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Aircrew Conditioning Programme Impact on +Gz Tolerance.

Slungaard E, Pollock RD, Stevenson AT, Green NDC, Newham DJ, Harridge SDR.

Aerosp Med Hum Perform. 2019 Sep 1;90(9):764-773. doi: 10.3357/AMHP.5318.2019.


Can physical activity ameliorate immunosenescence and thereby reduce age-related multi-morbidity?

Duggal NA, Niemiro G, Harridge SDR, Simpson RJ, Lord JM.

Nat Rev Immunol. 2019 Sep;19(9):563-572. doi: 10.1038/s41577-019-0177-9. Review.


VGLL3 operates via TEAD1, TEAD3 and TEAD4 to influence myogenesis in skeletal muscle.

Figeac N, Mohamed AD, Sun C, Schönfelder M, Matallanas D, Garcia-Munoz A, Missiaglia E, Collie-Duguid E, De Mello V, Pobbati AV, Pruller J, Jaka O, Harridge SDR, Hong W, Shipley J, Vargesson N, Zammit PS, Wackerhage H.

J Cell Sci. 2019 Jul 5;132(13). pii: jcs225946. doi: 10.1242/jcs.225946.


β-Hydroxy-β-methylbutyrate and its impact on skeletal muscle mass and physical function in clinical practice: a systematic review and meta-analysis.

Bear DE, Langan A, Dimidi E, Wandrag L, Harridge SDR, Hart N, Connolly B, Whelan K.

Am J Clin Nutr. 2019 Apr 1;109(4):1119-1132. doi: 10.1093/ajcn/nqy373.


Inorganic nitrate, hypoxia, and the regulation of cardiac mitochondrial respiration-probing the role of PPARα.

Horscroft JA, O'Brien KA, Clark AD, Lindsay RT, Steel AS, Procter NEK, Devaux J, Frenneaux M, Harridge SDR, Murray AJ.

FASEB J. 2019 Jun;33(6):7563-7577. doi: 10.1096/fj.201900067R. Epub 2019 Mar 14.


Copenhagen Consensus statement 2019: physical activity and ageing.

Bangsbo J, Blackwell J, Boraxbekk CJ, Caserotti P, Dela F, Evans AB, Jespersen AP, Gliemann L, Kramer AF, Lundbye-Jensen J, Mortensen EL, Lassen AJ, Gow AJ, Harridge SDR, Hellsten Y, Kjaer M, Kujala UM, Rhodes RE, Pike ECJ, Skinner T, Skovgaard T, Troelsen J, Tulle E, Tully MA, van Uffelen JGZ, Viña J.

Br J Sports Med. 2019 Jul;53(14):856-858. doi: 10.1136/bjsports-2018-100451. Epub 2019 Feb 21.


Metabolomic and lipidomic plasma profile changes in human participants ascending to Everest Base Camp.

O'Brien KA, Atkinson RA, Richardson L, Koulman A, Murray AJ, Harridge SDR, Martin DS, Levett DZH, Mitchell K, Mythen MG, Montgomery HE, Grocott MPW, Griffin JL, Edwards LM.

Sci Rep. 2019 Feb 19;9(1):2297. doi: 10.1038/s41598-019-38832-z.


Evidence of higher intramyocellular fat among normal and overweight Indians with prediabetes.

Sucharita S, Pranathi R, Correa M, Keerthana P, Ramesh LJ, Bantwal G, Venkatappa HM, Mahadev KP, Thomas T, Bosch RJ, Harridge SDR, Kurpad AV.

Eur J Clin Nutr. 2019 Oct;73(10):1373-1381. doi: 10.1038/s41430-019-0402-4. Epub 2019 Feb 6.


The relationships and interactions between age, exercise and physiological function.

Lazarus NR, Lord JM, Harridge SDR.

J Physiol. 2019 Mar;597(5):1299-1309. doi: 10.1113/JP277071. Epub 2018 Dec 17.


The Inherent Human Aging Process and the Facilitating Role of Exercise.

Lazarus NR, Harridge SDR.

Front Physiol. 2018 Oct 8;9:1135. doi: 10.3389/fphys.2018.01135. eCollection 2018. Review.


Prelamin A causes aberrant myonuclear arrangement and results in muscle fiber weakness.

Levy Y, Ross JA, Niglas M, Snetkov VA, Lynham S, Liao CY, Puckelwartz MJ, Hsu YM, McNally EM, Alsheimer M, Harridge SD, Young SG, Fong LG, Español Y, Lopez-Otin C, Kennedy BK, Lowe DA, Ochala J.

JCI Insight. 2018 Oct 4;3(19). pii: 120920. doi: 10.1172/jci.insight.120920.


