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Items: 34

1.

Syntheses of Atypically Fluorinated Peptidyl Macrocycles through Sequential Vinylic Substitutions.

Tsunemi T, Bernardino SJ, Mendoza A, Jones CG, Harran PG.

Angew Chem Int Ed Engl. 2019 Nov 6. doi: 10.1002/anie.201910136. [Epub ahead of print]

PMID:
31693283
2.

Anomalous Chromophore Disruption Enables an Eight-Step Synthesis and Stereochemical Reassignment of (+)-Marineosin A.

Feng Z, Allred TK, Hurlow EE, Harran PG.

J Am Chem Soc. 2019 Feb 13;141(6):2274-2278. doi: 10.1021/jacs.9b00396. Epub 2019 Jan 31.

PMID:
30691264
3.

Cascading Auto-oxidative Biproline Guanylations Form Optically Active Dispacamide Dimers and Permit an Eight-Step Synthesis of (-)-Ageliferin.

Ding H, Roberts AG, Chiang R, Harran PG.

J Org Chem. 2018 Jul 6;83(13):7231-7238. doi: 10.1021/acs.joc.8b00631. Epub 2018 May 7.

PMID:
29708748
4.

Assembly of Complex Macrocycles by Incrementally Amalgamating Unprotected Peptides with a Designed Four-Armed Insert.

Curtin BH, Manoni F, Park J, Sisto LJ, Lam YH, Gravel M, Roulston A, Harran PG.

J Org Chem. 2018 Mar 16;83(6):3090-3108. doi: 10.1021/acs.joc.7b02958. Epub 2018 Mar 7.

PMID:
29494773
5.

Unconventional Fragment Usage Enables a Concise Total Synthesis of (-)-Callyspongiolide.

Manoni F, Rumo C, Li L, Harran PG.

J Am Chem Soc. 2018 Jan 31;140(4):1280-1284. doi: 10.1021/jacs.7b13591. Epub 2018 Jan 19.

PMID:
29332397
6.

Exploring the Boundaries of "Practical": De Novo Syntheses of Complex Natural Product-Based Drug Candidates.

Allred TK, Manoni F, Harran PG.

Chem Rev. 2017 Sep 27;117(18):11994-12051. doi: 10.1021/acs.chemrev.7b00126. Epub 2017 Jun 12. Review.

PMID:
28603978
7.

The synthetic diazonamide DZ-2384 has distinct effects on microtubule curvature and dynamics without neurotoxicity.

Wieczorek M, Tcherkezian J, Bernier C, Prota AE, Chaaban S, Rolland Y, Godbout C, Hancock MA, Arezzo JC, Ocal O, Rocha C, Olieric N, Hall A, Ding H, Bramoullé A, Annis MG, Zogopoulos G, Harran PG, Wilkie TM, Brekken RA, Siegel PM, Steinmetz MO, Shore GC, Brouhard GJ, Roulston A.

Sci Transl Med. 2016 Nov 16;8(365):365ra159. Erratum in: Sci Transl Med. 2017 Dec 20;9(421):.

8.

On the prevalence of bridged macrocyclic pyrroloindolines formed in regiodivergent alkylations of tryptophan.

Rose TE, Curtin BH, Lawson KV, Simon A, Houk KN, Harran PG.

Chem Sci. 2016 Jul 1;7(7):4158-4166. doi: 10.1039/c5sc04612b. Epub 2016 Mar 9.

9.

Tailored fragments of roseophilin selectively antagonize Mcl-1 in vitro.

Bracken JD, Carlson AD, Frederich JH, Nguyen M, Shore GC, Harran PG.

Tetrahedron Lett. 2015 Jun 3;56(23):3612-3616.

10.

Large ring-forming alkylations provide facile access to composite macrocycles.

Rose TE, Lawson KV, Harran PG.

Chem Sci. 2015 Apr 16;6(4):2219-2223. doi: 10.1039/c4sc03848g. Epub 2015 Feb 9.

11.

Electrolytic macrocyclizations: scalable synthesis of a diazonamide-based drug development candidate.

Ding H, DeRoy PL, Perreault C, Larivée A, Siddiqui A, Caldwell CG, Harran S, Harran PG.

Angew Chem Int Ed Engl. 2015 Apr 13;54(16):4818-22. doi: 10.1002/anie.201411663. Epub 2015 Feb 26.

PMID:
25729008
12.

Template-constrained macrocyclic peptides prepared from native, unprotected precursors.

Lawson KV, Rose TE, Harran PG.

Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):E3753-60. doi: 10.1073/pnas.1311706110. Epub 2013 Sep 16.

13.

Template-induced macrocycle diversity through large ring-forming alkylations of tryptophan.

Lawson KV, Rose TE, Harran PG.

