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Items: 47


STAT4 Directs a Protective Innate Lymphoid Cell Response to Gastrointestinal Infection.

Dulson SJ, Watkins EE, Crossman DK, Harrington LE.

J Immunol. 2019 Sep 27. pii: ji1900719. doi: 10.4049/jimmunol.1900719. [Epub ahead of print]


IL-21 Controls ILC3 Cytokine Production and Promotes a Protective Phenotype in a Mouse Model of Colitis.

Poholek CH, Dulson SJ, Zajac AJ, Harrington LE.

Immunohorizons. 2019 Jun 4;3(6):194-202. doi: 10.4049/immunohorizons.1900005.


Urinary T cells correlate with rate of renal function loss in autosomal dominant polycystic kidney disease.

Zimmerman KA, Gonzalez NM, Chumley P, Chacana T, Harrington LE, Yoder BK, Mrug M.

Physiol Rep. 2019 Jan;7(1):e13951. doi: 10.14814/phy2.13951.


Inscribing the core memories of killers.

Dulson SJ, Harrington LE, Zajac AJ.

Cell Mol Immunol. 2019 Feb;16(2):104-105. doi: 10.1038/s41423-018-0178-9. Epub 2018 Nov 7. No abstract available.


Effector CD4 T cells with progenitor potential mediate chronic intestinal inflammation.

Shin B, Kress RL, Kramer PA, Darley-Usmar VM, Bellis SL, Harrington LE.

J Exp Med. 2018 Jul 2;215(7):1803-1812. doi: 10.1084/jem.20172335. Epub 2018 Jun 18.


IL-10 Regulates Memory T Cell Development and the Balance between Th1 and Follicular Th Cell Responses during an Acute Viral Infection.

Tian Y, Mollo SB, Harrington LE, Zajac AJ.

J Immunol. 2016 Aug 15;197(4):1308-21. doi: 10.4049/jimmunol.1502481. Epub 2016 Jul 8.


STAT4 controls GM-CSF production by both Th1 and Th17 cells during EAE.

McWilliams IL, Rajbhandari R, Nozell S, Benveniste E, Harrington LE.

J Neuroinflammation. 2015 Jun 30;12:128. doi: 10.1186/s12974-015-0351-3.


Tissue-resident T cells lose their S1P1 exit visas.

Zajac AJ, Harrington LE.

Cell Mol Immunol. 2014 May;11(3):221-3. doi: 10.1038/cmi.2014.7. Epub 2014 Feb 24. No abstract available.


Astrocytes modulate the polarization of CD4+ T cells to Th1 cells.

Beurel E, Harrington LE, Buchser W, Lemmon V, Jope RS.

PLoS One. 2014 Jan 28;9(1):e86257. doi: 10.1371/journal.pone.0086257. eCollection 2014.


IFNγ inhibits Th17 differentiation and function via Tbet-dependent and Tbet-independent mechanisms.

Yeh WI, McWilliams IL, Harrington LE.

J Neuroimmunol. 2014 Feb 15;267(1-2):20-7. doi: 10.1016/j.jneuroim.2013.12.001. Epub 2013 Dec 12.


Therapeutic efficacy of suppressing the Jak/STAT pathway in multiple models of experimental autoimmune encephalomyelitis.

Liu Y, Holdbrooks AT, De Sarno P, Rowse AL, Yanagisawa LL, McFarland BC, Harrington LE, Raman C, Sabbaj S, Benveniste EN, Qin H.

J Immunol. 2014 Jan 1;192(1):59-72. doi: 10.4049/jimmunol.1301513. Epub 2013 Dec 9.


Virus-specific CD4 and CD8 T cell responses in the absence of Th1-associated transcription factors.

Mollo SB, Ingram JT, Kress RL, Zajac AJ, Harrington LE.

J Leukoc Biol. 2014 May;95(5):705-713. Epub 2013 Nov 14.


Temporal requirements for B cells in the establishment of CD4 T cell memory.

Mollo SB, Zajac AJ, Harrington LE.

J Immunol. 2013 Dec 15;191(12):6052-9. doi: 10.4049/jimmunol.1302033. Epub 2013 Nov 11.


Regulation of Th1 cells and experimental autoimmune encephalomyelitis by glycogen synthase kinase-3.

Beurel E, Kaidanovich-Beilin O, Yeh WI, Song L, Palomo V, Michalek SM, Woodgett JR, Harrington LE, Eldar-Finkelman H, Martinez A, Jope RS.

J Immunol. 2013 May 15;190(10):5000-11. doi: 10.4049/jimmunol.1203057. Epub 2013 Apr 19.


Inflammatory T helper 17 cells promote depression-like behavior in mice.

