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Items: 23


Cyclooxygenase-1, not cyclooxygenase-2, is responsible for physiological production of prostacyclin in the cardiovascular system.

Kirkby NS, Lundberg MH, Harrington LS, Leadbeater PD, Milne GL, Potter CM, Al-Yamani M, Adeyemi O, Warner TD, Mitchell JA.

Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17597-602. doi: 10.1073/pnas.1209192109. Epub 2012 Oct 8. Erratum in: Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):1561.


Role of RhoB in the regulation of pulmonary endothelial and smooth muscle cell responses to hypoxia.

Wojciak-Stothard B, Zhao L, Oliver E, Dubois O, Wu Y, Kardassis D, Vasilaki E, Huang M, Mitchell JA, Harrington LS, Prendergast GC, Wilkins MR.

Circ Res. 2012 May 25;110(11):1423-34. doi: 10.1161/CIRCRESAHA.112.264473. Epub 2012 Apr 26. Erratum in: Circ Res. 2012 Aug 17;111(5):e163. Louise, Harrington [corrected to Harrington, Louise S].


Reduced endothelial dependent vasodilation in vessels from TLR4(-/-) mice is associated with increased superoxide generation.

Harrington LS, Lundberg MH, Waight M, Rozario A, Mitchell JA.

Biochem Biophys Res Commun. 2011 May 20;408(4):511-5. doi: 10.1016/j.bbrc.2011.04.024. Epub 2011 Apr 13.


Role of shear stress in endothelial cell morphology and expression of cyclooxygenase isoforms.

Potter CM, Lundberg MH, Harrington LS, Warboys CM, Warner TD, Berson RE, Moshkov AV, Gorelik J, Weinberg PD, Mitchell JA.

Arterioscler Thromb Vasc Biol. 2011 Feb;31(2):384-91. doi: 10.1161/ATVBAHA.110.214031. Epub 2010 Dec 2.


Nucleotide oligomerization domain 1 is a dominant pathway for NOS2 induction in vascular smooth muscle cells: comparison with Toll-like receptor 4 responses in macrophages.

Moreno L, McMaster SK, Gatheral T, Bailey LK, Harrington LS, Cartwright N, Armstrong PC, Warner TD, Paul-Clark M, Mitchell JA.

Br J Pharmacol. 2010 Aug;160(8):1997-2007. doi: 10.1111/j.1476-5381.2010.00814.x.


The PPARbeta/delta agonist GW0742 relaxes pulmonary vessels and limits right heart hypertrophy in rats with hypoxia-induced pulmonary hypertension.

Harrington LS, Moreno L, Reed A, Wort SJ, Desvergne B, Garland C, Zhao L, Mitchell JA.

PLoS One. 2010 Mar 4;5(3):e9526. doi: 10.1371/journal.pone.0009526.


COX-1, and not COX-2 activity, regulates airway function: relevance to aspirin-sensitive asthma.

Harrington LS, Lucas R, McMaster SK, Moreno L, Scadding G, Warner TD, Mitchell JA.

FASEB J. 2008 Nov;22(11):4005-10. doi: 10.1096/fj.08-107979. Epub 2008 Aug 27.


Evidence for a specific influence of the nitrergic pathway on the peripheral pulse waveform in rabbits.

Nier BA, Harrington LS, Carrier MJ, Weinberg PD.

Exp Physiol. 2008 Apr;93(4):503-12. doi: 10.1113/expphysiol.2007.041129. Epub 2008 Jan 25.


Homeostatic role of Toll-like receptor 4 in the endothelium and heart.

Harrington LS, Belcher E, Moreno L, Carrier MJ, Mitchell JA.

J Cardiovasc Pharmacol Ther. 2007 Dec;12(4):322-6. doi: 10.1177/1074248407306217.


Delta-like 4 Notch ligand regulates tumor angiogenesis, improves tumor vascular function, and promotes tumor growth in vivo.

Li JL, Sainson RC, Shi W, Leek R, Harrington LS, Preusser M, Biswas S, Turley H, Heikamp E, Hainfellner JA, Harris AL.

Cancer Res. 2007 Dec 1;67(23):11244-53.


Role of nitric oxide and prostacyclin as vasoactive hormones released by the endothelium.

Mitchell JA, Ali F, Bailey L, Moreno L, Harrington LS.

Exp Physiol. 2008 Jan;93(1):141-7. Epub 2007 Oct 26. Review.


Regulation of multiple angiogenic pathways by Dll4 and Notch in human umbilical vein endothelial cells.

Harrington LS, Sainson RC, Williams CK, Taylor JM, Shi W, Li JL, Harris AL.

Microvasc Res. 2008 Mar;75(2):144-54. Epub 2007 Jun 29.


Purinergic 2X1 receptors mediate endothelial dependent vasodilation to ATP.

Harrington LS, Evans RJ, Wray J, Norling L, Swales KE, Vial C, Ali F, Carrier MJ, Mitchell JA.

Mol Pharmacol. 2007 Nov;72(5):1132-6. Epub 2007 Aug 3.


Elucidation of the temporal relationship between endothelial-derived NO and EDHF in mesenteric vessels.

Harrington LS, Carrier MJ, Gallagher N, Gilroy D, Garland CJ, Mitchell JA.

Am J Physiol Heart Circ Physiol. 2007 Sep;293(3):H1682-8. Epub 2007 Jun 8.


Life-term inmates' right to procreate via artificial insemination: why so much fuss over the contents of a plastic cup?

Harrington LS.

McGeorge Law Rev. 2002;33(3):521-49. No abstract available.


P2X1 receptors and the endothelium.

Harrington LS, Mitchell JA.

Mem Inst Oswaldo Cruz. 2005 Mar;100 Suppl 1:111-2. Epub 2005 Jun 14.


TSC1-2 tumour suppressor and regulation of mTOR signalling: linking cell growth and proliferation?

Findlay GM, Harrington LS, Lamb RF.

Curr Opin Genet Dev. 2005 Feb;15(1):69-76.


Restraining PI3K: mTOR signalling goes back to the membrane.

Harrington LS, Findlay GM, Lamb RF.

Trends Biochem Sci. 2005 Jan;30(1):35-42. Review.


Not so EEZE: the 'EDHF' antagonist 14, 15 epoxyeicosa-5(Z)-enoic acid has vasodilator properties in mesenteric arteries.

Harrington LS, Falck JR, Mitchell JA.

Eur J Pharmacol. 2004 Dec 15;506(2):165-8.


Novel role for P2X receptor activation in endothelium-dependent vasodilation.

Harrington LS, Mitchell JA.

Br J Pharmacol. 2004 Nov;143(5):611-7. Epub 2004 Oct 4.


The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins.

Harrington LS, Findlay GM, Gray A, Tolkacheva T, Wigfield S, Rebholz H, Barnett J, Leslie NR, Cheng S, Shepherd PR, Gout I, Downes CP, Lamb RF.

J Cell Biol. 2004 Jul 19;166(2):213-23. Epub 2004 Jul 12.


Coordinate regulation of metabolic enzyme encoding genes during cardiac development and following carvedilol therapy in spontaneously hypertensive rats.

Sack MN, Harrington LS, Jonassen AK, Mjøs OD, Yellon DM.

Cardiovasc Drugs Ther. 2000 Feb;14(1):31-9.


Soluble and membrane-bound forms of brain acetylcholinesterase in Alzheimer's disease.

Schegg KM, Harrington LS, Neilsen S, Zweig RM, Peacock JH.

Neurobiol Aging. 1992 Nov-Dec;13(6):697-704.


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