Tetrahedron. 2013 Sep 9;69(36):7683-7691.

14.

Substituted 2,2'-bipyrroles and pyrrolylfurans via intermediate isoxazolylpyrroles.

Frederich JH, Matsui JK, Chang RO, Harran PG.

Tetrahedron Lett. 2013 May 22;54(21):2645-2647.

15.

Total Synthesis of Ageliferin via Acyl N-amidinyliminium Ion Rearrangement.

Ding H, Roberts AG, Harran PG.

Chem Sci. 2013 Jan 1;4(1):303-306.

16.

Modular access to complex prodiginines: total synthesis of (+)-roseophilin via its 2-azafulvene prototropisomer.

Frederich JH, Harran PG.

J Am Chem Soc. 2013 Mar 13;135(10):3788-91. doi: 10.1021/ja400473v. Epub 2013 Mar 1.

17.

Synthetic (±)-axinellamines deficient in halogen.

Ding H, Roberts AG, Harran PG.

Angew Chem Int Ed Engl. 2012 Apr 27;51(18):4340-3. doi: 10.1002/anie.201200205. Epub 2012 Mar 19. No abstract available.

18.

Exploring symmetry-based logic for a synthesis of palau'amine.

Li Q, Hurley P, Ding H, Roberts AG, Akella R, Harran PG.

J Org Chem. 2009 Aug 21;74(16):5909-19. doi: 10.1021/jo900755r.

19.

Acid promoted cinnamyl ion mobility within peptide derived macrocycles.

Zhao H, Negash L, Wei Q, LaCour TG, Estill SJ, Capota E, Pieper AA, Harran PG.

J Am Chem Soc. 2008 Oct 22;130(42):13864-6. doi: 10.1021/ja803299h. Epub 2008 Sep 24.

PMID:
18811162
20.

Diazonamide toxins reveal an unexpected function for ornithine delta-amino transferase in mitotic cell division.

Wang G, Shang L, Burgett AW, Harran PG, Wang X.

Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2068-73. Epub 2007 Feb 7.

21.

Therapeutic anticancer efficacy of a synthetic diazonamide analog in the absence of overt toxicity.

Williams NS, Burgett AW, Atkins AS, Wang X, Harran PG, McKnight SL.

Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2074-9. Epub 2007 Feb 7.

22.

A missense mutation in Caenorhabditis elegans prohibitin 2 confers an atypical multidrug resistance.

Zubovych I, Doundoulakis T, Harran PG, Roth MG.

Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15523-8. Epub 2006 Oct 10.

23.

Spirocycloisomerization of tethered alkylidene glycocyamidines: synthesis of a base template common to the palau'amine family of alkaloids.

Garrido-Hernandez H, Nakadai M, Vimolratana M, Li Q, Doundoulakis T, Harran PG.

Angew Chem Int Ed Engl. 2005 Jan 21;44(5):765-9. No abstract available.

PMID:
15624220
24.

A small molecule Smac mimic potentiates TRAIL- and TNFalpha-mediated cell death.

Li L, Thomas RM, Suzuki H, De Brabander JK, Wang X, Harran PG.

Science. 2004 Sep 3;305(5689):1471-4.

25.

A concise and flexible total synthesis of (-)-diazonamide A.

Burgett AW, Li Q, Wei Q, Harran PG.

Angew Chem Int Ed Engl. 2003 Oct 20;42(40):4961-6. No abstract available.

PMID:
14579451
26.

Dolastatin 15 binds in the vinca domain of tubulin as demonstrated by Hummel-Dreyer chromatography.

Cruz-Monserrate Z, Mullaney JT, Harran PG, Pettit GR, Hamel E.

Eur J Biochem. 2003 Sep;270(18):3822-8.

27.

Preview.

Li J, Burgett AW, Esser L, Amezcua C, Harran PG.

Angew Chem Int Ed Engl. 2001 Dec 17;40(24):4776. No abstract available.

PMID:
12404413
31.

Synthetic seco Forms of (-)-Diazonamide A.

Li J, Chen X, Burgett AWG, Harran PG.

Angew Chem Int Ed Engl. 2001 Jul 16;40(14):2682-2685. doi: 10.1002/1521-3773(20010716)40:14<2682::AID-ANIE2682>3.0.CO;2-R.

PMID:
29712335
32.

Two Useful Photolabile Surfaces for Solid-Phase Synthesis.

Ryba TD, Harran PG.

Org Lett. 2000 Mar 23;2(6):851-853.

PMID:
10814440
34.

The design, computer modeling, solution structure, and biological evaluation of synthetic analogs of bryostatin 1.

Wender PA, DeBrabander J, Harran PG, Jimenez JM, Koehler MF, Lippa B, Park CM, Siedenbiedel C, Pettit GR.

Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6624-9.

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