Content Validity of Level Two of the Royal Air Force Aircrew Conditioning Programme.

Slungaard E, Green NDC, Newham DJ, Harridge SDR.

Aerosp Med Hum Perform. 2018 Oct 1;89(10):896-904. doi: 10.3357/AMHP.4994.2018.


Exercise and glucose control in children with insulin resistance: prevalence of non-responders.

Álvarez C, Ramírez-Campillo R, Cano-Montoya J, Ramírez-Vélez R, Harridge SDR, Alonso-Martínez AM, Izquierdo M.

Pediatr Obes. 2018 Dec;13(12):794-802. doi: 10.1111/ijpo.12437. Epub 2018 Sep 11.


Exercise Deficiency Diseases of Ageing: The Primacy of Exercise and Muscle Strengthening as First-Line Therapeutic Agents to Combat Frailty.

Lazarus NR, Izquierdo M, Higginson IJ, Harridge SDR.

J Am Med Dir Assoc. 2018 Sep;19(9):741-743. doi: 10.1016/j.jamda.2018.04.014. No abstract available.


PPARα-independent effects of nitrate supplementation on skeletal muscle metabolism in hypoxia.

O'Brien KA, Horscroft JA, Devaux J, Lindsay RT, Steel AS, Clark AD, Philp A, Harridge SDR, Murray AJ.

Biochim Biophys Acta Mol Basis Dis. 2019 Apr 1;1865(4):844-853. doi: 10.1016/j.bbadis.2018.07.027. Epub 2018 Jul 25.


Metabolic phenotype of skeletal muscle in early critical illness.

Puthucheary ZA, Astin R, Mcphail MJW, Saeed S, Pasha Y, Bear DE, Constantin D, Velloso C, Manning S, Calvert L, Singer M, Batterham RL, Gomez-Romero M, Holmes E, Steiner MC, Atherton PJ, Greenhaff P, Edwards LM, Smith K, Harridge SD, Hart N, Montgomery HE.

Thorax. 2018 Oct;73(10):926-935. doi: 10.1136/thoraxjnl-2017-211073. Epub 2018 Jul 6.


Human physiological and metabolic responses to an attempted winter crossing of Antarctica: the effects of prolonged hypobaric hypoxia.

O'Brien KA, Pollock RD, Stroud M, Lambert RJ, Kumar A, Atkinson RA, Green DA, Anton-Solanas A, Edwards LM, Harridge SDR.

Physiol Rep. 2018 Mar;6(5). doi: 10.14814/phy2.13613.


Properties of the vastus lateralis muscle in relation to age and physiological function in master cyclists aged 55-79 years.

Pollock RD, O'Brien KA, Daniels LJ, Nielsen KB, Rowlerson A, Duggal NA, Lazarus NR, Lord JM, Philp A, Harridge SDR.

Aging Cell. 2018 Apr;17(2). doi: 10.1111/acel.12735. Epub 2018 Mar 8.


Cardiorespiratory fitness not sedentary time or physical activity is associated with cardiometabolic risk in active older adults.

Pollock RD, Duggal NA, Lazarus NR, Lord JM, Harridge SDR.

Scand J Med Sci Sports. 2018 Jun;28(6):1653-1660. doi: 10.1111/sms.13071. Epub 2018 Feb 27.


The Scandinavian Foundation of Medicine & Science in Sports.

Berge HM, Harridge SDR.

Scand J Med Sci Sports. 2017 Dec;27(12):1536. doi: 10.1111/sms.12996. No abstract available.


Active GSK3β and an intact β-catenin TCF complex are essential for the differentiation of human myogenic progenitor cells.

Agley CC, Lewis FC, Jaka O, Lazarus NR, Velloso C, Francis-West P, Ellison-Hughes GM, Harridge SDR.

Sci Rep. 2017 Oct 13;7(1):13189. doi: 10.1038/s41598-017-10731-1.


Incidence of G-Induced Loss of Consciousness and Almost Loss of Consciousness in the Royal Air Force.

Slungaard E, McLeod J, Green NDC, Kiran A, Newham DJ, Harridge SDR.

Aerosp Med Hum Perform. 2017 Jun 1;88(6):550-555. doi: 10.3357/AMHP.4752.2017.


Physical Activity, Aging, and Physiological Function.

Harridge SD, Lazarus NR.

Physiology (Bethesda). 2017 Mar;32(2):152-161. doi: 10.1152/physiol.00029.2016. Review.


Rectus Femoris Cross-Sectional Area and Muscle Layer Thickness: Comparative Markers of Muscle Wasting and Weakness.

