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Items: 1 to 50 of 58

1.

Human and environmental health challenges for the next decade (2010–2020).

Bonnefoi MS, Belanger SE, Devlin DJ, Doerrer NG, Embry MR, Fukushima S, Harpur ES, Hines RN, Holsapple MP, Kim JH, MacDonald JS, O'Lone R, Pettit SD, Stevens JL, Takei AS, Tinkle SS, van der Laan JW.

Crit Rev Toxicol. 2010 Nov;40(10):893-911. doi: 10.3109/10408444.2010.506640. Review.

PMID:
20854192
2.

Recommendations for safety planning, data collection, evaluation and reporting during drug, biologic and vaccine development: a report of the safety planning, evaluation, and reporting team.

Crowe BJ, Xia HA, Berlin JA, Watson DJ, Shi H, Lin SL, Kuebler J, Schriver RC, Santanello NC, Rochester G, Porter JB, Oster M, Mehrotra DV, Li Z, King EC, Harpur ES, Hall DB.

Clin Trials. 2009 Oct;6(5):430-40. doi: 10.1177/1740774509344101.

PMID:
19846894
3.

Careers in toxicology in Europe--options and requirements. Report of a workshop organized on behalf of the Individual Members of EUROTOX during the EUROTOX Congress 2000 in London (September 17-20, 2000).

Ettlin RA, Dybing E, Eistrup C, Forster R, Harpur ES, Hodel CM, Kobel W, Nelson E, Pratt I, Stemplewski H, Virgo D.

Arch Toxicol. 2001 Jul;75(5):251-61.

PMID:
11548117
4.
5.

Neurotoxic potential of gadodiamide after injection into the lateral cerebral ventricle of rats.

Ray DE, Holton JL, Nolan CC, Cavanagh JB, Harpur ES.

AJNR Am J Neuroradiol. 1998 Sep;19(8):1455-62.

6.
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8.

A study of the nephrotoxicity of three cephalosporins in rabbits using 1H NMR spectroscopy.

Halligan S, Byard SJ, Spencer AJ, Gray TJ, Harpur ES, Bonner FW.

Toxicol Lett. 1995 Nov;81(1):15-21.

PMID:
8525494
9.

The relative hypolipidaemic activity and hepatic effects of ciprofibrate enantiomers in the rat.

Graham MJ, Winham MA, Harpur ES, Bonner FW, Gray TJ.

Biochem Pharmacol. 1994 Dec 16;48(12):2163-71.

PMID:
7811297
10.

In vitro toxicity of cephalosporin and aminoglycoside antibiotics to LLC-PK(1) cells assessed by changes in glucose uptake.

Blackmore M, Richardson JC, Costello S, Harpur ES, Gray TJ.

Toxicol In Vitro. 1994 Aug;8(4):771-3.

PMID:
20693008
11.

Effects of gentamicin, neomycin and tobramycin on renal calcium and magnesium handling in two rat strains.

Garland HO, Birdsey TJ, Davidge CG, McLaughlin JT, Oakes LM, Smith AJ, Harpur ES.

Clin Exp Pharmacol Physiol. 1994 Feb;21(2):109-15.

PMID:
8039262
12.

The role of investigative toxicology in pharmaceutical industry.

Harpur ES, Bonner FW.

Arch Toxicol Suppl. 1994;16:176-82. Review.

PMID:
8192579
13.

Preclinical safety assessment and pharmacokinetics of gadodiamide injection, a new magnetic resonance imaging contrast agent.

Harpur ES, Worah D, Hals PA, Holtz E, Furuhama K, Nomura H.

Invest Radiol. 1993 Mar;28 Suppl 1:S28-43. Review.

PMID:
8486501
14.

Toxicology of sensory systems: a perspective.

Lock EA, Harpur ES.

Hum Exp Toxicol. 1992 Nov;11(6):442-8. Review.

PMID:
1361131
15.

Gentamicin-induced hypercalciuria in the rat: assessment of nephron site involved.

Garland HO, Phipps DJ, Harpur ES.

J Pharmacol Exp Ther. 1992 Oct;263(1):293-7.

PMID:
1403791
16.

An investigation of the acute effect of gentamicin on the renal handling of electrolytes in the rat.

Foster JE, Harpur ES, Garland HO.

J Pharmacol Exp Ther. 1992 Apr;261(1):38-43.

PMID:
1560382
18.

Differential expression and ciprofibrate induction of hepatic UDP-glucuronyltransferases for thyroxine and triiodothyronine in Fischer rats.

Visser TJ, Kaptein E, Harpur ES.

Biochem Pharmacol. 1991 Jul 5;42(2):444-6. No abstract available.

PMID:
1907145
19.
20.

Efflux of bis-carboxyethyl-carboxyfluorescein (BCECF) by a novel ATP-dependent transport mechanism in epithelial cells.

Allen CN, Harpur ES, Gray TJ, Simmons NL, Hirst BH.

Biochem Biophys Res Commun. 1990 Oct 15;172(1):262-7.

PMID:
2222473
21.

Comparison of the renal response of male Fischer 344, Sprague-Dawley and Wistar rats to administration of gentamicin.

Phipps DJ, Spencer AJ, Harpur ES.

Toxicol Lett. 1990 Sep;53(1-2):203-5. No abstract available.

PMID:
2219168
22.

A quantitative method for the measurement of urinary glycosaminoglycans--potential use in studies of xenobiotic nephrotoxicity.

Halligan S, Graham MJ, Gray TJ, Harpur ES, Bonner FW.

