj.12606. Epub 2016 Aug 25.

PMID:
27363591
45.

The Opioid Epidemic: AMA's response.

Harris PA.

Am Fam Physician. 2016 Jun 15;93(12):975.

46.

PheKB: a catalog and workflow for creating electronic phenotype algorithms for transportability.

Kirby JC, Speltz P, Rasmussen LV, Basford M, Gottesman O, Peissig PL, Pacheco JA, Tromp G, Pathak J, Carrell DS, Ellis SB, Lingren T, Thompson WK, Savova G, Haines J, Roden DM, Harris PA, Denny JC.

J Am Med Inform Assoc. 2016 Nov;23(6):1046-1052. doi: 10.1093/jamia/ocv202. Epub 2016 Mar 28.

47.

DNA-Encoded Library Screening Identifies Benzo[b][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors.

Harris PA, King BW, Bandyopadhyay D, Berger SB, Campobasso N, Capriotti CA, Cox JA, Dare L, Dong X, Finger JN, Grady LC, Hoffman SJ, Jeong JU, Kang J, Kasparcova V, Lakdawala AS, Lehr R, McNulty DE, Nagilla R, Ouellette MT, Pao CS, Rendina AR, Schaeffer MC, Summerfield JD, Swift BA, Totoritis RD, Ward P, Zhang A, Zhang D, Marquis RW, Bertin J, Gough PJ.

J Med Chem. 2016 Mar 10;59(5):2163-78. doi: 10.1021/acs.jmedchem.5b01898. Epub 2016 Feb 23.

PMID:
26854747
48.

Antioxidant Activity of 3-[N-(Acylhydrazono)ethyl]-4-hydroxy-coumarins.

Kotali A, Nasiopoulou DA, Tsoleridis CA, Harris PA, Kontogiorgis CA, Hadjipavlou-Litina DJ.

Molecules. 2016 Jan 23;21(2):138. doi: 10.3390/molecules21020138.

49.

Effects of threonine supplementation on whole-body protein synthesis and plasma metabolites in growing and mature horses.

Mastellar SL, Moffet A, Harris PA, Urschel KL.

Vet J. 2016 Jan;207:147-153. doi: 10.1016/j.tvjl.2015.09.026. Epub 2015 Oct 8.

PMID:
26670331
50.

Recommendations to Facilitate Expanded Access to Investigational Therapies for Seriously Ill Patients.

Jerome RN, Edwards TL, Boswell HC, Bernard GR, Harris PA, Pulley JM.

Acad Med. 2016 Mar;91(3):305-9. doi: 10.1097/ACM.0000000000000914.

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