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Items: 1 to 50 of 129

1.

Ligation of free HMGB1 to TLR2 in the absence of ligand is negatively regulated by the C-terminal tail domain.

Aucott H, Sowinska A, Harris HE, Lundback P.

Mol Med. 2018 May 4;24(1):19. doi: 10.1186/s10020-018-0021-x.

2.

Brain-released alarmins and stress response synergize in accelerating atherosclerosis progression after stroke.

Roth S, Singh V, Tiedt S, Schindler L, Huber G, Geerlof A, Antoine DJ, Anfray A, Orset C, Gauberti M, Fournier A, Holdt LM, Harris HE, Engelhardt B, Bianchi ME, Vivien D, Haffner C, Bernhagen J, Dichgans M, Liesz A.

Sci Transl Med. 2018 Mar 14;10(432). pii: eaao1313. doi: 10.1126/scitranslmed.aao1313.

PMID:
29540615
3.

Fragmented hyaluronan has no alarmin function assessed in arthritis synovial fibroblast and chondrocyte cultures.

Olsson M, Bremer L, Aulin C, Harris HE.

Innate Immun. 2018 Feb;24(2):131-141. doi: 10.1177/1753425918759590.

PMID:
29495940
4.

Collectively Improving Our Teaching: Attempting Biology Department-wide Professional Development in Scientific Teaching.

Owens MT, Trujillo G, Seidel SB, Harrison CD, Farrar KM, Benton HP, Blair JR, Boyer KE, Breckler JL, Burrus LW, Byrd DT, Caporale N, Carpenter EJ, Chan YM, Chen JC, Chen L, Chen LH, Chu DS, Cochlan WP, Crook RJ, Crow KD, de la Torre JR, Denetclaw WF, Dowdy LM, Franklin D, Fuse M, Goldman MA, Govindan B, Green M, Harris HE, He ZH, Ingalls SB, Ingmire P, Johnson ARB, Knight JD, LeBuhn G, Light TL, Low C, Lund L, Márquez-Magaña LM, Miller-Sims VC, Moffatt CA, Murdock H, Nusse GL, Parker VT, Pasion SG, Patterson R, Pennings PS, Ramirez JC, Ramirez RM, Riggs B, Rohlfs RV, Romeo JM, Rothman BS, Roy SW, Russo-Tait T, Sehgal RNM, Simonin KA, Spicer GS, Stillman JH, Swei A, Tempe LC, Vredenburg VT, Weinstein SL, Zink AG, Kelley LA, Domingo CR, Tanner KD.

CBE Life Sci Educ. 2018 Spring;17(1). pii: ar2. doi: 10.1187/cbe.17-06-0106. Erratum in: CBE Life Sci Educ. 2018 Spring;17 (1):.

5.

Expression of High Mobility Group Protein B1 in Cardiac Tissue of Elderly Patients with Coronary Artery Disease with or without Inflammatory Rheumatic Disease.

Bruton M, Hollan I, Xiao J, Lindroos E, Mikkelsen K, Rynning SE, Saatvedt K, Almdahl SM, Harris HE, Lundberg IE, Wick C.

Gerontology. 2017;63(4):337-349. doi: 10.1159/000471763. Epub 2017 Apr 21.

PMID:
28427050
6.

Classroom sound can be used to classify teaching practices in college science courses.

Owens MT, Seidel SB, Wong M, Bejines TE, Lietz S, Perez JR, Sit S, Subedar ZS, Acker GN, Akana SF, Balukjian B, Benton HP, Blair JR, Boaz SM, Boyer KE, Bram JB, Burrus LW, Byrd DT, Caporale N, Carpenter EJ, Chan YM, Chen L, Chovnick A, Chu DS, Clarkson BK, Cooper SE, Creech C, Crow KD, de la Torre JR, Denetclaw WF, Duncan KE, Edwards AS, Erickson KL, Fuse M, Gorga JJ, Govindan B, Green LJ, Hankamp PZ, Harris HE, He ZH, Ingalls S, Ingmire PD, Jacobs JR, Kamakea M, Kimpo RR, Knight JD, Krause SK, Krueger LE, Light TL, Lund L, Márquez-Magaña LM, McCarthy BK, McPheron LJ, Miller-Sims VC, Moffatt CA, Muick PC, Nagami PH, Nusse GL, Okimura KM, Pasion SG, Patterson R, Pennings PS, Riggs B, Romeo J, Roy SW, Russo-Tait T, Schultheis LM, Sengupta L, Small R, Spicer GS, Stillman JH, Swei A, Wade JM, Waters SB, Weinstein SL, Willsie JK, Wright DW, Harrison CD, Kelley LA, Trujillo G, Domingo CR, Schinske JN, Tanner KD.

Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):3085-3090. doi: 10.1073/pnas.1618693114. Epub 2017 Mar 6.

7.

LACC1 polymorphisms in inflammatory bowel disease and juvenile idiopathic arthritis.

Assadi G, Saleh R, Hadizadeh F, Vesterlund L, Bonfiglio F, Halfvarson J, Törkvist L, Eriksson AS, Harris HE, Sundberg E, D'Amato M.

Genes Immun. 2016 Jun;17(4):261-4. doi: 10.1038/gene.2016.17. Epub 2016 Apr 21.

PMID:
27098602
8.

New treatments for hepatitis C virus (HCV): scope for preventing liver disease and HCV transmission in England.

Harris RJ, Martin NK, Rand E, Mandal S, Mutimer D, Vickerman P, Ramsay ME, De Angelis D, Hickman M, Harris HE.

J Viral Hepat. 2016 Aug;23(8):631-43. doi: 10.1111/jvh.12529. Epub 2016 Mar 29.

9.

How to Motivate Patients with Rheumatoid Arthritis to Quit Smoking.

Harris HE, Tweedie F, White M, Samson K.

J Rheumatol. 2016 Apr;43(4):691-8. doi: 10.3899/jrheum.141368. Epub 2016 Feb 15.

PMID:
26879360
10.

Retrospective cohort study of liver transplantation in the United Kingdom between 1994 and 2010: the impact of hepatitis C infection.

Edeghere O, Verlander NQ, Aboulhab J, Costella A, Harris HE, Balogun MA, Ramsay ME.

Public Health. 2015 May;129(5):509-16. doi: 10.1016/j.puhe.2015.01.024. Epub 2015 Feb 25.

PMID:
25726124
11.

MD-2 is required for disulfide HMGB1-dependent TLR4 signaling.

Yang H, Wang H, Ju Z, Ragab AA, Lundbäck P, Long W, Valdes-Ferrer SI, He M, Pribis JP, Li J, Lu B, Gero D, Szabo C, Antoine DJ, Harris HE, Golenbock DT, Meng J, Roth J, Chavan SS, Andersson U, Billiar TR, Tracey KJ, Al-Abed Y.

J Exp Med. 2015 Jan 12;212(1):5-14. doi: 10.1084/jem.20141318. Epub 2015 Jan 5.

12.

Characterization of the Inflammatory Properties of Actively Released HMGB1 in Juvenile Idiopathic Arthritis.

Lundbäck P, Stridh P, Klevenvall L, Jenkins RE, Fischer M, Sundberg E, Andersson U, Antoine DJ, Harris HE.

Antioxid Redox Signal. 2016 Apr 20;24(12):605-19. doi: 10.1089/ars.2014.6039. Epub 2015 Feb 6.

13.

High systemic levels of the cytokine-inducing HMGB1 isoform secreted in severe macrophage activation syndrome.

Palmblad K, Schierbeck H, Sundberg E, Horne AC, Harris HE, Henter JI, Antoine DJ, Andersson U.

Mol Med. 2015 Jan 27;20:538-47. doi: 10.2119/molmed.2014.00183.

14.

Increased uptake and new therapies are needed to avert rising hepatitis C-related end stage liver disease in England: modelling the predicted impact of treatment under different scenarios.

Harris RJ, Thomas B, Griffiths J, Costella A, Chapman R, Ramsay M, De Angelis D, Harris HE.

