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Large-Scale Whole-Genome Sequencing Reveals the Genetic Architecture of Primary Membranoproliferative GN and C3 Glomerulopathy.

Levine AP, Chan MMY, Sadeghi-Alavijeh O, Wong EKS, Cook HT, Ashford S, Carss K, Christian MT, Hall M, Harris CL, McAlinden P, Marchbank KJ, Marks SD, Maxwell H, Megy K, Penkett CJ, Mozere M, Stirrups KE, Tuna S, Wessels J, Whitehorn D; MPGN/DDD/C3 Glomerulopathy Rare Disease Group; NIHR BioResource, Johnson SA, Gale DP.

J Am Soc Nephrol. 2020 Feb;31(2):365-373. doi: 10.1681/ASN.2019040433. Epub 2020 Jan 9.


Severe type I interferonopathy and unrestrained interferon signaling due to a homozygous germline mutation in STAT2.

Duncan CJA, Thompson BJ, Chen R, Rice GI, Gothe F, Young DF, Lovell SC, Shuttleworth VG, Brocklebank V, Corner B, Skelton AJ, Bondet V, Coxhead J, Duffy D, Fourrage C, Livingston JH, Pavaine J, Cheesman E, Bitetti S, Grainger A, Acres M, Innes BA, Mikulasova A, Sun R, Hussain R, Wright R, Wynn R, Zarhrate M, Zeef LAH, Wood K, Hughes SM, Harris CL, Engelhardt KR, Crow YJ, Randall RE, Kavanagh D, Hambleton S, Briggs TA.

Sci Immunol. 2019 Dec 13;4(42). pii: eaav7501. doi: 10.1126/sciimmunol.aav7501.


Improved Neurodevelopmental Outcomes Associated with Bovine Milk Fat Globule Membrane and Lactoferrin in Infant Formula: A Randomized, Controlled Trial.

Li F, Wu SS, Berseth CL, Harris CL, Richards JD, Wampler JL, Zhuang W, Cleghorn G, Rudolph CD, Liu B, Shaddy DJ, Colombo J.

J Pediatr. 2019 Dec;215:24-31.e8. doi: 10.1016/j.jpeds.2019.08.030. Epub 2019 Oct 24.


Compendium of current complement therapeutics.

Zelek WM, Xie L, Morgan BP, Harris CL.

Mol Immunol. 2019 Oct;114:341-352. doi: 10.1016/j.molimm.2019.07.030. Epub 2019 Aug 22. Review.


Growth, tolerance, and DHA and ARA status of healthy term infants receiving formula with two different ARA concentrations: Double-blind, randomized, controlled trial.

Hoffman DR, Harris CL, Wampler JL, Patterson AC, Berseth CL.

Prostaglandins Leukot Essent Fatty Acids. 2019 Jul;146:19-27. doi: 10.1016/j.plefa.2019.04.007. Epub 2019 Apr 30.


Intestinal epithelial Notch-1 protects from colorectal mucinous adenocarcinoma.

Dunkin D, Iuga AC, Mimouna S, Harris CL, Haure-Mirande JV, Bozec D, Yeretssian G, Dahan S.

Oncotarget. 2018 Sep 11;9(71):33536-33548. doi: 10.18632/oncotarget.26086. eCollection 2018 Sep 11.


Developments in anti-complement therapy; from disease to clinical trial.

Harris CL, Pouw RB, Kavanagh D, Sun R, Ricklin D.

Mol Immunol. 2018 Oct;102:89-119. doi: 10.1016/j.molimm.2018.06.008. Epub 2018 Aug 16. Review.


Vitamin A administration at birth promotes calf growth and intramuscular fat development in Angus beef cattle.

Harris CL, Wang B, Deavila JM, Busboom JR, Maquivar M, Parish SM, McCann B, Nelson ML, Du M.

J Anim Sci Biotechnol. 2018 Jul 23;9:55. doi: 10.1186/s40104-018-0268-7. eCollection 2018.


Extracting the barbs from complement assays: Identification and optimisation of a safe substitute for traditional buffers.

Zelek WM, Harris CL, Morgan BP.

