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Items: 46

1.

Glutathione Restricts Serine Metabolism to Preserve Regulatory T Cell Function.

Kurniawan H, Franchina DG, Guerra L, Bonetti L, -Baguet LS, Grusdat M, Schlicker L, Hunewald O, Dostert C, Merz MP, Binsfeld C, Duncan GS, Farinelle S, Nonnenmacher Y, Haight J, Das Gupta D, Ewen A, Taskesen R, Halder R, Chen Y, Jäger C, Ollert M, Wilmes P, Vasiliou V, Harris IS, Knobbe-Thomsen CB, Turner JD, Mak TW, Lohoff M, Meiser J, Hiller K, Brenner D.

Cell Metab. 2020 Mar 16. pii: S1550-4131(20)30119-4. doi: 10.1016/j.cmet.2020.03.004. [Epub ahead of print]

PMID:
32213345
2.

Author Correction: Human somatic cell mutagenesis creates genetically tractable sarcomas.

Molyneux SD, Waterhouse PD, Shelton D, Shao YW, Watling CM, Tang QL, Harris IS, Dickson BC, Tharmapalan P, Sandve GK, Zhang X, Bailey SD, Berman H, Wunder JS, Izsvák Z, Lupien M, Mak TW, Khokha R.

Nat Genet. 2020 Feb 24. doi: 10.1038/s41588-020-0589-2. [Epub ahead of print]

PMID:
32094913
3.

United They Stand, Divided They Fall.

Harris IS, Brugge JS.

Cell Metab. 2019 Oct 1;30(4):624-625. doi: 10.1016/j.cmet.2019.09.008.

PMID:
31577930
4.

Age- and Lesion-Related Comorbidity Burden Among US Adults With Congenital Heart Disease: A Population-Based Study.

Agarwal A, Thombley R, Broberg CS, Harris IS, Foster E, Mahadevan VS, John A, Vittinghoff E, Marcus GM, Dudley RA.

J Am Heart Assoc. 2019 Oct 15;8(20):e013450. doi: 10.1161/JAHA.119.013450. Epub 2019 Oct 2.

5.

Pregnancy complications and premature cardiovascular events among 1.6 million California pregnancies.

Arnaout R, Nah G, Marcus G, Tseng Z, Foster E, Harris IS, Divanji P, Klein L, Gonzalez J, Parikh N.

Open Heart. 2019 Feb 27;6(1):e000927. doi: 10.1136/openhrt-2018-000927. eCollection 2019.

6.

Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion.

Harris IS, Endress JE, Coloff JL, Selfors LM, McBrayer SK, Rosenbluth JM, Takahashi N, Dhakal S, Koduri V, Oser MG, Schauer NJ, Doherty LM, Hong AL, Kang YP, Younger ST, Doench JG, Hahn WC, Buhrlage SJ, DeNicola GM, Kaelin WG Jr, Brugge JS.

Cell Metab. 2019 May 7;29(5):1166-1181.e6. doi: 10.1016/j.cmet.2019.01.020. Epub 2019 Feb 21.

PMID:
30799286
7.

Contraceptive Choices in the Immediate Postpartum Period in Women With Cardiac Disease.

Sobhani NC, Schultz H, Kheiwa A, Killion M, Parikh NI, Harris IS, Gonzalez JM, Agarwal A.

Am J Cardiol. 2019 Apr 15;123(8):1364-1369. doi: 10.1016/j.amjcard.2019.01.006. Epub 2019 Jan 25.

PMID:
30712772
8.

Inhibition of epithelial cell migration and Src/FAK signaling by SIRT3.

Lee JJ, van de Ven RAH, Zaganjor E, Ng MR, Barakat A, Demmers JJPG, Finley LWS, Gonzalez Herrera KN, Hung YP, Harris IS, Jeong SM, Danuser G, McAllister SS, Haigis MC.

Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):7057-7062. doi: 10.1073/pnas.1800440115. Epub 2018 Jun 18.

9.

Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance.

Takahashi N, Chen HY, Harris IS, Stover DG, Selfors LM, Bronson RT, Deraedt T, Cichowski K, Welm AL, Mori Y, Mills GB, Brugge JS.

Cancer Cell. 2018 Jun 11;33(6):985-1003.e7. doi: 10.1016/j.ccell.2018.05.001. Epub 2018 May 24.

