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Negligible senescence in naked mole rats may be a consequence of well-maintained splicing regulation.

Lee BP, Smith M, Buffenstein R, Harries LW.

Geroscience. 2020 Jan 11. doi: 10.1007/s11357-019-00150-7. [Epub ahead of print]


circRNAs expressed in human peripheral blood are associated with human aging phenotypes, cellular senescence and mouse lifespan.

Haque S, Ames RM, Moore K, Pilling LC, Peters LL, Bandinelli S, Ferrucci L, Harries LW.

Geroscience. 2019 Dec 6. doi: 10.1007/s11357-019-00120-z. [Epub ahead of print]


Corrigendum to: The Longevity-Associated SH2B3 (LNK) Genetic Variant: Selected Aging Phenotypes in 379,758 Subjects.

Kuo CL, Joaquim M, Kuchel GA, Ferrucci L, Harries LW, Pilling LC, Melzer D.

J Gerontol A Biol Sci Med Sci. 2019 Nov 29. pii: glz268. doi: 10.1093/gerona/glz268. [Epub ahead of print] No abstract available.


To help aging populations, classify organismal senescence.

Calimport SRG, Bentley BL, Stewart CE, Pawelec G, Scuteri A, Vinciguerra M, Slack C, Chen D, Harries LW, Marchant G, Fleming GA, Conboy M, Antebi A, Small GW, Gil J, Lakatta EG, Richardson A, Rosen C, Nikolich K, Wyss-Coray T, Steinman L, Montine T, de Magalhães JP, Campisi J, Church G.

Science. 2019 Nov 1;366(6465):576-578. doi: 10.1126/science.aay7319. No abstract available.


Astrocyte senescence may drive alterations in GFAPα, CDKN2A p14ARF, and TAU3 transcript expression and contribute to cognitive decline.

Lye JJ, Latorre E, Lee BP, Bandinelli S, Holley JE, Gutowski NJ, Ferrucci L, Harries LW.

Geroscience. 2019 Oct;41(5):561-573. doi: 10.1007/s11357-019-00100-3. Epub 2019 Oct 25.


A dynamical systems model for the measurement of cellular senescence.

Galvis D, Walsh D, Harries LW, Latorre E, Rankin J.

J R Soc Interface. 2019 Oct 31;16(159):20190311. doi: 10.1098/rsif.2019.0311. Epub 2019 Oct 9.


Corrigendum to "miRNAs responsive to the diabetic microenvironment in the human beta cell line EndoC βH1 may target genes in the FOXO, HIPPO and Lysine degradation pathways" [Exp. Cell Res. 29 (2019) 111559].

Jeffery N, Harries LW.

Exp Cell Res. 2019 Dec 1;385(1):111654. doi: 10.1016/j.yexcr.2019.111654. Epub 2019 Oct 4. No abstract available.


Dietary restriction in ILSXISS mice is associated with widespread changes in splicing regulatory factor expression levels.

Lee BP, Mulvey L, Barr G, Garratt J, Goodman E, Selman C, Harries LW.

Exp Gerontol. 2019 Dec;128:110736. doi: 10.1016/j.exger.2019.110736. Epub 2019 Sep 12.


Androgen-regulated transcription of ESRP2 drives alternative splicing patterns in prostate cancer.

Munkley J, Li L, Krishnan SRG, Hysenaj G, Scott E, Dalgliesh C, Oo HZ, Maia TM, Cheung K, Ehrmann I, Livermore KE, Zielinska H, Thompson O, Knight B, McCullagh P, McGrath J, Crundwell M, Harries LW, Daugaard M, Cockell S, Barbosa-Morais NL, Oltean S, Elliott DJ.

Elife. 2019 Sep 3;8. pii: e47678. doi: 10.7554/eLife.47678.


miRNAs responsive to the diabetic microenvironment in the human beta cell line EndoC-βH1 may target genes in the FOXO, HIPPO and Lysine degradation pathways.

Jeffery N, Harries LW.