J Hepatol. 2014 Sep;61(3):530-7. doi: 10.1016/j.jhep.2014.05.008. Epub 2014 May 10.

15.

Proteasome inhibitor MG132 modulates inflammatory pain by central mechanisms in adjuvant arthritis.

Ahmed AS, Ahmed M, Li J, Gu HF, Bakalkin G, Stark A, Harris HE.

Int J Rheum Dis. 2017 Jan;20(1):25-32. doi: 10.1111/1756-185X.12353. Epub 2014 Apr 5.

PMID:
24702728
16.

A systematic nomenclature for the redox states of high mobility group box (HMGB) proteins.

Antoine DJ, Harris HE, Andersson U, Tracey KJ, Bianchi ME.

Mol Med. 2014 Mar 24;20:135-7. doi: 10.2119/molmed.2014.00022.

17.

HMGB1 levels are increased in patients with juvenile idiopathic arthritis, correlate with early onset of disease, and are independent of disease duration.

Schierbeck H, Pullerits R, Pruunsild C, Fischer M, Holzinger D, Laestadius Å, Sundberg E, Harris HE.

J Rheumatol. 2013 Sep;40(9):1604-13. doi: 10.3899/jrheum.120987. Epub 2013 Jul 15.

PMID:
23858044
18.

IL-1β/HMGB1 complexes promote The PGE2 biosynthesis pathway in synovial fibroblasts.

Leclerc P, Wähämaa H, Idborg H, Jakobsson PJ, Harris HE, Korotkova M.

Scand J Immunol. 2013 May;77(5):350-60. doi: 10.1111/sji.12041.

19.

TLR4 as receptor for HMGB1 induced muscle dysfunction in myositis.

Zong M, Bruton JD, Grundtman C, Yang H, Li JH, Alexanderson H, Palmblad K, Andersson U, Harris HE, Lundberg IE, Westerblad H.

Ann Rheum Dis. 2013 Aug;72(8):1390-9. doi: 10.1136/annrheumdis-2012-202207. Epub 2012 Nov 12.

PMID:
23148306
20.

HMGB1: a multifunctional alarmin driving autoimmune and inflammatory disease.

Harris HE, Andersson U, Pisetsky DS.

Nat Rev Rheumatol. 2012 Jan 31;8(4):195-202. doi: 10.1038/nrrheum.2011.222. Review.

PMID:
22293756
21.

Improved hepatitis C treatment response in younger patients: findings from the UK HCV National Register cohort study.

Harris HE, Costella A, Amirthalingam G, Alexander G, Ramsay ME, Andrews N; UK HCV National Register Collaborators; UK HCV National Register Steering Group.

Epidemiol Infect. 2012 Oct;140(10):1830-7. Epub 2011 Nov 29.

22.

High mobility group box protein 1 (HMGB1)-partner molecule complexes enhance cytokine production by signaling through the partner molecule receptor.

Hreggvidsdóttir HS, Lundberg AM, Aveberger AC, Klevenvall L, Andersson U, Harris HE.

Mol Med. 2012 Mar 27;18:224-30. doi: 10.2119/molmed.2011.00327.

23.

High mobility group box protein 1 in complex with lipopolysaccharide or IL-1 promotes an increased inflammatory phenotype in synovial fibroblasts.

Wähämaa H, Schierbeck H, Hreggvidsdottir HS, Palmblad K, Aveberger AC, Andersson U, Harris HE.

Arthritis Res Ther. 2011 Aug 26;13(4):R136. doi: 10.1186/ar3450.

24.

Spontaneous loss of hepatitis C virus RNA from serum is associated with genotype 1 and younger age at exposure.

Rolfe KJ, Curran MD, Alexander GJ, Woodall T, Andrews N, Harris HE.

J Med Virol. 2011 Aug;83(8):1338-44. doi: 10.1002/jmv.22115. Epub 2011 May 26.

PMID:
21618556
25.

First report of anti-calcium-sensing receptor antibodies in a patient with Sjogren's syndrome and primary hypoparathyroidism.

Harris HE, Kemp EH, Brown EM, Weetman AP, Swaminathan K.