10.

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, Bazan NG, Bernassola F, Bertrand MJM, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Boya P, Brenner C, Campanella M, Candi E, Carmona-Gutierrez D, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Cohen GM, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D'Angiolella V, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, DeBerardinis RJ, Deshmukh M, Di Daniele N, Di Virgilio F, Dixit VM, Dixon SJ, Duckett CS, Dynlacht BD, El-Deiry WS, Elrod JW, Fimia GM, Fulda S, García-Sáez AJ, Garg AD, Garrido C, Gavathiotis E, Golstein P, Gottlieb E, Green DR, Greene LA, Gronemeyer H, Gross A, Hajnoczky G, Hardwick JM, Harris IS, Hengartner MO, Hetz C, Ichijo H, Jäättelä M, Joseph B, Jost PJ, Juin PP, Kaiser WJ, Karin M, Kaufmann T, Kepp O, Kimchi A, Kitsis RN, Klionsky DJ, Knight RA, Kumar S, Lee SW, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lowe SW, Luedde T, Lugli E, MacFarlane M, Madeo F, Malewicz M, Malorni W, Manic G, Marine JC, Martin SJ, Martinou JC, Medema JP, Mehlen P, Meier P, Melino S, Miao EA, Molkentin JD, Moll UM, Muñoz-Pinedo C, Nagata S, Nuñez G, Oberst A, Oren M, Overholtzer M, Pagano M, Panaretakis T, Pasparakis M, Penninger JM, Pereira DM, Pervaiz S, Peter ME, Piacentini M, Pinton P, Prehn JHM, Puthalakath H, Rabinovich GA, Rehm M, Rizzuto R, Rodrigues CMP, Rubinsztein DC, Rudel T, Ryan KM, Sayan E, Scorrano L, Shao F, Shi Y, Silke J, Simon HU, Sistigu A, Stockwell BR, Strasser A, Szabadkai G, Tait SWG, Tang D, Tavernarakis N, Thorburn A, Tsujimoto Y, Turk B, Vanden Berghe T, Vandenabeele P, Vander Heiden MG, Villunger A, Virgin HW, Vousden KH, Vucic D, Wagner EF, Walczak H, Wallach D, Wang Y, Wells JA, Wood W, Yuan J, Zakeri Z, Zhivotovsky B, Zitvogel L, Melino G, Kroemer G.

Cell Death Differ. 2018 Mar;25(3):486-541. doi: 10.1038/s41418-017-0012-4. Epub 2018 Jan 23. Review.

11.

Identification of cancer genes that are independent of dominant proliferation and lineage programs.

Selfors LM, Stover DG, Harris IS, Brugge JS, Coloff JL.

Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):E11276-E11284. doi: 10.1073/pnas.1714877115. Epub 2017 Dec 11.

12.

Cardiopulmonary exercise testing in the evaluation of liver disease in adults who have had the Fontan operation.

Agarwal A, Cunnington C, Sabanayagam A, Zier L, McCulloch CE, Harris IS, Foster E, Atkinson D, Bryan A, Jenkins P, Dua J, Parker MJ, Karunaratne D, Moore JA, Meadows J, Clarke B, Hoschtitzky JA, Mahadevan VS.

Arch Cardiovasc Dis. 2018 Apr;111(4):276-284. doi: 10.1016/j.acvd.2017.09.001. Epub 2017 Dec 1.

13.

Glutathione Primes T Cell Metabolism for Inflammation.

Mak TW, Grusdat M, Duncan GS, Dostert C, Nonnenmacher Y, Cox M, Binsfeld C, Hao Z, Brüstle A, Itsumi M, Jäger C, Chen Y, Pinkenburg O, Camara B, Ollert M, Bindslev-Jensen C, Vasiliou V, Gorrini C, Lang PA, Lohoff M, Harris IS, Hiller K, Brenner D.

Immunity. 2017 Jun 20;46(6):1089-1090. doi: 10.1016/j.immuni.2017.06.009. No abstract available.

14.

The efficacy of a video-based marker-less tracking system for gait analysis.

Ong A, Harris IS, Hamill J.

Comput Methods Biomech Biomed Engin. 2017 Aug;20(10):1089-1095. doi: 10.1080/10255842.2017.1334768. Epub 2017 Jun 1.

PMID:
28569549
15.