Exp Cell Res. 2019 Nov 1;384(1):111559. doi: 10.1016/j.yexcr.2019.111559. Epub 2019 Aug 16. Erratum in: Exp Cell Res. 2019 Dec 1;385(1):111654.


The transcript expression levels of HNRNPM, HNRNPA0 and AKAP17A splicing factors may be predictively associated with ageing phenotypes in human peripheral blood.

Lee BP, Pilling LC, Bandinelli S, Ferrucci L, Melzer D, Harries LW.

Biogerontology. 2019 Oct;20(5):649-663. doi: 10.1007/s10522-019-09819-0. Epub 2019 Jul 10.


Alternative splicing in serotonergic system: Implications in neuropsychiatric disorders.

Latorre E, Mesonero JE, Harries LW.

J Psychopharmacol. 2019 Nov;33(11):1352-1363. doi: 10.1177/0269881119856546. Epub 2019 Jun 18.


Cellular stressors may alter islet hormone cell proportions by moderation of alternative splicing patterns.

Jeffery N, Richardson S, Chambers D, Morgan NG, Harries LW.

Hum Mol Genet. 2019 Aug 15;28(16):2763-2774. doi: 10.1093/hmg/ddz094.


RNA Biology Provides New Therapeutic Targets for Human Disease.

Harries LW.

Front Genet. 2019 Mar 8;10:205. doi: 10.3389/fgene.2019.00205. eCollection 2019. Review.


Obesity impacts the regulation of miR-10b and its targets in primary breast tumors.

Meerson A, Eliraz Y, Yehuda H, Knight B, Crundwell M, Ferguson D, Lee BP, Harries LW.

BMC Cancer. 2019 Jan 18;19(1):86. doi: 10.1186/s12885-019-5300-6.


Altered cellular redox homeostasis and redox responses under standard oxygen cell culture conditions versus physioxia.

Ferguson DCJ, Smerdon GR, Harries LW, Dodd NJF, Murphy MP, Curnow A, Winyard PG.

Free Radic Biol Med. 2018 Oct;126:322-333. doi: 10.1016/j.freeradbiomed.2018.08.025. Epub 2018 Aug 22.


FOXO1 and ETV6 genes may represent novel regulators of splicing factor expression in cellular senescence.

Latorre E, Ostler EL, Faragher RGA, Harries LW.

FASEB J. 2019 Jan;33(1):1086-1097. doi: 10.1096/fj.201801154R. Epub 2018 Aug 8.


Mitochondria-targeted hydrogen sulfide attenuates endothelial senescence by selective induction of splicing factors HNRNPD and SRSF2.

Latorre E, Torregrossa R, Wood ME, Whiteman M, Harries LW.

Aging (Albany NY). 2018 Jul 19;10(7):1666-1681. doi: 10.18632/aging.101500.


The Common HNF1A Variant I27L Is a Modifier of Age at Diabetes Diagnosis in Individuals With HNF1A-MODY.

Locke JM, Saint-Martin C, Laver TW, Patel KA, Wood AR, Sharp SA, Ellard S, Bellanné-Chantelot C, Hattersley AT, Harries LW, Weedon MN.

Diabetes. 2018 Sep;67(9):1903-1907. doi: 10.2337/db18-0133. Epub 2018 Jun 12.


An engaged research study to assess the effect of a 'real-world' dietary intervention on urinary bisphenol A (BPA) levels in teenagers.

Galloway TS, Baglin N, Lee BP, Kocur AL, Shepherd MH, Steele AM; BPA Schools Study Consortium, Harries LW.

BMJ Open. 2018 Feb 3;8(2):e018742. doi: 10.1136/bmjopen-2017-018742.


The VEGFA156b isoform is dysregulated in senescent endothelial cells and may be associated with prevalent and incident coronary heart disease.

Latorre E, Pilling LC, Lee BP, Bandinelli S, Melzer D, Ferrucci L, Harries LW.

Clin Sci (Lond). 2018 Feb 2;132(3):313-325. doi: 10.1042/CS20171556. Print 2018 Feb 14.