Rheumatology (Oxford). 2011 Jun;50(6):1173-5. doi: 10.1093/rheumatology/ker128. Epub 2011 Mar 30. No abstract available.

PMID:
21454310
26.

Protective targeting of high mobility group box chromosomal protein 1 in a spontaneous arthritis model.

Ostberg T, Kawane K, Nagata S, Yang H, Chavan S, Klevenvall L, Bianchi ME, Harris HE, Andersson U, Palmblad K.

Arthritis Rheum. 2010 Oct;62(10):2963-72. doi: 10.1002/art.27590.

27.

Immunomodulatory drugs regulate HMGB1 release from activated human monocytes.

Schierbeck H, Wähämaa H, Andersson U, Harris HE.

Mol Med. 2010 Sep-Oct;16(9-10):343-51. doi: 10.2119/molmed.2010.00031. Epub 2010 Apr 9.

28.

The role of HMGB1 in the pathogenesis of rheumatic disease.

Andersson U, Harris HE.

Biochim Biophys Acta. 2010 Jan-Feb;1799(1-2):141-8. doi: 10.1016/j.bbagrm.2009.11.003. Review.

PMID:
20123076
29.

Effects of HMGB1 on in vitro responses of isolated muscle fibers and functional aspects in skeletal muscles of idiopathic inflammatory myopathies.

Grundtman C, Bruton J, Yamada T, Ostberg T, Pisetsky DS, Harris HE, Andersson U, Lundberg IE, Westerblad H.

FASEB J. 2010 Feb;24(2):570-8. doi: 10.1096/fj.09-144782. Epub 2009 Oct 16.

PMID:
19837864
30.

The alarmin HMGB1 acts in synergy with endogenous and exogenous danger signals to promote inflammation.

Hreggvidsdottir HS, Ostberg T, Wähämaa H, Schierbeck H, Aveberger AC, Klevenvall L, Palmblad K, Ottosson L, Andersson U, Harris HE.

J Leukoc Biol. 2009 Sep;86(3):655-62. doi: 10.1189/jlb.0908548. Epub 2009 Jun 29.

PMID:
19564572
31.

High mobility group box chromosomal protein 1 acts as a proliferation signal for activated T lymphocytes.

Sundberg E, Fasth AE, Palmblad K, Harris HE, Andersson U.

Immunobiology. 2009;214(4):303-9. doi: 10.1016/j.imbio.2008.09.006. Epub 2008 Oct 25.

PMID:
19201506
32.

Diagnoses of, and deaths from, severe liver disease due to hepatitis C in England between 2000 and 2005 estimated using multiple data sources.

Mann AG, Ramsay ME, Brant LJ, Balogun MA, Costella A, Harris HE.

Epidemiol Infect. 2009 Apr;137(4):513-8. doi: 10.1017/S0950268808001350. Epub 2008 Sep 16.

PMID:
18796172
33.

Systemic TNF blockade does not modulate synovial expression of the pro-inflammatory mediator HMGB1 in rheumatoid arthritis patients--a prospective clinical study.

Sundberg E, Grundtman C, Af Klint E, Lindberg J, Ernestam S, Ulfgren AK, Harris HE, Andersson U.

Arthritis Res Ther. 2008;10(2):R33. doi: 10.1186/ar2387. Epub 2008 Mar 17.

34.

Suppressive effects of a quinoxaline-analogue (Rob 803) on pathogenic immune mechanisms in collagen-induced arthritis.

Westman E, Thi Ngoc DD, Klareskog L, Harris HE.

Clin Exp Immunol. 2008 Apr;152(1):192-9. doi: 10.1111/j.1365-2249.2008.03613.x. Epub 2008 Feb 25.

35.

Oxaliplatin retains HMGB1 intranuclearly and ameliorates collagen type II-induced arthritis.

Ostberg T, Wähämaa H, Palmblad K, Ito N, Stridh P, Shoshan M, Lotze MT, Harris HE, Andersson U.

Arthritis Res Ther. 2008;10(1):R1. doi: 10.1186/ar2347. Epub 2008 Jan 7.

36.

