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Items: 36


Myocardial Functional Decline During Prolonged Ex Situ Heart Perfusion.

Hatami S, White CW, Shan S, Haromy A, Qi X, Ondrus M, Kinnear A, Himmat S, Michelakis E, Nagendran J, Freed DH.

Ann Thorac Surg. 2019 Aug;108(2):499-507. doi: 10.1016/j.athoracsur.2019.01.076. Epub 2019 Mar 12.


A Leukocyte Filter Does Not Provide Further Benefit During Ex Vivo Lung Perfusion.

Luc JGY, Aboelnazar NS, Himmat S, Hatami S, Haromy A, Matsumura N, Vasanthan V, White CW, Mengel M, Freed DH, Nagendran J.

ASAIO J. 2017 Sep/Oct;63(5):672-678. doi: 10.1097/MAT.0000000000000550.


Effect of fatty acids on human bone marrow mesenchymal stem cell energy metabolism and survival.

Fillmore N, Huqi A, Jaswal JS, Mori J, Paulin R, Haromy A, Onay-Besikci A, Ionescu L, Thébaud B, Michelakis E, Lopaschuk GD.

PLoS One. 2015 Mar 13;10(3):e0120257. doi: 10.1371/journal.pone.0120257. eCollection 2015.


A miR-208-Mef2 axis drives the decompensation of right ventricular function in pulmonary hypertension.

Paulin R, Sutendra G, Gurtu V, Dromparis P, Haromy A, Provencher S, Bonnet S, Michelakis ED.

Circ Res. 2015 Jan 2;116(1):56-69. doi: 10.1161/CIRCRESAHA.115.303910. Epub 2014 Oct 6.


Sirtuin 3 deficiency is associated with inhibited mitochondrial function and pulmonary arterial hypertension in rodents and humans.

Paulin R, Dromparis P, Sutendra G, Gurtu V, Zervopoulos S, Bowers L, Haromy A, Webster L, Provencher S, Bonnet S, Michelakis ED.

Cell Metab. 2014 Nov 4;20(5):827-839. doi: 10.1016/j.cmet.2014.08.011. Epub 2014 Oct 2.


A nuclear pyruvate dehydrogenase complex is important for the generation of acetyl-CoA and histone acetylation.

Sutendra G, Kinnaird A, Dromparis P, Paulin R, Stenson TH, Haromy A, Hashimoto K, Zhang N, Flaim E, Michelakis ED.

Cell. 2014 Jul 3;158(1):84-97. doi: 10.1016/j.cell.2014.04.046.


Exogenous hydrogen sulfide (H2S) protects alveolar growth in experimental O2-induced neonatal lung injury.

Vadivel A, Alphonse RS, Ionescu L, Machado DS, O'Reilly M, Eaton F, Haromy A, Michelakis ED, Thébaud B.

PLoS One. 2014 Mar 6;9(3):e90965. doi: 10.1371/journal.pone.0090965. eCollection 2014.


A metabolic remodeling in right ventricular hypertrophy is associated with decreased angiogenesis and a transition from a compensated to a decompensated state in pulmonary hypertension.

Sutendra G, Dromparis P, Paulin R, Zervopoulos S, Haromy A, Nagendran J, Michelakis ED.

J Mol Med (Berl). 2013 Nov;91(11):1315-27. doi: 10.1007/s00109-013-1059-4. Epub 2013 Jul 12.


Targeting cell motility in pulmonary arterial hypertension.

Paulin R, Meloche J, Courboulin A, Lambert C, Haromy A, Courchesne A, Bonnet P, Provencher S, Michelakis ED, Bonnet S.

Eur Respir J. 2014 Feb;43(2):531-44. doi: 10.1183/09031936.00181312. Epub 2013 Jul 11.


Phosphatidylethanolamine deficiency in Mammalian mitochondria impairs oxidative phosphorylation and alters mitochondrial morphology.

Tasseva G, Bai HD, Davidescu M, Haromy A, Michelakis E, Vance JE.

J Biol Chem. 2013 Feb 8;288(6):4158-73. doi: 10.1074/jbc.M112.434183. Epub 2012 Dec 18.


Endothelin axis is upregulated in human and rat right ventricular hypertrophy.

Nagendran J, Sutendra G, Paterson I, Champion HC, Webster L, Chiu B, Haromy A, Rebeyka IM, Ross DB, Michelakis ED.

Circ Res. 2013 Jan 18;112(2):347-54. doi: 10.1161/CIRCRESAHA.111.300448. Epub 2012 Dec 10. Erratum in: Circ Res. 2014 Mar 14;114(6):e32.


Attenuating endoplasmic reticulum stress as a novel therapeutic strategy in pulmonary hypertension.

Dromparis P, Paulin R, Stenson TH, Haromy A, Sutendra G, Michelakis ED.

Circulation. 2013 Jan 1;127(1):115-25. doi: 10.1161/CIRCULATIONAHA.112.133413. Epub 2012 Nov 13.