Human longevity: 25 genetic loci associated in 389,166 UK biobank participants.

Pilling LC, Kuo CL, Sicinski K, Tamosauskaite J, Kuchel GA, Harries LW, Herd P, Wallace R, Ferrucci L, Melzer D.

Aging (Albany NY). 2017 Dec 6;9(12):2504-2520. doi: 10.18632/aging.101334.


Circular RNAs (circRNAs) in Health and Disease.

Haque S, Harries LW.

Genes (Basel). 2017 Nov 28;8(12). pii: E353. doi: 10.3390/genes8120353. Review.


The species origin of the cellular microenvironment influences markers of beta cell fate and function in EndoC-βH1 cells.

Jeffery N, Richardson S, Beall C, Harries LW.

Exp Cell Res. 2017 Dec 15;361(2):284-291. doi: 10.1016/j.yexcr.2017.10.028. Epub 2017 Oct 31.


Nanoscale Properties of Human Telomeres Measured with a Dual Purpose X-ray Fluorescence and Super Resolution Microscopy Gold Nanoparticle Probe.

Jeynes JCG, Geraki K, Jeynes C, Zhaohong M, Bettiol AA, Latorre E, Harries LW, Soeller C.

ACS Nano. 2017 Dec 26;11(12):12632-12640. doi: 10.1021/acsnano.7b07064. Epub 2017 Nov 7.


Small molecule modulation of splicing factor expression is associated with rescue from cellular senescence.

Latorre E, Birar VC, Sheerin AN, Jeynes JCC, Hooper A, Dawe HR, Melzer D, Cox LS, Faragher RGA, Ostler EL, Harries LW.

BMC Cell Biol. 2017 Oct 17;18(1):31. doi: 10.1186/s12860-017-0147-7.


Red blood cell distribution width: Genetic evidence for aging pathways in 116,666 volunteers.

Pilling LC, Atkins JL, Duff MO, Beaumont RN, Jones SE, Tyrrell J, Kuo CL, Ruth KS, Tuke MA, Yaghootkar H, Wood AR, Murray A, Weedon MN, Harries LW, Kuchel GA, Ferrucci L, Frayling TM, Melzer D.

PLoS One. 2017 Sep 28;12(9):e0185083. doi: 10.1371/journal.pone.0185083. eCollection 2017.


The cancer-associated cell migration protein TSPAN1 is under control of androgens and its upregulation increases prostate cancer cell migration.

Munkley J, McClurg UL, Livermore KE, Ehrmann I, Knight B, Mccullagh P, Mcgrath J, Crundwell M, Harries LW, Leung HY, Mills IG, Robson CN, Rajan P, Elliott DJ.

Sci Rep. 2017 Jul 12;7(1):5249. doi: 10.1038/s41598-017-05489-5.


An ABCC8 Nonsense Mutation Causing Neonatal Diabetes Through Altered Transcript Expression.

Flanagan SE, Dũng VC, Houghton JAL, De Franco E, Ngoc CTB, Damhuis A, Ashcroft FM, Harries LW, Ellard S.

J Clin Res Pediatr Endocrinol. 2017 Sep 1;9(3):260-264. doi: 10.4274/jcrpe.4624. Epub 2017 Jun 30.


Splicing regulatory factors, ageing and age-related disease.

Latorre E, Harries LW.

Ageing Res Rev. 2017 Jul;36:165-170. doi: 10.1016/j.arr.2017.04.004. Epub 2017 Apr 26. Review.


MicroRNAs miR-203-3p, miR-664-3p and miR-708-5p are associated with median strain lifespan in mice.

Lee BP, Burić I, George-Pandeth A, Flurkey K, Harrison DE, Yuan R, Peters LL, Kuchel GA, Melzer D, Harries LW.

Sci Rep. 2017 Mar 17;7:44620. doi: 10.1038/srep44620.


Peripheral Blood Transcriptomic Signatures of Fasting Glucose and Insulin Concentrations.