Progressive multifocal leucoencephalopathy in a patient with systemic lupus erythematosus treated with rituximab.

Harris HE.

Rheumatology (Oxford). 2008 Feb;47(2):224-5. Epub 2007 Nov 28. No abstract available.

PMID:
18045807
38.

A national sample of individuals who acquired hepatitis C virus infections in childhood or adolescence: risk factors for advanced disease.

Harris HE, Mieli-Vergani G, Kelly D, Davison S, Gibb DM, Ramsay ME; HCV National Register Steering Group.

J Pediatr Gastroenterol Nutr. 2007 Sep;45(3):335-41.

PMID:
17873746
39.

The burden of hepatitis C in England.

Sweeting MJ, De Angelis D, Brant LJ, Harris HE, Mann AG, Ramsay ME.

J Viral Hepat. 2007 Aug;14(8):570-6.

PMID:
17650291
40.

Morphological characterization of intra-articular HMGB1 expression during the course of collagen-induced arthritis.

Palmblad K, Sundberg E, Diez M, Söderling R, Aveberger AC, Andersson U, Harris HE.

Arthritis Res Ther. 2007;9(2):R35.

41.

Does the clinical outcome of hepatitis C infection vary with the infecting hepatitis C virus type?

Harris HE, Eldridge KP, Harbour S, Alexander G, Teo CG, Ramsay ME; HCV National Register Steering Group*.

J Viral Hepat. 2007 Mar;14(3):213-20.

PMID:
17305887
42.

HMGB1-secreting capacity of multiple cell lineages revealed by a novel HMGB1 ELISPOT assay.

Wähämaa H, Vallerskog T, Qin S, Lunderius C, LaRosa G, Andersson U, Harris HE.

J Leukoc Biol. 2007 Jan;81(1):129-36. Epub 2006 Sep 15.

PMID:
16980509
43.

Alarmin(g) news about danger: workshop on innate danger signals and HMGB1.

Harris HE, Raucci A.

EMBO Rep. 2006 Aug;7(8):774-8. Epub 2006 Jul 21. Review. No abstract available.

44.
45.

HMGB1 activates replication of latent HIV-1 in a monocytic cell-line, but inhibits HIV-1 replication in primary macrophages.

Nowak P, Barqasho B, Treutiger CJ, Harris HE, Tracey KJ, Andersson J, Sönnerborg A.

Cytokine. 2006 Apr;34(1-2):17-23. Epub 2006 May 11.

PMID:
16697213
46.

Estimated progression rates in three United Kingdom hepatitis C cohorts differed according to method of recruitment.

Sweeting MJ, De Angelis D, Neal KR, Ramsay ME, Irving WL, Wright M, Brant L, Harris HE; Trent HCV Study Group; HCV National Register Steering Group.

J Clin Epidemiol. 2006 Feb;59(2):144-52.

PMID:
16426949
47.

A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination.

Klareskog L, Stolt P, Lundberg K, Källberg H, Bengtsson C, Grunewald J, Rönnelid J, Harris HE, Ulfgren AK, Rantapää-Dahlqvist S, Eklund A, Padyukov L, Alfredsson L.

Arthritis Rheum. 2006 Jan;54(1):38-46.

48.

Survival of a national cohort of hepatitis C virus infected patients, 16 years after exposure.

Harris HE, Ramsay ME, Andrews NJ; HCV National Register Steering Group.

Epidemiol Infect. 2006 Jun;134(3):472-7. Epub 2005 Oct 28.

49.

Pathways of care and resource utilization in a national cohort of patients with transfusion-acquired hepatitis C.

Brant L, Harris HE, Ramsay ME, Grieve R, Roberts J; HCV National Register Steering Group*.

J Viral Hepat. 2005 Nov;12(6):618-26.

PMID:
16255763
50.

Increased expression of the novel proinflammatory cytokine high mobility group box chromosomal protein 1 in skin lesions of patients with lupus erythematosus.

Popovic K, Ek M, Espinosa A, Padyukov L, Harris HE, Wahren-Herlenius M, Nyberg F.

Arthritis Rheum. 2005 Nov;52(11):3639-45.

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