Immunobiology. 2018 Dec;223(12):744-749. doi: 10.1016/j.imbio.2018.07.016. Epub 2018 Jul 20.


Characterizing a pH-switch anti-C5 antibody as a tool for human and mouse complement C5 purification and cross-species inhibition of classical and reactive lysis.

Zelek WM, Stott M, Walters D, Harris CL, Morgan BP.

Immunology. 2018 Nov;155(3):396-403. doi: 10.1111/imm.12982. Epub 2018 Jul 30.


Expanding horizons in complement drug discovery: challenges and emerging strategies.

Harris CL.

Semin Immunopathol. 2018 Jan;40(1):125-140. doi: 10.1007/s00281-017-0655-8. Epub 2017 Oct 6. Review.


Tissue microarray methodology identifies complement pathway activation and dysregulation in progressive multiple sclerosis.

Loveless S, Neal JW, Howell OW, Harding KE, Sarkies P, Evans R, Bevan RJ, Hakobyan S, Harris CL, Robertson NP, Morgan BP.

Brain Pathol. 2018 Jul;28(4):507-520. doi: 10.1111/bpa.12546. Epub 2017 Jul 30.


Sudden Increase in EtCO2 During Upper Endoscopy Under General Endotracheal Anesthesia Suggests the Presence of Tracheoesophageal Fistula: A Case Report.

Garcia Getting RE, Harris CL.

A A Case Rep. 2017 Aug 15;9(4):109-111. doi: 10.1213/XAA.0000000000000540.


Endoscopic ultrasonography complements computed tomography in predicting portal or superior mesenteric vein resection in patients with borderline resectable pancreatic carcinoma.

Glazer ES, Rashid OM, Klapman JB, Harris CL, Hodul PJ, Pimiento JM, Malafa MP.

Pancreatology. 2017 Jan - Feb;17(1):130-134. doi: 10.1016/j.pan.2016.12.001. Epub 2016 Dec 5.


Growth and tolerance of infants fed formula with a new algal source of docosahexaenoic acid: Double-blind, randomized, controlled trial.

Yeiser M, Harris CL, Kirchoff AL, Patterson AC, Wampler JL, Zissman EN, Berseth CL.

Prostaglandins Leukot Essent Fatty Acids. 2016 Dec;115:89-96. doi: 10.1016/j.plefa.2016.09.001. Epub 2016 Sep 29.


Complement Biomarkers as Predictors of Disease Progression in Alzheimer's Disease.

Hakobyan S, Harding K, Aiyaz M, Hye A, Dobson R, Baird A, Liu B, Harris CL, Lovestone S, Morgan BP.

J Alzheimers Dis. 2016 Sep 6;54(2):707-16. doi: 10.3233/JAD-160420.


Perceived Physician-informed Weight Status Predicts Accurate Weight Self-Perception and Weight Self-Regulation in Low-income, African American Women.

Harris CL, Strayhorn G, Moore S, Goldman B, Martin MY.

J Health Care Poor Underserved. 2016;27(3):1441-63. doi: 10.1353/hpu.2016.0140.


Nutrigenomic regulation of adipose tissue development - role of retinoic acid: A review.

Wang B, Yang Q, Harris CL, Nelson ML, Busboom JR, Zhu MJ, Du M.

Meat Sci. 2016 Oct;120:100-106. doi: 10.1016/j.meatsci.2016.04.003. Epub 2016 Apr 8. Review.


Endoscopic ultrasound-guided fiducial marker placement for image-guided radiation therapy without fluoroscopy: safety and technical feasibility.

Dhadham GC, Hoffe S, Harris CL, Klapman JB.

Endosc Int Open. 2016 Mar;4(3):E378-82. doi: 10.1055/s-0042-100720. Epub 2016 Mar 3.


Developing a Cookbook with Lifestyle Tips: A Community-Engaged Approach to Promoting Diet-Related Cancer Prevention Guidelines.

Smith SA, Sheats JQ, Whitehead MS, Delmoor E, Britt T, Harris CL, Robinson-Flint J, Porche-Smith LM, Umeakunne KE, Coughlin SS.

Jacobs J Food Nutr. 2015;2(2). pii: 012. Epub 2015 Jul 24.