Chen BH, Hivert MF, Peters MJ, Pilling LC, Hogan JD, Pham LM, Harries LW, Fox CS, Bandinelli S, Dehghan A, Hernandez DG, Hofman A, Hong J, Joehanes R, Johnson AD, Munson PJ, Rybin DV, Singleton AB, Uitterlinden AG, Ying S; MAGIC Investigators, Melzer D, Levy D, van Meurs JB, Ferrucci L, Florez JC, Dupuis J, Meigs JB, Kolaczyk ED.

Diabetes. 2016 Dec;65(12):3794-3804. Epub 2016 Sep 13.


β-cell differentiation status in type 2 diabetes.

Jeffery N, Harries LW.

Diabetes Obes Metab. 2016 Dec;18(12):1167-1175. doi: 10.1111/dom.12778. Epub 2016 Sep 21. Review.


Longer-Lived Parents and Cardiovascular Outcomes: 8-Year Follow-Up In 186,000 U.K. Biobank Participants.

Atkins JL, Pilling LC, Ble A, Dutta A, Harries LW, Murray A, Brayne C, Robine JM, Kuchel GA, Ferrucci L, Melzer D.

J Am Coll Cardiol. 2016 Aug 23;68(8):874-5. doi: 10.1016/j.jacc.2016.05.072. No abstract available.


Glycosylation is an Androgen-Regulated Process Essential for Prostate Cancer Cell Viability.

Munkley J, Vodak D, Livermore KE, James K, Wilson BT, Knight B, Mccullagh P, Mcgrath J, Crundwell M, Harries LW, Leung HY, Robson CN, Mills IG, Rajan P, Elliott DJ.

EBioMedicine. 2016 Jun;8:103-116. doi: 10.1016/j.ebiom.2016.04.018. Epub 2016 Apr 20.


Changes in the expression of splicing factor transcripts and variations in alternative splicing are associated with lifespan in mice and humans.

Lee BP, Pilling LC, Emond F, Flurkey K, Harrison DE, Yuan R, Peters LL, Kuchel GA, Ferrucci L, Melzer D, Harries LW.

Aging Cell. 2016 Oct;15(5):903-13. doi: 10.1111/acel.12499. Epub 2016 Jun 30.


The DDX6-4E-T interaction mediates translational repression and P-body assembly.

Kamenska A, Simpson C, Vindry C, Broomhead H, Bénard M, Ernoult-Lange M, Lee BP, Harries LW, Weil D, Standart N.

Nucleic Acids Res. 2016 Jul 27;44(13):6318-34. doi: 10.1093/nar/gkw565. Epub 2016 Jun 24.


Human longevity is influenced by many genetic variants: evidence from 75,000 UK Biobank participants.

Pilling LC, Atkins JL, Bowman K, Jones SE, Tyrrell J, Beaumont RN, Ruth KS, Tuke MA, Yaghootkar H, Wood AR, Freathy RM, Murray A, Weedon MN, Xue L, Lunetta K, Murabito JM, Harries LW, Robine JM, Brayne C, Kuchel GA, Ferrucci L, Frayling TM, Melzer D.

Aging (Albany NY). 2016 Mar;8(3):547-60.


Functional characterisation of ADIPOQ variants using individuals recruited by genotype.

Lee BP, Lloyd-Laney HO, Locke JM, McCulloch LJ, Knight B, Yaghootkar H, Cory G, Kos K, Frayling TM, Harries LW.

Mol Cell Endocrinol. 2016 Jun 15;428:49-57. doi: 10.1016/j.mce.2016.03.020. Epub 2016 Mar 17.


The PI3K regulatory subunit gene PIK3R1 is under direct control of androgens and repressed in prostate cancer cells.

Munkley J, Livermore KE, McClurg UL, Kalna G, Knight B, McCullagh P, McGrath J, Crundwell M, Leung HY, Robson CN, Harries LW, Rajan P, Elliott DJ.

Oncoscience. 2015 Sep 14;2(9):755-64. eCollection 2015.