Puthucheary ZA, McNelly AS, Rawal J, Connolly B, Sidhu PS, Rowlerson A, Moxham J, Harridge SD, Hart N, Montgomery HE.

Am J Respir Crit Care Med. 2017 Jan 1;195(1):136-138. doi: 10.1164/rccm.201604-0875LE. No abstract available.


Ret function in muscle stem cells points to tyrosine kinase inhibitor therapy for facioscapulohumeral muscular dystrophy.

Moyle LA, Blanc E, Jaka O, Prueller J, Banerji CR, Tedesco FS, Harridge SD, Knight RD, Zammit PS.

Elife. 2016 Nov 14;5. pii: e11405. doi: 10.7554/eLife.11405.


Declining performance of master athletes: silhouettes of the trajectory of healthy human ageing?

Lazarus NR, Harridge SDR.

J Physiol. 2017 May 1;595(9):2941-2948. doi: 10.1113/JP272443. Epub 2017 Jan 18. Review.


An Exploratory Study of Long-Term Outcome Measures in Critical Illness Survivors: Construct Validity of Physical Activity, Frailty, and Health-Related Quality of Life Measures.

McNelly AS, Rawal J, Shrikrishna D, Hopkinson NS, Moxham J, Harridge SD, Hart N, Montgomery HE, Puthucheary ZA.

Crit Care Med. 2016 Jun;44(6):e362-9. doi: 10.1097/CCM.0000000000001645.


25 years of the Scandinavian Journal of Medicine and Science in Sports.

Harridge SD.

Scand J Med Sci Sports. 2015 Dec;25(6):735. doi: 10.1111/sms.12622. No abstract available.


Reply from Ross D. Pollock, Norman R. Lazarus, Janet M. Lord and Stephen D. R. Harridge.

Pollock RD, Lazarus NR, Lord JM, Harridge SD.

J Physiol. 2015 Jul 15;593(14):3221-2. doi: 10.1113/JP270642. No abstract available.


A pilot study of change in fracture risk in patients with acute respiratory distress syndrome.

Rawal J, McPhail MJ, Ratnayake G, Chan P, Moxham J, Harridge SD, Hart N, Montgomery HE, Puthucheary ZA.

Crit Care. 2015 Apr 14;19:165. doi: 10.1186/s13054-015-0892-y.


Isolation and quantitative immunocytochemical characterization of primary myogenic cells and fibroblasts from human skeletal muscle.

Agley CC, Rowlerson AM, Velloso CP, Lazarus NL, Harridge SD.

J Vis Exp. 2015 Jan 12;(95):52049. doi: 10.3791/52049.


An investigation into the relationship between age and physiological function in highly active older adults.

Pollock RD, Carter S, Velloso CP, Duggal NA, Lord JM, Lazarus NR, Harridge SD.

J Physiol. 2015 Feb 1;593(3):657-80; discussion 680. doi: 10.1113/jphysiol.2014.282863. Epub 2015 Jan 6.


The lingering effects of testosterone abuse - it seems muscles have long memories.

Harridge SD, Kadi F.

Scand J Med Sci Sports. 2014 Dec;24(6):869-70. doi: 10.1111/sms.12382. No abstract available.


Defining the nociceptor transcriptome.

Thakur M, Crow M, Richards N, Davey GI, Levine E, Kelleher JH, Agley CC, Denk F, Harridge SD, McMahon SB.

Front Mol Neurosci. 2014 Nov 11;7:87. doi: 10.3389/fnmol.2014.00087. eCollection 2014.


Acute skeletal muscle wasting in critical illness.

Puthucheary ZA, Rawal J, McPhail M, Connolly B, Ratnayake G, Chan P, Hopkinson NS, Phadke R, Dew T, Sidhu PS, Velloso C, Seymour J, Agley CC, Selby A, Limb M, Edwards LM, Smith K, Rowlerson A, Rennie MJ, Moxham J, Harridge SD, Hart N, Montgomery HE.

JAMA. 2013 Oct 16;310(15):1591-600. Erratum in: JAMA. 2014 Feb 12;311(6):625. Padhke, Rahul [corrected to Phadke, Rahul].


Human skeletal muscle fibroblasts, but not myogenic cells, readily undergo adipogenic differentiation.

Agley CC, Rowlerson AM, Velloso CP, Lazarus NR, Harridge SD.

J Cell Sci. 2013 Dec 15;126(Pt 24):5610-25. doi: 10.1242/jcs.132563. Epub 2013 Oct 7.


The effects of two weeks of recombinant growth hormone administration on the response of IGF-I and N-terminal pro-peptide of collagen type III (P-III-NP) during a single bout of high resistance exercise in resistance trained young men.