Glutathione Primes T Cell Metabolism for Inflammation.

Mak TW, Grusdat M, Duncan GS, Dostert C, Nonnenmacher Y, Cox M, Binsfeld C, Hao Z, Brüstle A, Itsumi M, Jäger C, Chen Y, Pinkenburg O, Camara B, Ollert M, Bindslev-Jensen C, Vasiliou V, Gorrini C, Lang PA, Lohoff M, Harris IS, Hiller K, Brenner D.

Immunity. 2017 Apr 18;46(4):675-689. doi: 10.1016/j.immuni.2017.03.019. Erratum in: Immunity. 2017 Jun 20;46(6):1089-1090.

16.

Coexistence of abnormal systolic motion of mitral valve in a consecutive group of 324 adult Tetralogy of Fallot patients assessed with echocardiography.

Agarwal A, Harris IS, Mahadevan VS, Foster E.

Open Heart. 2016 Dec 30;3(2):e000518. doi: 10.1136/openhrt-2016-000518. eCollection 2016.

17.

Making sense of reAKTive oxygen species.

DeNicola GM, Harris IS.

Cell Death Differ. 2016 Aug;23(8):1269-70. doi: 10.1038/cdd.2016.57. Epub 2016 Jun 17. No abstract available.

18.

Maternal arrhythmia and perinatal outcomes.

Henry D, Gonzalez JM, Harris IS, Sparks TN, Killion M, Thiet MP, Bianco K.

J Perinatol. 2016 Oct;36(10):823-7. doi: 10.1038/jp.2016.90. Epub 2016 Jun 16.

19.

Differential Glutamate Metabolism in Proliferating and Quiescent Mammary Epithelial Cells.

Coloff JL, Murphy JP, Braun CR, Harris IS, Shelton LM, Kami K, Gygi SP, Selfors LM, Brugge JS.

Cell Metab. 2016 May 10;23(5):867-80. doi: 10.1016/j.cmet.2016.03.016. Epub 2016 Apr 28.

20.

MEF2C regulates outflow tract alignment and transcriptional control of Tdgf1.

Barnes RM, Harris IS, Jaehnig EJ, Sauls K, Sinha T, Rojas A, Schachterle W, McCulley DJ, Norris RA, Black BL.

Development. 2016 Mar 1;143(5):774-9. doi: 10.1242/dev.126383. Epub 2016 Jan 25.

21.

Cancer: The enemy of my enemy is my friend.

Harris IS, Brugge JS.

Nature. 2015 Nov 12;527(7577):170-1. doi: 10.1038/nature15644. Epub 2015 Oct 21. No abstract available.

PMID:
26503052
22.

Longitudinal development of obesity in the post-Fontan population.

Wellnitz K, Harris IS, Sapru A, Fineman JR, Radman M.

Eur J Clin Nutr. 2015 Oct;69(10):1105-8. doi: 10.1038/ejcn.2015.68. Epub 2015 Apr 29.

PMID:
25920422
23.

Idh1 protects murine hepatocytes from endotoxin-induced oxidative stress by regulating the intracellular NADP(+)/NADPH ratio.

Itsumi M, Inoue S, Elia AJ, Murakami K, Sasaki M, Lind EF, Brenner D, Harris IS, Chio II, Afzal S, Cairns RA, Cescon DW, Elford AR, Ye J, Lang PA, Li WY, Wakeham A, Duncan GS, Haight J, You-Ten A, Snow B, Yamamoto K, Ohashi PS, Mak TW.

Cell Death Differ. 2015 Nov;22(11):1837-45. doi: 10.1038/cdd.2015.38. Epub 2015 Apr 17.

24.

Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression.

Harris IS, Treloar AE, Inoue S, Sasaki M, Gorrini C, Lee KC, Yung KY, Brenner D, Knobbe-Thomsen CB, Cox MA, Elia A, Berger T, Cescon DW, Adeoye A, Brüstle A, Molyneux SD, Mason JM, Li WY, Yamamoto K, Wakeham A, Berman HK, Khokha R, Done SJ, Kavanagh TJ, Lam CW, Mak TW.

Cancer Cell. 2015 Feb 9;27(2):211-22. doi: 10.1016/j.ccell.2014.11.019. Epub 2015 Jan 22. Erratum in: Cancer Cell. 2015 Feb 9;27(2):314.