Human internal mammary artery (IMA) transplantation and stenting: a human model to study the development of in-stent restenosis.

Hua X, Deuse T, Michelakis ED, Haromy A, Tsao PS, Maegdefessel L, Erben RG, Bergow C, Behnisch BB, Reichenspurner H, Robbins RC, Schrepfer S.

J Vis Exp. 2012 May 9;(63):e3663. doi: 10.3791/3663.


Mitochondrial activation by inhibition of PDKII suppresses HIF1a signaling and angiogenesis in cancer.

Sutendra G, Dromparis P, Kinnaird A, Stenson TH, Haromy A, Parker JM, McMurtry MS, Michelakis ED.

Oncogene. 2013 Mar 28;32(13):1638-50. doi: 10.1038/onc.2012.198. Epub 2012 May 21.


Critical role of the axonal guidance cue EphrinB2 in lung growth, angiogenesis, and repair.

Vadivel A, van Haaften T, Alphonse RS, Rey-Parra GJ, Ionescu L, Haromy A, Eaton F, Michelakis E, Thébaud B.

Am J Respir Crit Care Med. 2012 Mar 1;185(5):564-74. doi: 10.1164/rccm.201103-0545OC. Epub 2011 Dec 8.


Pyruvate dehydrogenase inhibition by the inflammatory cytokine TNFα contributes to the pathogenesis of pulmonary arterial hypertension.

Sutendra G, Dromparis P, Bonnet S, Haromy A, McMurtry MS, Bleackley RC, Michelakis ED.

J Mol Med (Berl). 2011 Aug;89(8):771-83. doi: 10.1007/s00109-011-0762-2. Epub 2011 Aug 2.


The role of Nogo and the mitochondria-endoplasmic reticulum unit in pulmonary hypertension.

Sutendra G, Dromparis P, Wright P, Bonnet S, Haromy A, Hao Z, McMurtry MS, Michalak M, Vance JE, Sessa WC, Michelakis ED.

Sci Transl Med. 2011 Jun 22;3(88):88ra55. doi: 10.1126/scitranslmed.3002194.


Fatty acid oxidation and malonyl-CoA decarboxylase in the vascular remodeling of pulmonary hypertension.

Sutendra G, Bonnet S, Rochefort G, Haromy A, Folmes KD, Lopaschuk GD, Dyck JR, Michelakis ED.

Sci Transl Med. 2010 Aug 11;2(44):44ra58. doi: 10.1126/scitranslmed.3001327.


Metabolic modulation of glioblastoma with dichloroacetate.

Michelakis ED, Sutendra G, Dromparis P, Webster L, Haromy A, Niven E, Maguire C, Gammer TL, Mackey JR, Fulton D, Abdulkarim B, McMurtry MS, Petruk KC.

Sci Transl Med. 2010 May 12;2(31):31ra34. doi: 10.1126/scitranslmed.3000677.


Dehydroepiandrosterone reverses systemic vascular remodeling through the inhibition of the Akt/GSK3-{beta}/NFAT axis.

Bonnet S, Paulin R, Sutendra G, Dromparis P, Roy M, Watson KO, Nagendran J, Haromy A, Dyck JR, Michelakis ED.

Circulation. 2009 Sep 29;120(13):1231-40. doi: 10.1161/CIRCULATIONAHA.109.848911. Epub 2009 Sep 14.


Airway delivery of mesenchymal stem cells prevents arrested alveolar growth in neonatal lung injury in rats.

van Haaften T, Byrne R, Bonnet S, Rochefort GY, Akabutu J, Bouchentouf M, Rey-Parra GJ, Galipeau J, Haromy A, Eaton F, Chen M, Hashimoto K, Abley D, Korbutt G, Archer SL, Thébaud B.

Am J Respir Crit Care Med. 2009 Dec 1;180(11):1131-42. doi: 10.1164/rccm.200902-0179OC. Epub 2009 Aug 27.


A dynamic and chamber-specific mitochondrial remodeling in right ventricular hypertrophy can be therapeutically targeted.

Nagendran J, Gurtu V, Fu DZ, Dyck JR, Haromy A, Ross DB, Rebeyka IM, Michelakis ED.

J Thorac Cardiovasc Surg. 2008 Jul;136(1):168-78, 178.e1-3. doi: 10.1016/j.jtcvs.2008.01.040. Epub 2008 May 23.


Blunted hypoxic pulmonary vasoconstriction in experimental neonatal chronic lung disease.

Rey-Parra GJ, Archer SL, Bland RD, Albertine KH, Carlton DP, Cho SC, Kirby B, Haromy A, Eaton F, Wu X, Thébaud B.

Am J Respir Crit Care Med. 2008 Aug 15;178(4):399-406. doi: 10.1164/rccm.200711-1631OC. Epub 2008 May 29.