An anticomplement agent that homes to the damaged brain and promotes recovery after traumatic brain injury in mice.

Ruseva MM, Ramaglia V, Morgan BP, Harris CL.

Proc Natl Acad Sci U S A. 2015 Nov 17;112(46):14319-24. doi: 10.1073/pnas.1513698112. Epub 2015 Nov 2.


Growth and tolerance of formula with lactoferrin in infants through one year of age: double-blind, randomized, controlled trial.

Johnston WH, Ashley C, Yeiser M, Harris CL, Stolz SI, Wampler JL, Wittke A, Cooper TR.

BMC Pediatr. 2015 Nov 7;15:173. doi: 10.1186/s12887-015-0488-3.


Complement, a target for therapy in inflammatory and degenerative diseases.

Morgan BP, Harris CL.

Nat Rev Drug Discov. 2015 Dec;14(12):857-77. doi: 10.1038/nrd4657. Epub 2015 Oct 23. Review.


A De Novo Deletion in the Regulators of Complement Activation Cluster Producing a Hybrid Complement Factor H/Complement Factor H-Related 3 Gene in Atypical Hemolytic Uremic Syndrome.

Challis RC, Araujo GS, Wong EK, Anderson HE, Awan A, Dorman AM, Waldron M, Wilson V, Brocklebank V, Strain L, Morgan BP, Harris CL, Marchbank KJ, Goodship TH, Kavanagh D.

J Am Soc Nephrol. 2016 Jun;27(6):1617-24. doi: 10.1681/ASN.2015010100. Epub 2015 Oct 21.


Radiosensitivity index predicts for survival with adjuvant radiation in resectable pancreatic cancer.

Strom T, Hoffe SE, Fulp W, Frakes J, Coppola D, Springett GM, Malafa MP, Harris CL, Eschrich SA, Torres-Roca JF, Shridhar R.

Radiother Oncol. 2015 Oct;117(1):159-64. doi: 10.1016/j.radonc.2015.07.018. Epub 2015 Jul 30.


Response to Comment on "Functional Analysis of a Complement Polymorphism (rs17611) Associated with Rheumatoid Arthritis".

Giles JL, Choy E, van den Berg C, Morgan BP, Harris CL.

J Immunol. 2015 Jul 1;195(1):4. doi: 10.4049/jimmunol.1500968. No abstract available.


The molecular and structural bases for the association of complement C3 mutations with atypical hemolytic uremic syndrome.

Martínez-Barricarte R, Heurich M, López-Perrote A, Tortajada A, Pinto S, López-Trascasa M, Sánchez-Corral P, Morgan BP, Llorca O, Harris CL, Rodríguez de Córdoba S.

Mol Immunol. 2015 Aug;66(2):263-73. doi: 10.1016/j.molimm.2015.03.248. Epub 2015 Apr 11.


Expression of membrane complement regulators, CD46, CD55 and CD59, in mesothelial cells of patients on peritoneal dialysis therapy.

Sei Y, Mizuno M, Suzuki Y, Imai M, Higashide K, Harris CL, Sakata F, Iguchi D, Fujiwara M, Kodera Y, Maruyama S, Matsuo S, Ito Y.

Mol Immunol. 2015 Jun;65(2):302-9. doi: 10.1016/j.molimm.2015.02.005. Epub 2015 Feb 25.


Functional analysis of a complement polymorphism (rs17611) associated with rheumatoid arthritis.

Giles JL, Choy E, van den Berg C, Morgan BP, Harris CL.

J Immunol. 2015 Apr 1;194(7):3029-34. doi: 10.4049/jimmunol.1402956. Epub 2015 Feb 27.


A complement C5 gene mutation, c.754G>A:p.A252T, is common in the Western Cape, South Africa and found to be homozygous in seven percent of Black African meningococcal disease cases.

Owen EP, Würzner R, Leisegang F, Rizkallah P, Whitelaw A, Simpson J, Thomas AD, Harris CL, Giles JL, Hellerud BC, Mollnes TE, Morgan BP, Potter PC, Orren A.

Mol Immunol. 2015 Mar;64(1):170-6. doi: 10.1016/j.molimm.2014.11.010. Epub 2014 Dec 19.


