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Items: 1 to 50 of 62


Interactions between RAMP2 and CRF receptors: The effect of receptor subtypes, splice variants and cell context.

Bailey S, Harris M, Barkan K, Winfield I, Harper MT, Simms J, Ladds G, Wheatley M, Poyner D.

Biochim Biophys Acta Biomembr. 2019 May 1;1861(5):997-1003. doi: 10.1016/j.bbamem.2019.02.008. Epub 2019 Feb 28.


Acceptance of flavored concentrate premixes by young ruminants following a short-term exposure.

Nedelkov K, Harper MT, Melgar A, Chen X, Räisänen S, Martins CMMR, Faugeron J, Wall EH, Hristov AN.

J Dairy Sci. 2019 Jan;102(1):388-394. doi: 10.3168/jds.2018-15400. Epub 2018 Oct 24.


Rapid kinetics of changes in oxygen consumption rate in thrombin-stimulated platelets measured by high-resolution respirometry.

Sowton AP, Millington-Burgess SL, Murray AJ, Harper MT.

Biochem Biophys Res Commun. 2018 Sep 18;503(4):2721-2727. doi: 10.1016/j.bbrc.2018.08.031. Epub 2018 Aug 7.


Lipid rafts are essential for release of phosphatidylserine-exposing extracellular vesicles from platelets.

Wei H, Malcor JM, Harper MT.

Sci Rep. 2018 Jul 3;8(1):9987. doi: 10.1038/s41598-018-28363-4.


Inclusion of brown midrib dwarf pearl millet silage in the diet of lactating dairy cows.

Harper MT, Melgar A, Oh J, Nedelkov K, Sanchez G, Roth GW, Hristov AN.

J Dairy Sci. 2018 Jun;101(6):5006-5019. doi: 10.3168/jds.2017-14036. Epub 2018 Mar 7.


Cross-reactivity of anti-HMGB1 antibodies for HMGB2.

Davies JE, Apta BHR, Harper MT.

J Immunol Methods. 2018 May;456:72-76. doi: 10.1016/j.jim.2018.02.006. Epub 2018 Feb 15.


Auranofin, a thioredoxin reductase inhibitor, causes platelet death through calcium overload.

Harper MT.

Platelets. 2019;30(1):98-104. doi: 10.1080/09537104.2017.1378809. Epub 2017 Dec 1.


Extracellular chloride is required for efficient platelet aggregation.

Taylor KA, Wilson DGS, Harper MT, Pugh N.

Platelets. 2018 Jan;29(1):79-83. doi: 10.1080/09537104.2017.1332367. Epub 2017 Jul 20.


Inclusion of wheat and triticale silage in the diet of lactating dairy cows.

Harper MT, Oh J, Giallongo F, Roth GW, Hristov AN.

J Dairy Sci. 2017 Aug;100(8):6151-6163. doi: 10.3168/jds.2017-12553. Epub 2017 Jun 7.


Using brown midrib 6 dwarf forage sorghum silage and fall-grown oat silage in lactating dairy cow rations.

Harper MT, Oh J, Giallongo F, Lopes JC, Roth GW, Hristov AN.

J Dairy Sci. 2017 Jul;100(7):5250-5265. doi: 10.3168/jds.2017-12552. Epub 2017 May 17.


Histidine deficiency has a negative effect on lactational performance of dairy cows.

Giallongo F, Harper MT, Oh J, Parys C, Shinzato I, Hristov AN.

J Dairy Sci. 2017 Apr;100(4):2784-2800. doi: 10.3168/jds.2016-11992. Epub 2017 Jan 26.


Effect of high-oleic-acid soybeans on production performance, milk fatty acid composition, and enteric methane emission in dairy cows.

Lopes JC, Harper MT, Giallongo F, Oh J, Smith L, Ortega-Perez AM, Harper SA, Melgar A, Kniffen DM, Fabin RA, Hristov AN.

J Dairy Sci. 2017 Feb;100(2):1122-1135. doi: 10.3168/jds.2016-11911. Epub 2016 Dec 14.


Thioredoxin Inhibitors Attenuate Platelet Function and Thrombus Formation.

Metcalfe C, Ramasubramoni A, Pula G, Harper MT, Mundell SJ, Coxon CH.