Beurel E, Harrington LE, Jope RS.

Biol Psychiatry. 2013 Apr 1;73(7):622-30. doi: 10.1016/j.biopsych.2012.09.021. Epub 2012 Nov 20.


Signal transducer and activator of transcription-3/suppressor of cytokine signaling-3 (STAT3/SOCS3) axis in myeloid cells regulates neuroinflammation.

Qin H, Yeh WI, De Sarno P, Holdbrooks AT, Liu Y, Muldowney MT, Reynolds SL, Yanagisawa LL, Fox TH 3rd, Park K, Harrington LE, Raman C, Benveniste EN.

Proc Natl Acad Sci U S A. 2012 Mar 27;109(13):5004-9. doi: 10.1073/pnas.1117218109. Epub 2012 Mar 12.


A study of M-X-BR3 (M = Pt, Pd or Rh; X = Cl or I) interactions in square planar ambiphilic ligand complexes: structural, spectroscopic, electrochemical and computational comparisons with borane-free analogues.

Emslie DJ, Cowie BE, Oakley SR, Huk NL, Jenkins HA, Harrington LE, Britten JF.

Dalton Trans. 2012 Mar 28;41(12):3523-35. doi: 10.1039/c2dt11991a. Epub 2012 Feb 3.


Autoreactive Tbet-positive CD4 T cells develop independent of classic Th1 cytokine signaling during experimental autoimmune encephalomyelitis.

Yeh WI, McWilliams IL, Harrington LE.

J Immunol. 2011 Nov 15;187(10):4998-5006. doi: 10.4049/jimmunol.1100031. Epub 2011 Oct 7.


Fluorous ligand capture (FLC): a chemoselective solution-phase strategy for isolating 99mTc-labelled compounds in high effective specific activity.

Hicks JW, Harrington LE, Valliant JF.

Chem Commun (Camb). 2011 Jul 14;47(26):7518-20. doi: 10.1039/c1cc11079a. Epub 2011 May 31.


Cytokines and the inception of CD8 T cell responses.

Cox MA, Harrington LE, Zajac AJ.

Trends Immunol. 2011 Apr;32(4):180-6. doi: 10.1016/ Epub 2011 Mar 2. Review.


Glycogen synthase kinase-3 is an early determinant in the differentiation of pathogenic Th17 cells.

Beurel E, Yeh WI, Michalek SM, Harrington LE, Jope RS.

J Immunol. 2011 Feb 1;186(3):1391-8. doi: 10.4049/jimmunol.1003511. Epub 2010 Dec 29.


Pronounced virus-dependent activation drives exhaustion but sustains IFN-γ transcript levels.

Mackerness KJ, Cox MA, Lilly LM, Weaver CT, Harrington LE, Zajac AJ.

J Immunol. 2010 Sep 15;185(6):3643-51. doi: 10.4049/jimmunol.1000841. Epub 2010 Aug 18.


Memory CD4 T cells emerge from effector T-cell progenitors.

Harrington LE, Janowski KM, Oliver JR, Zajac AJ, Weaver CT.

Nature. 2008 Mar 20;452(7185):356-60. doi: 10.1038/nature06672. Epub 2008 Mar 5.



Cheng H, Djukic B, Harrington LE, Britten JF, Lemaire MT.

Acta Crystallogr Sect E Struct Rep Online. 2008 Mar 14;64(Pt 4):o719. doi: 10.1107/S1600536808004960.



Djukic B, Harrington LE, Britten JF, Lemaire MT.

Acta Crystallogr Sect E Struct Rep Online. 2008 Jan 16;64(Pt 2):o463. doi: 10.1107/S1600536808001190.


Strength of stimulus and clonal competition impact the rate of memory CD8 T cell differentiation.

Sarkar S, Teichgräber V, Kalia V, Polley A, Masopust D, Harrington LE, Ahmed R, Wherry EJ.

J Immunol. 2007 Nov 15;179(10):6704-14.


Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3- precursor cells in the absence of interleukin 10.

Maynard CL, Harrington LE, Janowski KM, Oliver JR, Zindl CL, Rudensky AY, Weaver CT.

Nat Immunol. 2007 Sep;8(9):931-41. Epub 2007 Aug 12.


Pharmacokinetic-pharmacodynamic correlation from mouse to human with pazopanib, a multikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity.

Kumar R, Knick VB, Rudolph SK, Johnson JH, Crosby RM, Crouthamel MC, Hopper TM, Miller CG, Harrington LE, Onori JA, Mullin RJ, Gilmer TM, Truesdale AT, Epperly AH, Boloor A, Stafford JA, Luttrell DK, Cheung M.

Mol Cancer Ther. 2007 Jul;6(7):2012-21.