Role of the pro-survival molecule Bfl-1 in melanoma.

Hind CK, Carter MJ, Harris CL, Chan HT, James S, Cragg MS.

Int J Biochem Cell Biol. 2015 Feb;59:94-102. doi: 10.1016/j.biocel.2014.11.015. Epub 2014 Dec 6.


Complement activation in multiple sclerosis plaques: an immunohistochemical analysis.

Ingram G, Loveless S, Howell OW, Hakobyan S, Dancey B, Harris CL, Robertson NP, Neal JW, Morgan BP.

Acta Neuropathol Commun. 2014 May 9;2:53. doi: 10.1186/2051-5960-2-53.


Liquid human milk fortifier significantly improves docosahexaenoic and arachidonic acid status in preterm infants.

Berseth CL, Harris CL, Wampler JL, Hoffman DR, Diersen-Schade DA.

Prostaglandins Leukot Essent Fatty Acids. 2014 Sep;91(3):97-103. doi: 10.1016/j.plefa.2014.03.002. Epub 2014 Mar 29.


A humanized antibody that regulates the alternative pathway convertase: potential for therapy of renal disease associated with nephritic factors.

Paixão-Cavalcante D, Torreira E, Lindorfer MA, Rodriguez de Cordoba S, Morgan BP, Taylor RP, Llorca O, Harris CL.

J Immunol. 2014 May 15;192(10):4844-51. doi: 10.4049/jimmunol.1303131. Epub 2014 Apr 11.


Characterization of a factor H mutation that perturbs the alternative pathway of complement in a family with membranoproliferative GN.

Wong EK, Anderson HE, Herbert AP, Challis RC, Brown P, Reis GS, Tellez JO, Strain L, Fluck N, Humphrey A, Macleod A, Richards A, Ahlert D, Santibanez-Koref M, Barlow PN, Marchbank KJ, Harris CL, Goodship TH, Kavanagh D.

J Am Soc Nephrol. 2014 Nov;25(11):2425-33. doi: 10.1681/ASN.2013070732. Epub 2014 Apr 10.


Minimally invasive mediastinal staging of non-small-cell lung cancer: emphasis on ultrasonography-guided fine-needle aspiration.

Harris CL, Toloza EM, Klapman JB, Vignesh S, Rodriguez K, Kaszuba FJ.

Cancer Control. 2014 Jan;21(1):15-20. Review.


Higher protein intake improves length, not weight, z scores in preterm infants.

Olsen IE, Harris CL, Lawson ML, Berseth CL.

J Pediatr Gastroenterol Nutr. 2014 Apr;58(4):409-16. doi: 10.1097/MPG.0000000000000237.


Conservative sharp wound debridement: an overview of Canadian education, practice, risk, and policy.

Rodd-Nielsen E, Harris CL.

J Wound Ostomy Continence Nurs. 2013 Nov-Dec;40(6):594-601. doi: 10.1097/WON.0b013e3182a9ae8c.


C3 glomerulopathy: consensus report.

Pickering MC, D'Agati VD, Nester CM, Smith RJ, Haas M, Appel GB, Alpers CE, Bajema IM, Bedrosian C, Braun M, Doyle M, Fakhouri F, Fervenza FC, Fogo AB, Frémeaux-Bacchi V, Gale DP, Goicoechea de Jorge E, Griffin G, Harris CL, Holers VM, Johnson S, Lavin PJ, Medjeral-Thomas N, Paul Morgan B, Nast CC, Noel LH, Peters DK, Rodríguez de Córdoba S, Servais A, Sethi S, Song WC, Tamburini P, Thurman JM, Zavros M, Cook HT.

Kidney Int. 2013 Dec;84(6):1079-89. doi: 10.1038/ki.2013.377. Epub 2013 Oct 30.


Genotype/phenotype correlations in complement factor H deficiency arising from uniparental isodisomy.

Wilson V, Darlay R, Wong W, Wood KM, McFarlane J, Schejbel L, Schmidt IM, Harris CL, Tellez J, Hunze EM, Marchbank K, Goodship JA, Goodship TH.