Statin therapy, alone or with rapamycin, does not reverse monocrotaline pulmonary arterial hypertension: the rapamcyin-atorvastatin-simvastatin study.

McMurtry MS, Bonnet S, Michelakis ED, Bonnet S, Haromy A, Archer SL.

Am J Physiol Lung Cell Mol Physiol. 2007 Oct;293(4):L933-40. Epub 2007 Aug 3.


Phosphodiesterase type 5 is highly expressed in the hypertrophied human right ventricle, and acute inhibition of phosphodiesterase type 5 improves contractility.

Nagendran J, Archer SL, Soliman D, Gurtu V, Moudgil R, Haromy A, St Aubin C, Webster L, Rebeyka IM, Ross DB, Light PE, Dyck JR, Michelakis ED.

Circulation. 2007 Jul 17;116(3):238-48. Epub 2007 Jul 2.


The nuclear factor of activated T cells in pulmonary arterial hypertension can be therapeutically targeted.

Bonnet S, Rochefort G, Sutendra G, Archer SL, Haromy A, Webster L, Hashimoto K, Bonnet SN, Michelakis ED.

Proc Natl Acad Sci U S A. 2007 Jul 3;104(27):11418-23. Epub 2007 Jun 27.


Oxygen activates the Rho/Rho-kinase pathway and induces RhoB and ROCK-1 expression in human and rabbit ductus arteriosus by increasing mitochondria-derived reactive oxygen species: a newly recognized mechanism for sustaining ductal constriction.

Kajimoto H, Hashimoto K, Bonnet SN, Haromy A, Harry G, Moudgil R, Nakanishi T, Rebeyka I, Thébaud B, Michelakis ED, Archer SL.

Circulation. 2007 Apr 3;115(13):1777-88. Epub 2007 Mar 12.


A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth.

Bonnet S, Archer SL, Allalunis-Turner J, Haromy A, Beaulieu C, Thompson R, Lee CT, Lopaschuk GD, Puttagunta L, Bonnet S, Harry G, Hashimoto K, Porter CJ, Andrade MA, Thebaud B, Michelakis ED.

Cancer Cell. 2007 Jan;11(1):37-51.


An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertension.

Bonnet S, Michelakis ED, Porter CJ, Andrade-Navarro MA, Thébaud B, Bonnet S, Haromy A, Harry G, Moudgil R, McMurtry MS, Weir EK, Archer SL.

Circulation. 2006 Jun 6;113(22):2630-41. Epub 2006 May 30.


Vascular endothelial growth factor gene therapy increases survival, promotes lung angiogenesis, and prevents alveolar damage in hyperoxia-induced lung injury: evidence that angiogenesis participates in alveolarization.

Thébaud B, Ladha F, Michelakis ED, Sawicka M, Thurston G, Eaton F, Hashimoto K, Harry G, Haromy A, Korbutt G, Archer SL.

Circulation. 2005 Oct 18;112(16):2477-86.


Gene therapy targeting survivin selectively induces pulmonary vascular apoptosis and reverses pulmonary arterial hypertension.

McMurtry MS, Archer SL, Altieri DC, Bonnet S, Haromy A, Harry G, Bonnet S, Puttagunta L, Michelakis ED.

J Clin Invest. 2005 Jun;115(6):1479-91.


Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis.

McMurtry MS, Bonnet S, Wu X, Dyck JR, Haromy A, Hashimoto K, Michelakis ED.

Circ Res. 2004 Oct 15;95(8):830-40. Epub 2004 Sep 16.


Oxygen-sensitive Kv channel gene transfer confers oxygen responsiveness to preterm rabbit and remodeled human ductus arteriosus: implications for infants with patent ductus arteriosus.

Thébaud B, Michelakis ED, Wu XC, Moudgil R, Kuzyk M, Dyck JR, Harry G, Hashimoto K, Haromy A, Rebeyka I, Archer SL.

Circulation. 2004 Sep 14;110(11):1372-9. Epub 2004 Sep 7.


The neurovascular mechanism of clitoral erection: nitric oxide and cGMP-stimulated activation of BKCa channels.

Gragasin FS, Michelakis ED, Hogan A, Moudgil R, Hashimoto K, Wu X, Bonnet S, Haromy A, Archer SL.

FASEB J. 2004 Sep;18(12):1382-91.


O2 sensing in the human ductus arteriosus: regulation of voltage-gated K+ channels in smooth muscle cells by a mitochondrial redox sensor.

Michelakis ED, Rebeyka I, Wu X, Nsair A, Thébaud B, Hashimoto K, Dyck JR, Haromy A, Harry G, Barr A, Archer SL.

Circ Res. 2002 Sep 20;91(6):478-86.


Diversity in mitochondrial function explains differences in vascular oxygen sensing.

Michelakis ED, Hampl V, Nsair A, Wu X, Harry G, Haromy A, Gurtu R, Archer SL.

Circ Res. 2002 Jun 28;90(12):1307-15.


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