PLoS One. 2016 Oct 7;11(10):e0163006. doi: 10.1371/journal.pone.0163006. eCollection 2016.


Short communication: Preference for flavored concentrate premixes by dairy cows.

Harper MT, Oh J, Giallongo F, Lopes JC, Weeks HL, Faugeron J, Hristov AN.

J Dairy Sci. 2016 Aug;99(8):6585-6589. doi: 10.3168/jds.2016-11001. Epub 2016 May 18.


Short communication: Comparison of the GreenFeed system with the sulfur hexafluoride tracer technique for measuring enteric methane emissions from dairy cows.

Hristov AN, Oh J, Giallongo F, Frederick T, Harper MT, Weeks H, Branco AF, Price WJ, Moate PJ, Deighton MH, Williams SRO, Kindermann M, Duval S.

J Dairy Sci. 2016 Jul;99(7):5461-5465. doi: 10.3168/jds.2016-10897. Epub 2016 May 4.


Effect of 3-nitrooxypropanol on methane and hydrogen emissions, methane isotopic signature, and ruminal fermentation in dairy cows.

Lopes JC, de Matos LF, Harper MT, Giallongo F, Oh J, Gruen D, Ono S, Kindermann M, Duval S, Hristov AN.

J Dairy Sci. 2016 Jul;99(7):5335-5344. doi: 10.3168/jds.2015-10832. Epub 2016 Apr 13.


Effects of rumen-protected methionine, lysine, and histidine on lactation performance of dairy cows.

Giallongo F, Harper MT, Oh J, Lopes JC, Lapierre H, Patton RA, Parys C, Shinzato I, Hristov AN.

J Dairy Sci. 2016 Jun;99(6):4437-4452. doi: 10.3168/jds.2015-10822. Epub 2016 Apr 6.


Identification of roles for the SNARE-associated protein, SNAP29, in mouse platelets.

Williams CM, Savage JS, Harper MT, Moore SF, Hers I, Poole AW.

Platelets. 2016 Jun;27(4):286-94. doi: 10.3109/09537104.2015.1100282. Epub 2015 Nov 20.


The Use of an Automated System (GreenFeed) to Monitor Enteric Methane and Carbon Dioxide Emissions from Ruminant Animals.

Hristov AN, Oh J, Giallongo F, Frederick T, Weeks H, Zimmerman PR, Harper MT, Hristova RA, Zimmerman RS, Branco AF.

J Vis Exp. 2015 Sep 7;(103). doi: 10.3791/52904.


Leukemia-associated Rho guanine-nucleotide exchange factor is not critical for RhoA regulation, yet is important for platelet activation and thrombosis in mice.

Williams CM, Harper MT, Goggs R, Walsh TG, Offermanns S, Poole AW.

J Thromb Haemost. 2015 Nov;13(11):2102-7. doi: 10.1111/jth.13129. Epub 2015 Oct 20.


An inhibitor persistently decreased enteric methane emission from dairy cows with no negative effect on milk production.

Hristov AN, Oh J, Giallongo F, Frederick TW, Harper MT, Weeks HL, Branco AF, Moate PJ, Deighton MH, Williams SR, Kindermann M, Duval S.

Proc Natl Acad Sci U S A. 2015 Aug 25;112(34):10663-8. doi: 10.1073/pnas.1504124112. Epub 2015 Jul 30. Erratum in: Proc Natl Acad Sci U S A. 2015 Sep 15;112(37):E5218.


Platelet dense granule secretion defects may obscure α-granule secretion mechanisms: evidence from Munc13-4-deficient platelets.

Harper MT, van den Bosch MT, Hers I, Poole AW.

Blood. 2015 May 7;125(19):3034-6. doi: 10.1182/blood-2014-12-618439. No abstract available.


Loss of the insulin receptor in murine megakaryocytes/platelets causes thrombocytosis and alterations in IGF signalling.

Moore SF, Williams CM, Brown E, Blair TA, Harper MT, Coward RJ, Poole AW, Hers I.

Cardiovasc Res. 2015 Jul 1;107(1):9-19. doi: 10.1093/cvr/cvv132. Epub 2015 Apr 22.


Syntaxin 8 regulates platelet dense granule secretion, aggregation, and thrombus stability.