Am J Kidney Dis. 2013 Nov;62(5):978-83. doi: 10.1053/j.ajkd.2013.05.020. Epub 2013 Jul 16.


C3 glomerulopathy-associated CFHR1 mutation alters FHR oligomerization and complement regulation.

Tortajada A, Yébenes H, Abarrategui-Garrido C, Anter J, García-Fernández JM, Martínez-Barricarte R, Alba-Domínguez M, Malik TH, Bedoya R, Cabrera Pérez R, López Trascasa M, Pickering MC, Harris CL, Sánchez-Corral P, Llorca O, Rodríguez de Córdoba S.

J Clin Invest. 2013 Jun;123(6):2434-46.


Factor H binds to the hypervariable region of many Streptococcus pyogenes M proteins but does not promote phagocytosis resistance or acute virulence.

Gustafsson MC, Lannergård J, Nilsson OR, Kristensen BM, Olsen JE, Harris CL, Ufret-Vincenty RL, Stålhammar-Carlemalm M, Lindahl G.

PLoS Pathog. 2013;9(4):e1003323. doi: 10.1371/journal.ppat.1003323. Epub 2013 Apr 18.


Dimerization of complement factor H-related proteins modulates complement activation in vivo.

Goicoechea de Jorge E, Caesar JJ, Malik TH, Patel M, Colledge M, Johnson S, Hakobyan S, Morgan BP, Harris CL, Pickering MC, Lea SM.

Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):4685-90. doi: 10.1073/pnas.1219260110. Epub 2013 Mar 4.


Polymerase chain displacement reaction.

Harris CL, Sanchez-Vargas IJ, Olson KE, Alphey L, Fu G.

Biotechniques. 2013 Feb;54(2):93-7. doi: 10.2144/000113951.


Engineered repressible lethality for controlling the pink bollworm, a lepidopteran pest of cotton.

Morrison NI, Simmons GS, Fu G, O'Connell S, Walker AS, Dafa'alla T, Walters M, Claus J, Tang G, Jin L, Marubbi T, Epton MJ, Harris CL, Staten RT, Miller E, Miller TA, Alphey L.

PLoS One. 2012;7(12):e50922. doi: 10.1371/journal.pone.0050922. Epub 2012 Dec 4.


Common polymorphisms in the complement system and susceptiblity to bacterial meningitis.

Adriani KS, Brouwer MC, Geldhoff M, Baas F, Zwinderman AH, Paul Morgan B, Harris CL, van der Ende A, van de Beek D.

J Infect. 2013 Mar;66(3):255-62. doi: 10.1016/j.jinf.2012.10.008. Epub 2012 Oct 13.


Detection and tracking of a novel genetically tagged biological simulant in the environment.

Emanuel PA, Buckley PE, Sutton TA, Edmonds JM, Bailey AM, Rivers BA, Kim MH, Ginley WJ, Keiser CC, Doherty RW, Kragl FJ, Narayanan FE, Katoski SE, Paikoff S, Leppert SP, Strawbridge JB, VanReenen DR, Biberos SS, Moore D, Phillips DW, Mingioni LR, Melles O, Ondercin DG, Hirsh B, Bieschke KM, Harris CL, Omberg KM, Rastogi VK, Van Cuyk S, Gibbons HS.

Appl Environ Microbiol. 2012 Dec;78(23):8281-8. doi: 10.1128/AEM.02006-12. Epub 2012 Sep 21.


Complement dysregulation and disease: from genes and proteins to diagnostics and drugs.

de Cordoba SR, Tortajada A, Harris CL, Morgan BP.

Immunobiology. 2012 Nov;217(11):1034-46. doi: 10.1016/j.imbio.2012.07.021. Review.


High-grade dysplasia and adenocarcinoma are frequent in side-branch intraductal papillary mucinous neoplasm measuring less than 3 cm on endoscopic ultrasound.

Wong J, Weber J, Centeno BA, Vignesh S, Harris CL, Klapman JB, Hodul P.

J Gastrointest Surg. 2013 Jan;17(1):78-84; discussion p.84-5. doi: 10.1007/s11605-012-2017-0. Epub 2012 Sep 5.


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