25.

Can appropriate use criteria lead to appropriate care?

Lin GA, Harris IS.

Circ Cardiovasc Qual Outcomes. 2015 Jan;8(1):4-5. doi: 10.1161/CIRCOUTCOMES.114.001585. Epub 2015 Jan 6. No abstract available.

PMID:
25563661
26.

Human somatic cell mutagenesis creates genetically tractable sarcomas.

Molyneux SD, Waterhouse PD, Shelton D, Shao YW, Watling CM, Tang QL, Harris IS, Dickson BC, Tharmapalan P, Sandve GK, Zhang X, Bailey SD, Berman H, Wunder JS, Izsvák Z, Lupien M, Mak TW, Khokha R.

Nat Genet. 2014 Sep;46(9):964-72. doi: 10.1038/ng.3065. Epub 2014 Aug 17. Erratum in: Nat Genet. 2014 Dec;46(12):1372. Iszvak, Zsuzsanna [corrected to Izsvák, Zsuzsanna. Erratum in: Nat Genet. 2020 Feb 24;:.

PMID:
25129143
27.

TAp73 is required for spermatogenesis and the maintenance of male fertility.

Inoue S, Tomasini R, Rufini A, Elia AJ, Agostini M, Amelio I, Cescon D, Dinsdale D, Zhou L, Harris IS, Lac S, Silvester J, Li WY, Sasaki M, Haight J, Brüstle A, Wakeham A, McKerlie C, Jurisicova A, Melino G, Mak TW.

Proc Natl Acad Sci U S A. 2014 Feb 4;111(5):1843-8. doi: 10.1073/pnas.1323416111. Epub 2014 Jan 21.

28.

Modulation of oxidative stress as an anticancer strategy.

Gorrini C, Harris IS, Mak TW.

Nat Rev Drug Discov. 2013 Dec;12(12):931-47. doi: 10.1038/nrd4002. Review.

PMID:
24287781
29.

BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival.

Gorrini C, Baniasadi PS, Harris IS, Silvester J, Inoue S, Snow B, Joshi PA, Wakeham A, Molyneux SD, Martin B, Bouwman P, Cescon DW, Elia AJ, Winterton-Perks Z, Cruickshank J, Brenner D, Tseng A, Musgrave M, Berman HK, Khokha R, Jonkers J, Mak TW, Gauthier ML.

J Exp Med. 2013 Jul 29;210(8):1529-44. doi: 10.1084/jem.20121337. Epub 2013 Jul 15.

30.

Functional significance of glutamate-cysteine ligase modifier for erythrocyte survival in vitro and in vivo.

Föller M, Harris IS, Elia A, John R, Lang F, Kavanagh TJ, Mak TW.

Cell Death Differ. 2013 Oct;20(10):1350-8. doi: 10.1038/cdd.2013.70. Epub 2013 Jun 21.

31.

Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15.

Inoue S, Hao Z, Elia AJ, Cescon D, Zhou L, Silvester J, Snow B, Harris IS, Sasaki M, Li WY, Itsumi M, Yamamoto K, Ueda T, Dominguez-Brauer C, Gorrini C, Chio II, Haight J, You-Ten A, McCracken S, Wakeham A, Ghazarian D, Penn LJ, Melino G, Mak TW.

Genes Dev. 2013 May 15;27(10):1101-14. doi: 10.1101/gad.214577.113.

32.

PTPN12 promotes resistance to oxidative stress and supports tumorigenesis by regulating FOXO signaling.

Harris IS, Blaser H, Moreno J, Treloar AE, Gorrini C, Sasaki M, Mason JM, Knobbe CB, Rufini A, Hallé M, Elia AJ, Wakeham A, Tremblay ML, Melino G, Done S, Mak TW.

Oncogene. 2014 Feb 20;33(8):1047-54. doi: 10.1038/onc.2013.24. Epub 2013 Feb 25.

PMID:
23435421
33.

Reactive oxygen species delay control of lymphocytic choriomeningitis virus.

Lang PA, Xu HC, Grusdat M, McIlwain DR, Pandyra AA, Harris IS, Shaabani N, Honke N, Maney SK, Lang E, Pozdeev VI, Recher M, Odermatt B, Brenner D, Häussinger D, Ohashi PS, Hengartner H, Zinkernagel RM, Mak TW, Lang KS.