Velloso CP, Aperghis M, Godfrey R, Blazevich AJ, Bartlett C, Cowan D, Holt RI, Bouloux P, Harridge SD, Goldspink G.

Growth Horm IGF Res. 2013 Jun;23(3):76-80. doi: 10.1016/j.ghir.2013.01.002. Epub 2013 Feb 19.


Primary human muscle precursor cells obtained from young and old donors produce similar proliferative, differentiation and senescent profiles in culture.

Alsharidah M, Lazarus NR, George TE, Agley CC, Velloso CP, Harridge SD.

Aging Cell. 2013 Jun;12(3):333-44. doi: 10.1111/acel.12051. Epub 2013 Mar 17.


More sports injuries, please!

Harridge SD.

Scand J Med Sci Sports. 2012 Aug;22(4):453. doi: 10.1111/j.1600-0838.2012.01508.x. No abstract available.


An image analysis method for the precise selection and quantitation of fluorescently labeled cellular constituents: application to the measurement of human muscle cells in culture.

Agley CC, Velloso CP, Lazarus NR, Harridge SD.

J Histochem Cytochem. 2012 Jun;60(6):428-38. doi: 10.1369/0022155412442897. Epub 2012 Apr 17.


Examination of the relationship between age and clinical function: missing the trees for the wood.

Lazarus NR, Harridge SD.

Aging Clin Exp Res. 2011 Aug;23(4):323-4. No abstract available.


Effects of endurance and strength-directed electrical stimulation training on the performance and histological properties of paralyzed human muscle: a pilot study.

Duffell LD, Rowlerson AM, Donaldson Nde N, Harridge SD, Newham DJ.

Muscle Nerve. 2010 Nov;42(5):756-63. doi: 10.1002/mus.21746. Erratum in: Muscle Nerve. 2011 Jan;43(1):154.


Sera from young and older humans equally sustain proliferation and differentiation of human myoblasts.

George T, Velloso CP, Alsharidah M, Lazarus NR, Harridge SD.

Exp Gerontol. 2010 Nov;45(11):875-81. doi: 10.1016/j.exger.2010.07.006. Epub 2010 Aug 3.


Comments on Point:Counterpoint: IGF is/is not the major physiological regulator of muscle mass. IGF-1--an enigma disguised as growth factor.

Harridge SD, Velloso C.

J Appl Physiol (1985). 2010 Jun;108(6):1828-9. doi: 10.1152/japplphysiol.00312.2010. No abstract available.


Exercise, physiological function, and the selection of participants for aging research.

Lazarus NR, Harridge SD.

J Gerontol A Biol Sci Med Sci. 2010 Aug;65(8):854-7. doi: 10.1093/gerona/glq016. Epub 2010 Feb 22.


Insulin-like growth factor-I E peptides: implications for aging skeletal muscle.

Velloso CP, Harridge SD.

Scand J Med Sci Sports. 2010 Feb;20(1):20-7. doi: 10.1111/j.1600-0838.2009.00997.x. Review.


High-throughput ultra-high-performance liquid chromatography/tandem mass spectrometry quantitation of insulin-like growth factor-I and leucine-rich alpha-2-glycoprotein in serum as biomarkers of recombinant human growth hormone administration.

Kay RG, Barton C, Velloso CP, Brown PR, Bartlett C, Blazevich AJ, Godfrey RJ, Goldspink G, Rees R, Ball GR, Cowan DA, Harridge SD, Roberts J, Teale P, Creaser CS.

Rapid Commun Mass Spectrom. 2009 Oct;23(19):3173-82. doi: 10.1002/rcm.4237.


Investigation of MGF mRNA expression in patients with amyotrophic lateral sclerosis using parallel in vivo and in vitro approaches.

Evans RM, Harridge SD, Velloso CP, Yang SY, Goldspink G, Orrell RW.

Amyotroph Lateral Scler. 2010;11(1-2):172-7. doi: 10.3109/17482960903089775.


IGF-I and GH: potential use in gene doping.

Harridge SD, Velloso CP.

Growth Horm IGF Res. 2009 Aug;19(4):378-82. doi: 10.1016/j.ghir.2009.04.016. Epub 2009 May 31. Review.


Serum IGF-I levels and IGF-I gene splicing in muscle of healthy young males receiving rhGH.

Aperghis M, Velloso CP, Hameed M, Brothwood T, Bradley L, Bouloux PM, Harridge SD, Goldspink G.

Growth Horm IGF Res. 2009 Feb;19(1):61-7. doi: 10.1016/j.ghir.2008.07.002. Epub 2008 Sep 16.


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