Toxicol Lett. 1990 Sep;53(1-2):183-5. No abstract available.

PMID:
2219163
23.

Comparison of the hepatotoxicity in mice and the mutagenicity of three nitroalkanes.

Dayal R, Gescher A, Harpur ES, Pratt I, Chipman JK.

Fundam Appl Toxicol. 1989 Aug;13(2):341-8.

PMID:
2676674
24.

Glutathione depletion in the guinea pig and its effect on the acute cochlear toxicity of ethacrynic acid.

Lazenby CM, Lee SJ, Harpur ES, Gescher A.

Biochem Pharmacol. 1988 Oct 1;37(19):3743-7.

PMID:
3178887
25.

Renal response to vasopressin and indomethacin in cisplatin-treated rats.

Lote CJ, Harpur ES, Thewles A, Phipps DJ.

Clin Sci (Lond). 1987 Oct;73(4):377-81.

PMID:
3478169
26.

The pathophysiology of hearing.

Harpur ES.

Br Med Bull. 1987 Oct;43(4):871-86. Review. No abstract available.

PMID:
3329930
27.

Hepatotoxicity of N-methylformamide in mice--II. Covalent binding of metabolites of [14C]-labelled N-methylformamide to hepatic proteins.

Pearson PG, Gescher A, Harpur ES, Threadgill MD.

Biochem Pharmacol. 1987 Feb 1;36(3):385-90.

PMID:
3814178
28.

Hepatotoxicity of N-methylformamide in mice--I. Relationship to glutathione status.

Pearson PG, Gescher A, Harpur ES.

Biochem Pharmacol. 1987 Feb 1;36(3):381-4.

PMID:
3814177
29.
30.

The antitumour effect and toxicity of cis-platinum and N-methylformamide in combination.

Harpur ES, Langdon SP, Fathalla SA, Ishmael J.

Cancer Chemother Pharmacol. 1986;16(2):139-47.

PMID:
3948299
31.
32.
33.

Clinical experience with a method for adjusting gentamicin dose from measured drug clearance.

Davey PG, Geddes AM, Gonda I, Harpur ES, Scott DK.

J Antimicrob Chemother. 1983 Dec;12(6):613-22.

PMID:
6662839
34.

Gentamicin-induced hypercalciuria in the rat.

Chahwala SB, Harpur ES.

Acta Pharmacol Toxicol (Copenh). 1983 Nov;53(5):358-62.

PMID:
6659964
35.

Ototoxicity of aminoglycosides.

Davey PG, Harpur ES.

Lancet. 1983 Jun 25;1(8339):1440-1. No abstract available.

PMID:
6134198
36.

A controlled study of the reliability of pure tone audiometry for the detection of gentamicin auditory toxicity.

Davey PG, Jabeen FJ, Harpur ES, Shenoi PM, Geddes AM.

J Laryngol Otol. 1983 Jan;97(1):27-36.

PMID:
6337228
37.

Studies of the pharmacology of N-methylformamide in mice.

Brindley C, Gescher A, Harpur ES, Ross D, Slack JA, Threadgill MD, Whitby H.

Cancer Treat Rep. 1982 Nov;66(11):1957-65.

PMID:
6814756
38.

Studies of a potential in vitro test for estimation of toxicity of aminoglycoside antibiotics and polyamines.

Langford PR, Harpur ES, Kayes JB, Gonda I.

J Antibiot (Tokyo). 1982 Oct;35(10):1387-93.

39.

Aminoglycoside trough levels: a source of error.

Scott DK, Davey PG, Gonda I, Harpur ES.

Lancet. 1982 Aug 21;2(8295):441. No abstract available.

PMID:
6124831
42.

The pharmacology of ototoxic drugs.

Harpur ES.

Br J Audiol. 1982 May;16(2):81-93.

PMID:
7093567
43.

The use of pure-tone audiometry in the assessment of gentamicin auditory toxicity.

Davey PG, Jabeen F, Harpur ES, Shenoi PM, Geddes AM.

Br J Audiol. 1982 May;16(2):151-4.

PMID:
7093565
44.

An investigation of the effects of aminoglycoside antibiotics on Na+-K+ ATPase as a possible mechanism of toxicity.

Chahwala SB, Harpur ES.

Res Commun Chem Pathol Pharmacol. 1982 Jan;35(1):63-78.

PMID:
6276955
45.

Assessment of renal function during high-dose cis-platinum therapy in patients with ovarian carcinoma.

Buamah PK, Howell A, Whitby H, Harpur ES, Gescher A.

Cancer Chemother Pharmacol. 1982;8(3):281-4.

PMID:
6127169
46.

Accumulation in the peripheral compartment of a linear two-compartment open model.

Gonda I, Harpur ES.

J Pharmacokinet Biopharm. 1980 Feb;8(1):99-104.

PMID:
7381694
47.

Methods for the Histopathological study of the drug-damaged guinea-pig organ of Corti.

Harpur ES, Jabeen F, Kingston R.

Br J Pharmacol. 1979 Jul;66(3):507P. No abstract available.

48.

Interaction of aminoglycoside antibiotics with phospholipid liposomes studies by microelectrophoresis.

Alexander AM, Gonda I, Harpur ES, Kayes JB.

J Antibiot (Tokyo). 1979 May;32(5):504-10.

50.

Ototoxic effects of gentamicin and kanamycin in the guinea-pig [proceedings].

Bridges JB, Harpur ES.

Br J Pharmacol. 1978 Jun;63(2):354P-355P. No abstract available.

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