Cell Death Differ. 2013 Apr;20(4):649-58. doi: 10.1038/cdd.2012.167. Epub 2013 Jan 18.

34.

TAp73 depletion accelerates aging through metabolic dysregulation.

Rufini A, Niklison-Chirou MV, Inoue S, Tomasini R, Harris IS, Marino A, Federici M, Dinsdale D, Knight RA, Melino G, Mak TW.

Genes Dev. 2012 Sep 15;26(18):2009-14. doi: 10.1101/gad.197640.112.

35.

D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function.

Sasaki M, Knobbe CB, Itsumi M, Elia AJ, Harris IS, Chio II, Cairns RA, McCracken S, Wakeham A, Haight J, Ten AY, Snow B, Ueda T, Inoue S, Yamamoto K, Ko M, Rao A, Yen KE, Su SM, Mak TW.

Genes Dev. 2012 Sep 15;26(18):2038-49. doi: 10.1101/gad.198200.112. Epub 2012 Aug 27.

36.

IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics.

Sasaki M, Knobbe CB, Munger JC, Lind EF, Brenner D, Brüstle A, Harris IS, Holmes R, Wakeham A, Haight J, You-Ten A, Li WY, Schalm S, Su SM, Virtanen C, Reifenberger G, Ohashi PS, Barber DL, Figueroa ME, Melnick A, Zúñiga-Pflücker JC, Mak TW.

Nature. 2012 Aug 30;488(7413):656-9. doi: 10.1038/nature11323.

37.

Global proteomic assessment of the classical protein-tyrosine phosphatome and "Redoxome".

Karisch R, Fernandez M, Taylor P, Virtanen C, St-Germain JR, Jin LL, Harris IS, Mori J, Mak TW, Senis YA, Östman A, Moran MF, Neel BG.

Cell. 2011 Sep 2;146(5):826-40. doi: 10.1016/j.cell.2011.07.020.

38.

Management of pregnancy in patients with congenital heart disease.

Harris IS.

Prog Cardiovasc Dis. 2011 Jan-Feb;53(4):305-11. doi: 10.1016/j.pcad.2010.08.001. Review.

39.

Regulation of cancer cell metabolism.

Cairns RA, Harris IS, Mak TW.

Nat Rev Cancer. 2011 Feb;11(2):85-95. doi: 10.1038/nrc2981. Review.

PMID:
21258394
40.

Development of the endocardium.

Harris IS, Black BL.

Pediatr Cardiol. 2010 Apr;31(3):391-9. doi: 10.1007/s00246-010-9642-8. Epub 2010 Feb 5. Review.

41.

Combinatorial regulation of endothelial gene expression by ets and forkhead transcription factors.

De Val S, Chi NC, Meadows SM, Minovitsky S, Anderson JP, Harris IS, Ehlers ML, Agarwal P, Visel A, Xu SM, Pennacchio LA, Dubchak I, Krieg PA, Stainier DY, Black BL.

Cell. 2008 Dec 12;135(6):1053-64. doi: 10.1016/j.cell.2008.10.049.

42.
43.

Determinants of myogenic specificity within MyoD are required for noncanonical E box binding.

Heidt AB, Rojas A, Harris IS, Black BL.

Mol Cell Biol. 2007 Aug;27(16):5910-20. Epub 2007 Jun 11.

44.

Phonocardiographic timing of third and fourth heart sounds during acute myocardial infarction.

Harris IS, Lee E, Yeghiazarians Y, Drew BJ, Michaels AD.

J Electrocardiol. 2006 Jul;39(3):305-9. Epub 2006 Mar 9. Review.

PMID:
16777517
45.

G-protein signaling participates in the development of diabetic cardiomyopathy.

Harris IS, Treskov I, Rowley MW, Heximer S, Kaltenbronn K, Finck BN, Gross RW, Kelly DP, Blumer KJ, Muslin AJ.

Diabetes. 2004 Dec;53(12):3082-90.

46.

Raf-1 kinase is required for cardiac hypertrophy and cardiomyocyte survival in response to pressure overload.

Harris IS, Zhang S, Treskov I, Kovacs A, Weinheimer C, Muslin AJ.

Circulation. 2004 Aug 10;110(6):718-23. Epub 2004 Aug 2.

PMID:
15289381

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