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Items: 11

1.

An innovative approach to characterize clinical ADME and pharmacokinetics of the inhaled drug nemiralisib using an intravenous microtracer combined with an inhaled dose, and an oral radiolabel dose in healthy male subjects.

Harrell AW, Wilson R, Lun Man Y, Riddell K, Jarvis E, Young G, Chambers R, Crossman L, Georgiou A, Pereira A, Kenworthy D, Beaumont C, Marotti M, Wilkes D, Hessel EM, Fahy WA.

Drug Metab Dispos. 2019 Oct 24. pii: dmd.119.088344. doi: 10.1124/dmd.119.088344. [Epub ahead of print]

2.

Interrogating the relationship between rat in vivo tissue distribution and drug property data for >200 structurally unrelated molecules.

Harrell AW, Sychterz C, Ho MY, Weber A, Valko K, Negash K.

Pharmacol Res Perspect. 2015 Oct;3(5):e00173. doi: 10.1002/prp2.173. Epub 2015 Aug 10.

3.

Metabolism and disposition of vilanterol, a long-acting β(2)-adrenoceptor agonist for inhalation use in humans.

Harrell AW, Siederer SK, Bal J, Patel NH, Young GC, Felgate CC, Pearce SJ, Roberts AD, Beaumont C, Emmons AJ, Pereira AI, Kempsford RD.

Drug Metab Dispos. 2013 Jan;41(1):89-100. doi: 10.1124/dmd.112.048603. Epub 2012 Oct 4.

PMID:
23043183
4.

Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.

Sakatis MZ, Reese MJ, Harrell AW, Taylor MA, Baines IA, Chen L, Bloomer JC, Yang EY, Ellens HM, Ambroso JL, Lovatt CA, Ayrton AD, Clarke SE.

Chem Res Toxicol. 2012 Oct 15;25(10):2067-82. doi: 10.1021/tx300075j. Epub 2012 Sep 19.

PMID:
22931300
5.

Localization of artesunate and its derivatives in the pregnant rat and fetus following oral administration and relationship to developmental toxicity.

Clark RL, Gristwood WE, Lewsley R, Wilson R, Harrell AW.

Birth Defects Res B Dev Reprod Toxicol. 2010 Oct;89(5):364-75. doi: 10.1002/bdrb.20256.

PMID:
20717981
6.

Long-Term Effects of Stressors on Relationship Well-Being and Parenting Among Rural African American Women.

Murry VM, Harrell AW, Brody GH, Chen YF, Simons RL, Black AR, Cutrona CE, Gibbons FX.

Fam Relat. 2008 Mar 31;57(2):117-127.

7.

Formation and protein binding of the acyl glucuronide of a leukotriene B4 antagonist (SB-209247): relation to species differences in hepatotoxicity.

Kenny JR, Maggs JL, Tettey JN, Harrell AW, Parker SG, Clarke SE, Park BK.

Drug Metab Dispos. 2005 Feb;33(2):271-81. Epub 2004 Nov 2.

PMID:
15523047
8.

Role of aldehyde oxidase in the in vitro conversion of famciclovir to penciclovir in human liver.

Clarke SE, Harrell AW, Chenery RJ.

Drug Metab Dispos. 1995 Feb;23(2):251-4.

PMID:
7736920
9.

Use of rat and human in vitro systems to assess the effectiveness and enzymology of deoxyguanine analogs as prodrugs of an antiviral agent.

Harrell AW, Wheeler SM, East P, Clarke SE, Chenery RJ.

Drug Metab Dispos. 1994 Mar-Apr;22(2):189-93.

PMID:
8013273
10.

Use of rat and human in vitro systems to assess the effectiveness and enzymology of deoxy-guanine analogues as prodrugs of an antiviral agent.

Harrell AW, Wheeler SM, East P, Clarke SE, Chenery RJ.

Drug Metab Dispos. 1994 Jan-Feb;22(1):124-8.

PMID:
8149871
11.

Evidence that famciclovir (BRL 42810) and its associated metabolites do not inhibit the 6 beta-hydroxylation of testosterone in human liver microsomes.

Harrell AW, Wheeler SM, Pennick M, Clarke SE, Chenery RJ.

Drug Metab Dispos. 1993 Jan-Feb;21(1):18-23.

PMID:
8095215

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