Gene transcripts associated with muscle strength: a CHARGE meta-analysis of 7,781 persons.

Pilling LC, Joehanes R, Kacprowski T, Peters M, Jansen R, Karasik D, Kiel DP, Harries LW, Teumer A, Powell J, Levy D, Lin H, Lunetta K, Munson P, Bandinelli S, Henley W, Hernandez D, Singleton A, Tanaka T, van Grootheest G, Hofman A, Uitterlinden AG, Biffar R, Gläser S, Homuth G, Malsch C, Völker U, Penninx B, van Meurs JB, Ferrucci L, Kocher T, Murabito J, Melzer D.

Physiol Genomics. 2016 Jan;48(1):1-11. doi: 10.1152/physiolgenomics.00054.2015. Epub 2015 Oct 20.


Role of microRNAs in the age-associated decline of pancreatic beta cell function in rat islets.

Tugay K, Guay C, Marques AC, Allagnat F, Locke JM, Harries LW, Rutter GA, Regazzi R.

Diabetologia. 2016 Jan;59(1):161-169. doi: 10.1007/s00125-015-3783-5.


The androgen receptor controls expression of the cancer-associated sTn antigen and cell adhesion through induction of ST6GalNAc1 in prostate cancer.

Munkley J, Oltean S, Vodák D, Wilson BT, Livermore KE, Zhou Y, Star E, Floros VI, Johannessen B, Knight B, McCullagh P, McGrath J, Crundwell M, Skotheim RI, Robson CN, Leung HY, Harries LW, Rajan P, Mills IG, Elliott DJ.

Oncotarget. 2015 Oct 27;6(33):34358-74. doi: 10.18632/oncotarget.6024.


Gene expression markers of age-related inflammation in two human cohorts.

Pilling LC, Joehanes R, Melzer D, Harries LW, Henley W, Dupuis J, Lin H, Mitchell M, Hernandez D, Ying SX, Lunetta KL, Benjamin EJ, Singleton A, Levy D, Munson P, Murabito JM, Ferrucci L.

Exp Gerontol. 2015 Oct;70:37-45. doi: 10.1016/j.exger.2015.05.012. Epub 2015 Jun 16.


Comparison of senescence-associated miRNAs in primary skin and lung fibroblasts.

Holly AC, Grellscheid S, van de Walle P, Dolan D, Pilling LC, Daniels DJ, von Zglinicki T, Ferrucci L, Melzer D, Harries LW.

Biogerontology. 2015 Aug;16(4):423-34. doi: 10.1007/s10522-015-9560-5. Epub 2015 Feb 21.


A cautionary tale: the non-causal association between type 2 diabetes risk SNP, rs7756992, and levels of non-coding RNA, CDKAL1-v1.

Locke JM, Wei FY, Tomizawa K, Weedon MN, Harries LW.

Diabetologia. 2015 Apr;58(4):745-8. doi: 10.1007/s00125-015-3508-9. Epub 2015 Jan 30.


PFOA and PFOS are associated with reduced expression of the parathyroid hormone 2 receptor (PTH2R) gene in women.

Galloway TS, Fletcher T, Thomas OJ, Lee BP, Pilling LC, Harries LW.

Chemosphere. 2015 Feb;120:555-62. doi: 10.1016/j.chemosphere.2014.09.066. Epub 2014 Oct 17.


Targeted allelic expression profiling in human islets identifies cis-regulatory effects for multiple variants identified by type 2 diabetes genome-wide association studies.

Locke JM, Hysenaj G, Wood AR, Weedon MN, Harries LW.

Diabetes. 2015 Apr;64(4):1484-91. doi: 10.2337/db14-0957. Epub 2014 Nov 12.


Changes in CEBPB expression in circulating leukocytes following eccentric elbow-flexion exercise.

Blackwell J, Harries LW, Pilling LC, Ferrucci L, Jones A, Melzer D.

J Physiol Sci. 2015 Jan;65(1):145-50. doi: 10.1007/s12576-014-0350-7. Epub 2014 Nov 13.

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