Golebiewska EM, Harper MT, Williams CM, Savage JS, Goggs R, Fischer von Mollard G, Poole AW.

J Biol Chem. 2015 Jan 16;290(3):1536-45. doi: 10.1074/jbc.M114.602615. Epub 2014 Nov 17.


SDF-1α is a novel autocrine activator of platelets operating through its receptor CXCR4.

Walsh TG, Harper MT, Poole AW.

Cell Signal. 2015 Jan;27(1):37-46. doi: 10.1016/j.cellsig.2014.09.021. Epub 2014 Oct 5.


Chloride channels are necessary for full platelet phosphatidylserine exposure and procoagulant activity.

Harper MT, Poole AW.

Cell Death Dis. 2013 Dec 19;4:e969. doi: 10.1038/cddis.2013.495.


RhoG protein regulates platelet granule secretion and thrombus formation in mice.

Goggs R, Harper MT, Pope RJ, Savage JS, Williams CM, Mundell SJ, Heesom KJ, Bass M, Mellor H, Poole AW.

J Biol Chem. 2013 Nov 22;288(47):34217-29. doi: 10.1074/jbc.M113.504100. Epub 2013 Oct 8.


Comment on "Platelet-derived nucleotides promote tumor cell transendothelial migration and metastasis via P2Y2 receptor" by Schumacher et al.

Harper MT, Savage JS, Poole AW.

Cancer Cell. 2013 Sep 9;24(3):287. doi: 10.1016/j.ccr.2013.08.016. No abstract available.


Transient receptor potential channels function as a coincidence signal detector mediating phosphatidylserine exposure.

Harper MT, Londoño JE, Quick K, Londoño JC, Flockerzi V, Philipp SE, Birnbaumer L, Freichel M, Poole AW.

Sci Signal. 2013 Jun 25;6(281):ra50. doi: 10.1126/scisignal.2003701.


PKCα negatively regulates in vitro proplatelet formation and in vivo platelet production in mice.

Williams CM, Harper MT, Poole AW.

Platelets. 2014;25(1):62-8. doi: 10.3109/09537104.2012.761686. Epub 2013 Feb 12.


Absence of platelet phenotype in mice lacking the motor protein myosin Va.

Harper MT, van den Bosch MT, Hers I, Poole AW.

PLoS One. 2013;8(1):e53239. doi: 10.1371/journal.pone.0053239. Epub 2013 Jan 18.


Munc13-4 is critical for thrombosis through regulating release of ADP from platelets.

Savage JS, Williams CM, Konopatskaya O, Hers I, Harper MT, Poole AW.

J Thromb Haemost. 2013 Apr;11(4):771-5. doi: 10.1111/jth.12138. No abstract available.


Dysfunction of the PI3 kinase/Rap1/integrin α(IIb)β(3) pathway underlies ex vivo platelet hypoactivity in essential thrombocythemia.

Moore SF, Hunter RW, Harper MT, Savage JS, Siddiq S, Westbury SK, Poole AW, Mumford AD, Hers I.

Blood. 2013 Feb 14;121(7):1209-19. doi: 10.1182/blood-2012-05-431288. Epub 2012 Dec 13.


WNT-3a modulates platelet function by regulating small GTPase activity.

Steele BM, Harper MT, Smolenski AP, Alkazemi N, Poole AW, Fitzgerald DJ, Maguire PB.

FEBS Lett. 2012 Jul 30;586(16):2267-72. doi: 10.1016/j.febslet.2012.05.060. Epub 2012 Jun 13.


Bcl-xL-inhibitory BH3 mimetic ABT-737 depletes platelet calcium stores.

Harper MT, Poole AW.

Blood. 2012 May 3;119(18):4337-8. doi: 10.1182/blood-2012-02-413070. No abstract available.


Store-operated calcium entry and non-capacitative calcium entry have distinct roles in thrombin-induced calcium signalling in human platelets.

Harper MT, Poole AW.

Cell Calcium. 2011 Oct;50(4):351-8. doi: 10.1016/j.ceca.2011.06.005. Epub 2011 Jul 8.


Unravelling the different functions of protein kinase C isoforms in platelets.

Heemskerk JW, Harper MT, Cosemans JM, Poole AW.

