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Items: 11


Pharmacologic and genetic inhibition of hsp90-dependent trafficking reduces aggregation and promotes degradation of the expanded glutamine androgen receptor without stress protein induction.

Thomas M, Harrell JM, Morishima Y, Peng HM, Pratt WB, Lieberman AP.

Hum Mol Genet. 2006 Jun 1;15(11):1876-83. Epub 2006 Apr 27.


Evidence for glucocorticoid receptor transport on microtubules by dynein.

Harrell JM, Murphy PJ, Morishima Y, Chen H, Mansfield JF, Galigniana MD, Pratt WB.

J Biol Chem. 2004 Dec 24;279(52):54647-54. Epub 2004 Oct 13.


Role of hsp90 and the hsp90-binding immunophilins in signalling protein movement.

Pratt WB, Galigniana MD, Harrell JM, DeFranco DB.

Cell Signal. 2004 Aug;16(8):857-72. Review.


Independent functions of hsp90 in neurotransmitter release and in the continuous synaptic cycling of AMPA receptors.

Gerges NZ, Tran IC, Backos DS, Harrell JM, Chinkers M, Pratt WB, Esteban JA.

J Neurosci. 2004 May 19;24(20):4758-66.


Pifithrin-alpha inhibits p53 signaling after interaction of the tumor suppressor protein with hsp90 and its nuclear translocation.

Murphy PJ, Galigniana MD, Morishima Y, Harrell JM, Kwok RP, Ljungman M, Pratt WB.

J Biol Chem. 2004 Jul 16;279(29):30195-201. Epub 2004 May 15.


Hsp90-binding immunophilins link p53 to dynein during p53 transport to the nucleus.

Galigniana MD, Harrell JM, O'Hagen HM, Ljungman M, Pratt WB.

J Biol Chem. 2004 May 21;279(21):22483-9. Epub 2004 Mar 5.


Androgen receptor acetylation site mutations cause trafficking defects, misfolding, and aggregation similar to expanded glutamine tracts.

Thomas M, Dadgar N, Aphale A, Harrell JM, Kunkel R, Pratt WB, Lieberman AP.

J Biol Chem. 2004 Feb 27;279(9):8389-95. Epub 2003 Dec 11.


CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex.

Zheng J, Yang X, Harrell JM, Ryzhikov S, Shim EH, Lykke-Andersen K, Wei N, Sun H, Kobayashi R, Zhang H.

Mol Cell. 2002 Dec;10(6):1519-26.


Binding of hsp90-associated immunophilins to cytoplasmic dynein: direct binding and in vivo evidence that the peptidylprolyl isomerase domain is a dynein interaction domain.

Galigniana MD, Harrell JM, Murphy PJ, Chinkers M, Radanyi C, Renoir JM, Zhang M, Pratt WB.

Biochemistry. 2002 Nov 19;41(46):13602-10.


All of the protein interactions that link steroid receptor.hsp90.immunophilin heterocomplexes to cytoplasmic dynein are common to plant and animal cells.

Harrell JM, Kurek I, Breiman A, Radanyi C, Renoir JM, Pratt WB, Galigniana MD.

Biochemistry. 2002 Apr 30;41(17):5581-7.


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