IL-17 family cytokines and the expanding diversity of effector T cell lineages.

Weaver CT, Hatton RD, Mangan PR, Harrington LE.

Annu Rev Immunol. 2007;25:821-52. Review.


A distal conserved sequence element controls Ifng gene expression by T cells and NK cells.

Hatton RD, Harrington LE, Luther RJ, Wakefield T, Janowski KM, Oliver JR, Lallone RL, Murphy KM, Weaver CT.

Immunity. 2006 Nov;25(5):717-29. Epub 2006 Oct 26.


Microwave-assisted synthesis of 3,1,2- and 2,1,8-Re(I) and 99mTc(I)-metallocarborane complexes.

Green AE, Causey PW, Louie AS, Armstrong AF, Harrington LE, Valliant JF.

Inorg Chem. 2006 Jul 24;45(15):5727-9.


Th17: an effector CD4 T cell lineage with regulatory T cell ties.

Weaver CT, Harrington LE, Mangan PR, Gavrieli M, Murphy KM.

Immunity. 2006 Jun;24(6):677-88. Review.


Transforming growth factor-beta induces development of the T(H)17 lineage.

Mangan PR, Harrington LE, O'Quinn DB, Helms WS, Bullard DC, Elson CO, Hatton RD, Wahl SM, Schoeb TR, Weaver CT.

Nature. 2006 May 11;441(7090):231-4. Epub 2006 Apr 30.


Expanding the effector CD4 T-cell repertoire: the Th17 lineage.

Harrington LE, Mangan PR, Weaver CT.

Curr Opin Immunol. 2006 Jun;18(3):349-56. Epub 2006 Apr 17. Review.


Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages.

Harrington LE, Hatton RD, Mangan PR, Turner H, Murphy TL, Murphy KM, Weaver CT.

Nat Immunol. 2005 Nov;6(11):1123-32. Epub 2005 Oct 2.


Antitumour efficacy of VEGFR2 tyrosine kinase inhibitor correlates with expression of VEGF and its receptor VEGFR2 in tumour models.

Dev IK, Dornsife RE, Hopper TM, Onori JA, Miller CG, Harrington LE, Dold KM, Mullin RJ, Johnson JH, Crosby RM, Truesdale AT, Epperly AH, Hinkle KW, Cheung M, Stafford JA, Luttrell DK, Kumar R.

Br J Cancer. 2004 Oct 4;91(7):1391-8.


Differential sensitivity of naive and memory CD8+ T cells to apoptosis in vivo.

Grayson JM, Harrington LE, Lanier JG, Wherry EJ, Ahmed R.

J Immunol. 2002 Oct 1;169(7):3760-70.


Dynamic regulation of T cell immunity by CD43.

Onami TM, Harrington LE, Williams MA, Galvan M, Larsen CP, Pearson TC, Manjunath N, Baum LG, Pearce BD, Ahmed R.

J Immunol. 2002 Jun 15;168(12):6022-31.


Yellow fever virus 17D envelope and NS3 proteins are major targets of the antiviral T cell response in mice.

van der Most RG, Harrington LE, Giuggio V, Mahar PL, Ahmed R.

Virology. 2002 Apr 25;296(1):117-24.


Role of CD28-B7 interactions in generation and maintenance of CD8 T cell memory.

Suresh M, Whitmire JK, Harrington LE, Larsen CP, Pearson TC, Altman JD, Ahmed R.

J Immunol. 2001 Nov 15;167(10):5565-73.


Analysis of Mitochondrial Function in Antigen Specific na ve, Effector and MEmory CD8 + T Cells.

Grayson JM, Lanier JG, Harrington LE, Altman JD, Ahmed R.

ScientificWorldJournal. 2001 Nov 2;1:53. doi: 10.1100/tsw.2001.188. eCollection 2001. No abstract available.


Characterization of virus-mediated inhibition of mixed chimerism and allospecific tolerance.

Williams MA, Tan JT, Adams AB, Durham MM, Shirasugi N, Whitmire JK, Harrington LE, Ahmed R, Pearson TC, Larsen CP.

J Immunol. 2001 Nov 1;167(9):4987-95.


Differentiating between memory and effector CD8 T cells by altered expression of cell surface O-glycans.

Harrington LE, Galvan M, Baum LG, Altman JD, Ahmed R.

J Exp Med. 2000 Apr 3;191(7):1241-6.


Structure-activity relationships of acyloxyamidine cytomegalovirus DNA polymerase inhibitors.

Tucker JA, Clayton TL, Chidester CG, Schulz MW, Harrington LE, Conrad SJ, Yagi Y, Oien NL, Yurek D, Kuo MS.

Bioorg Med Chem. 2000 Mar;8(3):601-15.


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