FEBS Lett. 2011 Jun 23;585(12):1711-6. doi: 10.1016/j.febslet.2011.05.017. Epub 2011 May 13.


Protein kinase C mediates platelet secretion and thrombus formation through protein kinase D2.

Konopatskaya O, Matthews SA, Harper MT, Gilio K, Cosemans JM, Williams CM, Navarro MN, Carter DA, Heemskerk JW, Leitges M, Cantrell D, Poole AW.

Blood. 2011 Jul 14;118(2):416-24. doi: 10.1182/blood-2010-10-312199. Epub 2011 Apr 28.


Protein kinase C alpha enhances sodium-calcium exchange during store-operated calcium entry in mouse platelets.

Harper MT, Molkentin JD, Poole AW.

Cell Calcium. 2010 Dec;48(6):333-40. doi: 10.1016/j.ceca.2010.10.006. Epub 2010 Nov 20.


Src family tyrosine kinases activate thrombin-induced non-capacitative cation entry in human platelets.

Harper MT, Sage SO.

Platelets. 2010;21(6):445-50. doi: 10.3109/09537104.2010.483295.


Functional divergence of platelet protein kinase C (PKC) isoforms in thrombus formation on collagen.

Gilio K, Harper MT, Cosemans JM, Konopatskaya O, Munnix IC, Prinzen L, Leitges M, Liu Q, Molkentin JD, Heemskerk JW, Poole AW.

J Biol Chem. 2010 Jul 23;285(30):23410-9. doi: 10.1074/jbc.M110.136176. Epub 2010 May 17.


Protein kinase Ctheta negatively regulates store-independent Ca2+ entry and phosphatidylserine exposure downstream of glycoprotein VI in platelets.

Harper MT, Poole AW.

J Biol Chem. 2010 Jun 25;285(26):19865-73. doi: 10.1074/jbc.M109.085654. Epub 2010 Apr 13.


Phorbol ester-evoked Ca2+ signaling in human platelets is via autocrine activation of P(2X1) receptors, not a novel non-capacitative Ca2+ entry.

Harper MT, Mason MJ, Sage SO, Harper AG.

J Thromb Haemost. 2010 Jul;8(7):1604-13. doi: 10.1111/j.1538-7836.2010.03867.x. Epub 2010 Mar 23.


Observations of market pigs following transport to a packing plant.

Kephart KB, Harper MT, Raines CR.

J Anim Sci. 2010 Jun;88(6):2199-203. doi: 10.2527/jas.2009-2440. Epub 2010 Feb 26.


Diverse functions of protein kinase C isoforms in platelet activation and thrombus formation.

Harper MT, Poole AW.

J Thromb Haemost. 2010 Mar;8(3):454-62. doi: 10.1111/j.1538-7836.2009.03722.x. Epub 2009 Dec 11. Review.


RGD-ligand mimetic antagonists of integrin alphaIIbbeta3 paradoxically enhance GPVI-induced human platelet activation.

Jones ML, Harper MT, Aitken EW, Williams CM, Poole AW.

J Thromb Haemost. 2010 Mar;8(3):567-76. doi: 10.1111/j.1538-7836.2009.03719.x. Epub 2009 Dec 11. Erratum in: J Thromb Haemost. 2010 Nov;8(11):2588.


Canonical Wnt signaling negatively regulates platelet function.

Steele BM, Harper MT, Macaulay IC, Morrell CN, Perez-Tamayo A, Foy M, Habas R, Poole AW, Fitzgerald DJ, Maguire PB.

Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):19836-41. doi: 10.1073/pnas.0906268106. Epub 2009 Nov 9.


PKCtheta in platelet activation.

Harper MT, Poole AW.

Blood. 2009 Jul 9;114(2):489-91; author reply 491-2. doi: 10.1182/blood-2009-03-208454. No abstract available.


PKCalpha regulates platelet granule secretion and thrombus formation in mice.

Konopatskaya O, Gilio K, Harper MT, Zhao Y, Cosemans JM, Karim ZA, Whiteheart SW, Molkentin JD, Verkade P, Watson SP, Heemskerk JW, Poole AW.

J Clin Invest. 2009 Feb;119(2):399-407. doi: 10.1172/JCI34665. Epub 2009 Jan 19.

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